LOCUS       NM_199286               1100 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens developmental pluripotency associated 3 (DPPA3), mRNA.
ACCESSION   NM_199286 XM_290555
VERSION     NM_199286.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Shiraishi,N., Konuma,T., Chiba,Y., Hokazono,S., Nakamura,N.,
            Islam,M.H., Nakanishi,M., Nishiyama,A. and Arita,K.
  TITLE     Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its
            functional and structural differences from mouse DPPA3
  JOURNAL   Commun Biol 7 (1), 746 (2024)
   PUBMED   38898124
  REMARK    GeneRIF: Structure of human DPPA3 bound to the UHRF1 PHD finger
            reveals its functional and structural differences from mouse DPPA3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Du,W., Dong,Q., Zhang,Z., Liu,B., Zhou,T., Xu,R.M., Wang,H., Zhu,B.
            and Li,Y.
  TITLE     Stella protein facilitates DNA demethylation by disrupting the
            chromatin association of the RING finger-type E3 ubiquitin ligase
            UHRF1
  JOURNAL   J Biol Chem 294 (22), 8907-8917 (2019)
   PUBMED   31018966
  REMARK    GeneRIF: Stella employs a multilayered mechanism to achieve robust
            UHRF1 inhibition, which involves the dissociation from chromatin
            and cytoplasmic sequestration of UHRF1.
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Farshchian,M., Matin,M.M., Bahrami,M., Geerts,D., Dastpak,M.,
            Shahriyari,M., Tajeran,M., Mirahmadi,M. and Bahrami,A.R.
  TITLE     Pluripotency induction in HEK293T cells by concurrent expression of
            STELLA, OCT4 and NANOS2
  JOURNAL   Biochem Biophys Res Commun 480 (4), 635-640 (2016)
   PUBMED   27794480
  REMARK    GeneRIF: We conclude that heterogeneous population of the HEK293T
            cells might be easily shifted towards expression of the
            pluripotency markers by ectopic expression of the SON factors or by
            growth in serum depleted media.
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Blinka,S., Reimer,M.H. Jr., Pulakanti,K. and Rao,S.
  TITLE     Super-Enhancers at the Nanog Locus Differentially Regulate
            Neighboring Pluripotency-Associated Genes
  JOURNAL   Cell Rep 17 (1), 19-28 (2016)
   PUBMED   27681417
  REMARK    GeneRIF: Super-enhancers at the Nanog locus differentially regulate
            neighboring pluripotency-associated genes, in particular, DPPA3.
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Bortvin,A., Goodheart,M., Liao,M. and Page,D.C.
  TITLE     Dppa3 / Pgc7 / stella is a maternal factor and is not required for
            germ cell specification in mice
  JOURNAL   BMC Dev Biol 4, 2 (2004)
   PUBMED   15018652
  REMARK    GeneRIF: In mice, knockout experiments show this gene may be a
            maternal factor in cleavage stage embryogenesis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1100)
  AUTHORS   Clark,A.T., Rodriguez,R.T., Bodnar,M.S., Abeyta,M.J., Cedars,M.I.,
            Turek,P.J., Firpo,M.T. and Reijo Pera,R.A.
  TITLE     Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent
            cells and map to chromosome 12p13, a hotspot for teratocarcinoma
  JOURNAL   Stem Cells 22 (2), 169-179 (2004)
   PUBMED   14990856
REFERENCE   8  (bases 1 to 1100)
  AUTHORS   Payer,B., Saitou,M., Barton,S.C., Thresher,R., Dixon,J.P., Zahn,D.,
            Colledge,W.H., Carlton,M.B., Nakano,T. and Surani,M.A.
  TITLE     Stella is a maternal effect gene required for normal early
            development in mice
  JOURNAL   Curr Biol 13 (23), 2110-2117 (2003)
   PUBMED   14654002
  REMARK    GeneRIF: In mice, a targeted mutation results in reduced female
            fertility and may function as a mammalian maternal effect gene.
REFERENCE   9  (bases 1 to 1100)
  AUTHORS   Bowles,J., Teasdale,R.P., James,K. and Koopman,P.
  TITLE     Dppa3 is a marker of pluripotency and has a human homologue that is
            expressed in germ cell tumours
  JOURNAL   Cytogenet Genome Res 101 (3-4), 261-265 (2003)
   PUBMED   14684992
REFERENCE   10 (bases 1 to 1100)
  AUTHORS   Sato,M., Kimura,T., Kurokawa,K., Fujita,Y., Abe,K., Masuhara,M.,
            Yasunaga,T., Ryo,A., Yamamoto,M. and Nakano,T.
  TITLE     Identification of PGC7, a new gene expressed specifically in
            preimplantation embryos and germ cells
  JOURNAL   Mech Dev 113 (1), 91-94 (2002)
   PUBMED   11900980
  REMARK    GeneRIF: In mice, this gene may play a role in oogenesis and
            primordial germ cell development.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006517.46 and AY317075.1.
            
            On Nov 23, 2018 this sequence version replaced NM_199286.3.
            
            Summary: This gene encodes a protein that in mice may function as a
            maternal factor during the preimplantation stage of development. In
            mice, this gene may play a role in transcriptional repression, cell
            division, and maintenance of cell pluripotentiality. In humans,
            related intronless loci are located on chromosomes 14 and X.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY317075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345088.3/ ENSP00000339250.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC006517.46        154274-154294       c
            22-645              AY317075.1         1-624
            646-646             AC006517.46        148622-148622       c
            647-1100            AY317075.1         626-1079
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1100
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /note="developmental pluripotency associated 3"
                     /db_xref="GeneID:359787"
                     /db_xref="HGNC:HGNC:19199"
                     /db_xref="MIM:608408"
     exon            1..220
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..618
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /note="stella-related protein"
                     /codon_start=1
                     /product="developmental pluripotency-associated protein 3"
                     /protein_id="NP_954980.1"
                     /db_xref="CCDS:CCDS8582.1"
                     /db_xref="GeneID:359787"
                     /db_xref="HGNC:HGNC:19199"
                     /db_xref="MIM:608408"
                     /translation="MDPSQFNPTYIPGSPQMLTEENSRDDSGASQISSETLIKNLSNL
                     TINASSESVSPLSEALLRRESVGAAVLREIEDEWLYSRRGVRTLLSVQREKMARLRYM
                     LLGGVRTHERRPTNKEPKGVKKESRPFKCPCSFCVSNGWDPSENARIGNQDTKPLQP"
     exon            221..465
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /inference="alignment:Splign:2.1.0"
     exon            466..507
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /inference="alignment:Splign:2.1.0"
     exon            508..1100
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /note="hexamer: AATAAA"
     polyA_site      1100
                     /gene="DPPA3"
                     /gene_synonym="Pgc7; STELLA"
                     /note="major polyA site"
ORIGIN      
        1 gtcagttctt tgaccattcg ttggagctcc ggttttcagc ctctttccgg gctacctggt
       61 agcaatttga ggctctgtca tcagtttctg ctacgtttca aagatcctgg agaagcctag
      121 tgttgtgtca agacgccgat ggacccatca cagtttaatc caacctacat cccagggtct
      181 ccacaaatgc tcaccgaaga aaattcccgg gacgattcag gggcctctca aatctcctcc
      241 gagacgttga taaagaacct tagtaacttg actatcaacg ctagtagcga atctgtttcc
      301 cctctatcgg aagctttact ccgtcgagag tctgtaggag cagcagtcct cagggaaatc
      361 gaagatgagt ggctttacag caggagagga gtaagaacat tgctgtctgt gcagagagaa
      421 aagatggcaa gattgagata catgttactc ggcggagttc gtacgcatga aagaagacca
      481 acaaacaagg agcctaaggg agttaagaag gaatcaagac cattcaaatg tccctgcagt
      541 ttctgcgtgt ctaatggatg ggatccttct gagaatgcta gaatagggaa tcaagacacc
      601 aagccacttc agccataaat cttattcttg cacctttttt tcttggtagt aattttatat
      661 agcaggttga gaaagctact ctatgctagt atagactata caccaataat tttgataatg
      721 agttctagga tgtatttttc ttgtatcttt ttcttcctac tatgatacta gtaattcata
      781 agggatctgt gtaatctgaa tgtatttgaa taactttagc tctactgttt gatttgaccc
      841 aaagaagcca agatgatata agtattccca tgtgtcttag aagcccaaag tcagtgagat
      901 gaaacccaac atcaagaaat tgaagcaaag ttacttatgg ataaagaaag cattaggtag
      961 ttgggctata gcataattag attttctggc tttcaaaaat ttggattgca atcacagcaa
     1021 actttgttat ttttacagtt ttcagtacaa aagtgtttat atagaaacaa taaagttgac
     1081 atttgagtac cttttaaaaa
//
