LOCUS       NM_001384635            2000 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 28,
            mRNA.
ACCESSION   NM_001384635
VERSION     NM_001384635.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 2000)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 2000)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 2000)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 2000)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 2000)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 2000)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 2000)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 2000)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 2000)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-260             AC005783.1         22542-22632         c
            261-517             AC005783.1         16772-17028         c
            518-630             AC005783.1         8549-8661           c
            631-804             AC005783.1         6822-6995           c
            805-973             AC005783.1         6577-6745           c
            974-1087            AC005783.1         5294-5407           c
            1088-1216           AC005783.1         4718-4846           c
            1217-1317           AC005594.1         37952-38052         c
            1318-2000           AC005594.1         34542-35224         c
FEATURES             Location/Qualifiers
     source          1..2000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2000
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..260
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1521
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 13 is encoded by transcript variant 28;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 13"
                     /protein_id="NP_001371564.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MRKVKKLRLDKENTGSWRSFSLNSEGAERMATTGTPTADRGDAA
                     ATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLY
                     YLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRER
                     KRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRM
                     DPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQ
                     EEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRY
                     PRTDRLDPGEGAGAALQLAVPEGGVHRQGRVDPGWQIVHDIFYPFPQSEGEDELCFLR
                     ANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEGEQSLTNAVDSSR"
     exon            261..517
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            518..630
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            631..804
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            805..973
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1087
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1216
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1317
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..2000
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1785..1790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: AATAAA"
     polyA_site      1826
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: AATAAA"
     polyA_site      2000
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg cacccctgcc
      181 ctcctgaggt cagctgagcg gttaatgcgg aaggttaaga aactgcgcct ggacaaggag
      241 aacaccggaa gttggagaag cttctcgctg aattccgagg gggctgagag gatggccacc
      301 accgggaccc caacggccga ccgaggcgac gcagccgcca cagatgaccc ggccgcccgc
      361 ttccaggtgc agaagcactc gtgggacggg ctccggagca tcatccacgg cagccgcaag
      421 tactcgggcc tcattgtcaa caaggcgccc cacgacttcc agtttgtgca gaagacggat
      481 gagtctgggc cccactccca ccgcctctac tacctgggaa tgccatatgg cagccgagag
      541 aactccctcc tctactctga gattcccaag aaggtccgga aagaggctct gctgctcctg
      601 tcctggaagc agatgctgga tcatttccag gccacgcccc accatggggt ctactctcgg
      661 gaggaggagc tgctgaggga gcggaaacgc ctgggggtct tcggcatcac ctcctacgac
      721 ttccacagcg agagtggcct cttcctcttc caggccagca acagcctctt ccactgccgc
      781 gacggcggca agaacggctt catggtgtcc cctatgaaac cgctggaaat caagacccag
      841 tgctcagggc cccggatgga ccccaaaatc tgccctgccg accctgcctt cttctccttc
      901 atcaataaca gcgacctgtg ggtggccaac atcgagacag gcgaggagcg gcggctgacc
      961 ttctgccacc aaggtttatc caatgtcctg gatgacccca agtctgcggg tgtggccacc
     1021 ttcgtcatac aggaagagtt cgaccgcttc actgggtact ggtggtgccc cacagcctcc
     1081 tgggaaggtt cagagggcct caagacgctg cgaatcctgt atgaggaagt cgatgagtcc
     1141 gaggtggagg tcattcacgt cccctctcct gcgctagaag aaaggaagac ggactcgtat
     1201 cggtacccca ggacagatcg tctcgaccca ggagaaggag ctggtgcagc ccttcagctc
     1261 gctgttcccg aaggtggagt acatcgccag ggccgggtgg acccgggatg gcaaatagtt
     1321 catgacatct tctatccctt cccccaatca gagggagagg acgagctctg ctttctccgc
     1381 gccaatgaat gcaagaccgg cttctgccat ttgtacaaag tcaccgccgt tttaaaatcc
     1441 cagggctacg attggagtga gcccttcagc cccggggaag gtgagcagag cctgacgaat
     1501 gctgtcgact catcgcgtta gtcacgtgtg gttcaatatg ctgtttgttc attggtcggc
     1561 ccccccactc agccagcaca ccctgcggga gaaggaacag ggatcggcag gaagccagcc
     1621 ttccccagtg actgcatgat ctggcagggc ttagagcacc caactgttgg cttattcagg
     1681 cagcagattt actgagcacc tcccctgtgc caggccctta gcacaaccag gggttggcca
     1741 cctacggccc acaggtcaaa tccggcccac cacctgtgtt cataaataaa gttttattgg
     1801 cactgagcca cagccacttg tttacagaga ctgtctgtgg tcgcttttgt gctgcagcag
     1861 cagaactggg tagtcccagc agaaactgtt gtgcaaggcc aagatttact gtctagccct
     1921 ttgtagaaac atttgccagc tcctgctgta ggtagctgtg atggaattgt tcactgtaaa
     1981 taaagaaaaa ggaaaatccc
//
