LOCUS       NM_013379               1601 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 7 (DPP7), mRNA.
ACCESSION   NM_013379 XM_939309
VERSION     NM_013379.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   Bezerra,G.A., Dobrovetsky,E., Dong,A., Seitova,A., Crombett,L.,
            Shewchuk,L.M., Hassell,A.M., Sweitzer,S.M., Sweitzer,T.D.,
            McDevitt,P.J., Johanson,K.O., Kennedy-Wilson,K.M., Cossar,D.,
            Bochkarev,A., Gruber,K. and Dhe-Paganon,S.
  TITLE     Structures of human DPP7 reveal the molecular basis of specific
            inhibition and the architectural diversity of proline-specific
            peptidases
  JOURNAL   PLoS One 7 (8), e43019 (2012)
   PUBMED   22952628
  REMARK    GeneRIF: human DPP7 structures reveal the molecular basis of
            specific inhibition and the architectural diversity of
            proline-specific peptidases
REFERENCE   2  (bases 1 to 1601)
  AUTHORS   Sulda,M.L., Abbott,C.A., Macardle,P.J., Hall,R.K. and Kuss,B.J.
  TITLE     Expression and prognostic assessment of dipeptidyl peptidase IV and
            related enzymes in B-cell chronic lymphocytic leukemia
  JOURNAL   Cancer Biol Ther 10 (2), 180-189 (2010)
   PUBMED   20534982
  REMARK    GeneRIF: The constitutive expression of dipeptidyl peptidase II
            mRNA in chronic lymphocytic leukemia was demonstrated.
REFERENCE   3  (bases 1 to 1601)
  AUTHORS   Mele,D.A., Bista,P., Baez,D.V. and Huber,B.T.
  TITLE     Dipeptidyl peptidase 2 is an essential survival factor in the
            regulation of cell quiescence
  JOURNAL   Cell Cycle 8 (15), 2425-2434 (2009)
   PUBMED   19556882
  REMARK    GeneRIF: DPP2 is essential for maintaining lymphocytes and
            fibroblasts in G(0), and its inhibition results in apoptosis
            mediated by induction of c-Myc and p53.
REFERENCE   4  (bases 1 to 1601)
  AUTHORS   Frohlich,E., Maier,E., Mack,A.F. and Garbe,C.
  TITLE     Dipeptidyl peptidase II is not a marker for progression in melanoma
  JOURNAL   J Dermatol Sci 53 (1), 68-71 (2009)
   PUBMED   18823758
  REMARK    GeneRIF: DPP II plays a minor role in the progression of malignant
            melanocytic lesions
REFERENCE   5  (bases 1 to 1601)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   6  (bases 1 to 1601)
  AUTHORS   Chiravuri,M., Schmitz,T., Yardley,K., Underwood,R., Dayal,Y. and
            Huber,B.T.
  TITLE     A novel apoptotic pathway in quiescent lymphocytes identified by
            inhibition of a post-proline cleaving aminodipeptidase: a candidate
            target protease, quiescent cell proline dipeptidase
  JOURNAL   J Immunol 163 (6), 3092-3099 (1999)
   PUBMED   10477574
REFERENCE   7  (bases 1 to 1601)
  AUTHORS   Demuth,H.U., Schlenzig,D., Schierhorn,A., Grosche,G.,
            Chapot-Chartier,M.P. and Gripon,J.C.
  TITLE     Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid
            pyrrolidides as potent inhibitors of proline-specific peptidases
  JOURNAL   FEBS Lett 320 (1), 23-27 (1993)
   PUBMED   8096464
REFERENCE   8  (bases 1 to 1601)
  AUTHORS   Fornas,E., Mayordomo,F., Renau-Piqueras,J. and Alborch,E.
  TITLE     Effect of cholesterol and its autooxidation derivatives on
            endocytosis and dipeptidyl peptidases of aortic endothelial cells
  JOURNAL   Histol Histopathol 7 (2), 163-168 (1992)
   PUBMED   1515698
REFERENCE   9  (bases 1 to 1601)
  AUTHORS   Roberts,V.J. and Gorenstein,C.
  TITLE     The effect of antimitotic agents on the intraneuronal distribution
            of lysosomes
  JOURNAL   Brain Res 521 (1-2), 62-72 (1990)
   PUBMED   2207678
REFERENCE   10 (bases 1 to 1601)
  AUTHORS   Andersen,K.J. and McDonald,J.K.
  TITLE     Lysosomal heterogeneity of dipeptidyl peptidase II active on
            collagen-related peptides
  JOURNAL   Ren Physiol Biochem 12 (1), 32-40 (1989)
   PUBMED   2727382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX400716.2, BC016961.1,
            AL533195.3 and AF154502.1.
            
            On Nov 24, 2018 this sequence version replaced NM_013379.2.
            
            Summary: The protein encoded by this gene is a post-proline
            cleaving aminopeptidase expressed in quiescent lymphocytes. The
            resting lymphocytes are maintained through suppression of
            apoptosis, a state which is disrupted by inhibition of this novel
            serine protease. The enzyme has strong sequence homology with
            prolylcarboxypeptidase and is active at both acidic and neutral pH.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.237332.1,
                                           SRR3476690.567783.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371579.7/ ENSP00000360635.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BX400716.2         13-27
            16-285              BC016961.1         1-270
            286-865             AL533195.3         277-856
            866-1126            BC016961.1         851-1111
            1127-1499           AF154502.1         1107-1479
            1500-1601           BC016961.1         1485-1586
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1601
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /note="dipeptidyl peptidase 7"
                     /db_xref="GeneID:29952"
                     /db_xref="HGNC:HGNC:14892"
                     /db_xref="MIM:610537"
     exon            1..87
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1499
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /EC_number="3.4.14.2"
                     /note="quiescent cell proline dipeptidase; dipeptidyl
                     aminopeptidase II; dipeptidyl-peptidase II; dipeptidyl
                     arylamidase II; carboxytripeptidase; dipeptidyl peptidase
                     2; DPP II"
                     /codon_start=1
                     /product="dipeptidyl peptidase 2 preproprotein"
                     /protein_id="NP_037511.2"
                     /db_xref="CCDS:CCDS7030.1"
                     /db_xref="GeneID:29952"
                     /db_xref="HGNC:HGNC:14892"
                     /db_xref="MIM:610537"
                     /translation="MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFN
                     FERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALL
                     VFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFG
                     GSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
                     GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPY
                     PTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD
                     PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP
                     DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRAS
                     HPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL"
     exon            88..201
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            202..341
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            342..505
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..641
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            642..723
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            724..890
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            891..951
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1070
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1227
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1292
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1363
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1601
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /note="hexamer: AATAAA"
     polyA_site      1601
                     /gene="DPP7"
                     /gene_synonym="DPP2; DPPII; QPP"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcccgc ggaaggcgac atgggctccg ctccctgggc cccggtcctg ctgctggcgc
       61 tcgggctgcg cggcctccag gcgggggccc gcagggcccc ggaccccggc ttccaggagc
      121 gcttcttcca gcagcgtctg gaccacttca acttcgagcg cttcggcaac aagaccttcc
      181 ctcagcgctt cctggtgtcg gacaggttct gggtccgggg cgaggggccc atcttcttct
      241 acactgggaa cgagggcgac gtgtgggcct tcgccaacaa ctcggccttc gtcgcggagc
      301 tggcggccga gcggggggct ctactggtct tcgcggagca ccgctactac gggaagtcgc
      361 tgccgttcgg tgcgcagtcc acgcagcgcg ggcacacgga gctgctgacg gtggagcagg
      421 ccctggccga cttcgcagag ctgctccgcg cgctacgacg cgacctcggg gcccaggatg
      481 cccccgccat cgccttcggt ggaagttatg gggggatgct cagtgcctac ctgaggatga
      541 agtatcccca cctggtggcg ggggcgctgg cggccagcgc gcccgttcta gctgtggcag
      601 gcctcggcga ctccaaccag ttcttccggg acgtcacggc ggactttgag ggccagagtc
      661 ccaaatgcac ccagggtgtg cgggaagcgt tccgacagat caaggacttg ttcctacagg
      721 gagcctacga cacggtccgc tgggagttcg gcacctgcca gccgctgtca gacgagaagg
      781 acctgaccca gctcttcatg ttcgcccgga atgccttcac cgtgctggcc atgatggact
      841 acccctaccc cactgacttc ctgggtcccc tccctgccaa ccccgtcaag gtgggctgtg
      901 atcggctgct gagtgaggcc cagaggatca cggggctgcg agcactggca gggctggtct
      961 acaacgcctc gggctccgag cactgctacg acatctaccg gctctaccac agctgtgctg
     1021 accccactgg ctgcggcacc ggccccgacg ccagggcctg ggactaccag gcctgcaccg
     1081 agatcaacct gaccttcgcc agcaacaatg tgaccgatat gttcccggac ctgcccttca
     1141 ctgacgagct ccgccagcgg tactgcctgg acacctgggg cgtgtggccc cggcccgact
     1201 ggctgctgac cagcttctgg gggggtgatc tcagagccgc cagcaacatc atcttctcca
     1261 acgggaacct ggacccctgg gcagggggcg ggattcggag gaacctgagt gcctcagtca
     1321 tcgccgtcac catccagggg ggagcgcacc acctcgacct cagagcctcc cacccagaag
     1381 atcctgcttc cgtggttgag gcgcggaagc tggaggccac catcatcggc gagtgggtaa
     1441 aggcagccag gcgtgagcag cagccagctc tgcgtggggg gcccagactc agcctctgag
     1501 cacaggactg gaggggtctc aaggctcctc atggagtggg ggcttcactc aagcagctgg
     1561 cggcagaggg aaggggctga ataaacgcct ggaggcctgg c
//
