LOCUS       NM_181787               6197 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dpy-19 like 4 (DPY19L4), mRNA.
ACCESSION   NM_181787
VERSION     NM_181787.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 6197)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP873374.1, BC110870.1 and AP003692.2.
            
            On Nov 22, 2018 this sequence version replaced NM_181787.2.
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.219160.1,
                                           SRR1660803.19639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414645.6/ ENSP00000389630.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BP873374.1         26-72
            48-4207             BC110870.1         1-4160
            4208-6197           AP003692.2         56180-58169
FEATURES             Location/Qualifiers
     source          1..6197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..6197
                     /gene="DPY19L4"
                     /note="dpy-19 like 4"
                     /db_xref="GeneID:286148"
                     /db_xref="HGNC:HGNC:27829"
                     /db_xref="MIM:613895"
     exon            1..115
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2271
                     /gene="DPY19L4"
                     /note="protein dpy-19 homolog 4; dpy-19-like protein 4"
                     /codon_start=1
                     /product="probable C-mannosyltransferase DPY19L4"
                     /protein_id="NP_861452.2"
                     /db_xref="CCDS:CCDS34924.1"
                     /db_xref="GeneID:286148"
                     /db_xref="HGNC:HGNC:27829"
                     /db_xref="MIM:613895"
                     /translation="MAEEEGPPVELRQRKKPKSSENKESAKEEKISDIPIPERAPKHV
                     LFQRFAKIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSY
                     YKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSLYPELIASILYQATGSNEIIEP
                     VYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRE
                     NWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAIS
                     LFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQ
                     LNVKKGSFVAKIIKVINFYLVCTLTITLNIIMKMFVPHKENGHMLKFLEVKFGLNMTK
                     NFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLK
                     ETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELW
                     MTLFKWLRLRTVHPILLALILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVE
                     LMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKR
                     SAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSK
                     YGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKINTVISFQS"
     exon            116..226
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            227..351
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            352..442
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            443..564
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            565..710
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            711..834
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            835..969
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1101
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1200
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1274
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1433
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1553
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1674
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1731
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1814
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1947
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2106
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..6197
                     /gene="DPY19L4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6174..6179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPY19L4"
                     /note="hexamer: AATAAA"
     polyA_site      6197
                     /gene="DPY19L4"
                     /note="major polyA site"
ORIGIN      
        1 aggagcgggc ccccggaggc cgaggggttc ggcgacgcgg agggagggag agtctgggcc
       61 gcgcgggagc cgcagggcgc cctagccttc gcagaaacga tggcggagga agaaggacca
      121 cctgtagagc tgcgccaaag aaaaaagcca aagtcttcag aaaataagga atctgccaaa
      181 gaagagaaaa tcagtgacat tccaattcct gaaagagctc caaaacatgt attatttcaa
      241 cgctttgcaa agattttcat tggctgtctt gcagcggtta ctagtggtat gatgtatgct
      301 ctctacttat cagcatacca tgaacggaaa ttctggtttt ccaacaggca ggagcttgaa
      361 cgggaaatca cgtttcaggg tgacagtgcc atttattact cctattataa agatatgtta
      421 aaggcacctt catttgaaag aggtgtttac gaactgacac acaataacaa aactgtatct
      481 ctgaagacta taaatgcagt gcagcaaatg tctctgtatc cggaacttat tgctagcatt
      541 ttatatcaag ccactggtag caatgagatt attgagccag tgtatttcta tattggcatt
      601 gtttttggat tgcaaggaat atatgttact gctttatttg ttacaagttg gcttatgagt
      661 ggaacatggc tagcaggaat gcttactgtt gcgtggttcg ttattaacag ggtagataca
      721 acaagaattg aatactccat tcctttaaga gaaaactggg cactaccata ttttgcatgc
      781 caaattgctg cacttacagg ctatttaaaa agcaacttaa atacttatgg agagaggttt
      841 tgctacttgt tgatgagtgc ttcaacttac acatttatga tgatgtggga gtatagccac
      901 tatctcctgt ttcttcaagc aatatctcta ttcctgctag ataccttttc agtggagcaa
      961 agtgacaagg tttatgaagt ttataaaatc tacatatttt ccctctttct gggatattta
     1021 ctacagtttg agaatccagc tttgttggta tctcctttat taagtttagt agcagcctta
     1081 atgcttgcta agtgccttca gctgaatgtg aagaaaggaa gttttgtagc taaaataata
     1141 aaagtgatta atttttactt ggtgtgtact ctgacaataa cattgaatat tataatgaag
     1201 atgtttgtcc cacacaaaga aaatgggcac atgctgaaat tccttgaagt aaaatttgga
     1261 ctaaatatga ccaagaattt tacaatgaat tggctcctct gtcaagaatc cctgcaggca
     1321 ccatctcaag atttttttct gcgattgaca cagtcttctt tattaccttt ctacattcta
     1381 gtgttaatta tttgttttct ttctatgttg caagttattt ttaggaggat taatggtaag
     1441 tccctgaagg aaactgttac tcttgaagat ggacgaattg gagaaagacc agaaataatt
     1501 tatcatgtaa ttcacactat tttattgggt tctcttgcaa tggttataga aggcttgaag
     1561 tacatctgga ttccttatgt gtgcatgtta gcagcatttg gtgtatgttc tcccgaactt
     1621 tggatgacac ttttcaagtg gcttcgatta agaactgtac acccaatatt gttggctctt
     1681 attctgagca tggccgtgcc tactataata ggtctcagct tatggaaaga gttttttccc
     1741 agattaatga cagaattaat ggaactacag gaattctatg acccagatac agtggaactt
     1801 atgacctgga taaaaaggca agctccagtt gcagctgtgt ttgcagggag tccacagtta
     1861 atgggtgcga ttaaattatg cactggatgg atggtgacaa gtttgcctct ttacaatgat
     1921 gatgatcttc tcaagagaaa tgaaaatatc taccaaatct attcaaagcg atctgctgag
     1981 gatatttata aaatactgac atcttacaaa gctaattacc taattgtaga ggatgctatc
     2041 tgcaatgagg tgggacccat gagaggctgt agggttaaag atttattaga cattgcaaat
     2101 ggccacatgg tttgtgaaga aggtgacaag ctaacctact caaaatatgg gcgattttgt
     2161 catgaggtca aaattaacta ttctccatat gtgaattatt tcactagagt atactggaac
     2221 agatcctact ttgtatataa aatcaacact gtgatatcct tccagtcttg aaaaataaca
     2281 gagccttcat ttcaaagact acctgaagta aaatgcagtt ttcttctacc tactcggtgt
     2341 cttttgcaga tcagagtatg gacatttgaa atattgctgc ttctttcccc cttctgctgt
     2401 taactggatc cagagttctg tgggaaatag aagatcaagc attactgtcc tttgattaaa
     2461 tgtgatatct accactctgc aatattccag acaggtgtct tccttaccgt tacatggtct
     2521 ttaacacttt tactgattgc aatattttcc ccataaaatc ttcattctat tataatattg
     2581 atcttgaatt tgaatatgtg caaggtcaga tacatttctc aaacataaca tttaataaat
     2641 aatgtgatat aattatttaa tagaaagaat aattccgacc ttcaagcaag tttctgaagg
     2701 tattttatga tgtataacaa ctgaagtttt acaataaaaa ctaatttaaa tgttagctga
     2761 agatatgtgg catttaaatt aaaatggaaa ttatataaag gaaagtgatt tttaaggata
     2821 tacataaaga tatatttaga attttcatga tactgttctc ctcatctact gcttatgtta
     2881 agtgagaact ttcttagtaa tacataatgc atgatgttac tgcattttct aaatgactag
     2941 taagtgatta gttttttcac ttatgcctat taatttgata ccaatttaat catgataaaa
     3001 caataaccgt taacatatat tttgttaaat ggacatttaa aagaatgttg ttcaggtttt
     3061 ttttttaaat actgatatgg ggcatacaat ctattcacat gttttctact gaagtactaa
     3121 gtaaaaaaat taaatcatta tcagaataaa aatatgtgtt ctaaaattag caacaatttc
     3181 tggggataca tgcagatgtt gttaaacgta cctctgcata cagatatatt ataaaacaca
     3241 agcaatgtta tttatgaaac tgtgatgcag tcttcaacat caagaaaaaa tgacaactat
     3301 aataaaattt acaacacagt ttcacagtct aaatgctatg ttcctttaag tattttcata
     3361 tttttaatca tttattaaga gaaaattgtg aaaagttaat ttggccttat agagagattc
     3421 aggatagatg tagcctatag atgtgtcatt ttaataagtt gggatacatg tttagttttt
     3481 ccttatattc ctgttcagtg aacagatttt cataattctc acttgttaaa gtgctgcaaa
     3541 aattgcattt tcagtactct aaattactac attagaagag agcatttctc cattgtcttt
     3601 attttctgtt atatatgtgt tgtaaaagta cactacatta gaagggagct tttccgttgt
     3661 ctttattttc tgttatacat gtgttgttaa agtacatgca ttcttagact aactctcaga
     3721 tgctttgctc ttttggagct gaagaattgt ttgatggtga tgtcatatat ctgatagatt
     3781 agtttcagtg gttctcattt cacttttata cgtaatttct taactatatt aagatagttg
     3841 caggcagtgt acctcaggtt gactctgtac atctgaatag tgagtcacta gtattttgct
     3901 tcaagccttc tgaaaatata accatagtta cctaagcaca cagtgaatag tcacatggta
     3961 gtacttgtga ttagagcatg taaaacaatg taattgaaaa gtcagcttcc atattttgta
     4021 ggggaaatag aacaccctac tttttatcta gtgtgaaata tttaatcgaa tttttgttga
     4081 tttatattat gttacctgtg ctgaattagg tttggtactt gtgttttgtt tgacatatta
     4141 gtaagttgct tttgcttctt tctgtcaact tattttttaa ataaaattga tctggaaaaa
     4201 ttgttaatgg gatgttttaa ataatgaatt tttcatccag catcagttga aaaggaaaag
     4261 aaagcttcat tatggaaatg acaatattga atatgacaga taagtttatt tgcttctgtt
     4321 ttaactgcag ttaatagtac tagacaactt taagtggaaa gcatttagtt tatttcttca
     4381 cttatttgta gagtgaacaa atgattcaca attctacaag taattccact taggtaactt
     4441 acagttgtta ggtttgacaa taaagatcta ctatgagagg agaagaattt atgggttttg
     4501 ggtggaagga atttctcaaa gaaataaaaa atgttctttg cccttgatac tgcaaaccca
     4561 ctgatacaag tgccttgaat ttattattat tattattttt tatttttttg agatggagtt
     4621 tcactcttgt ctcccaggct ggagtgcaat ggcgcgatct tggctcactg caacctccgc
     4681 tcgctgcaac ctccgcctcc caggttcaag tgattctcct gcctcagcct ccggagtagc
     4741 tgggattaca ggcacctgcc accaagcacg gctaattttt gtatttttag tagaaacggg
     4801 gtttcgccat gttggccagg ctggtctcga actcctgacc tcagatgatc cactcacccc
     4861 agcctcccaa agtgctggga ttacagacgt gagccactgc gcccggcgca agtctttgtt
     4921 aaaagtagag atggaggcca ggcgcagtgg ctcactcctg taatcccagc actttgggag
     4981 gctgaggcag gcagatcacg aggtcaggag atcgagacca tcttggctaa cacggtgaaa
     5041 ccccgtctct actgaaaata caaaaaatta gccgggcagg gtggcgggcg cctgtagtcc
     5101 cagctactcc gaggctgaag caggagaatg gcgtcaagcg gcgaggcgga gcttgcggtg
     5161 agccgagatc atgccgctgc actccagcct gggcaacaga gcaagactcc atctcaaaaa
     5221 gaaaaaaaaa gtagagatgg gatctctagc ctcctaagtt aatttagcct cccaaatgcc
     5281 agacaaagaa tctaacataa aatttacctt gaataagata tatgatattg attctgagct
     5341 gctttgtatt ttttctgact ttggcatctg tatcttggtg ctttctgtta gactggtaga
     5401 gtttaagaac ctaaggagta tgcattgtac ttcagtgcta acttttttct tcatttactt
     5461 tctgtgtata taggcagcat attttttttg tagaacatta acccagattg ctaatagctt
     5521 catgttacgg cattcttcca cacagtccag attgatttaa ggaaaagcag aaatggaagt
     5581 caaagtgtgt tataaattga gactgaaaaa catgctttaa aaaatagatt taatttctta
     5641 cactgtgaat agccattgta ttgttttgtt tctgataaat cagttgtttt gggcccctat
     5701 ttttgaactg ttaaaaaatt ttgatgcttt tcgtggataa aagtagtgcc tctctttata
     5761 caactgatgg ggttttaaaa agtgtaaatt gccttttttg ttaaacttat tttaaatgct
     5821 ttagtattta aagggtgtat gttattaatt aatctgcata tttgtaacgc aaataactac
     5881 ttcctgattt acatctcaat atattcttct ttcatttgcc caatttaaaa aatacgtagt
     5941 ctctattgtt gctgtttact aatagtttta gatcccaatg tgtattagaa ttatagctac
     6001 aaaaagttgc aagtaaaatt tagcaatttc ctattcaaac aggatctcat tagtatgttt
     6061 tttaatgtgt agaattaaca ctttaaaata aacaggtgtg aaaattataa aggaatatat
     6121 atgacaatta ttttctgtac attaatgtct aaacattata cttacttttt cataataaag
     6181 gaaattttgg aaccaaa
//
