LOCUS       NM_001366673            5030 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dpy-19 like C-mannosyltransferase 1 (DPY19L1),
            transcript variant 1, mRNA.
ACCESSION   NM_001366673 XM_011515245
VERSION     NM_001366673.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Shcherbakova,A., Tiemann,B., Buettner,F.F. and Bakker,H.
  TITLE     Distinct C-mannosylation of netrin receptor thrombospondin type 1
            repeats by mammalian DPY19L1 and DPY19L3
  JOURNAL   Proc Natl Acad Sci U S A 114 (10), 2574-2579 (2017)
   PUBMED   28202721
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    Erratum:[Development. 2012 Mar;139(6):1225]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005401.1, AC004712.1, AC005271.1 and AC004711.1.
            
            On Oct 13, 2018 this sequence version replaced XM_011515245.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.217658.1,
                                           SRR1660807.57592.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638088.2/ ENSP00000490722.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AC005401.1         31336-31724         c
            390-414             AC005401.1         12811-12835         c
            415-502             AC005401.1         12121-12208         c
            503-640             AC005401.1         7807-7944           c
            641-761             AC005401.1         5569-5689           c
            762-855             AC005401.1         4707-4800           c
            856-913             AC004712.1         16911-16968         c
            914-1005            AC004712.1         541-632             c
            1006-1105           AC005271.1         35519-35618         c
            1106-1183           AC005271.1         32980-33057         c
            1184-1270           AC005271.1         24070-24156         c
            1271-1330           AC005271.1         21394-21453         c
            1331-1411           AC005271.1         20784-20864         c
            1412-1513           AC005271.1         15883-15984         c
            1514-1585           AC005271.1         13716-13787         c
            1586-1635           AC005271.1         11753-11802         c
            1636-1660           AC005271.1         8701-8725           c
            1661-1780           AC005271.1         7851-7970           c
            1781-1955           AC005271.1         6239-6413           c
            1956-2055           AC005271.1         5362-5461           c
            2056-2181           AC005271.1         4080-4205           c
            2182-5030           AC004711.1         34496-37344         c
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2"
     gene            1..5030
                     /gene="DPY19L1"
                     /note="dpy-19 like C-mannosyltransferase 1"
                     /db_xref="GeneID:23333"
                     /db_xref="HGNC:HGNC:22205"
                     /db_xref="MIM:613892"
     exon            1..389
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2338
                     /gene="DPY19L1"
                     /EC_number="2.4.1.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein dpy-19 homolog 1; DPY-19-like protein 1; probable
                     C-mannosyltransferase DPY19L1; protein
                     C-mannosyl-transferase DPY19L1"
                     /codon_start=1
                     /product="protein C-mannosyl-transferase DPY19L1 isoform
                     1"
                     /protein_id="NP_001353602.1"
                     /db_xref="CCDS:CCDS94084.1"
                     /db_xref="GeneID:23333"
                     /db_xref="HGNC:HGNC:22205"
                     /db_xref="MIM:613892"
                     /translation="MVLQARNKHREAAPKPPQPPRASQSPLRGASDVGAGEPGPERAP
                     LSPGRKGAAGRKGPRAEPGAPPAGGGLGGRLAARLRWALGLRRAGRGRTWTTLLLAVF
                     AAVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMI
                     MNDKLTEYPLVINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSP
                     IESCEGLGDPACFYVAVIFILNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECT
                     RVMWTPPLRESFSYPFLVLQMLLVTHILRATKLYRGSLIALCISNVFFMLPWQFAQFV
                     LLTQIASLFAVYVVGYIDICKLRKIIYIHMISLALCFVLMFGNSMLLTSYYASSLVII
                     WGILAMKPHFLKINVSELSLWVIQGCFWLFGTVILKYLTSKIFGIADDAHIGNLLTSK
                     FFSYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVVFVAIVRKIISDMWGVLA
                     KQQTHVRKHQFDHGELVYHALQLLAYTALGILIMRLKLFLTPHMCVMASLICSRQLFG
                     WLFCKVHPGAIVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIKYSTKPDAV
                     FAGAMPTMASVKLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKAAEEVKRELIKLKV
                     NYYILEESWCVRRSKPGCSMPEIWDVEDPANAGKTPLCNLLVKDSKPHFTTVFQNSVY
                     KVLEVVKE"
     exon            390..414
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..502
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..640
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..761
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..855
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..913
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1005
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1105
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1183
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1270
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1330
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1411
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1513
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1585
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1635
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1660
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1780
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1955
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2055
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2181
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..5030
                     /gene="DPY19L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5007..5012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPY19L1"
                     /note="hexamer: ATTAAA"
     polyA_site      5030
                     /gene="DPY19L1"
                     /note="major polyA site"
ORIGIN      
        1 ggagagtgag ctgcgcccag ccgcccagcc agcccgccgt tctctggccg ccgtccgggc
       61 gcgcgcagcg agcgggcgcg actatgccaa gatggtcctg caggcgcgga acaagcaccg
      121 ggaggcggct cccaagccgc cccagccacc ccgcgcctca cagtcgccgc tgaggggggc
      181 gtcggacgtc ggcgccgggg agccggggcc cgagcgcgcg cccctgtccc cggggcgcaa
      241 gggcgccgcg ggcaggaagg ggccccgcgc cgagcccggc gcgccgcccg ccgggggcgg
      301 ccttgggggg cgcctggccg cccggctgcg ctgggcgctg ggcctgcggc gcgcggggcg
      361 cggccggacc tggaccacgc tcctgttagc tgtttttgca gcagtgttgc actggagcca
      421 tataacacac ctctttgaaa atgaccgtca tttttctcac ctctcaacat tggaaaggga
      481 gatggctttt cgcactgaaa tgggactata ttattcctat ttcaagacta ttgtggaagc
      541 accctcattt ttgaatggag tatggatgat tatgaatgat aaactgactg aataccccct
      601 tgtcattaat acattaaaaa gattcaatct ttaccctgag gtaattttgg ccagttggta
      661 ccggatttat accaaaataa tggacttgat tggtattcaa accaagatat gttggacggt
      721 taccagagga gaaggactca gtcctattga aagctgtgaa ggattgggag atcctgcttg
      781 cttttatgtt gctgtaattt ttattttaaa tggactaatg atggcattat tcttcatata
      841 tggcacatat ttaagtggca gccgattagg aggcctggtt acagtgttgt gcttcttttt
      901 caatcatgga gagtgtaccc gtgtaatgtg gacaccacct ctccgtgaaa gcttctcata
      961 tccatttctt gttcttcaga tgttgctagt gactcatatt ctcagggcta caaaacttta
     1021 tagaggaagc ttgattgcac tctgcatttc caatgtattt ttcatgcttc cttggcagtt
     1081 tgctcagttt gtacttctta ctcagattgc atcattattt gcagtatatg ttgtcgggta
     1141 cattgatata tgtaaattac ggaagatcat ttatatacac atgatttctc ttgcactttg
     1201 ttttgttttg atgtttggga actcaatgtt attaacttct tattatgctt cttctttggt
     1261 aattatttgg ggtattctgg caatgaaacc acatttcctg aaaataaatg tatctgaact
     1321 tagtttatgg gttattcaag gatgtttttg gttatttgga actgtcatac ttaaatactt
     1381 gacatctaaa atttttggta ttgcagatga cgctcatatt ggcaacttac taacatcaaa
     1441 attctttagt tataaggatt ttgatacttt attgtatacc tgtgcagcgg agtttgactt
     1501 tatggaaaaa gagactccac tgagatacac aaagacatta ttgcttccag ttgttcttgt
     1561 agtgtttgtt gctattgtta gaaagattat tagtgatatg tggggtgtct tagctaaaca
     1621 acagacacat gtaagaaaac accagtttga tcatggagag ctggtttacc atgcattgca
     1681 attgttagca tatacagccc ttggtatttt aattatgaga ctaaaactct tcttgacacc
     1741 acacatgtgt gttatggcat cactgatctg ctcaagacag ctatttggat ggctcttttg
     1801 caaagtacat cctggtgcta ttgtgtttgc tatattagca gcaatgtcaa tacaaggttc
     1861 agcaaatctg caaacccagt ggaatattgt aggggagttc agcaatttgc cccaagaaga
     1921 acttatagaa tggatcaaat atagtactaa accagatgca gtgtttgcgg gtgccatgcc
     1981 cacgatggca agtgttaagc tctctgcact tcggcccatt gtgaatcatc cacattatga
     2041 agacgcaggc ttgagagcca gaacaaaaat agtatactca atgtatagtc ggaaagcagc
     2101 cgaagaagtg aagcgagaac tgataaagtt aaaagtgaac tattacattc tagaagagtc
     2161 atggtgtgta agaagatcca agcctggttg cagtatgcct gaaatttggg atgtagaaga
     2221 tcctgccaat gctgggaaaa ctcccttatg taacctcttg gtgaaggatt ccaaacctca
     2281 cttcaccact gtattccaga acagtgttta caaagtccta gaagttgtaa aagaatgact
     2341 gctacatgac ctgctgccta cggagaacta catctgtaat ggttttaatg ttttgctaag
     2401 tcatgtgttg ttcatatccc aaaaactttt ataggtaact gttttcaaat agaaaacgtt
     2461 ttatttggtc aatttgaatg tcattctaat tataaaaatg acttacacct ttatcaattg
     2521 gttactattt caatgcaccc tttaaaattt gctatgcaaa tgagtatatg cttgtacttg
     2581 actttaatat ttgtgctaaa gtgagcaaag ctacctgtat aaagaaaaca cagtgggttg
     2641 tgacaaggat gacatgaaaa tacaggacaa ttctgacaat gtaggggctg attttatagt
     2701 gtaagaacta ttaatgcccc ttgcttcttt tttctgcctc ttgctcttgt cttttggaca
     2761 tttcagtgat tgtaagttct tcggtcatgt cagcccctgt catcaacttg agttacagta
     2821 gatggggcag acatggagtg tttgctatat agaactatct gtttgtttta cttccttgtg
     2881 cgctttttgt tctctgttct cttgttaatg aagcttttcc tgcccattat taatccaaac
     2941 tcttggacct tgtggttagg aaattccctt aacttccagc catatggcat tatcgtgtct
     3001 ctttctctct ctctcttgct ctctctcttc tcctcttccc catattttct gtcaaataag
     3061 tactgtttac tcatttagtt gcttatcaag tacttattct tggttttaaa aaaaattaat
     3121 ggtaactgta tttttctcat ttttagcatt attcaaatgt ttatatttta atacctttaa
     3181 accactttaa agttttttca tgtttaatta tagttttaag aaaaactatt ttgaacaacc
     3241 ccaaatatag tgcatctaga aactaatgta tatttgatta gacatcattt atagtggaac
     3301 agtagactgt agtacatggt aatttttctt ttactattaa gatacaataa aacatgacta
     3361 attttgctgt caaaaatgta aagaataatg ataaatggag tttttatatt ttacttttaa
     3421 gattgcctgt ctttaataag acaaagcctt aagccttatg ttataatttt ggttctaaaa
     3481 accatcattt cagtataagg aataagtata tttcgtcctc ctctttagtt tttttcttcc
     3541 tatttatttt tattttgaaa aatttctaca ccttctttga attccttgta tgaatttttg
     3601 tttcttagaa gttaatttgt gtgaaatgag attcttcaaa acgatgaaac ctcatagctc
     3661 tgagaaaagg ttttagggtt ttaaattcta agcaaagcgt gactatggct gacagactac
     3721 acatttaatt atacagcttc tctttcttaa ccacaggcag attaacctca ttgtggattg
     3781 tccttcagac cttagtcctc aggcatggtt tctggtgccc actcctggaa gccgctgttc
     3841 cctttctacc ttcttaccag agcccaaggg caggcctggt cccggggaag cagcagcttg
     3901 ctgacataag tcagctgcaa aggctgagga gtgtgccctc agagaagcac cgccccccag
     3961 tcttgtgcca gcgcctagag ccgcagctcc cagggatgct ccttccctgg aggcagccca
     4021 ggagagggac tctggcagcg ttcttcagat ttgtggccac tgtttctcat ttgctggttg
     4081 actgttttta tttcttaggc ttttgctagt tttagaaaat agggaagcag cccttgattt
     4141 gtggattaaa agcaacattt gagcgatgat gcacaacagt ccaggaaaat gggcggtgga
     4201 cacttgaggc tgaggatggg agttgacatg agcagggaga gggaggtgcg cgctgcttat
     4261 ctgtgattgt tgctcacctg agtgtggctg attgtgtaca tccagcagtt acaattttta
     4321 aaaattatac ttttacattt attttatatt tttctcaccc ccagtaattt ccttccaaag
     4381 aagttcacat gtaataagta gaaattctgt ataggaaaaa agcattaaaa atactattat
     4441 aactgcttca tttgctggga accattaaaa gtaatataaa ttagcttttt ccagaaggat
     4501 ccttttgtag cagtgtttat gaatgtaacc cccagcaaaa tatggctata tattagggga
     4561 gccagtttgg agcagaggcc tgaaggtccc tgctatgcag ccgtggccac agctcgcagc
     4621 ccaagcactg tggagcatcc acacctttga tggcaatgca gattggtagc aggttccata
     4681 ggcgtacaaa acagtattaa agctcagtgt tttgcatatt gttagcattt acaaatattt
     4741 ttgctttagt atgaggaaag taaggatggg caaagaagcg atcaaaatag ctattgctac
     4801 aacattttcg aaaacaaagt tggggctgta tttctttaaa aagataagcc tctaaaaatg
     4861 cttggcaaaa aaaatatagt gttaaaatag gccagtgata ttaatgagaa aatgaaagta
     4921 tgtatcagga ataaagtgat attgcatagg agtattgtat ttttatgaat tttatgccag
     4981 ttgtttacat gtactatata tgttaaatta aaaaaaatca tgagtaatga
//
