LOCUS       NM_001384631            4033 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 24,
            mRNA.
ACCESSION   NM_001384631
VERSION     NM_001384631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4033)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 4033)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 4033)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 4033)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 4033)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 4033)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 4033)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 4033)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 4033)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 4033)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.304105.1,
                                           SRR14038192.4200007.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-222             AC005783.1         25190-25242         c
            223-313             AC005783.1         22542-22632         c
            314-570             AC005783.1         16772-17028         c
            571-683             AC005783.1         8549-8661           c
            684-857             AC005783.1         6822-6995           c
            858-1026            AC005783.1         6577-6745           c
            1027-1140           AC005783.1         5294-5407           c
            1141-1269           AC005783.1         4718-4846           c
            1270-1370           AC005594.1         37952-38052         c
            1371-1533           AC005594.1         35062-35224         c
            1534-1613           AC005594.1         31279-31358         c
            1614-1766           AC005594.1         29971-30123         c
            1767-1902           AC005594.1         29158-29293         c
            1903-2048           AC005594.1         26027-26172         c
            2049-2195           AC005594.1         25064-25210         c
            2196-2348           AC005594.1         23878-24030         c
            2349-2491           AC005594.1         23097-23239         c
            2492-2603           AC005594.1         20236-20347         c
            2604-4033           AC005594.1         15628-17057         c
FEATURES             Location/Qualifiers
     source          1..4033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4033
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..222
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            223..313
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2696
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 10 is encoded by transcript variant 24;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 10"
                     /protein_id="NP_001371560.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MRKVKKLRLDKENTGSWRSFSLNSEGAERMATTGTPTADRGDAA
                     ATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLY
                     YLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRER
                     KRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRM
                     DPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQ
                     EEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRY
                     PRTDRLDPGEGAGAALQLAVPEGGVHRQGRVDPGWQIVHDIFYPFPQSEGEDELCFLR
                     ANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHG
                     SKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMF
                     VSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRS
                     DVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVV
                     VIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGG
                     FLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVE
                     KLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGE
                     HYEVTLLHFLQEYL"
     exon            314..570
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            571..683
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            684..857
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1026
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1140
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1269
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1370
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1533
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1613
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1766
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1902
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2048
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2195
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2348
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2491
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2603
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..4033
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4008..4013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: ATTAAA"
     polyA_site      4033
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg tctgtgtccc
      181 acgcctgcag ctggaatgga ggctctctgg accctttaga aggcacccct gccctcctga
      241 ggtcagctga gcggttaatg cggaaggtta agaaactgcg cctggacaag gagaacaccg
      301 gaagttggag aagcttctcg ctgaattccg agggggctga gaggatggcc accaccggga
      361 ccccaacggc cgaccgaggc gacgcagccg ccacagatga cccggccgcc cgcttccagg
      421 tgcagaagca ctcgtgggac gggctccgga gcatcatcca cggcagccgc aagtactcgg
      481 gcctcattgt caacaaggcg ccccacgact tccagtttgt gcagaagacg gatgagtctg
      541 ggccccactc ccaccgcctc tactacctgg gaatgccata tggcagccga gagaactccc
      601 tcctctactc tgagattccc aagaaggtcc ggaaagaggc tctgctgctc ctgtcctgga
      661 agcagatgct ggatcatttc caggccacgc cccaccatgg ggtctactct cgggaggagg
      721 agctgctgag ggagcggaaa cgcctggggg tcttcggcat cacctcctac gacttccaca
      781 gcgagagtgg cctcttcctc ttccaggcca gcaacagcct cttccactgc cgcgacggcg
      841 gcaagaacgg cttcatggtg tcccctatga aaccgctgga aatcaagacc cagtgctcag
      901 ggccccggat ggaccccaaa atctgccctg ccgaccctgc cttcttctcc ttcatcaata
      961 acagcgacct gtgggtggcc aacatcgaga caggcgagga gcggcggctg accttctgcc
     1021 accaaggttt atccaatgtc ctggatgacc ccaagtctgc gggtgtggcc accttcgtca
     1081 tacaggaaga gttcgaccgc ttcactgggt actggtggtg ccccacagcc tcctgggaag
     1141 gttcagaggg cctcaagacg ctgcgaatcc tgtatgagga agtcgatgag tccgaggtgg
     1201 aggtcattca cgtcccctct cctgcgctag aagaaaggaa gacggactcg tatcggtacc
     1261 ccaggacaga tcgtctcgac ccaggagaag gagctggtgc agcccttcag ctcgctgttc
     1321 ccgaaggtgg agtacatcgc cagggccggg tggacccggg atggcaaata gttcatgaca
     1381 tcttctatcc cttcccccaa tcagagggag aggacgagct ctgctttctc cgcgccaatg
     1441 aatgcaagac cggcttctgc catttgtaca aagtcaccgc cgttttaaaa tcccagggct
     1501 acgattggag tgagcccttc agccccgggg aagatgaatt taagtgcccc attaaggaag
     1561 agattgctct gaccagcggt gaatgggagg ttttggcgag gcacggctcc aagatctggg
     1621 tcaatgagga gaccaagctg gtgtacttcc agggcaccaa ggacacgccg ctggagcacc
     1681 acctctacgt ggtcagctat gaggcggccg gcgagatcgt acgcctcacc acgcccggct
     1741 tctcccatag ctgctccatg agccagaact tcgacatgtt cgtcagccac tacagcagcg
     1801 tgagcacgcc gccctgcgtg cacgtctaca agctgagcgg ccccgacgac gaccccctgc
     1861 acaagcagcc ccgcttctgg gctagcatga tggaggcagc cagctgcccc ccggattatg
     1921 ttcctccaga gatcttccat ttccacacgc gctcggatgt gcggctctac ggcatgatct
     1981 acaagcccca cgccttgcag ccagggaaga agcaccccac cgtcctcttt gtatatggag
     2041 gcccccaggt gcagctggtg aataactcct tcaaaggcat caagtacttg cggctcaaca
     2101 cactggcctc cctgggctac gccgtggttg tgattgacgg caggggctcc tgtcagcgag
     2161 ggcttcggtt cgaaggggcc ctgaaaaacc aaatgggcca ggtggagatc gaggaccagg
     2221 tggagggcct gcagttcgtg gccgagaagt atggcttcat cgacctgagc cgagttgcca
     2281 tccatggctg gtcctacggg ggcttcctct cgctcatggg gctaatccac aagccccagg
     2341 tgttcaaggt ggccatcgcg ggtgccccgg tcaccgtctg gatggcctac gacacagggt
     2401 acactgagcg ctacatggac gtccctgaga acaaccagca cggctatgag gcgggttccg
     2461 tggccctgca cgtggagaag ctgcccaatg agcccaaccg cttgcttatc ctccacggct
     2521 tcctggacga aaacgtgcac tttttccaca caaacttcct cgtctcccaa ctgatccgag
     2581 cagggaaacc ttaccagctc cagatctacc ccaacgagag acacagtatt cgctgccccg
     2641 agtcgggcga gcactatgaa gtcacgttgc tgcactttct acaggaatac ctctgagcct
     2701 gcccaccggg agccgccaca tcacagcaca agtggctgca gcctccgcgg ggaaccaggc
     2761 gggagggact gagtggcccg cgggccccag tgaggcactt tgtcccgccc agcgctggcc
     2821 agccccgagg agccgctgcc ttcaccgccc cgacgccttt tatccttttt taaacgctct
     2881 tgggttttat gtccgctgct tcttggttgc cgagacagag agatggtggt ctcgggccag
     2941 cccctcctct ccccgccttc tgggaggagg aggtcacacg ctgatgggca ctggagaggc
     3001 cagaagagac tcagaggagc gggctgcctt ccgcctgggg ctccctgtga cctctcagtc
     3061 ccctggcccg gccagccacc gtccccagca cccaagcatg caattgcctg tcccccccgg
     3121 ccagcctccc caacttgatg tttgtgtttt gtttgggggg atatttttca taattattta
     3181 aaagacaggc cgggcgcggt ggctcacgtc tgtaatccca gcactttggg aggctgaggc
     3241 gggcggatca cctgaggttg ggagttcaag accagcctgg ccaacatggg gaaaccccgt
     3301 ctctactaaa aatacaaaaa attagccggg tgtggtggcg cgtgcctata atcccagcta
     3361 ctcgggaggc tgaggcagga gaatcgcttg aacccgggag gtggaggttg cggtgagcca
     3421 agatcgcacc attgcactcc agcctgggca acaagagcga aactctgtct caaaataaat
     3481 aaaaaataaa agacagaaag caaggggtgc ctaaatctag acttggggtc cacaccgggc
     3541 agcggggttg caacccagca cctggtaggc tccatttctt cccaagcccg agcagagggt
     3601 catgcgggcc ccacaggaga agcggccagg gcccgcgggg ggcaccacct gtggacagcc
     3661 ctcctgtccc caagctttca ggcaggcact gaaacgcacc gaacttccac gctctgctgg
     3721 tcagtggcgg ctgtcccctc cccagcccag ccgcccagcc acatgtgtct gcctgacccg
     3781 tacacaccag gggttccggg gttgggagct gaaccatccc cacctcaggg ttatatttcc
     3841 ctctcccctt ccctccccgc caagagctct gccaggggcg ggcaaaaaaa aaagtaaaaa
     3901 gaaaagaaaa aaaaaaaaaa gaaacaaacc acctctacat attatggaaa gaaaatattt
     3961 ttgtcgattc ttattctttt ataattatgc gtggaagaag tagacacatt aaacgattcc
     4021 agttggaaac atg
//
