LOCUS       NM_001365987            2293 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 9 (DPP9), transcript variant 2,
            mRNA.
ACCESSION   NM_001365987
VERSION     NM_001365987.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
            Huang,X. and Hu,R.
  TITLE     DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
            in liver cancer cells
  JOURNAL   Redox Biol 75, 103292 (2024)
   PUBMED   39094401
  REMARK    GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
            chemotherapy in liver cancer cells.
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
            Khokha,R., Brummer,T. and Reinheckel,T.
  TITLE     Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
            metastasis in breast cancer
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
   PUBMED   38531482
  REMARK    GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
            tumorigenesis and metastasis in breast cancer.
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
            Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
  TITLE     DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
            Resistance in Clear Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res 83 (23), 3940-3955 (2023)
   PUBMED   37713596
  REMARK    GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
            Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
            Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
            and Lee-Kirsch,M.A.
  TITLE     Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
            de novo mutation in DPP9
  JOURNAL   J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
   PUBMED   37544411
  REMARK    GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
            due to a de novo mutation in DPP9.
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
            Okada,H. and Morikawa,Y.
  TITLE     Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
            role of the signal sequence and overexpression in Escherichia coli
  JOURNAL   Protein Expr Purif 41 (2), 241-251 (2005)
   PUBMED   15866709
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
  TITLE     Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
            cytoplasmic localization and DPIV-like peptidase activity
  JOURNAL   Biochim Biophys Acta 1679 (1), 18-28 (2004)
   PUBMED   15245913
  REMARK    GeneRIF: identification of two forms, their tissue distribution,
            cytoplasmic localization
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 2293)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 2293)
  AUTHORS   Olsen,C. and Wagtmann,N.
  TITLE     Identification and characterization of human DPP9, a novel
            homologue of dipeptidyl peptidase IV
  JOURNAL   Gene 299 (1-2), 185-193 (2002)
   PUBMED   12459266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005783.1 and AC005594.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001365987.1.
            
            Summary: This gene encodes a protein that is a member of the S9B
            family in clan SC of the serine proteases. The protein has been
            shown to have post-proline dipeptidyl aminopeptidase activity,
            cleaving Xaa-Pro dipeptides from the N-termini of proteins.
            Although the activity of this protein is similar to that of
            dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
            bound. In general, dipeptidyl peptidases appear to be involved in
            the regulation of the activity of their substrates and have been
            linked to a variety of diseases including type 2 diabetes, obesity
            and cancer. Several transcript variants of this gene have been
            described but not fully characterized. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2), as well as variant 9, encodes
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2572018.1,
                                           SRR14038197.729215.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: locus in the vicinity of disease-associated
                                   variant(s)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC005783.1         26365-26533         c
            170-222             AC005783.1         25190-25242         c
            223-313             AC005783.1         22542-22632         c
            314-570             AC005783.1         16772-17028         c
            571-683             AC005783.1         8549-8661           c
            684-857             AC005783.1         6822-6995           c
            858-1026            AC005783.1         6577-6745           c
            1027-1140           AC005783.1         5294-5407           c
            1141-1269           AC005783.1         4718-4846           c
            1270-1331           AC005783.1         2907-2968           c
            1332-1432           AC005594.1         37952-38052         c
            1433-1610           AC005594.1         35779-35956         c
            1611-2293           AC005594.1         34542-35224         c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2293
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="dipeptidyl peptidase 9"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
     exon            1..169
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            170..222
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            223..313
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1814
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /EC_number="3.4.14.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dipeptidyl peptidase IV-related protein-2; dipeptidyl
                     peptidase IX; dipeptidyl peptidase-like protein 9"
                     /codon_start=1
                     /product="dipeptidyl peptidase 9 isoform 2"
                     /protein_id="NP_001352916.1"
                     /db_xref="CCDS:CCDS92492.1"
                     /db_xref="GeneID:91039"
                     /db_xref="HGNC:HGNC:18648"
                     /db_xref="MIM:608258"
                     /translation="MRKVKKLRLDKENTGSWRSFSLNSEGAERMATTGTPTADRGDAA
                     ATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLY
                     YLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRER
                     KRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRM
                     DPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQ
                     EEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRY
                     PRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKY
                     AWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWI
                     NVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEGEQ
                     SLTNAVDSSR"
     exon            314..570
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            571..683
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            684..857
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1026
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1140
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1269
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1331
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1432
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1610
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..2293
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="major polyA site"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="DPP9"
                     /gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
                     IMD111"
ORIGIN      
        1 aacttccggg tcaaaggtgc ctgagccggc gggtcccctg tgtccgccgc ggctgtcgtc
       61 ccccgctccc gccacttccg gggtcgcagt cccgggcatg gagccgcgac cgtgaggcgc
      121 cgctggaccc gggacgacct gcccagtccg gccgccgccc cacgtcccgg tctgtgtccc
      181 acgcctgcag ctggaatgga ggctctctgg accctttaga aggcacccct gccctcctga
      241 ggtcagctga gcggttaatg cggaaggtta agaaactgcg cctggacaag gagaacaccg
      301 gaagttggag aagcttctcg ctgaattccg agggggctga gaggatggcc accaccggga
      361 ccccaacggc cgaccgaggc gacgcagccg ccacagatga cccggccgcc cgcttccagg
      421 tgcagaagca ctcgtgggac gggctccgga gcatcatcca cggcagccgc aagtactcgg
      481 gcctcattgt caacaaggcg ccccacgact tccagtttgt gcagaagacg gatgagtctg
      541 ggccccactc ccaccgcctc tactacctgg gaatgccata tggcagccga gagaactccc
      601 tcctctactc tgagattccc aagaaggtcc ggaaagaggc tctgctgctc ctgtcctgga
      661 agcagatgct ggatcatttc caggccacgc cccaccatgg ggtctactct cgggaggagg
      721 agctgctgag ggagcggaaa cgcctggggg tcttcggcat cacctcctac gacttccaca
      781 gcgagagtgg cctcttcctc ttccaggcca gcaacagcct cttccactgc cgcgacggcg
      841 gcaagaacgg cttcatggtg tcccctatga aaccgctgga aatcaagacc cagtgctcag
      901 ggccccggat ggaccccaaa atctgccctg ccgaccctgc cttcttctcc ttcatcaata
      961 acagcgacct gtgggtggcc aacatcgaga caggcgagga gcggcggctg accttctgcc
     1021 accaaggttt atccaatgtc ctggatgacc ccaagtctgc gggtgtggcc accttcgtca
     1081 tacaggaaga gttcgaccgc ttcactgggt actggtggtg ccccacagcc tcctgggaag
     1141 gttcagaggg cctcaagacg ctgcgaatcc tgtatgagga agtcgatgag tccgaggtgg
     1201 aggtcattca cgtcccctct cctgcgctag aagaaaggaa gacggactcg tatcggtacc
     1261 ccaggacagg cagcaagaat cccaagattg ccttgaaact ggctgagttc cagactgaca
     1321 gccagggcaa gatcgtctcg acccaggaga aggagctggt gcagcccttc agctcgctgt
     1381 tcccgaaggt ggagtacatc gccagggccg ggtggacccg ggatggcaaa tacgcctggg
     1441 ccatgttcct ggaccggccc cagcagtggc tccagctcgt cctcctcccc ccggccctgt
     1501 tcatcccgag cacagagaat gaggagcagc ggctagcctc tgccagagct gtccccagga
     1561 atgtccagcc gtatgtggtg tacgaggagg tcaccaacgt ctggatcaat gttcatgaca
     1621 tcttctatcc cttcccccaa tcagagggag aggacgagct ctgctttctc cgcgccaatg
     1681 aatgcaagac cggcttctgc catttgtaca aagtcaccgc cgttttaaaa tcccagggct
     1741 acgattggag tgagcccttc agccccgggg aaggtgagca gagcctgacg aatgctgtcg
     1801 actcatcgcg ttagtcacgt gtggttcaat atgctgtttg ttcattggtc ggccccccca
     1861 ctcagccagc acaccctgcg ggagaaggaa cagggatcgg caggaagcca gccttcccca
     1921 gtgactgcat gatctggcag ggcttagagc acccaactgt tggcttattc aggcagcaga
     1981 tttactgagc acctcccctg tgccaggccc ttagcacaac caggggttgg ccacctacgg
     2041 cccacaggtc aaatccggcc caccacctgt gttcataaat aaagttttat tggcactgag
     2101 ccacagccac ttgtttacag agactgtctg tggtcgcttt tgtgctgcag cagcagaact
     2161 gggtagtccc agcagaaact gttgtgcaag gccaagattt actgtctagc cctttgtaga
     2221 aacatttgcc agctcctgct gtaggtagct gtgatggaat tgttcactgt aaataaagaa
     2281 aaaggaaaat ccc
//
