LOCUS       NM_001384627            4581 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 20,
            mRNA.
ACCESSION   NM_001384627
VERSION     NM_001384627.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4581)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 4581)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 4581)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 4581)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 4581)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 4581)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 4581)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 4581)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 4581)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 4581)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (20), as well as variants 16-19,
            encodes isoform 7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3781797.1,
                                           SRR18074969.1939480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-222             AC005783.1         25190-25242         c
            223-332             AC005783.1         24886-24995         c
            333-423             AC005783.1         22542-22632         c
            424-621             AC005783.1         18220-18417         c
            622-878             AC005783.1         16772-17028         c
            879-991             AC005783.1         8549-8661           c
            992-1165            AC005783.1         6822-6995           c
            1166-1334           AC005783.1         6577-6745           c
            1335-1448           AC005783.1         5294-5407           c
            1449-1577           AC005783.1         4718-4846           c
            1578-1639           AC005783.1         2907-2968           c
            1640-1740           AC005594.1         37952-38052         c
            1741-1918           AC005594.1         35779-35956         c
            1919-2081           AC005594.1         35062-35224         c
            2082-2161           AC005594.1         31279-31358         c
            2162-2314           AC005594.1         29971-30123         c
            2315-2450           AC005594.1         29158-29293         c
            2451-2596           AC005594.1         26027-26172         c
            2597-2743           AC005594.1         25064-25210         c
            2744-2896           AC005594.1         23878-24030         c
            2897-3039           AC005594.1         23097-23239         c
            3040-3151           AC005594.1         20236-20347         c
            3152-4581           AC005594.1         15628-17057         c
FEATURES             Location/Qualifiers
     source          1..4581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4581
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..222
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            223..332
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            333..423
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            424..621
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            622..878
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..3244
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 7 is encoded by transcript variant 20;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 7"
                     /protein_id="NP_001371556.1"
                     /db_xref="CCDS:CCDS92491.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKY
                     SGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLL
                     LSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLF
                     HCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGE
                     ERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRIL
                     YEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQ
                     EKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTEN
                     EEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTG
                     FCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNE
                     ETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSV
                     STPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGM
                     IYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGS
                     CQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGL
                     IHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPN
                     RLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLL
                     HFLQEYL"
     exon            879..991
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1165
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1334
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1448
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1577
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1639
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1740
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1918
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2081
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2161
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2314
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2450
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2596
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2743
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2896
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3039
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3151
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..4581
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4556..4561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: ATTAAA"
     polyA_site      4581
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg tctgtgtccc
      181 acgcctgcag ctggaatgga ggctctctgg accctttaga agctgcccct ggaaggagct
      241 ttttgaaggc tttgaggaga ggaaggggag agtgctgatt tcagcaggat ttggtggagg
      301 ggtgcctgga tccacctaca ctgcctgacc cggcacccct gccctcctga ggtcagctga
      361 gcggttaatg cggaaggtta agaaactgcg cctggacaag gagaacaccg gaagttggag
      421 aaggctctgg aacttccagt gaaggccaag catctccccg gctggacagc aagccaacag
      481 cacaggtgac caggatggat tttcattcct tcacgcccgg gcctctcccg agacccagca
      541 tgtctccccg cgagcccact gagagataat cattccacag tgctccgtgg aatgcctgcc
      601 acgtgccagc caccagctaa gcttctcgct gaattccgag ggggctgaga ggatggccac
      661 caccgggacc ccaacggccg accgaggcga cgcagccgcc acagatgacc cggccgcccg
      721 cttccaggtg cagaagcact cgtgggacgg gctccggagc atcatccacg gcagccgcaa
      781 gtactcgggc ctcattgtca acaaggcgcc ccacgacttc cagtttgtgc agaagacgga
      841 tgagtctggg ccccactccc accgcctcta ctacctggga atgccatatg gcagccgaga
      901 gaactccctc ctctactctg agattcccaa gaaggtccgg aaagaggctc tgctgctcct
      961 gtcctggaag cagatgctgg atcatttcca ggccacgccc caccatgggg tctactctcg
     1021 ggaggaggag ctgctgaggg agcggaaacg cctgggggtc ttcggcatca cctcctacga
     1081 cttccacagc gagagtggcc tcttcctctt ccaggccagc aacagcctct tccactgccg
     1141 cgacggcggc aagaacggct tcatggtgtc ccctatgaaa ccgctggaaa tcaagaccca
     1201 gtgctcaggg ccccggatgg accccaaaat ctgccctgcc gaccctgcct tcttctcctt
     1261 catcaataac agcgacctgt gggtggccaa catcgagaca ggcgaggagc ggcggctgac
     1321 cttctgccac caaggtttat ccaatgtcct ggatgacccc aagtctgcgg gtgtggccac
     1381 cttcgtcata caggaagagt tcgaccgctt cactgggtac tggtggtgcc ccacagcctc
     1441 ctgggaaggt tcagagggcc tcaagacgct gcgaatcctg tatgaggaag tcgatgagtc
     1501 cgaggtggag gtcattcacg tcccctctcc tgcgctagaa gaaaggaaga cggactcgta
     1561 tcggtacccc aggacaggca gcaagaatcc caagattgcc ttgaaactgg ctgagttcca
     1621 gactgacagc cagggcaaga tcgtctcgac ccaggagaag gagctggtgc agcccttcag
     1681 ctcgctgttc ccgaaggtgg agtacatcgc cagggccggg tggacccggg atggcaaata
     1741 cgcctgggcc atgttcctgg accggcccca gcagtggctc cagctcgtcc tcctcccccc
     1801 ggccctgttc atcccgagca cagagaatga ggagcagcgg ctagcctctg ccagagctgt
     1861 ccccaggaat gtccagccgt atgtggtgta cgaggaggtc accaacgtct ggatcaatgt
     1921 tcatgacatc ttctatccct tcccccaatc agagggagag gacgagctct gctttctccg
     1981 cgccaatgaa tgcaagaccg gcttctgcca tttgtacaaa gtcaccgccg ttttaaaatc
     2041 ccagggctac gattggagtg agcccttcag ccccggggaa gatgaattta agtgccccat
     2101 taaggaagag attgctctga ccagcggtga atgggaggtt ttggcgaggc acggctccaa
     2161 gatctgggtc aatgaggaga ccaagctggt gtacttccag ggcaccaagg acacgccgct
     2221 ggagcaccac ctctacgtgg tcagctatga ggcggccggc gagatcgtac gcctcaccac
     2281 gcccggcttc tcccatagct gctccatgag ccagaacttc gacatgttcg tcagccacta
     2341 cagcagcgtg agcacgccgc cctgcgtgca cgtctacaag ctgagcggcc ccgacgacga
     2401 ccccctgcac aagcagcccc gcttctgggc tagcatgatg gaggcagcca gctgcccccc
     2461 ggattatgtt cctccagaga tcttccattt ccacacgcgc tcggatgtgc ggctctacgg
     2521 catgatctac aagccccacg ccttgcagcc agggaagaag caccccaccg tcctctttgt
     2581 atatggaggc ccccaggtgc agctggtgaa taactccttc aaaggcatca agtacttgcg
     2641 gctcaacaca ctggcctccc tgggctacgc cgtggttgtg attgacggca ggggctcctg
     2701 tcagcgaggg cttcggttcg aaggggccct gaaaaaccaa atgggccagg tggagatcga
     2761 ggaccaggtg gagggcctgc agttcgtggc cgagaagtat ggcttcatcg acctgagccg
     2821 agttgccatc catggctggt cctacggggg cttcctctcg ctcatggggc taatccacaa
     2881 gccccaggtg ttcaaggtgg ccatcgcggg tgccccggtc accgtctgga tggcctacga
     2941 cacagggtac actgagcgct acatggacgt ccctgagaac aaccagcacg gctatgaggc
     3001 gggttccgtg gccctgcacg tggagaagct gcccaatgag cccaaccgct tgcttatcct
     3061 ccacggcttc ctggacgaaa acgtgcactt tttccacaca aacttcctcg tctcccaact
     3121 gatccgagca gggaaacctt accagctcca gatctacccc aacgagagac acagtattcg
     3181 ctgccccgag tcgggcgagc actatgaagt cacgttgctg cactttctac aggaatacct
     3241 ctgagcctgc ccaccgggag ccgccacatc acagcacaag tggctgcagc ctccgcgggg
     3301 aaccaggcgg gagggactga gtggcccgcg ggccccagtg aggcactttg tcccgcccag
     3361 cgctggccag ccccgaggag ccgctgcctt caccgccccg acgcctttta tcctttttta
     3421 aacgctcttg ggttttatgt ccgctgcttc ttggttgccg agacagagag atggtggtct
     3481 cgggccagcc cctcctctcc ccgccttctg ggaggaggag gtcacacgct gatgggcact
     3541 ggagaggcca gaagagactc agaggagcgg gctgccttcc gcctggggct ccctgtgacc
     3601 tctcagtccc ctggcccggc cagccaccgt ccccagcacc caagcatgca attgcctgtc
     3661 ccccccggcc agcctcccca acttgatgtt tgtgttttgt ttggggggat atttttcata
     3721 attatttaaa agacaggccg ggcgcggtgg ctcacgtctg taatcccagc actttgggag
     3781 gctgaggcgg gcggatcacc tgaggttggg agttcaagac cagcctggcc aacatgggga
     3841 aaccccgtct ctactaaaaa tacaaaaaat tagccgggtg tggtggcgcg tgcctataat
     3901 cccagctact cgggaggctg aggcaggaga atcgcttgaa cccgggaggt ggaggttgcg
     3961 gtgagccaag atcgcaccat tgcactccag cctgggcaac aagagcgaaa ctctgtctca
     4021 aaataaataa aaaataaaag acagaaagca aggggtgcct aaatctagac ttggggtcca
     4081 caccgggcag cggggttgca acccagcacc tggtaggctc catttcttcc caagcccgag
     4141 cagagggtca tgcgggcccc acaggagaag cggccagggc ccgcgggggg caccacctgt
     4201 ggacagccct cctgtcccca agctttcagg caggcactga aacgcaccga acttccacgc
     4261 tctgctggtc agtggcggct gtcccctccc cagcccagcc gcccagccac atgtgtctgc
     4321 ctgacccgta cacaccaggg gttccggggt tgggagctga accatcccca cctcagggtt
     4381 atatttccct ctccccttcc ctccccgcca agagctctgc caggggcggg caaaaaaaaa
     4441 agtaaaaaga aaagaaaaaa aaaaaaaaga aacaaaccac ctctacatat tatggaaaga
     4501 aaatattttt gtcgattctt attcttttat aattatgcgt ggaagaagta gacacattaa
     4561 acgattccag ttggaaacat g
//
