LOCUS       NM_130797               4826 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 6 (DPP6), transcript variant
            1, mRNA.
ACCESSION   NM_130797
VERSION     NM_130797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4826)
  AUTHORS   Miah,M.M., Zinnia,M.A., Tabassum,N. and Islam,A.B.M.M.K.
  TITLE     Association between DPP6 gene rs10260404 polymorphism and increased
            risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis
  JOURNAL   Neurol Sci 45 (7), 3225-3243 (2024)
   PUBMED   38381392
  REMARK    GeneRIF: Association between DPP6 gene rs10260404 polymorphism and
            increased risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis.
REFERENCE   2  (bases 1 to 4826)
  AUTHORS   Naujock,M., Speidel,A., Fischer,S., Kizner,V., Dorner-Ciossek,C.
            and Gillardon,F.
  TITLE     Neuronal Differentiation of Induced Pluripotent Stem Cells from
            Schizophrenia Patients in Two-Dimensional and in Three-Dimensional
            Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6
            That Contributes to Decreased Neuronal Activity
  JOURNAL   Stem Cells Dev 29 (24), 1577-1587 (2020)
   PUBMED   33143549
  REMARK    GeneRIF: Neuronal Differentiation of Induced Pluripotent Stem Cells
            from Schizophrenia Patients in Two-Dimensional and in
            Three-Dimensional Cultures Reveals Increased Expression of the
            Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.
REFERENCE   3  (bases 1 to 4826)
  AUTHORS   Zhao,X., Cao,D., Ren,Z., Liu,Z., Lv,S., Zhu,J., Li,L., Lang,R. and
            He,Q.
  TITLE     Dipeptidyl peptidase like 6 promoter methylation is a potential
            prognostic biomarker for pancreatic ductal adenocarcinoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32701143
  REMARK    GeneRIF: Dipeptidyl peptidase like 6 promoter methylation is a
            potential prognostic biomarker for pancreatic ductal
            adenocarcinoma.
REFERENCE   4  (bases 1 to 4826)
  AUTHORS   Ji,C.C., Yao,F.J., Cheng,Y.J., Yao,H., Fan,J., Chen,X.M.,
            Zheng,Z.H., Dong,Y.G. and Wu,S.H.
  TITLE     A novel DPP6 variant in Chinese families causes early
            repolarization syndrome
  JOURNAL   Exp Cell Res 384 (1), 111561 (2019)
   PUBMED   31476289
  REMARK    GeneRIF: The slope of the activation curve of DPP6-L747P was
            slightly decreased.
REFERENCE   5  (bases 1 to 4826)
  AUTHORS   Cacace,R., Heeman,B., Van Mossevelde,S., De Roeck,A.,
            Hoogmartens,J., De Rijk,P., Gossye,H., De Vos,K., De Coster,W.,
            Strazisar,M., De Baets,G., Schymkowitz,J., Rousseau,F., Geerts,N.,
            De Pooter,T., Peeters,K., Sieben,A., Martin,J.J., Engelborghs,S.,
            Salmon,E., Santens,P., Vandenberghe,R., Cras,P., P De Deyn,P., C
            van Swieten,J., M van Duijn,C., van der Zee,J., Sleegers,K. and Van
            Broeckhoven,C.
  CONSRTM   BELNEU Consortium
  TITLE     Loss of DPP6 in neurodegenerative dementia: a genetic player in the
            dysfunction of neuronal excitability
  JOURNAL   Acta Neuropathol 137 (6), 901-918 (2019)
   PUBMED   30874922
  REMARK    GeneRIF: In an unresolved autosomal dominant dementia family
            significantly linked to 7q36, there was a chromosomal inversion of
            ca. 4 Mb, segregating on the disease haplotype and disrupting the
            coding sequence of DPP6. The missense variants found in patients
            destabilize DPP6 and reduce its membrane expression. DPP6 loss
            plays a in dementia.
REFERENCE   6  (bases 1 to 4826)
  AUTHORS   Nadal,M.S., Ozaita,A., Amarillo,Y., Vega-Saenz de Miera,E., Ma,Y.,
            Mo,W., Goldberg,E.M., Misumi,Y., Ikehara,Y., Neubert,T.A. and
            Rudy,B.
  TITLE     The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a
            critical component of neuronal A-type K+ channels
  JOURNAL   Neuron 37 (3), 449-461 (2003)
   PUBMED   12575952
REFERENCE   7  (bases 1 to 4826)
  AUTHORS   Kin,Y., Misumi,Y. and Ikehara,Y.
  TITLE     Biosynthesis and characterization of the brain-specific membrane
            protein DPPX, a dipeptidyl peptidase IV-related protein
  JOURNAL   J Biochem 129 (2), 289-295 (2001)
   PUBMED   11173531
REFERENCE   8  (bases 1 to 4826)
  AUTHORS   Zhu,X.R., Wulf,A., Schwarz,M., Isbrandt,D. and Pongs,O.
  TITLE     Characterization of human Kv4.2 mediating a rapidly-inactivating
            transient voltage-sensitive K+ current
  JOURNAL   Recept Channels 6 (5), 387-400 (1999)
   PUBMED   10551270
REFERENCE   9  (bases 1 to 4826)
  AUTHORS   Yokotani,N., Doi,K., Wenthold,R.J. and Wada,K.
  TITLE     Non-conservation of a catalytic residue in a dipeptidyl
            aminopeptidase IV-related protein encoded by a gene on human
            chromosome 7
  JOURNAL   Hum Mol Genet 2 (7), 1037-1039 (1993)
   PUBMED   8103397
REFERENCE   10 (bases 1 to 4826)
  AUTHORS   Wada,K., Yokotani,N., Hunter,C., Doi,K., Wenthold,R.J. and
            Shimasaki,S.
  TITLE     Differential expression of two distinct forms of mRNA encoding
            members of a dipeptidyl aminopeptidase family
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 197-201 (1992)
   PUBMED   1729689
  REMARK    GeneRIF: Analysis of the differential expression of two distinct
            forms of mRNA for the cow and rat orthologs. Names the variants S
            and L.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006019.2, BC035912.1,
            BC150304.1, HY037545.1, AC024239.7, DA156107.1 and AC073336.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_130797.3.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the peptidase S9B family of serine proteases.
            This protein has no detectable protease activity, most likely due
            to the absence of the conserved serine residue normally present in
            the catalytic domain of serine proteases. However, it does bind
            specific voltage-gated potassium channels and alters their
            expression and biophysical properties. Variations in this gene may
            be associated with susceptibility to amyotrophic lateral sclerosis
            and with idiopathic ventricular fibrillation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also referred to as
            L).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96859.1, SRR1803616.34569.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377770.8/ ENSP00000367001.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC006019.2         58427-58446         c
            21-270              BC035912.1         12-261
            271-311             AC006019.2         58136-58176         c
            312-1050            BC035912.1         300-1038
            1051-1079           BC150304.1         1022-1050
            1080-1080           HY037545.1         166-166
            1081-1145           BC150304.1         1052-1116
            1146-1146           AC024239.7         66465-66465
            1147-2318           BC150304.1         1118-2289
            2319-2426           DA156107.1         189-296
            2427-3267           BC150304.1         2398-3238
            3268-4826           AC073336.6         133332-134890
FEATURES             Location/Qualifiers
     source          1..4826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.2"
     gene            1..4826
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="dipeptidyl peptidase like 6"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
     exon            1..666
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..3021
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dipeptidyl aminopeptidase IV-related protein; dipeptidyl
                     peptidase IV-related protein; dipeptidyl
                     aminopeptidase-like protein 6; DPP VI; dipeptidyl
                     peptidase VI; dipeptidyl-peptidase 6; A-type potassium
                     channel modulatory protein DPP6"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein DPP6
                     isoform 1"
                     /protein_id="NP_570629.2"
                     /db_xref="CCDS:CCDS75683.1"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
                     /translation="MASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPL
                     GPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEEDELVGSNPPQRNWKGIAIALLV
                     ILVICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYRE
                     QKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGY
                     YVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVV
                     STGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGS
                     IYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATST
                     KVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIR
                     AIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDL
                     PRRRQLYSANTVGNFNRQCLSCDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHN
                     TTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPL
                     LLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGL
                     LEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALS
                     PITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQ
                     HTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTV
                     TAKEDEEED"
     exon            667..781
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..880
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..975
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1050
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1103
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1185
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1306
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1461
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1559
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1683
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1722
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1830
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1922
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1970
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2089
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2137
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2236
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2306
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2501
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2556
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2668
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2727
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2800
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2874
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..4826
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="hexamer: AATAAA"
     polyA_site      4826
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="major polyA site"
ORIGIN      
        1 ggaatgtgtg ccggtctcta ggtggtgcca aattctgggg cctaggcatt tccctcgctt
       61 tatgtttttg gttttttttc ttccttcaat ctctttgatt aggccgtacg tggctgtggc
      121 aaggagttgg ggaaaaaaat tataaaaaca ggaaagagag aaagcacagc cagagccccg
      181 gcttcgcgag ccgccgggga gggggcggag gaggctgagc caggcagagt cgccagcgga
      241 gactcgcgag tggcgcgcgg gaggagcggc cgccggcgct gggcttgcct tgctgctgct
      301 gctgctgctg cctccccacc gccttttttt ttttttaatc tggagcgggg tggggagtgg
      361 gaaccggaga gaaagcaaaa tattaaaaag ccccaaagac agccagcagg agcgcggtgc
      421 ccgatggctt cgctgtacca gaggttcact ggcaagatca acacctcgag gtccttcccc
      481 gcgcccccgg aggcgagtca cctcctgggc ggccaggggc ccgaggagga cggcggcgca
      541 ggagccaagc ccctcggccc gcgggcgcag gcggcggcgc cccgggagcg cggcggcggc
      601 ggcggcggcg cgggtggccg gccccggttc cagtaccagg cgcggagcga tggtgacgag
      661 gaggacgagc tggtggggag taaccctccg cagaggaatt ggaaaggaat agcaattgca
      721 ctgcttgtca ttctggtcat ctgctccttg atcgtcacct cggtcatact tctgacacca
      781 gcggaagata atagtctgtc tcaaaagaag aaggtcactg tagaagatct cttcagtgaa
      841 gacttcaaaa ttcatgaccc cgaggctaag tggataagtg atacagaatt catctacaga
      901 gaacagaaag gaacagtgag actgtggaat gttgaaacaa atacttctac tgtcttaata
      961 gaaggcaaaa aaattgaatc attaagagcc atcagatatg aaatatctcc agatagagag
     1021 tatgcacttt tttcatacaa tgtggaaccc atatatcaac actcgtatac tggatattac
     1081 gtcctgagca aaattcctca tggggatcct caaagtctgg acccaccaga agtcagcaat
     1141 gcaaaacttc agtatgcagg atggggccct aaaggccaac agctgatatt tatttttgaa
     1201 aacaatatct actactgtgc acatgtcggg aaacaggcca tccgtgtggt ctccactggc
     1261 aaggaaggtg tgatttacaa tggcctcagt gactggctgt atgaagagga gattttgaag
     1321 acacacatcg cacactggtg gtctccggat ggcacgagac tcgcctacgc cgccatcaat
     1381 gattcccgtg tccccatcat ggagctccca acttacaccg gctccatcta ccccaccgtg
     1441 aagccctacc actatcccaa ggctggaagt gagaacccca gcatttccct acacgttatt
     1501 ggcttaaatg gacccaccca tgatctggag atgatgccgc ctgatgatcc acggatgagg
     1561 gagtactaca tcaccatggt gaagtgggcc accagcacca aggtcgccgt gacctggctg
     1621 aaccgggcgc agaacgtgtc catcctcacc ctctgcgacg ccaccacggg ggtctgcacg
     1681 aagaaacacg aggatgaaag tgaggcctgg ctccacagac agaatgaaga acctgtgttc
     1741 tccaaggatg gccgaaagtt tttcttcatc agagccatcc cccagggagg acgagggaaa
     1801 ttctatcaca tcacggtgtc ctcgtcccag cccaacagca gcaacgacaa catccagtcc
     1861 atcacctccg gggactggga cgtgaccaag atcctagcct acgatgagaa ggggaataag
     1921 atctacttcc tgagcacgga ggacctgcct cggagacgac aactctacag tgccaacacg
     1981 gtgggcaact tcaacaggca gtgcctctcc tgtgacctgg ttgagaactg cacctacttc
     2041 agcgcttcct tcagccatag catggacttc ttcctgctca agtgcgaagg tcctggtgtt
     2101 cctatggtga cggtgcacaa cacaacagat aagaaaaaaa tgtttgacct agaaacaaat
     2161 gaacatgtca agaaggccat aaatgaccga cagatgccta aagtggaata cagggacatt
     2221 gagattgatg attacaacct gcccatgcag atactgaagc cagcaacctt caccgacacc
     2281 acccactacc ctctgctcct ggtggtggat ggcaccccag gcagccagag tgtggctgag
     2341 aagttcgagg tgagctggga gacggtgatg gtgagcagcc acggcgcggt ggtggtaaag
     2401 tgtgacggcc gtggcagcgg cttccaaggg accaagctcc tgcacgaagt gaggcggcgg
     2461 ctgggcttgc tggaggagaa ggaccagatg gaggccgtgc ggacgatgct gaaggagcag
     2521 tacattgaca ggacgcgcgt ggccgtgttt gggaaggatt acggtggcta cctgagcacc
     2581 tacatcctcc cagcaaaggg agaaaatcaa ggccagacat tcacctgcgg ctctgctctc
     2641 tctccaataa cagacttcaa actctatgcc tctgcgtttt ccgagaggta cttgggcctc
     2701 catggacttg acaacagagc atacgagatg accaaggtag cccatcgagt ctccgcgctg
     2761 gaagaacagc agttcctgat cattcatccc actgccgatg aaaaaattca tttccagcac
     2821 acagcagaac tcattacaca actaattagg ggaaaggcta attacagctt acagatttac
     2881 ccggacgaaa gccattactt taccagctcc agcctcaaac agcatctgta ccggtccatc
     2941 atcaacttct tcgtggaatg cttcaggatc caggacaaac tgctgacagt cacagcgaaa
     3001 gaggacgagg aggaggacta agctcaggtc gctctaagca caaacgtggc tctttctaca
     3061 accagatgca accgagggat ttccctgccc tccctcttcc ctcggagggg cggggcgggg
     3121 cggggccggg tgttccatag catgtgtgtc tcggatgcgg aaggcagttt tgcttgggaa
     3181 acaagctcct tccccggggt catcactcac ggcctccatg gcaccaggga caacgctgtc
     3241 cccgcagcag cgcctcctcc cggcgcccga gagaccggca cgccacggcc cctcccccaa
     3301 ggaacagagc aaaggatggt ggccgcaggc cccacgcgag cccacaggac accggcccct
     3361 agattccagc caccaagcgg aagcatgaga cccgcccaca ctagcctctg tgttcccgtt
     3421 agggacatca caccctgtct cacgtcgcag tgccatggac gcagcagtta cagcaccatt
     3481 gttttagcag tgcgtgttca tatatgggct tgctacttcc tgtaatgagg acgttcaaca
     3541 tggtgagggg ctacaagaaa acgcttttct gtacagagtc ttactgtagc tacgctaatg
     3601 gttaacctga tagaattaac tcgtattttt ctatggtttt aacctgatgc tccactgtct
     3661 ccgtcatggg gttgttttgc tgtttggggt tgggccttgt ttccctttcc tttctccagt
     3721 ccacgtgtag actttgcgct tgatgaagaa gcagatcgga agtaactgct ccctcctcaa
     3781 ggttgtcttc agacgtcttg gggacgttcc taaacactga gggggaagac agccaatagc
     3841 acccattaaa agaaatacct aaataaaacc tctctcccac tcagctatgc tagggcttgg
     3901 ctgtaggtgt gcactgtcta tttacatccg tccttacaac catccttgtc ctccttggta
     3961 ccgtatcaag ctctttccca tgacatttgg tttaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4021 acagaaaaaa gacaaagcgt caactccacc cacaggcccg ctgtgtgtgc tcgggccacg
     4081 ggagtcctga gggttctgtg ggcctgcgcg catccctctc ccatcgtggg ggtggctccg
     4141 tgaccttcct gccacgagca ggaggttgat gatgtgctac gttagccttg taagatacac
     4201 ccccaccaaa tgtgcagccg gtgttcccag tgtatatttc attctcttgt atataaagga
     4261 agcaatgtgt gtcaggcctc tgtgcagtca acccagcctc ctcccgccag tgctaacccc
     4321 gtgttgagcc tgcatgctga cactgtggcc gatctggact ctagaagtgc tagtttgaaa
     4381 tatatccatt actgtcattt ccttttgagc ttgtggacaa gctgaatgtc aggactgact
     4441 tcgccagctc ccagccctgc gggggtgtcc ttggcatccc atcagcagag gagatgcgtc
     4501 cctgttgcat tttggcgttt ggggctttgg gtttatccac atgagctctg aacgtccgtt
     4561 atagttaggg tgattggaag gtctccatca ctgggtgttt taaaggtgat tcaccaccat
     4621 ttgtgaaagg accaacgtgc tgataaacag gaccgatccg agtgctacat gactgtgcgt
     4681 ttgctatttc aatgggcctg aacgactaca aagccagcta ggtctggaag gggaagccag
     4741 ctctggccac gacatctggt cggagggaag tggggatgtg gcatggtagc gtctgttcat
     4801 ccatggaata aaacattatt ttacca
//
