LOCUS       NM_197961               7264 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 8 (DPP8), transcript variant 4,
            mRNA.
ACCESSION   NM_197961
VERSION     NM_197961.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7264)
  AUTHORS   Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
            Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
  TITLE     DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
            deposition of extracellular matrix (ECM) in human mesangial cells
            via Smad and Akt signaling pathways
  JOURNAL   Toxicol Lett 395, 1-10 (2024)
   PUBMED   38458339
  REMARK    GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
            excessive deposition of extracellular matrix (ECM) in human
            mesangial cells via Smad and Akt signaling pathways.
REFERENCE   2  (bases 1 to 7264)
  AUTHORS   Zhang,Y., Li,K., Li,Y., Zhao,W., Wang,L., Chen,Z., Ma,X., Yao,T.,
            Wang,J., Dong,W., Li,X., Tian,X. and Fu,R.
  TITLE     Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the
            proximal renal tubule epithelial cells
  JOURNAL   Pharmacol Res 169, 105630 (2021)
   PUBMED   33932609
  REMARK    GeneRIF: Profibrotic mechanisms of DPP8 and DPP9 highly expressed
            in the proximal renal tubule epithelial cells.
REFERENCE   3  (bases 1 to 7264)
  AUTHORS   Hollingsworth,L.R., Sharif,H., Griswold,A.R., Fontana,P.,
            Mintseris,J., Dagbay,K.B., Paulo,J.A., Gygi,S.P., Bachovchin,D.A.
            and Wu,H.
  TITLE     DPP9 sequesters the C terminus of NLRP1 to repress inflammasome
            activation
  JOURNAL   Nature 592 (7856), 778-783 (2021)
   PUBMED   33731932
REFERENCE   4  (bases 1 to 7264)
  AUTHORS   Huang,M., Zhang,X., Toh,G.A., Gong,Q., Wang,J., Han,Z., Wu,B.,
            Zhong,F. and Chai,J.
  TITLE     Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
  JOURNAL   Nature 592 (7856), 773-777 (2021)
   PUBMED   33731929
REFERENCE   5  (bases 1 to 7264)
  AUTHORS   Suski,M., Wisniewska,A., Kus,K., Kiepura,A., Stachowicz,A.,
            Stachyra,K., Czepiel,K., Madej,J. and Olszanecki,R.
  TITLE     Decrease of the pro-inflammatory M1-like response by inhibition of
            dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative
            proteomics of the proteome and secretome
  JOURNAL   Mol Immunol 127, 193-202 (2020)
   PUBMED   32998073
  REMARK    GeneRIF: Decrease of the pro-inflammatory M1-like response by
            inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages -
            quantitative proteomics of the proteome and secretome.
REFERENCE   6  (bases 1 to 7264)
  AUTHORS   Chen,Y.S., Chien,C.H., Goparaju,C.M., Hsu,J.T., Liang,P.H. and
            Chen,X.
  TITLE     Purification and characterization of human prolyl dipeptidase DPP8
            in Sf9 insect cells
  JOURNAL   Protein Expr Purif 35 (1), 142-146 (2004)
   PUBMED   15039077
REFERENCE   7  (bases 1 to 7264)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   8  (bases 1 to 7264)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
REFERENCE   9  (bases 1 to 7264)
  AUTHORS   Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
            McCaughan,G.W. and Gorrell,M.D.
  TITLE     Structural requirements for catalysis, expression, and dimerization
            in the CD26/DPIV gene family
  JOURNAL   Biochemistry 42 (3), 694-701 (2003)
   PUBMED   12534281
REFERENCE   10 (bases 1 to 7264)
  AUTHORS   Abbott,C.A., Yu,D.M., Woollatt,E., Sutherland,G.R., McCaughan,G.W.
            and Gorrell,M.D.
  TITLE     Cloning, expression and chromosomal localization of a novel human
            dipeptidyl peptidase (DPP) IV homolog, DPP8
  JOURNAL   Eur J Biochem 267 (20), 6140-6150 (2000)
   PUBMED   11012666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030688.2, AC105129.4 and
            BU753778.1.
            
            On May 31, 2019 this sequence version replaced NM_197961.3.
            
            Summary: This gene encodes a member of the peptidase S9B family, a
            small family of dipeptidyl peptidases that are able to cleave
            peptide substrates at a prolyl bond. The encoded protein shares
            similarity with dipeptidyl peptidase IV in that it is ubiquitously
            expressed, and hydrolyzes the same substrates. These similarities
            suggest that, like dipeptidyl peptidase IV, this protein may play a
            role in T-cell activation and immune function. Alternatively
            spliced transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) contains an alternate exon in
            the 5' UTR and 5' coding region and lacks an exon in the 3' coding
            region compared to variant 1. These diferences result in the use of
            an alternate start codon compared to variant 1. The encoded isoform
            (4) is shorter and has a distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030688.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3110              BC030688.2         16-3125
            3111-7213           AC105129.4         39136-43238
            7214-7264           BU753778.1         21-71               c
FEATURES             Location/Qualifiers
     source          1..7264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..7264
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /note="dipeptidyl peptidase 8"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
     exon            1..204
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            205..340
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2847
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /EC_number="3.4.14.5"
                     /note="isoform 4 is encoded by transcript variant 4;
                     prolyl dipeptidase DPP8; dipeptidyl peptidase VIII; DPP
                     VIII; dipeptidyl peptidase IV-related protein 1"
                     /codon_start=1
                     /product="dipeptidyl peptidase 8 isoform 4"
                     /protein_id="NP_932065.1"
                     /db_xref="CCDS:CCDS10208.1"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
                     /translation="MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQD
                     RPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYL
                     AMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKR
                     IGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDP
                     KLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEE
                     FDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKT
                     GTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWS
                     ILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIH
                     DIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPI
                     KEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRL
                     TDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSA
                     GPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFK
                     GVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMVAIAGAPVTLWIFYDTGY
                     TERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLV
                     RAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI"
     exon            341..610
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            611..723
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            724..897
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1066
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1177
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1306
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1368
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1469
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1647
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1807
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1887
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2040
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2176
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2322
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2469
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2612
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2724
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..7264
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /note="hexamer: AAGAAA"
     polyA_site      4802
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
     regulatory      7242..7247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /note="hexamer: AATAAA"
     polyA_site      7264
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgcta aagcctccga ggccaaggcc gctgctactg ccgccgctgc ttcttagtgc
       61 cgcgttcgcc gcctgggttg tcaccggcgc cgccgccgag gaagccactg caaccaggac
      121 cggagtggag gcggcgcagc atgaagcggc gcaggcccgc tccatagcgc acgtcgggac
      181 ggtccgggcg gggccggggg gaaggctttg atggtgagga aaggaaagat tcctgtgaga
      241 agagcaggat gagcagaggg attctatgct tgaagtcgag tcacttgaaa aagatctctt
      301 tgaatgtgga agagatctga gcagatgaaa ataaaatcag gaaaatgcaa catggcagca
      361 gcaatggaaa cagaacagct gggtgttgag atatttgaaa ctgcggactg tgaggagaat
      421 attgaatcac aggatcggcc taaattggag cctttttatg ttgagcggta ttcctggagt
      481 cagcttaaaa agctgcttgc cgataccaga aaatatcatg gctacatgat ggctaaggca
      541 ccacatgatt tcatgtttgt gaagaggaat gatccagatg gacctcattc agacagaatc
      601 tattaccttg ccatgtctgg tgagaacaga gaaaatacac tgttttattc tgaaattccc
      661 aaaactatca atagagcagc agtcttaatg ctctcttgga agcctctttt ggatcttttt
      721 caggcaacac tggactatgg aatgtattct cgagaagaag aactattaag agaaagaaaa
      781 cgcattggaa cagtcggaat tgcttcttac gattatcacc aaggaagtgg aacatttctg
      841 tttcaagccg gtagtggaat ttatcacgta aaagatggag ggccacaagg atttacgcaa
      901 caacctttaa ggcccaatct agtggaaact agttgtccca acatacggat ggatccaaaa
      961 ttatgccctg ctgatccaga ctggattgct tttatacata gcaacgatat ttggatatct
     1021 aacatcgtaa ccagagaaga aaggagactc acttatgtgc acaatgagct agccaacatg
     1081 gaagaagatg ccagatcagc tggagtcgct acctttgttc tccaagaaga atttgataga
     1141 tattctggct attggtggtg tccaaaagct gaaacaactc ccagtggtgg taaaattctt
     1201 agaattctat atgaagaaaa tgatgaatct gaggtggaaa ttattcatgt tacatcccct
     1261 atgttggaaa caaggagggc agattcattc cgttatccta aaacaggtac agcaaatcct
     1321 aaagtcactt ttaagatgtc agaaataatg attgatgctg aaggaaggat catagatgtc
     1381 atagataagg aactaattca accttttgag attctatttg aaggagttga atatattgcc
     1441 agagctggat ggactcctga gggaaaatat gcttggtcca tcctactaga tcgctcccag
     1501 actcgcctac agatagtgtt gatctcacct gaattattta tcccagtaga agatgatgtt
     1561 atggaaaggc agagactcat tgagtcagtg cctgattctg tgacgccact aattatctat
     1621 gaagaaacaa cagacatctg gataaatatc catgacatct ttcatgtttt tccccaaagt
     1681 cacgaagagg aaattgagtt tatttttgcc tctgaatgca aaacaggttt ccgtcattta
     1741 tacaaaatta catctatttt aaaggaaagc aaatataaac gatccagtgg tgggctgcct
     1801 gctccaagtg atttcaagtg tcctatcaaa gaggagatag caattaccag tggtgaatgg
     1861 gaagttcttg gccggcatgg atctaatatc caagttgatg aagtcagaag gctggtatat
     1921 tttgaaggca ccaaagactc ccctttagag catcacctgt acgtagtcag ttacgtaaat
     1981 cctggagagg tgacaaggct gactgaccgt ggctactcac attcttgctg catcagtcag
     2041 cactgtgact tctttataag taagtatagt aaccagaaga atccacactg tgtgtccctt
     2101 tacaagctat caagtcctga agatgaccca acttgcaaaa caaaggaatt ttgggccacc
     2161 attttggatt cagcaggtcc tcttcctgac tatactcctc cagaaatttt ctcttttgaa
     2221 agtactactg gatttacatt gtatgggatg ctctacaagc ctcatgatct acagcctgga
     2281 aagaaatatc ctactgtgct gttcatatat ggtggtcctc aggtgcagtt ggtgaataat
     2341 cggtttaaag gagtcaagta tttccgcttg aataccctag cctctctagg ttatgtggtt
     2401 gtagtgatag acaacagggg atcctgtcac cgagggctta aatttgaagg cgcctttaaa
     2461 tataaaatgg ttgctattgc tggggcccca gtcactctgt ggatcttcta tgatacagga
     2521 tacacggaac gttatatggg tcaccctgac cagaatgaac agggctatta cttaggatct
     2581 gtggccatgc aagcagaaaa gttcccctct gaaccaaatc gtttactgct cttacatggt
     2641 ttcctggatg agaatgtcca ttttgcacat accagtatat tactgagttt tttagtgagg
     2701 gctggaaagc catatgattt acagatctat cctcaggaga gacacagcat aagagttcct
     2761 gaatcgggag aacattatga actgcatctt ttgcactacc ttcaagaaaa ccttggatca
     2821 cgtattgctg ctctaaaagt gatataattt tgacctgtgt agaactctct ggtatacact
     2881 ggctatttaa ccaaatgagg aggtttaatc aacagaaaac acagaattga tcatcacatt
     2941 ttgatacctg ccatgtaaca tctactcctg aaaataaatg tggtgccatg caggggtcta
     3001 cggtttgtgg tagtaatcta ataccttaac cccacatgct caaaatcaaa tgatacatat
     3061 tcctgagaga cccagcaata ccataagaat tactaaaaaa aaaaaaaaaa aaaagacatt
     3121 agcaccatgt attcatacta ccctattttc acttttaata gtattataaa cttcatgaac
     3181 ttaattagtg tatttttaca gtatactttt gagtttgtta aaatatgatg atattagtga
     3241 ttggtttggt tcagttccag aatctttgac tagttacaga tttgatagca cttaaatgta
     3301 attgaatagc ttatgcttca ttgcttgggc atatccagca tgttatgaac taataactat
     3361 taaacttgac ttaaccagtc attcattaat aatttttcaa ggataactta gtggcctcct
     3421 aaagacactt gttttggcac tgaccagttt ttagccaatt taatctgtat ctagtataaa
     3481 taattctcat ttttctttga tgatattaac agagtgggct tttccttttg cataaaggct
     3541 agtaactgta tatgtagcat ggatttaatt agtcatgata ttgataatta caggcagaaa
     3601 atttttaatc aaatgattag agcttaaata tttgcaggca agtttttttt tttcctttaa
     3661 gaaaaggaaa aagtacacat tcactagaat tcttcagaaa atttagtggt gccagtttcc
     3721 atttggtatt tccttattaa aatattctag aattttaagg agattgaagg gaatcacagt
     3781 ggggtgggga gacctgggtt tggggaatga cagagagaag aggtggtgag ggcctgatta
     3841 aaaactaagc agaagtagtt ttaacaaaaa tactcatgaa aatgtttgga aactgaaatt
     3901 taaacaactg taatattaag gaaaccagaa tcaataaatc actgtcttgc cagcacagct
     3961 acagagtaac atgattcagg ggaggaaaag ttccttagag ttacttttat aattcttttt
     4021 ttttttcctc ttaggtttag aaatcttaca aatttaaact ttatcctttt aaaattattt
     4081 gaacataatt tagatattgt aagcttaaaa tacaaatgtt tatagataac ctctttacca
     4141 taaactaatc cctggcaagc catggctctc tttttttttt tggtgtttaa agcctgtaaa
     4201 cagtttttct gaatgatcat gaacttttct tggtttagca ctaggattta gctatgaaga
     4261 gagctcatag gctttcaggt gctaattgag atctgccctg ttagagtctt ggggtgctag
     4321 attggtcaca ttgacaccag tggcagggaa ggcatctatg agtttgatgc tttttatcac
     4381 acacttcagt gtttagaaag ttattaccaa tacttttaaa caacactcca agaaaatttg
     4441 ctatatttct ttctcatcac tacagagaga gtagatttcc ccatagagag cacagcctcc
     4501 attagtaagg ttggtgacta ttggtaagag gtggacttca ttgacaccaa gtgggaggta
     4561 gggaaagccc agaaatggca ggatgatatg gtggttctgt cgttgggaaa ggtattgggt
     4621 tttgctgttt gtatttatac tgtataatag ataccacgct ttttcttatt atctgtatat
     4681 gtattgcttt tcatgtttga tattttccca tgccaagatt tgtttatata tattttcaat
     4741 gttaaattaa attgatttgg gtaactttct tccccaagaa agtattttcc cccttaagta
     4801 tatatctgac tgtggagggt gttttgtttt gttttgtttt gttttgtttg gactaactgg
     4861 cctcgaagga tctatcctta taatatatgc aaagtagaaa tggtatacag tagcttttaa
     4921 gcagctactc cattgaaacc tctcacccat taaggctgtt tcttcaaagt ggcatctctt
     4981 attttaccga aacaaactta gaaaacttca tgtactctgg agttcacagg tgttttcctt
     5041 ttgcatgttg ccttctcctt tcctcctatc acaaagaatg cttctattat cactcccagt
     5101 cacttaaatg ccattctgct tctttagcag gaaaaaatac ctgaatgaat tctcttacag
     5161 aaagacagtt tgactgaatt tgctttttac aatcagtgtg gaaaatatca tagtcaattg
     5221 aggcaatcag tagaaatctc actaaaagtt tgtaccccct gagtatgggt aacagcttaa
     5281 acggcaagaa tatataaaag tagcaacagt ttagtgggag ccaaaaagca ctaggttaaa
     5341 tatcatacta cgtttttaaa gacttgataa atgtgtacac ttgaacaacc atccagaggg
     5401 atagttactt gagcattaca gagtagtgga actcaaaatc taagattcat ctgggatact
     5461 tctaaaagaa atgtagagtt ttgaatctca ctcttaaaaa tgtgtattcc caggctaggc
     5521 atggtggctc acgcctgtaa tcctagcact ttgggaggcc aaggcgggtg aatcacttga
     5581 agtcaggaga tcaagaccag cttggtcgac atggtgaaac cccgtctcta ctaaaagtac
     5641 aaaaaaatta gctgggcatg atggcgtgtg cctataatcc cacctactcg ggaggctgag
     5701 gcaggagaat cgcttgaacc tgggaggcgg aagttgcagt gagccgagat ggcgccactg
     5761 tagtccagtc tgggcgacag agtgagattc tgcctcaaaa taaataaata aataaaaatt
     5821 tgtattccat tgatttgggt agacaccagg aatgtgcatt tctaacaagc tttccaggcg
     5881 atcctatagt aagtcatctg tggactactt taagaaactc ttctatagag aatggagttg
     5941 gattaataat aggtgatttt ttacactgga ctgattcaca agaacctaaa cagtagtcca
     6001 tgaagctgct catctgtggt aactatttgg ccccgtctca ctctgaaagc agcaggagat
     6061 gttgtttact ttgtttctat cccctttgtc tggagattaa ttttggaatg aaagtttttc
     6121 tctctatgcc attcctggtt cttttccaaa gcctcataca agaggattag gtcacaatgc
     6181 atgcattacc ttttaaaaga atgcgatatt gataccgatg cttacttttt tttttttact
     6241 acttgtttta ttccttccag aaagtatagc ccgcctttct atagcatagt tctctttagg
     6301 tggaatgatt cctataagat ttctcattat taaatcatgc atttttcaag atggaatcaa
     6361 tatttgattt aatctaagct gatattctca tttgttagaa gaacaaccta catgctagag
     6421 agagaggagg aaatataccc acgaccacac agccagttag tatccagttg gtgctggact
     6481 ccagccaggt gtcctgcctc atggtagtta aatgatatat agaaaaggta aatttttaaa
     6541 gaaatattta ttaatatatt cctataaaac attttaaagg taaccacata aaaatggtta
     6601 atttttccat tccaaagtaa atgctaagca tgtttattaa tgaagcagta cttctgatta
     6661 gtatatgaca ttctgaagtt aattaaactc attgcactaa atgtgtcttc cttggtatag
     6721 tggaggattt gaggattgga atatagagta gagtgcttgc ttaagcctgg gagcccatct
     6781 ttatagctat ttgatgtaag aaaagagaca tggccatttc taaactatat aaggtgagtg
     6841 tgtctattcc cagcagatat aaaggaaaaa ggaaactttt ttgattccca ccttcccagc
     6901 ctcacctagc catcttccag cctcaaatat agagatgtta gtgcaaggtc ctgggctcta
     6961 ggtgatcatt tcataagtcc tttacagata aagaaaaagt agtgtttgta tgtttgtttt
     7021 taagtaaccc caaaacaaat ttatattgta ttcagcaaaa ttggaattca ggtgtttaat
     7081 tttagaacat gaagtgcctg ctgttttaag cattgacttg tataaaaaga attgcatgtc
     7141 tccagtaagc ttatgggttt tctcattttt aggtatatgg cttttaatca tgtaaagtga
     7201 aacattagtt ttcttgcatt ttattacagg ttctttgttg caataaagat gctgctgaaa
     7261 ttaa
//
