LOCUS       NM_001025290             659 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens developmental pluripotency associated 5 (DPPA5), mRNA.
ACCESSION   NM_001025290 XM_291161
VERSION     NM_001025290.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 659)
  AUTHORS   Taei,A., Kiani,T., Taghizadeh,Z., Moradi,S., Samadian,A.,
            Mollamohammadi,S., Sharifi-Zarchi,A., Guenther,S., Akhlaghpour,A.,
            Asgari Abibeiglou,B., Najar-Asl,M., Karamzadeh,R., Khalooghi,K.,
            Braun,T., Hassani,S.N. and Baharvand,H.
  TITLE     Temporal activation of LRH-1 and RAR-gamma in human pluripotent
            stem cells induces a functional naive-like state
  JOURNAL   EMBO Rep 21 (10), e47533 (2020)
   PUBMED   33252195
REFERENCE   2  (bases 1 to 659)
  AUTHORS   Qian,X., Kim,J.K., Tong,W., Villa-Diaz,L.G. and Krebsbach,P.H.
  TITLE     DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG
            Turnover
  JOURNAL   Stem Cells 34 (3), 588-600 (2016)
   PUBMED   26661329
  REMARK    GeneRIF: Our study provides new insight into the function of DPPA5
            and NANOG regulation in human pluripotent stem cell .
REFERENCE   3  (bases 1 to 659)
  AUTHORS   Aoki,T., Ohnishi,H., Oda,Y., Tadokoro,M., Sasao,M., Kato,H.,
            Hattori,K. and Ohgushi,H.
  TITLE     Generation of induced pluripotent stem cells from human
            adipose-derived stem cells without c-MYC
  JOURNAL   Tissue Eng Part A 16 (7), 2197-2206 (2010)
   PUBMED   20146561
REFERENCE   4  (bases 1 to 659)
  AUTHORS   Tian,X., Pascal,G., Fouchecourt,S., Pontarotti,P. and Monget,P.
  TITLE     Gene birth, death, and divergence: the different scenarios of
            reproduction-related gene evolution
  JOURNAL   Biol Reprod 80 (4), 616-621 (2009)
   PUBMED   19129511
  REMARK    Review article
REFERENCE   5  (bases 1 to 659)
  AUTHORS   Dansranjavin,T., Krehl,S., Mueller,T., Mueller,L.P., Schmoll,H.J.
            and Dammann,R.H.
  TITLE     The role of promoter CpG methylation in the epigenetic control of
            stem cell related genes during differentiation
  JOURNAL   Cell Cycle 8 (6), 916-924 (2009)
   PUBMED   19221495
REFERENCE   6  (bases 1 to 659)
  AUTHORS   Pierre,A., Gautier,M., Callebaut,I., Bontoux,M., Jeanpierre,E.,
            Pontarotti,P. and Monget,P.
  TITLE     Atypical structure and phylogenomic evolution of the new eutherian
            oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family
  JOURNAL   Genomics 90 (5), 583-594 (2007)
   PUBMED   17913455
REFERENCE   7  (bases 1 to 659)
  AUTHORS   Lagarkova,M.A., Volchkov,P.Y., Lyakisheva,A.V., Philonenko,E.S. and
            Kiselev,S.L.
  TITLE     Diverse epigenetic profile of novel human embryonic stem cell lines
  JOURNAL   Cell Cycle 5 (4), 416-420 (2006)
   PUBMED   16479162
REFERENCE   8  (bases 1 to 659)
  AUTHORS   Western,P., Maldonado-Saldivia,J., van den Bergen,J., Hajkova,P.,
            Saitou,M., Barton,S. and Surani,M.A.
  TITLE     Analysis of Esg1 expression in pluripotent cells and the germline
            reveals similarities with Oct4 and Sox2 and differences between
            human pluripotent cell lines
  JOURNAL   Stem Cells 23 (10), 1436-1442 (2005)
   PUBMED   16166252
REFERENCE   9  (bases 1 to 659)
  AUTHORS   Adjaye,J., Huntriss,J., Herwig,R., BenKahla,A., Brink,T.C.,
            Wierling,C., Hultschig,C., Groth,D., Yaspo,M.L., Picton,H.M.,
            Gosden,R.G. and Lehrach,H.
  TITLE     Primary differentiation in the human blastocyst: comparative
            molecular portraits of inner cell mass and trophectoderm cells
  JOURNAL   Stem Cells 23 (10), 1514-1525 (2005)
   PUBMED   16081659
REFERENCE   10 (bases 1 to 659)
  AUTHORS   Kim,S.K., Suh,M.R., Yoon,H.S., Lee,J.B., Oh,S.K., Moon,S.Y.,
            Moon,S.H., Lee,J.Y., Hwang,J.H., Cho,W.J. and Kim,K.S.
  TITLE     Identification of developmental pluripotency associated 5
            expression in human pluripotent stem cells
  JOURNAL   Stem Cells 23 (4), 458-462 (2005)
   PUBMED   15790765
  REMARK    GeneRIF: Dppa5 is specifically and differentially expressed in
            human cells that have pluripotency and can be used as a marker of
            pluripotent stem cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC137549.1 and AI365263.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001025290.2.
            
            Summary: This gene encodes a protein that may function in the
            control of cell pluripotency and early embryogenesis. Expression of
            this gene is a specific marker for pluripotent stem cells.
            Pseudogenes of this gene are located on the short arm of chromosome
            10 and the long arm of chromosomes 14 and 19. [provided by RefSeq,
            Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX092581.1, BC137549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370370.4/ ENSP00000359396.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               BC137549.1         1-422
            423-659             AI365263.1         2-238               c
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..659
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /note="developmental pluripotency associated 5"
                     /db_xref="GeneID:340168"
                     /db_xref="HGNC:HGNC:19201"
                     /db_xref="MIM:611111"
     exon            1..163
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..402
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /note="embryonal stem cell specific gene 1"
                     /codon_start=1
                     /product="developmental pluripotency-associated 5 protein"
                     /protein_id="NP_001020461.1"
                     /db_xref="CCDS:CCDS34483.1"
                     /db_xref="GeneID:340168"
                     /db_xref="HGNC:HGNC:19201"
                     /db_xref="MIM:611111"
                     /translation="MGTLPARRHIPPWVKVPEDLKDPEVFQVQTRLLKAIFGPDGSRI
                     PYIEQVSKAMLELKALESSDLTEVVVYGSYLYKLRTKWMLQSMAEWHRQRQERGMLKL
                     AEAMNALELGPWMK"
     exon            164..343
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..659
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /note="hexamer: AATAAA"
     polyA_site      659
                     /gene="DPPA5"
                     /gene_synonym="ESG1"
                     /note="major polyA site"
ORIGIN      
        1 gattaggcct ggtttgcgct ggagagtggt cttggttgtg agggtcataa gatgggaact
       61 ctcccggcac gtagacatat cccgccgtgg gtgaaagttc ccgaagacct gaaagatcca
      121 gaggtgttcc aggtccagac gcggctgctg aaagccattt tcggcccgga cggatctcga
      181 atcccttaca tcgagcaggt gagcaaggcc atgctcgagc tgaaggctct ggagtcttca
      241 gacctcaccg aggtcgtggt ttacggctcc tatttgtaca agctccggac caagtggatg
      301 ctccagtcca tggctgagtg gcaccgccag cgccaggagc gagggatgct caaacttgcc
      361 gaagccatga atgccctcga actaggccct tggatgaagt gaaccagttt ccagccaatg
      421 caatgaagcc gggttgcaga gattaggttg tggccagagc tagagtgatt ccttaagctt
      481 gttttaaaat ctgctccagc ctaaagagtt aagggaaaac catttgttcc cttaaagagt
      541 taagggaaaa cccttggctc tgagtcttgt tgtgaatatt tctttgatga ttgttaataa
      601 aaagtgtttt ttcttttttc ccatttttaa aaataacaat aaagttttaa ataagttga
//
