LOCUS       NM_138815               1383 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens developmental pluripotency associated 2 (DPPA2), mRNA.
ACCESSION   NM_138815
VERSION     NM_138815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1383)
  AUTHORS   Yao,H., Shao,Q. and Shao,Y.
  TITLE     Transcription Factor CTCFL Promotes Cell Proliferation, Migration,
            and Invasion in Gastric Cancer via Activating DPPA2
  JOURNAL   Comput Math Methods Med 2021, 9097931 (2021)
   PUBMED   34721660
  REMARK    GeneRIF: Transcription Factor CTCFL Promotes Cell Proliferation,
            Migration, and Invasion in Gastric Cancer via Activating DPPA2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1383)
  AUTHORS   Li,H., Long,C., Xiang,J., Liang,P., Li,X. and Zuo,Y.
  TITLE     Dppa2/4 as a trigger of signaling pathways to promote zygote genome
            activation by binding to CG-rich region
  JOURNAL   Brief Bioinform 22 (4) (2021)
   PUBMED   33316032
  REMARK    GeneRIF: Dppa2/4 as a trigger of signaling pathways to promote
            zygote genome activation by binding to CG-rich region.
REFERENCE   3  (bases 1 to 1383)
  AUTHORS   Wang,J., Zhuang,H., Zhang,H., Li,Q., Cao,X., Lin,Z., Lin,T.,
            Chen,X., Ni,X., Yang,J., Zhao,Y., Shen,L., Wang,H., Zhu,J., Ye,M.
            and Jin,X.
  TITLE     SPOP suppresses testicular germ cell tumors progression through
            ubiquitination and degradation of DPPA2
  JOURNAL   Biochem Biophys Res Commun 557, 55-61 (2021)
   PUBMED   33862460
  REMARK    GeneRIF: SPOP suppresses testicular germ cell tumors progression
            through ubiquitination and degradation of DPPA2.
REFERENCE   4  (bases 1 to 1383)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1383)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1383)
  AUTHORS   Nakamura,T., Nakagawa,M., Ichisaka,T., Shiota,A. and Yamanaka,S.
  TITLE     Essential roles of ECAT15-2/Dppa2 in functional lung development
  JOURNAL   Mol Cell Biol 31 (21), 4366-4378 (2011)
   PUBMED   21896782
REFERENCE   7  (bases 1 to 1383)
  AUTHORS   Tchabo,N.E., Mhawech-Fauceglia,P., Caballero,O.L., Villella,J.,
            Beck,A.F., Miliotto,A.J., Liao,J., Andrews,C., Lele,S., Old,L.J.
            and Odunsi,K.
  TITLE     Expression and serum immunoreactivity of developmentally restricted
            differentiation antigens in epithelial ovarian cancer
  JOURNAL   Cancer Immun 9, 6 (2009)
   PUBMED   19705800
  REMARK    GeneRIF: In normal tissues, PLAC1 expression was restricted to the
            placenta while DPPA2 expression was restricted to the placenta and
            testis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1383)
  AUTHORS   John,T., Caballero,O.L., Svobodova,S.J., Kong,A., Chua,R.,
            Browning,J., Fortunato,S., Deb,S., Hsu,M., Gedye,C.A., Davis,I.D.,
            Altorki,N., Simpson,A.J., Chen,Y.T., Monk,M. and Cebon,J.S.
  TITLE     ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with
            cancer-testis antigens in non-small cell lung cancer
  JOURNAL   Clin Cancer Res 14 (11), 3291-3298 (2008)
   PUBMED   18519755
  REMARK    GeneRIF: ECSA/DPPA2 is a promising target for antigen-specific
            immunotherapy in non-small cell lung cancers
REFERENCE   9  (bases 1 to 1383)
  AUTHORS   Monk,M., Hitchins,M. and Hawes,S.
  TITLE     Differential expression of the embryo/cancer gene ECSA(DPPA2), the
            cancer/testis gene BORIS and the pluripotency structural gene OCT4,
            in human preimplantation development
  JOURNAL   Mol Hum Reprod 14 (6), 347-355 (2008)
   PUBMED   18467432
  REMARK    GeneRIF: Differential expression of the embryo/cancer gene
            ECSA(DPPA2) in human preimplantation development.
REFERENCE   10 (bases 1 to 1383)
  AUTHORS   Du,J., Lin,G., Nie,Z.Y. and Lu,G.X.
  TITLE     [Molecular cloning and characterization analysis of HPESCRG1, a
            novel gene expressed specifically in human embryonic stem cell]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21 (6), 542-547 (2004)
   PUBMED   15583978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY283672.1, BC018070.1 and AA460929.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138815.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.3259.1, BC018070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478945.1/ ENSP00000417710.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AY283672.1         1-124
            125-1377            BC018070.1         3-1255
            1378-1383           AA460929.1         37-42               c
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..1383
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="developmental pluripotency associated 2"
                     /db_xref="GeneID:151871"
                     /db_xref="HGNC:HGNC:19197"
                     /db_xref="MIM:614445"
     exon            1..234
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..280
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1144
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="cancer/testis antigen 100; pluripotent embryonic
                     stem cell-related gene 1 protein; embryonic stem cell
                     (ESC) associated transcript 15-2"
                     /codon_start=1
                     /product="developmental pluripotency-associated protein 2"
                     /protein_id="NP_620170.3"
                     /db_xref="CCDS:CCDS2956.1"
                     /db_xref="GeneID:151871"
                     /db_xref="HGNC:HGNC:19197"
                     /db_xref="MIM:614445"
                     /translation="MSDANLDSSKKNFLEGEVDDEESVILTLVPVKDDANMEQMEPSV
                     SSTSDVKLEKPKKYNPGHLLQTNEQFTAPQKARCKIPALPLPTILPPINKVCRDTLRD
                     WCQQLGLSTNGKKIEVYLRLHRHAYPEQRQDMPEMSQETRLQRCSRKRKAVTKRARLQ
                     RSYEMNERAEETNTVEVITSAPGAMLASWARIAARAVQPKALNSCSIPVSVEAFLMQA
                     SGVRWCVVHGRLLSADTKGWVRLQFHAGQAWVPTTHRRMISLFLLPACIFPSPGIEDN
                     MLCPDCAKRNKKMMKRLMTVEK"
     exon            281..428
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..589
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..905
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1101
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1166
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1383
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="hexamer: ATTAAA"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="major polyA site"
     polyA_site      1383
                     /gene="DPPA2"
                     /gene_synonym="CT100; ECAT15-2; PESCRG1"
                     /note="major polyA site"
ORIGIN      
        1 agccctttgt ttatggcctg atctagctaa ggcttctaga cttcaggagc ttaagaatcg
       61 tccggagggc tgggcgtggc ggtgcaggcc tgtagtccca cccactccga aggctgcgga
      121 gggaggatca acttgagtct gggaactcag ccaggaattc aagaccagcc tgggcaacac
      181 agtgaggccc cctacccaca tcctctccgt ccccgcaatc tccttccatc ccagggtgtt
      241 gctgaaaatg tcagatgcaa atttggatag cagcaagaag aatttcttgg agggggaagt
      301 agatgatgag gaaagtgtga ttttgacact ggtgccagtt aaagatgacg caaatatgga
      361 acaaatggaa ccaagcgttt cttcaacttc tgatgtcaaa ctggagaagc ctaagaaata
      421 caatccaggt catctacttc aaacaaatga gcaatttaca gctccacaaa aagctagatg
      481 caaaatacca gcccttccct tgccgaccat tttgcctccc attaataagg tgtgtcggga
      541 cactttgcgg gactggtgtc aacaactcgg tttgagtact aatggcaaga aaatcgaagt
      601 ttatctgagg cttcataggc atgcttaccc tgaacaacgg caagatatgc ctgaaatgtc
      661 acaagagacc agattacagc gatgttcgag gaaacgcaag gcagtgacca agagagcaag
      721 gcttcagaga agttatgaga tgaatgagag agcagaagag accaatacag ttgaagtgat
      781 aacttcagca ccgggagcca tgttggcatc atgggcaaga attgctgcaa gagctgttca
      841 gcctaaggct ttgaattcat gttccattcc tgtttctgtt gaggcctttt tgatgcaagc
      901 ctctggcgtc aggtggtgtg tggtccatgg cagacttctc tcggcagaca caaagggttg
      961 ggtacgcctg cagtttcatg caggtcaggc ctgggtgcct accactcaca ggaggatgat
     1021 ttctctcttc ttgttacctg cctgcatttt cccatcccca ggcatagaag ataatatgtt
     1081 atgccccgac tgtgctaaga ggaataagaa gatgatgaaa agattaatga cagtagagaa
     1141 gtagcagcaa cctgtttgaa tacaatgtac taaaggaggg atgtactttc agatcatgta
     1201 acctattacg aaggagtgga agaggagaca atttgaatga atcctcatga tctacaaaac
     1261 aaaatcatag tgactaggac tccacagtga agatggttga ctagtgacac agccccatct
     1321 aaagaatccc tttctgtatg tctgaaaacc cattaaaata aagtcactgc aattggcctt
     1381 gta
//
