LOCUS       NM_001012728             710 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens divergent-paired related homeobox (DPRX), mRNA.
ACCESSION   NM_001012728
VERSION     NM_001012728.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 710)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 710)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 710)
  AUTHORS   Booth,H.A. and Holland,P.W.
  TITLE     Annotation, nomenclature and evolution of four novel homeobox genes
            expressed in the human germ line
  JOURNAL   Gene 387 (1-2), 7-14 (2007)
   PUBMED   17005330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Anne Booth and Peter Holland. The reference
            sequence was derived from AC011487.5.
            
            On Aug 13, 2021 this sequence version replaced NM_001012728.1.
            
            Summary: Homeobox genes encode DNA-binding proteins, many of which
            are thought to be involved in early embryonic development. Homeobox
            genes encode a DNA-binding domain of 60 to 63 amino acids referred
            to as the homeodomain. This gene is a member of the DPRX homeobox
            gene family. Evidence of mRNA expression has not yet been found for
            this gene. Multiple, related processed pseudogenes have been found
            which are thought to reflect expression of this gene in the germ
            line or embryonic cells. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN651088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376650.2/ ENSP00000365838.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC011487.5         12089-12224         c
            137-291             AC011487.5         9538-9692           c
            292-710             AC011487.5         7209-7627           c
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..710
                     /gene="DPRX"
                     /note="divergent-paired related homeobox"
                     /db_xref="GeneID:503834"
                     /db_xref="HGNC:HGNC:32166"
                     /db_xref="MIM:611165"
     exon            1..136
                     /gene="DPRX"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..684
                     /gene="DPRX"
                     /codon_start=1
                     /product="divergent paired-related homeobox"
                     /protein_id="NP_001012746.1"
                     /db_xref="CCDS:CCDS33103.1"
                     /db_xref="GeneID:503834"
                     /db_xref="HGNC:HGNC:32166"
                     /db_xref="MIM:611165"
                     /translation="MPGSEDLRKGKDQMHSHRKRTMFTKKQLEDLNILFNENPYPNPS
                     LQKEMASKIDIHPTVLQVWFKNHRAKLKKAKCKHIHQKQETPQPPIPEGGVSTSVGLR
                     NADTLPRLPNAAHPIGLVYTGHRVPSFQLILYPNLKVPANDFIGHRIVHFGCCRDPNI
                     YCLYPILESQVCAPSFHSGSPACSSNQSRER"
     exon            137..291
                     /gene="DPRX"
                     /inference="alignment:Splign:2.1.0"
     exon            292..710
                     /gene="DPRX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      687..692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPRX"
                     /note="hexamer: AATACA"
     polyA_site      710
                     /gene="DPRX"
                     /note="major polyA site"
ORIGIN      
        1 ggaggtggga gtcgggtgtg gctgtggagg aagctactta aatccggatt tgatctttgc
       61 tagttcttat ccctggacct gaacccaggc gcacatctgg attagaagat gccaggctca
      121 gaggatcttc gtaaaggcaa ggaccagatg cattcacaca ggaaacgaac catgttcact
      181 aagaagcaac tggaagatct gaacatcttg ttcaatgaga acccataccc aaaccccagc
      241 cttcagaaag aaatggcctc gaaaatagac atacacccaa cagtactgca ggtctggttc
      301 aagaatcaca gagcaaaact caagaaagcg aaatgcaagc atattcatca aaaacaagaa
      361 actccacaac cgccaatacc agagggtggg gtctccacca gtgtcggcct gagaaatgca
      421 gacacactac ccagattgcc caacgctgct cacccgatcg gcctggtgta cacgggtcat
      481 cgagtcccct cattccagct catcctgtac cccaacctca aggtccctgc aaatgacttc
      541 attggccaca gaatagtcca ttttggctgc tgccgagatc ctaatatata ctgcctctac
      601 cccattttgg aatcccaagt ttgcgctcca agcttccatt ctggctctcc tgcctgttca
      661 tctaaccaaa gtcgagagag atgataaata caaaaagtca catgttgtaa
//
