LOCUS       NM_001384625            4335 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 18,
            mRNA.
ACCESSION   NM_001384625
VERSION     NM_001384625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4335)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 4335)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 4335)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 4335)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 4335)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 4335)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 4335)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 4335)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 4335)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 4335)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (18), as well as variants 16,
            17,19, and 20, encodes isoform 7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3339141.1,
                                           SRR14038195.2441860.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-222             AC005783.1         25190-25242         c
            223-313             AC005783.1         22542-22632         c
            314-375             AC005783.1         18356-18417         c
            376-632             AC005783.1         16772-17028         c
            633-745             AC005783.1         8549-8661           c
            746-919             AC005783.1         6822-6995           c
            920-1088            AC005783.1         6577-6745           c
            1089-1202           AC005783.1         5294-5407           c
            1203-1331           AC005783.1         4718-4846           c
            1332-1393           AC005783.1         2907-2968           c
            1394-1494           AC005594.1         37952-38052         c
            1495-1672           AC005594.1         35779-35956         c
            1673-1835           AC005594.1         35062-35224         c
            1836-1915           AC005594.1         31279-31358         c
            1916-2068           AC005594.1         29971-30123         c
            2069-2204           AC005594.1         29158-29293         c
            2205-2350           AC005594.1         26027-26172         c
            2351-2497           AC005594.1         25064-25210         c
            2498-2650           AC005594.1         23878-24030         c
            2651-2793           AC005594.1         23097-23239         c
            2794-2905           AC005594.1         20236-20347         c
            2906-4335           AC005594.1         15628-17057         c
FEATURES             Location/Qualifiers
     source          1..4335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4335
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..222
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            223..313
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            314..375
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            376..632
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..2998
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 7 is encoded by transcript variant 18;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 7"
                     /protein_id="NP_001371554.1"
                     /db_xref="CCDS:CCDS92491.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKY
                     SGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLL
                     LSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLF
                     HCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGE
                     ERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRIL
                     YEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQ
                     EKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTEN
                     EEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTG
                     FCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNE
                     ETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSV
                     STPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGM
                     IYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGS
                     CQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGL
                     IHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPN
                     RLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLL
                     HFLQEYL"
     exon            633..745
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            746..919
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1088
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1202
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1331
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1393
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1494
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1672
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1835
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1915
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2068
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2204
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2350
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2497
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2650
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2793
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2905
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..4335
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4310..4315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: ATTAAA"
     polyA_site      4335
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg tctgtgtccc
      181 acgcctgcag ctggaatgga ggctctctgg accctttaga aggcacccct gccctcctga
      241 ggtcagctga gcggttaatg cggaaggtta agaaactgcg cctggacaag gagaacaccg
      301 gaagttggag aaggctctgg aacttccagt gaaggccaag catctccccg gctggacagc
      361 aagccaacag cacagcttct cgctgaattc cgagggggct gagaggatgg ccaccaccgg
      421 gaccccaacg gccgaccgag gcgacgcagc cgccacagat gacccggccg cccgcttcca
      481 ggtgcagaag cactcgtggg acgggctccg gagcatcatc cacggcagcc gcaagtactc
      541 gggcctcatt gtcaacaagg cgccccacga cttccagttt gtgcagaaga cggatgagtc
      601 tgggccccac tcccaccgcc tctactacct gggaatgcca tatggcagcc gagagaactc
      661 cctcctctac tctgagattc ccaagaaggt ccggaaagag gctctgctgc tcctgtcctg
      721 gaagcagatg ctggatcatt tccaggccac gccccaccat ggggtctact ctcgggagga
      781 ggagctgctg agggagcgga aacgcctggg ggtcttcggc atcacctcct acgacttcca
      841 cagcgagagt ggcctcttcc tcttccaggc cagcaacagc ctcttccact gccgcgacgg
      901 cggcaagaac ggcttcatgg tgtcccctat gaaaccgctg gaaatcaaga cccagtgctc
      961 agggccccgg atggacccca aaatctgccc tgccgaccct gccttcttct ccttcatcaa
     1021 taacagcgac ctgtgggtgg ccaacatcga gacaggcgag gagcggcggc tgaccttctg
     1081 ccaccaaggt ttatccaatg tcctggatga ccccaagtct gcgggtgtgg ccaccttcgt
     1141 catacaggaa gagttcgacc gcttcactgg gtactggtgg tgccccacag cctcctggga
     1201 aggttcagag ggcctcaaga cgctgcgaat cctgtatgag gaagtcgatg agtccgaggt
     1261 ggaggtcatt cacgtcccct ctcctgcgct agaagaaagg aagacggact cgtatcggta
     1321 ccccaggaca ggcagcaaga atcccaagat tgccttgaaa ctggctgagt tccagactga
     1381 cagccagggc aagatcgtct cgacccagga gaaggagctg gtgcagccct tcagctcgct
     1441 gttcccgaag gtggagtaca tcgccagggc cgggtggacc cgggatggca aatacgcctg
     1501 ggccatgttc ctggaccggc cccagcagtg gctccagctc gtcctcctcc ccccggccct
     1561 gttcatcccg agcacagaga atgaggagca gcggctagcc tctgccagag ctgtccccag
     1621 gaatgtccag ccgtatgtgg tgtacgagga ggtcaccaac gtctggatca atgttcatga
     1681 catcttctat cccttccccc aatcagaggg agaggacgag ctctgctttc tccgcgccaa
     1741 tgaatgcaag accggcttct gccatttgta caaagtcacc gccgttttaa aatcccaggg
     1801 ctacgattgg agtgagccct tcagccccgg ggaagatgaa tttaagtgcc ccattaagga
     1861 agagattgct ctgaccagcg gtgaatggga ggttttggcg aggcacggct ccaagatctg
     1921 ggtcaatgag gagaccaagc tggtgtactt ccagggcacc aaggacacgc cgctggagca
     1981 ccacctctac gtggtcagct atgaggcggc cggcgagatc gtacgcctca ccacgcccgg
     2041 cttctcccat agctgctcca tgagccagaa cttcgacatg ttcgtcagcc actacagcag
     2101 cgtgagcacg ccgccctgcg tgcacgtcta caagctgagc ggccccgacg acgaccccct
     2161 gcacaagcag ccccgcttct gggctagcat gatggaggca gccagctgcc ccccggatta
     2221 tgttcctcca gagatcttcc atttccacac gcgctcggat gtgcggctct acggcatgat
     2281 ctacaagccc cacgccttgc agccagggaa gaagcacccc accgtcctct ttgtatatgg
     2341 aggcccccag gtgcagctgg tgaataactc cttcaaaggc atcaagtact tgcggctcaa
     2401 cacactggcc tccctgggct acgccgtggt tgtgattgac ggcaggggct cctgtcagcg
     2461 agggcttcgg ttcgaagggg ccctgaaaaa ccaaatgggc caggtggaga tcgaggacca
     2521 ggtggagggc ctgcagttcg tggccgagaa gtatggcttc atcgacctga gccgagttgc
     2581 catccatggc tggtcctacg ggggcttcct ctcgctcatg gggctaatcc acaagcccca
     2641 ggtgttcaag gtggccatcg cgggtgcccc ggtcaccgtc tggatggcct acgacacagg
     2701 gtacactgag cgctacatgg acgtccctga gaacaaccag cacggctatg aggcgggttc
     2761 cgtggccctg cacgtggaga agctgcccaa tgagcccaac cgcttgctta tcctccacgg
     2821 cttcctggac gaaaacgtgc actttttcca cacaaacttc ctcgtctccc aactgatccg
     2881 agcagggaaa ccttaccagc tccagatcta ccccaacgag agacacagta ttcgctgccc
     2941 cgagtcgggc gagcactatg aagtcacgtt gctgcacttt ctacaggaat acctctgagc
     3001 ctgcccaccg ggagccgcca catcacagca caagtggctg cagcctccgc ggggaaccag
     3061 gcgggaggga ctgagtggcc cgcgggcccc agtgaggcac tttgtcccgc ccagcgctgg
     3121 ccagccccga ggagccgctg ccttcaccgc cccgacgcct tttatccttt tttaaacgct
     3181 cttgggtttt atgtccgctg cttcttggtt gccgagacag agagatggtg gtctcgggcc
     3241 agcccctcct ctccccgcct tctgggagga ggaggtcaca cgctgatggg cactggagag
     3301 gccagaagag actcagagga gcgggctgcc ttccgcctgg ggctccctgt gacctctcag
     3361 tcccctggcc cggccagcca ccgtccccag cacccaagca tgcaattgcc tgtccccccc
     3421 ggccagcctc cccaacttga tgtttgtgtt ttgtttgggg ggatattttt cataattatt
     3481 taaaagacag gccgggcgcg gtggctcacg tctgtaatcc cagcactttg ggaggctgag
     3541 gcgggcggat cacctgaggt tgggagttca agaccagcct ggccaacatg gggaaacccc
     3601 gtctctacta aaaatacaaa aaattagccg ggtgtggtgg cgcgtgccta taatcccagc
     3661 tactcgggag gctgaggcag gagaatcgct tgaacccggg aggtggaggt tgcggtgagc
     3721 caagatcgca ccattgcact ccagcctggg caacaagagc gaaactctgt ctcaaaataa
     3781 ataaaaaata aaagacagaa agcaaggggt gcctaaatct agacttgggg tccacaccgg
     3841 gcagcggggt tgcaacccag cacctggtag gctccatttc ttcccaagcc cgagcagagg
     3901 gtcatgcggg ccccacagga gaagcggcca gggcccgcgg ggggcaccac ctgtggacag
     3961 ccctcctgtc cccaagcttt caggcaggca ctgaaacgca ccgaacttcc acgctctgct
     4021 ggtcagtggc ggctgtcccc tccccagccc agccgcccag ccacatgtgt ctgcctgacc
     4081 cgtacacacc aggggttccg gggttgggag ctgaaccatc cccacctcag ggttatattt
     4141 ccctctcccc ttccctcccc gccaagagct ctgccagggg cgggcaaaaa aaaaagtaaa
     4201 aagaaaagaa aaaaaaaaaa aagaaacaaa ccacctctac atattatgga aagaaaatat
     4261 ttttgtcgat tcttattctt ttataattat gcgtggaaga agtagacaca ttaaacgatt
     4321 ccagttggaa acatg
//
