LOCUS       NM_001937               1719 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens dermatopontin (DPT), mRNA.
ACCESSION   NM_001937
VERSION     NM_001937.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Sun,Y., Yang,H., Guo,J., Du,J., Han,S. and Yang,X.
  TITLE     Identification of HTRA1, DPT and MXRA5 as potential biomarkers
            associated with osteoarthritis progression and immune infiltration
  JOURNAL   BMC Musculoskelet Disord 25 (1), 647 (2024)
   PUBMED   39148085
  REMARK    GeneRIF: Identification of HTRA1, DPT and MXRA5 as potential
            biomarkers associated with osteoarthritis progression and immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Xu,P., Li,S., Liu,K., Fan,R., Liu,F., Zhang,H., Liu,D. and Shen,D.
  TITLE     Downregulation of dermatopontin in cholangiocarcinoma cells
            suppresses CCL19 secretion of macrophages and immune infiltration
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 66 (2024)
   PUBMED   38300311
  REMARK    GeneRIF: Downregulation of dermatopontin in cholangiocarcinoma
            cells suppresses CCL19 secretion of macrophages and immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Su,Y., Du,Y., Ye,S., Jia,G., Ding,B. and Yu,J.
  TITLE     Clinical importance and PI3K/Akt pathway-dependent
            anti-proliferative role of PALMD and DPT in breast cancer
  JOURNAL   Pathol Res Pract 249, 154717 (2023)
   PUBMED   37556876
  REMARK    GeneRIF: Clinical importance and PI3K/Akt pathway-dependent
            anti-proliferative role of PALMD and DPT in breast cancer.
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Ye,D., Wang,Y., Deng,X., Zhou,X., Liu,D., Zhou,B., Zheng,W.,
            Wang,X. and Fang,L.
  TITLE     DNMT3a-dermatopontin axis suppresses breast cancer malignancy via
            inactivating YAP
  JOURNAL   Cell Death Dis 14 (2), 106 (2023)
   PUBMED   36774339
  REMARK    GeneRIF: DNMT3a-dermatopontin axis suppresses breast cancer
            malignancy via inactivating YAP.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Ding,Y., Li,P., Wang,W. and Liu,F.
  TITLE     A Potential Four-Gene Signature and Nomogram for Predicting the
            Overall Survival of Papillary Thyroid Cancer
  JOURNAL   Dis Markers 2022, 8735551 (2022)
   PUBMED   36193505
  REMARK    GeneRIF: A Potential Four-Gene Signature and Nomogram for
            Predicting the Overall Survival of Papillary Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Pochampally,R.R., Ylostalo,J., Penfornis,P., Matz,R.R., Smith,J.R.
            and Prockop,D.J.
  TITLE     Histamine receptor H1 and dermatopontin: new downstream targets of
            the vitamin D receptor
  JOURNAL   J Bone Miner Res 22 (9), 1338-1349 (2007)
   PUBMED   17547532
  REMARK    GeneRIF: roles of dermatopontin and histamine receptor H1 genes as
            downstream targets for the VDR were confirmed by gel
            electromotility shift and chromatin immunoprecipitation assays that
            showed the presence of VDR complex binding sequences
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Kuroda,K., Okamoto,O. and Shinkai,H.
  TITLE     Dermatopontin expression is decreased in hypertrophic scar and
            systemic sclerosis skin fibroblasts and is regulated by
            transforming growth factor-beta1, interleukin-4, and matrix
            collagen
  JOURNAL   J Invest Dermatol 112 (5), 706-710 (1999)
   PUBMED   10233760
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Okamoto,O., Fujiwara,S., Abe,M. and Sato,Y.
  TITLE     Dermatopontin interacts with transforming growth factor beta and
            enhances its biological activity
  JOURNAL   Biochem J 337 (Pt 3) (Pt 3), 537-541 (1999)
   PUBMED   9895299
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Forbes,E.G., Cronshaw,A.D., MacBeath,J.R. and Hulmes,D.J.
  TITLE     Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated
            and widely distributed protein of the extracellular matrix
  JOURNAL   FEBS Lett 351 (3), 433-436 (1994)
   PUBMED   8082810
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Superti-Furga,A., Rocchi,M., Schafer,B.W. and Gitzelmann,R.
  TITLE     Complementary DNA sequence and chromosomal mapping of a human
            proteoglycan-binding cell-adhesion protein (dermatopontin)
  JOURNAL   Genomics 17 (2), 463-467 (1993)
   PUBMED   8104875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049798.7, BP257325.1 and BC033736.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001937.4.
            
            Summary: Dermatopontin is an extracellular matrix protein with
            possible functions in cell-matrix interactions and matrix assembly.
            The protein is found in various tissues and many of its tyrosine
            residues are sulphated. Dermatopontin is postulated to modify the
            behavior of TGF-beta through interaction with decorin. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.76823.1,
                                           SRR5189667.139882.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367817.4/ ENSP00000356791.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL049798.7         47234-47235         c
            3-566               BP257325.1         1-564
            567-1719            BC033736.1         551-1703
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1719
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /note="dermatopontin"
                     /db_xref="GeneID:1805"
                     /db_xref="HGNC:HGNC:3011"
                     /db_xref="MIM:125597"
     exon            1..337
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..638
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /note="tyrosine-rich acidic matrix protein"
                     /codon_start=1
                     /product="dermatopontin precursor"
                     /protein_id="NP_001928.2"
                     /db_xref="CCDS:CCDS1275.1"
                     /db_xref="GeneID:1805"
                     /db_xref="HGNC:HGNC:3011"
                     /db_xref="MIM:125597"
                     /translation="MDLSLLWVLLPLVTMAWGQYGDYGYPYQQYHDYSDDGWVNLNRQ
                     GFSYQCPQGQVIVAVRSIFSKKEGSDRQWNYACMPTPQSLGEPTECWWEEINRAGMEW
                     YQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWLTTEYPGHYGEEMDMI
                     SYNYDYYIRGATTTFSAVERDRQWKFIMCRMTEYDCEFANV"
     exon            338..463
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..571
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1719
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /note="hexamer: AATAAA"
     polyA_site      837
                     /gene="DPT"
                     /gene_synonym="TRAMP"
                     /note="major polyA site"
ORIGIN      
        1 gagtgacatt gtttgccaaa atcccaggca gcatggacct cagtcttctc tgggtacttc
       61 tgcccctagt caccatggcc tggggccagt atggcgatta tggataccca taccagcagt
      121 atcatgacta cagcgatgat gggtgggtga atttgaaccg gcaaggcttc agctaccagt
      181 gtccccaggg gcaggtgata gtggccgtga ggagcatctt cagcaagaag gaaggttctg
      241 acagacaatg gaactacgcc tgcatgccca cgccacagag cctcggggaa cccacggagt
      301 gctggtggga ggagatcaac agggctggca tggaatggta ccagacgtgc tccaacaatg
      361 ggctggtggc aggattccag agccgctact tcgagtcagt gctggatcgg gagtggcagt
      421 tttactgttg tcgctacagc aagaggtgcc catattcctg ctggctaaca acagaatatc
      481 caggtcacta tggtgaggaa atggacatga tttcctacaa ttatgattac tatatccgag
      541 gagcaacaac cactttctct gcagtggaaa gggatcgcca gtggaagttc ataatgtgcc
      601 ggatgactga atacgactgt gaatttgcaa atgtttagat ttgccacata ccaaatctgg
      661 gtgaaaggaa aggggccggg gacaggaggg tgtccacata tgttaacatc agttggatct
      721 cctatagaag tttctgctgc tctctttcct tctccctgag ctggtaactg caatgccaac
      781 ttcctgggcc tttctgacta gtatcacact tctaataaaa tccacaatta aaccatgttt
      841 ctcacttttc acatgtttca tagcaactgc tttatatgac tgatgatggc ttccttgcac
      901 accacatata cagtgcgcat gcttacagcc gggcttctgg agcaccagct gcagcctggc
      961 tactgctttt tactgcagaa tgaactgcaa gttcagcata gtggagggga gaggcagaac
     1021 tggaggagag gtgcagtgaa ggttctctac agctaagcct gtttgaatga tacgtaggtt
     1081 ccccaccaaa agcaggcttt ctgccctgag ggacatcttc ccactcccct gctccacatg
     1141 agccatgcat gcttagcaat ccaagtgcag agctctttgc tccaggagtg aggagactgg
     1201 gaggtgaaat ggggaaatgg aagggtttgg aggcagagct gaaaacaggg ttggaaggat
     1261 ttcctgaatt agaagacaaa cgttagcata cccagtaagg aaaatgagtg caggggccag
     1321 gggaacccgt gaggatcact ctcaaatgag attaaaaaca aggaagcaga gaatggtcag
     1381 agaatgggat tcagattggg aacttgtggg gatgagagtg accaggttga actgggaagt
     1441 ggaaaaagga gtttgagtca ctggcaccta gaagcctgcc cacgattcct aggaaggctg
     1501 gcagacaccc tggaaccctg gggagctact ggcaaactct cctggattgg gcctgatttt
     1561 tttggtggga aaggctgccc tggggatcaa ctttccttct gtgtgtggct caggagttct
     1621 tctgcagaga tggcgctatc tttcctcctc ctgtgatgtc ctgctcccaa ccatttgtac
     1681 tcttcattac aaaagaaata aaaatattaa cgttcacta
//
