LOCUS       NM_001321209             688 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dpy-30 histone methyltransferase complex regulatory
            subunit (DPY30), transcript variant 2, mRNA.
ACCESSION   NM_001321209 XM_006712119
VERSION     NM_001321209.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 688)
  AUTHORS   Su,W.C., Mao,X.M., Li,S.Y., Luo,C.Y., Fan,R., Jiang,H.F.,
            Zhang,L.J., Wang,Y.T., Su,G.Q. and Shen,D.Y.
  TITLE     DPY30 Promotes Proliferation and Cell Cycle Progression of
            Colorectal Cancer Cells via Mediating H3K4 Trimethylation
  JOURNAL   Int J Med Sci 20 (7), 901-917 (2023)
   PUBMED   37324189
  REMARK    GeneRIF: DPY30 Promotes Proliferation and Cell Cycle Progression of
            Colorectal Cancer Cells via Mediating H3K4 Trimethylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 688)
  AUTHORS   Dixit,D., Prager,B.C., Gimple,R.C., Miller,T.E., Wu,Q.,
            Yomtoubian,S., Kidwell,R.L., Lv,D., Zhao,L., Qiu,Z., Zhang,G.,
            Lee,D., Park,D.E., Wechsler-Reya,R.J., Wang,X., Bao,S. and
            Rich,J.N.
  TITLE     Glioblastoma stem cells reprogram chromatin in vivo to generate
            selective therapeutic dependencies on DPY30 and phosphodiesterases
  JOURNAL   Sci Transl Med 14 (626), eabf3917 (2022)
   PUBMED   34985972
  REMARK    GeneRIF: Glioblastoma stem cells reprogram chromatin in vivo to
            generate selective therapeutic dependencies on DPY30 and
            phosphodiesterases.
REFERENCE   3  (bases 1 to 688)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 688)
  AUTHORS   Lee,Y.T., Ayoub,A., Park,S.H., Sha,L., Xu,J., Mao,F., Zheng,W.,
            Zhang,Y., Cho,U.S. and Dou,Y.
  TITLE     Mechanism for DPY30 and ASH2L intrinsically disordered regions to
            modulate the MLL/SET1 activity on chromatin
  JOURNAL   Nat Commun 12 (1), 2953 (2021)
   PUBMED   34012049
  REMARK    GeneRIF: Mechanism for DPY30 and ASH2L intrinsically disordered
            regions to modulate the MLL/SET1 activity on chromatin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 688)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 688)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
  REMARK    GeneRIF: hDPY-30 (dpy-30-like protein) binds ASH2L directly. The
            evolutionarily conserved hDPY-30, ASH2L, RBBP5 and WDR5 likely
            constitute a subcomplex that is shared by all human Set1-like HMT
            complexes.
REFERENCE   7  (bases 1 to 688)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   8  (bases 1 to 688)
  AUTHORS   Dong,X., Peng,Y., Peng,Y., Xu,F., He,X., Wang,F., Peng,X.,
            Qiang,B., Yuan,J. and Rao,Z.
  TITLE     Characterization and crystallization of human DPY-30-like protein,
            an essential component of dosage compensation complex
  JOURNAL   Biochim Biophys Acta 1753 (2), 257-262 (2005)
   PUBMED   16260194
REFERENCE   9  (bases 1 to 688)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 688)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ276899.1, BC015970.1 and BM505380.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001321209.1.
            
            Summary: This gene encodes an integral core subunit of the SET1/MLL
            family of H3K4 methyltransferases. The encoded protein directly
            controls cell cycle regulators and plays an important role in the
            proliferation and differentiation of human hematopoietic progenitor
            cells. [provided by RefSeq, Mar 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.186655.1,
                                           SRR5189652.190175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342166.10/ ENSP00000345837.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BQ276899.1         31-74
            45-528              BC015970.1         37-520
            529-688             BM505380.1         29-188              c
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.3"
     gene            1..688
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /note="dpy-30 histone methyltransferase complex regulatory
                     subunit"
                     /db_xref="GeneID:84661"
                     /db_xref="HGNC:HGNC:24590"
                     /db_xref="MIM:612032"
     exon            1..73
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /inference="alignment:Splign:2.1.0"
     exon            74..145
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..409
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /note="isoform 1 is encoded by transcript variant 2;
                     dpy-30-like protein; protein dpy-30 homolog; dpy-30L"
                     /codon_start=1
                     /product="protein dpy-30 homolog isoform 1"
                     /protein_id="NP_001308138.1"
                     /db_xref="CCDS:CCDS1777.1"
                     /db_xref="GeneID:84661"
                     /db_xref="HGNC:HGNC:24590"
                     /db_xref="MIM:612032"
                     /translation="MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQ
                     KVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN"
     exon            146..193
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /inference="alignment:Splign:2.1.0"
     exon            194..336
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /inference="alignment:Splign:2.1.0"
     exon            337..688
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      669..674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /note="hexamer: AATAAA"
     polyA_site      688
                     /gene="DPY30"
                     /gene_synonym="Cps25; HDPY-30; Saf19"
                     /note="major polyA site"
ORIGIN      
        1 acggccggag ctgtttgtgc tgggagctgg tggcgcggtg cagggctctt aagaacgaac
       61 ggcttgggcg cggactggta tccggggact gtgacttgca gggtccgcca tggagccaga
      121 gcagatgctg gagggacaaa cgcaggttgc agaaaatcct cactctgagt acggtctcac
      181 agacaacgtt gagagaatag tagaaaatga gaagattaat gcagaaaagt catcaaagca
      241 gaaggtagat ctccagtctt tgccaactcg tgcctacctg gatcagacag ttgtgcctat
      301 cttattacag ggacttgctg tgcttgcaaa ggaaagacca ccaaatccca ttgaatttct
      361 agcatcttat cttttaaaaa acaaggcaca gtttgaagat cgaaactgac ttaatgggaa
      421 gaacagaaaa atttagttgc tactgtagat ttacatgatt aagaggcagc tttaattgcc
      481 atgatcattc cctctttttg gatgtataag aaccttccgg acaacagaac ctatttctgg
      541 aattgcagaa gataacatat ttcccttatt ttgatttaat caccataaac catacctatt
      601 taatgagtgt attctgtgca atttttttct cagattgtct ttaactttgt ttttaaaatg
      661 accttcaaaa taaactgtca aaacacca
//
