LOCUS       NM_001384623            4419 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 16,
            mRNA.
ACCESSION   NM_001384623
VERSION     NM_001384623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4419)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 4419)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 4419)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 4419)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 4419)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 4419)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 4419)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 4419)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 4419)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 4419)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (16), as well as variants 17-20,
            encodes isoform 7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2504471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-222             AC005783.1         25190-25242         c
            223-313             AC005783.1         22542-22632         c
            314-413             AC005783.1         18744-18843         c
            414-459             AC005783.1         18356-18401         c
            460-716             AC005783.1         16772-17028         c
            717-829             AC005783.1         8549-8661           c
            830-1003            AC005783.1         6822-6995           c
            1004-1172           AC005783.1         6577-6745           c
            1173-1286           AC005783.1         5294-5407           c
            1287-1415           AC005783.1         4718-4846           c
            1416-1477           AC005783.1         2907-2968           c
            1478-1578           AC005594.1         37952-38052         c
            1579-1756           AC005594.1         35779-35956         c
            1757-1919           AC005594.1         35062-35224         c
            1920-1999           AC005594.1         31279-31358         c
            2000-2152           AC005594.1         29971-30123         c
            2153-2288           AC005594.1         29158-29293         c
            2289-2434           AC005594.1         26027-26172         c
            2435-2581           AC005594.1         25064-25210         c
            2582-2734           AC005594.1         23878-24030         c
            2735-2877           AC005594.1         23097-23239         c
            2878-2989           AC005594.1         20236-20347         c
            2990-4419           AC005594.1         15628-17057         c
FEATURES             Location/Qualifiers
     source          1..4419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4419
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..222
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            223..313
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            314..413
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            414..459
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            460..716
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..3082
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 7 is encoded by transcript variant 16;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 7"
                     /protein_id="NP_001371552.1"
                     /db_xref="CCDS:CCDS92491.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKY
                     SGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLL
                     LSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLF
                     HCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGE
                     ERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRIL
                     YEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQ
                     EKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTEN
                     EEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTG
                     FCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNE
                     ETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSV
                     STPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGM
                     IYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGS
                     CQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGL
                     IHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPN
                     RLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLL
                     HFLQEYL"
     exon            717..829
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1003
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1172
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1286
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1415
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1477
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1578
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1756
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1919
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1999
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2152
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2288
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2434
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2581
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2734
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2877
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2989
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..4419
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: ATTAAA"
     polyA_site      4419
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg tctgtgtccc
      181 acgcctgcag ctggaatgga ggctctctgg accctttaga aggcacccct gccctcctga
      241 ggtcagctga gcggttaatg cggaaggtta agaaactgcg cctggacaag gagaacaccg
      301 gaagttggag aagtccctgc tgtccactcc cgcgggtttt cccacttcct ccaagcaagc
      361 agcgacttcc ccaagccaag ctgttggtcc cggaggacag ggcttctggc aagtgaaggc
      421 caagcatctc cccggctgga cagcaagcca acagcacagc ttctcgctga attccgaggg
      481 ggctgagagg atggccacca ccgggacccc aacggccgac cgaggcgacg cagccgccac
      541 agatgacccg gccgcccgct tccaggtgca gaagcactcg tgggacgggc tccggagcat
      601 catccacggc agccgcaagt actcgggcct cattgtcaac aaggcgcccc acgacttcca
      661 gtttgtgcag aagacggatg agtctgggcc ccactcccac cgcctctact acctgggaat
      721 gccatatggc agccgagaga actccctcct ctactctgag attcccaaga aggtccggaa
      781 agaggctctg ctgctcctgt cctggaagca gatgctggat catttccagg ccacgcccca
      841 ccatggggtc tactctcggg aggaggagct gctgagggag cggaaacgcc tgggggtctt
      901 cggcatcacc tcctacgact tccacagcga gagtggcctc ttcctcttcc aggccagcaa
      961 cagcctcttc cactgccgcg acggcggcaa gaacggcttc atggtgtccc ctatgaaacc
     1021 gctggaaatc aagacccagt gctcagggcc ccggatggac cccaaaatct gccctgccga
     1081 ccctgccttc ttctccttca tcaataacag cgacctgtgg gtggccaaca tcgagacagg
     1141 cgaggagcgg cggctgacct tctgccacca aggtttatcc aatgtcctgg atgaccccaa
     1201 gtctgcgggt gtggccacct tcgtcataca ggaagagttc gaccgcttca ctgggtactg
     1261 gtggtgcccc acagcctcct gggaaggttc agagggcctc aagacgctgc gaatcctgta
     1321 tgaggaagtc gatgagtccg aggtggaggt cattcacgtc ccctctcctg cgctagaaga
     1381 aaggaagacg gactcgtatc ggtaccccag gacaggcagc aagaatccca agattgcctt
     1441 gaaactggct gagttccaga ctgacagcca gggcaagatc gtctcgaccc aggagaagga
     1501 gctggtgcag cccttcagct cgctgttccc gaaggtggag tacatcgcca gggccgggtg
     1561 gacccgggat ggcaaatacg cctgggccat gttcctggac cggccccagc agtggctcca
     1621 gctcgtcctc ctccccccgg ccctgttcat cccgagcaca gagaatgagg agcagcggct
     1681 agcctctgcc agagctgtcc ccaggaatgt ccagccgtat gtggtgtacg aggaggtcac
     1741 caacgtctgg atcaatgttc atgacatctt ctatcccttc ccccaatcag agggagagga
     1801 cgagctctgc tttctccgcg ccaatgaatg caagaccggc ttctgccatt tgtacaaagt
     1861 caccgccgtt ttaaaatccc agggctacga ttggagtgag cccttcagcc ccggggaaga
     1921 tgaatttaag tgccccatta aggaagagat tgctctgacc agcggtgaat gggaggtttt
     1981 ggcgaggcac ggctccaaga tctgggtcaa tgaggagacc aagctggtgt acttccaggg
     2041 caccaaggac acgccgctgg agcaccacct ctacgtggtc agctatgagg cggccggcga
     2101 gatcgtacgc ctcaccacgc ccggcttctc ccatagctgc tccatgagcc agaacttcga
     2161 catgttcgtc agccactaca gcagcgtgag cacgccgccc tgcgtgcacg tctacaagct
     2221 gagcggcccc gacgacgacc ccctgcacaa gcagccccgc ttctgggcta gcatgatgga
     2281 ggcagccagc tgccccccgg attatgttcc tccagagatc ttccatttcc acacgcgctc
     2341 ggatgtgcgg ctctacggca tgatctacaa gccccacgcc ttgcagccag ggaagaagca
     2401 ccccaccgtc ctctttgtat atggaggccc ccaggtgcag ctggtgaata actccttcaa
     2461 aggcatcaag tacttgcggc tcaacacact ggcctccctg ggctacgccg tggttgtgat
     2521 tgacggcagg ggctcctgtc agcgagggct tcggttcgaa ggggccctga aaaaccaaat
     2581 gggccaggtg gagatcgagg accaggtgga gggcctgcag ttcgtggccg agaagtatgg
     2641 cttcatcgac ctgagccgag ttgccatcca tggctggtcc tacgggggct tcctctcgct
     2701 catggggcta atccacaagc cccaggtgtt caaggtggcc atcgcgggtg ccccggtcac
     2761 cgtctggatg gcctacgaca cagggtacac tgagcgctac atggacgtcc ctgagaacaa
     2821 ccagcacggc tatgaggcgg gttccgtggc cctgcacgtg gagaagctgc ccaatgagcc
     2881 caaccgcttg cttatcctcc acggcttcct ggacgaaaac gtgcactttt tccacacaaa
     2941 cttcctcgtc tcccaactga tccgagcagg gaaaccttac cagctccaga tctaccccaa
     3001 cgagagacac agtattcgct gccccgagtc gggcgagcac tatgaagtca cgttgctgca
     3061 ctttctacag gaatacctct gagcctgccc accgggagcc gccacatcac agcacaagtg
     3121 gctgcagcct ccgcggggaa ccaggcggga gggactgagt ggcccgcggg ccccagtgag
     3181 gcactttgtc ccgcccagcg ctggccagcc ccgaggagcc gctgccttca ccgccccgac
     3241 gccttttatc cttttttaaa cgctcttggg ttttatgtcc gctgcttctt ggttgccgag
     3301 acagagagat ggtggtctcg ggccagcccc tcctctcccc gccttctggg aggaggaggt
     3361 cacacgctga tgggcactgg agaggccaga agagactcag aggagcgggc tgccttccgc
     3421 ctggggctcc ctgtgacctc tcagtcccct ggcccggcca gccaccgtcc ccagcaccca
     3481 agcatgcaat tgcctgtccc ccccggccag cctccccaac ttgatgtttg tgttttgttt
     3541 ggggggatat ttttcataat tatttaaaag acaggccggg cgcggtggct cacgtctgta
     3601 atcccagcac tttgggaggc tgaggcgggc ggatcacctg aggttgggag ttcaagacca
     3661 gcctggccaa catggggaaa ccccgtctct actaaaaata caaaaaatta gccgggtgtg
     3721 gtggcgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc
     3781 cgggaggtgg aggttgcggt gagccaagat cgcaccattg cactccagcc tgggcaacaa
     3841 gagcgaaact ctgtctcaaa ataaataaaa aataaaagac agaaagcaag gggtgcctaa
     3901 atctagactt ggggtccaca ccgggcagcg gggttgcaac ccagcacctg gtaggctcca
     3961 tttcttccca agcccgagca gagggtcatg cgggccccac aggagaagcg gccagggccc
     4021 gcggggggca ccacctgtgg acagccctcc tgtccccaag ctttcaggca ggcactgaaa
     4081 cgcaccgaac ttccacgctc tgctggtcag tggcggctgt cccctcccca gcccagccgc
     4141 ccagccacat gtgtctgcct gacccgtaca caccaggggt tccggggttg ggagctgaac
     4201 catccccacc tcagggttat atttccctct ccccttccct ccccgccaag agctctgcca
     4261 ggggcgggca aaaaaaaaag taaaaagaaa agaaaaaaaa aaaaaagaaa caaaccacct
     4321 ctacatatta tggaaagaaa atatttttgt cgattcttat tcttttataa ttatgcgtgg
     4381 aagaagtaga cacattaaac gattccagtt ggaaacatg
//
