LOCUS       NM_001172774            5978 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dpy-19 like C-mannosyltransferase 3 (DPY19L3),
            transcript variant 2, mRNA.
ACCESSION   NM_001172774
VERSION     NM_001172774.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5978)
  AUTHORS   Baydoun,H., Kato,Y., Kamo,H., Husch,A., Mizuta,H., Kawahara,R. and
            Simizu,S.
  TITLE     DPY19L3 promotes vasculogenic mimicry by its C-mannosyltransferase
            activity
  JOURNAL   Oncol Res 32 (4), 607-614 (2024)
   PUBMED   38560568
  REMARK    GeneRIF: DPY19L3 promotes vasculogenic mimicry by its
            C-mannosyltransferase activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5978)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5978)
  AUTHORS   Niwa,Y., Nakano,Y., Suzuki,T., Yamagishi,M., Otani,K., Dohmae,N.
            and Simizu,S.
  TITLE     Topological analysis of DPY19L3, a human C-mannosyltransferase
  JOURNAL   FEBS J 285 (6), 1162-1174 (2018)
   PUBMED   29405629
  REMARK    GeneRIF: Data indicate that N-glycosylations of
            C-mannosyltransferase DPY19L3 (DPY19L3) do not have any roles for
            its enzymatic activity.
REFERENCE   4  (bases 1 to 5978)
  AUTHORS   Niwa,Y., Suzuki,T., Dohmae,N. and Simizu,S.
  TITLE     Identification of DPY19L3 as the C-mannosyltransferase of
            R-spondin1 in human cells
  JOURNAL   Mol Biol Cell 27 (5), 744-756 (2016)
   PUBMED   26764097
  REMARK    GeneRIF: DPY19L3 is the C-mannosyltransferase of Rspo1 at
            tryptophan(156).
REFERENCE   5  (bases 1 to 5978)
  AUTHORS   Smith,E.N., Bloss,C.S., Badner,J.A., Barrett,T., Belmonte,P.L.,
            Berrettini,W., Byerley,W., Coryell,W., Craig,D., Edenberg,H.J.,
            Eskin,E., Foroud,T., Gershon,E., Greenwood,T.A., Hipolito,M.,
            Koller,D.L., Lawson,W.B., Liu,C., Lohoff,F., McInnis,M.G.,
            McMahon,F.J., Mirel,D.B., Murray,S.S., Nievergelt,C.,
            Nurnberger,J., Nwulia,E.A., Paschall,J., Potash,J.B., Rice,J.,
            Schulze,T.G., Scheftner,W., Panganiban,C., Zaitlen,N., Zandi,P.P.,
            Zollner,S., Schork,N.J. and Kelsoe,J.R.
  TITLE     Genome-wide association study of bipolar disorder in European
            American and African American individuals
  JOURNAL   Mol Psychiatry 14 (8), 755-763 (2009)
   PUBMED   19488044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA852420.1, AK129497.1, AK126757.1 and AL833713.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001172774.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Both variants 1 and 2
            encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.211580.1,
                                           SRR1803615.195009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392250.7/ ENSP00000376081.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA852420.1         22-22
            2-824               AK129497.1         4-826
            825-825             AK126757.1         863-863
            826-2536            AK129497.1         828-2538
            2537-3858           AK126757.1         2575-3896
            3859-5978           AL833713.1         3859-5978
FEATURES             Location/Qualifiers
     source          1..5978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..5978
                     /gene="DPY19L3"
                     /note="dpy-19 like C-mannosyltransferase 3"
                     /db_xref="GeneID:147991"
                     /db_xref="HGNC:HGNC:27120"
                     /db_xref="MIM:613894"
     exon            1..140
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            141..280
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..2328
                     /gene="DPY19L3"
                     /note="protein dpy-19 homolog 3; dpy-19-like protein 3;
                     probable C-mannosyltransferase DPY19L3; dpy-19-like 3;
                     dpy-19 like 3"
                     /codon_start=1
                     /product="protein C-mannosyl-transferase DPY19L3"
                     /protein_id="NP_001166245.1"
                     /db_xref="CCDS:CCDS12422.1"
                     /db_xref="GeneID:147991"
                     /db_xref="HGNC:HGNC:27120"
                     /db_xref="MIM:613894"
                     /translation="MMSIRQRREIRATEVSEDFPAQEENVKLENKLPSGCTSRRLWKI
                     LSLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQML
                     QAPTLVQGFHGLIYDNKTESMKTINLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYI
                     YTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLRENWALP
                     FFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLD
                     SLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKT
                     GSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGLGATRDFDA
                     NLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTNQQSVG
                     KMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELL
                     LKSVHLYNPKRICIMRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWIN
                     SNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVH
                     ALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPR
                     FCEEIKRNLPPYVAYFTRVFQNKTFHVYKLSRNK"
     exon            281..414
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..505
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..627
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..773
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..897
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1032
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1164
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1266
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1340
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1499
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1622
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1734
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1791
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1874
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2007
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2166
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..5978
                     /gene="DPY19L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5957..5962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPY19L3"
                     /note="hexamer: AGTAAA"
     polyA_site      5978
                     /gene="DPY19L3"
                     /note="major polyA site"
ORIGIN      
        1 atttccacaa agctccgcgg cggttctgcc ctccttgtac ccgcggcgcg ctgcggcccg
       61 tggcgcggcc ccgttcccgc ctagccccgt cggcctcctt cccctcccgg agccgcgcgt
      121 gaggacggct gaggccgcag gagtgatttg gagaacaatg catgtaagtc tgacatcatg
      181 atgtccatcc ggcaaagaag agaaataaga gccacagaag tttctgaaga ctttccagcc
      241 caagaagaaa atgtgaagtt ggaaaataaa ttgccatctg gttgtaccag tagaagatta
      301 tggaagattt tgtcattgac aattggtgga accattgccc tttgcattgg acttcttaca
      361 tctgtctacc ttgccacgtt acatgaaaat gatttatggt tttctaatat taaggaagtg
      421 gagcgagaaa tctcattcag aacagagtgt ggcctgtatt actcctacta caagcagatg
      481 ctgcaggctc caaccctcgt gcaaggtttt catggcctaa tatatgataa taaaactgaa
      541 tctatgaaga caattaacct ccttcagcga atgaatattt accaagaggt ttttctcagt
      601 attttatata gagttctacc catacagaaa tatttagagc cagtttattt ttatatttac
      661 accttatttg ggctccaggc gatctatgtc acagctctct acataaccag ctggctactc
      721 agtggtacat ggctgtcagg actgttggca gctttctggt atgtcacaaa tagaatagat
      781 accacaagag ttgagtttac catcccactg agggagaact gggcgctgcc attctttgca
      841 attcagatag cagcaattac atatttcctg agaccaaact tacagcctct ttctgaaagg
      901 ctgacacttc ttgccatttt catatcaact tttctcttta gtctgacatg gcaatttaat
      961 caatttatga tgctgatgca agcattagtg ctgttcacac tggactccct ggacatgctg
     1021 ccagcagtga aggcgacatg gctgtatgga atacagataa caagtttact cctggtctgc
     1081 attcttcagt tttttaattc catgattctt ggatcactgc ttatcagttt taacctttca
     1141 gtattcattg caagaaaact tcagaaaaat ctgaaaactg gaagcttcct taataggctt
     1201 gggaaacttt tgttacattt atttatggtt ttatgtttga cactttttct caacaacata
     1261 attaagaaaa ttcttaacct gaagtcagat gaacacatat ttaaatttct gaaggcaaaa
     1321 tttgggcttg gagcaacaag ggattttgat gcaaatctct atctgtgtga agaagctttt
     1381 ggcctcctgc cttttaatac atttggaagg ctttcagata ctctgctttt ttatgcttac
     1441 atattcgttc tgtccatcac agtgattgta gcattcgttg ttgcctttca taatctcagt
     1501 gattctacaa atcaacaatc cgtgggtaaa atggaaaaag gcacagttga cctgaaacca
     1561 gaaactgcct acaacttaat acataccatt ctgtttggat tcttggcatt gagtacaatg
     1621 agaatgaagt acctctggac gtcacacatg tgtgtgttcg catcattcgg cctatgtagc
     1681 cctgaaatat gggagttact tctgaagtca gtccatcttt ataacccaaa gaggatatgt
     1741 ataatgcgat attcagtacc gatattaata ctgctgtatc tatgctataa gttctggcca
     1801 ggaatgatgg atgaactctc cgagttgaga gaattctatg atccagatac agtggagctg
     1861 atgaactgga ttaactctaa cactccaaga aaggctgtgt ttgcgggaag catgcagttg
     1921 ctggccggag tcaagctgtg cacgggaagg accctaacca accacccgca ctatgaagac
     1981 agcagcctga gagagcggac cagagcggtt tatcagatat atgccaagag ggcaccagag
     2041 gaagtgcatg ccctcctaag gtccttcggc actgactacg taatcctgga agacagcatc
     2101 tgctacgagc ggaggcaccg ccggggctgc cgactccggg acctgctgga cattgccaac
     2161 ggccacatga tggatggccc aggagagaat gatcctgatt tgaaacctgc agaccaccct
     2221 cgcttctgtg aagagatcaa aagaaacctg cctccctacg tggcctactt caccagagtg
     2281 ttccagaaca aaaccttcca cgtttacaag ctgtccagaa acaagtagcg cagatttctg
     2341 cccagtgtct atttttgata cggagaaact gcatcatgat gaaactcaat agatgacgtt
     2401 tcctatgtaa gtaggtagcc caaaccttca agctgtgata tgagtaagtt ctacagatgt
     2461 ttacacaagt gttgccatct ttgaaagcat cttctacaag cagaagtctt tttcgttgtg
     2521 tgtctatctt tctcattaat gttctttagc ctaaatgtta acaactttct aagagtgacc
     2581 tagaattatg ttgttggaga gaatgatgtg tgttccatgg atacctggat aggcacataa
     2641 catgttggaa gatgagcacc tgctcaggat ttgaaatacg tttaattttc aggtgactta
     2701 agacagctat gattgaatca actagagatg atgatcgact tatttaatat gatttcactg
     2761 gtgaagacca attggtagct ttttaaaaag cactttagtg tcctgtttta ccttaaaatg
     2821 ttataatatt ttccagttgt catgctgtca acattaacaa aaaaaatcat gttaaggctt
     2881 tgtatcaaac attttgttac actctgtctg aaatgtaatg tggagtactt cagcagtatg
     2941 tgtcatgtat tgtgtgtgtc tgtgtgtgtg catgtgcaca catgtgtttt aatgctgggc
     3001 acagaaaagt gttacaagtt ccatatcgta agtccttaaa ggggcagaaa tatatgtagc
     3061 caagtagaat ttattacatt ttagtgttat tattttaaaa cttactgata ctctttaacc
     3121 tctcctgcag taatagtttt gctttatttc ttactcattt caatttattg ggtttgcaaa
     3181 attttgtaaa ctttttgtgt ttttagcctt tgtatttttt acagcctaga atcttgcaaa
     3241 gtctgaatat tttttaaatg ttctatctta actagttcac taatacagta tttttagcag
     3301 acagcatttt cagacagcat tttcatacca agtttgactt gtggtctcca atcttactgg
     3361 gaaggccctg gtagtgtaat tcttttcctt attaaaaggt aaccaagtgc ctctaagtca
     3421 tgcttatttg taaacaacaa agaagagtat atgtacctgc tcaaaatttt tttgataatc
     3481 gcttatataa ttaatttcta atgatgagga catgtaaaag ttgccagtaa gaacatagta
     3541 tgcatttaat taaatcaaga tggctaatgg aattaacttt ctcccctgtt cttgccaggt
     3601 ggaaatgatt taagcatttc tccttgcagt tgtattgaag taaattacca taggcatcaa
     3661 gatggctgca tcacattttc aaatgatttt atattcagtt gctacttata aagcagcatt
     3721 caaaaagtct tttacactgt catgttggac acaagcagac tcagctttta tcaaaacttg
     3781 tttaaataaa aaattgacag tagctgggtt attaaattat gcaactgaaa ctcctgaatt
     3841 atatcttttc tgtatccctt aataagattg gagaccactg ccgtttagga taatacaata
     3901 ataaaacgtt ttaatcagta ctaaaacttt aattaagcca ataatgatgc atgcctgttg
     3961 tagctgacag catgggtcag tacatccttc agcgagtgcc ttactctaat tgaaaccaag
     4021 cacacgtaag gtacaatatg ttagactctg tgattttgtt ttcaaaatcc tctgttatgg
     4081 ctatatttaa atttatttta aatattcctg tatgtattca tctaagcatt tgggcatttg
     4141 gagtcttaat atacaagaaa cacgtactta aatttttatg cttatcaccg caatgatggc
     4201 aaacagtgat tttttttttc atagtttagg tgtcattgtt gccagcacct ttagtgctca
     4261 gtcttcagtg aaaaatataa agtgccaaaa aaatcttgca agacagaatc catacttaac
     4321 actctttcca agacactgtg accatgtaca gtagctattt cctgatgacc aaatctctca
     4381 acgaatcatg ttattaataa atatttttag cactcatcag tattctccaa tgtgaccttc
     4441 tcattggagt acacagaagg aaagcaaaga agagcatctg acttctagct ctggcttaca
     4501 gcctctctac caggccgaag caagagaccc gcggcagcag ctccccgcca ctcagacctg
     4561 ggtggtgata acctcaaaga atggctctgt tttctattga cagaaaaccc acttgatttt
     4621 gcttctgagt tagcagtcag aagaccctct aagtacaata gaagtgctct taacggactc
     4681 tgcctgtgtg actcccaggc cccggagtct ccatctctct cgtaagccac ctgccacagc
     4741 acagctggag gctgttctct ggtgttctca gcgctccggc tccctccctg gagttgtgca
     4801 cccgtcccaa actcctccat gcaagttctg cttcctctta taagtacaca actcagttaa
     4861 gtattcacat acacacagaa aatacgggtg tgaaaagaaa gaattttctg taaaaattaa
     4921 gttgaatact ttggtaaaaa gtgataaagg ctgagttgcc aataaaagtt gcttttaaat
     4981 taggtgtggc tgggaatatt ataagatatt ggggaaaata tacaaatcaa gaaaatttct
     5041 gagcttagat tgcttcatag atttatttaa gtactcatcc cacctttaaa acctctaaac
     5101 tgagaagaag ggacccaaat catgttattg gtgtgattta tgtgagaagt agaactgtag
     5161 tcattggacc cttaggcaaa ggaaaatccg tgtctttata tcagaagatc ggcaaacgaa
     5221 tgtatattac acagtttagg ttatgattcc ctactttaac ctacttactt tattaaatga
     5281 ccaactactg atactgatca caatagttat tagagattct aatttagttg gaaggttcta
     5341 atcactttca ttacaggcat ttgaaaaata gggattcatt tcgaatatat tagccaggag
     5401 catagttaga tgttacccag gccatttatc atcctgttaa tgatgatttt cccgaccctt
     5461 gtgagatcag cgtgacagga gtgtgtgtgt gtgtgtgtgt ttctgtgggt gtgtggtttt
     5521 ggttgggtgc tgccaggtgg caaaggcata tgtaaataca tctgatctgc atctttattt
     5581 cacagttaac taaaagtaaa aatgtctatt ctgattccat attgattttg tctaagatgt
     5641 aaaaatttga gttcatcttt ggccaaaacc tacctgaatt aacatacaaa atatttgatt
     5701 tttaaaattt aattcaaatc tcaaaatcaa ttaagtattc tcagatccta tatcttggtt
     5761 aatatgctcc cagatacttt aaacatggca accttttggc ctaagagaat gtttgttcat
     5821 ggaaaaaagc ttttgagatg agagggtgtc ttactttctt gtggcaattg attttctgtt
     5881 ttaacaccct ttgggtaaaa tcttgcaaag agcttttata atttgtttta ctgaattgta
     5941 tggagattgt ataccaagta aagctctttt aaattaca
//
