LOCUS       NM_001936               4553 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 6 (DPP6), transcript variant
            2, mRNA.
ACCESSION   NM_001936
VERSION     NM_001936.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Miah,M.M., Zinnia,M.A., Tabassum,N. and Islam,A.B.M.M.K.
  TITLE     Association between DPP6 gene rs10260404 polymorphism and increased
            risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis
  JOURNAL   Neurol Sci 45 (7), 3225-3243 (2024)
   PUBMED   38381392
  REMARK    GeneRIF: Association between DPP6 gene rs10260404 polymorphism and
            increased risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis.
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Naujock,M., Speidel,A., Fischer,S., Kizner,V., Dorner-Ciossek,C.
            and Gillardon,F.
  TITLE     Neuronal Differentiation of Induced Pluripotent Stem Cells from
            Schizophrenia Patients in Two-Dimensional and in Three-Dimensional
            Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6
            That Contributes to Decreased Neuronal Activity
  JOURNAL   Stem Cells Dev 29 (24), 1577-1587 (2020)
   PUBMED   33143549
  REMARK    GeneRIF: Neuronal Differentiation of Induced Pluripotent Stem Cells
            from Schizophrenia Patients in Two-Dimensional and in
            Three-Dimensional Cultures Reveals Increased Expression of the
            Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Zhao,X., Cao,D., Ren,Z., Liu,Z., Lv,S., Zhu,J., Li,L., Lang,R. and
            He,Q.
  TITLE     Dipeptidyl peptidase like 6 promoter methylation is a potential
            prognostic biomarker for pancreatic ductal adenocarcinoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32701143
  REMARK    GeneRIF: Dipeptidyl peptidase like 6 promoter methylation is a
            potential prognostic biomarker for pancreatic ductal
            adenocarcinoma.
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Ji,C.C., Yao,F.J., Cheng,Y.J., Yao,H., Fan,J., Chen,X.M.,
            Zheng,Z.H., Dong,Y.G. and Wu,S.H.
  TITLE     A novel DPP6 variant in Chinese families causes early
            repolarization syndrome
  JOURNAL   Exp Cell Res 384 (1), 111561 (2019)
   PUBMED   31476289
  REMARK    GeneRIF: The slope of the activation curve of DPP6-L747P was
            slightly decreased.
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Cacace,R., Heeman,B., Van Mossevelde,S., De Roeck,A.,
            Hoogmartens,J., De Rijk,P., Gossye,H., De Vos,K., De Coster,W.,
            Strazisar,M., De Baets,G., Schymkowitz,J., Rousseau,F., Geerts,N.,
            De Pooter,T., Peeters,K., Sieben,A., Martin,J.J., Engelborghs,S.,
            Salmon,E., Santens,P., Vandenberghe,R., Cras,P., P De Deyn,P., C
            van Swieten,J., M van Duijn,C., van der Zee,J., Sleegers,K. and Van
            Broeckhoven,C.
  CONSRTM   BELNEU Consortium
  TITLE     Loss of DPP6 in neurodegenerative dementia: a genetic player in the
            dysfunction of neuronal excitability
  JOURNAL   Acta Neuropathol 137 (6), 901-918 (2019)
   PUBMED   30874922
  REMARK    GeneRIF: In an unresolved autosomal dominant dementia family
            significantly linked to 7q36, there was a chromosomal inversion of
            ca. 4 Mb, segregating on the disease haplotype and disrupting the
            coding sequence of DPP6. The missense variants found in patients
            destabilize DPP6 and reduce its membrane expression. DPP6 loss
            plays a in dementia.
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Nadal,M.S., Ozaita,A., Amarillo,Y., Vega-Saenz de Miera,E., Ma,Y.,
            Mo,W., Goldberg,E.M., Misumi,Y., Ikehara,Y., Neubert,T.A. and
            Rudy,B.
  TITLE     The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a
            critical component of neuronal A-type K+ channels
  JOURNAL   Neuron 37 (3), 449-461 (2003)
   PUBMED   12575952
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Kin,Y., Misumi,Y. and Ikehara,Y.
  TITLE     Biosynthesis and characterization of the brain-specific membrane
            protein DPPX, a dipeptidyl peptidase IV-related protein
  JOURNAL   J Biochem 129 (2), 289-295 (2001)
   PUBMED   11173531
REFERENCE   8  (bases 1 to 4553)
  AUTHORS   Zhu,X.R., Wulf,A., Schwarz,M., Isbrandt,D. and Pongs,O.
  TITLE     Characterization of human Kv4.2 mediating a rapidly-inactivating
            transient voltage-sensitive K+ current
  JOURNAL   Recept Channels 6 (5), 387-400 (1999)
   PUBMED   10551270
REFERENCE   9  (bases 1 to 4553)
  AUTHORS   Yokotani,N., Doi,K., Wenthold,R.J. and Wada,K.
  TITLE     Non-conservation of a catalytic residue in a dipeptidyl
            aminopeptidase IV-related protein encoded by a gene on human
            chromosome 7
  JOURNAL   Hum Mol Genet 2 (7), 1037-1039 (1993)
   PUBMED   8103397
REFERENCE   10 (bases 1 to 4553)
  AUTHORS   Wada,K., Yokotani,N., Hunter,C., Doi,K., Wenthold,R.J. and
            Shimasaki,S.
  TITLE     Differential expression of two distinct forms of mRNA encoding
            members of a dipeptidyl aminopeptidase family
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 197-201 (1992)
   PUBMED   1729689
  REMARK    GeneRIF: Analysis of the differential expression of two distinct
            forms of mRNA for the cow and rat orthologs. Names the variants S
            and L.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099341.4, AK308993.1,
            BC150304.1, HY037545.1, AC024239.7, DA156107.1 and AC073336.6.
            
            On May 31, 2019 this sequence version replaced NM_001936.4.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the peptidase S9B family of serine proteases.
            This protein has no detectable protease activity, most likely due
            to the absence of the conserved serine residue normally present in
            the catalytic domain of serine proteases. However, it does bind
            specific voltage-gated potassium channels and alters their
            expression and biophysical properties. Variations in this gene may
            be associated with susceptibility to amyotrophic lateral sclerosis
            and with idiopathic ventricular fibrillation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (2) contains an alternate 5'-most
            exon and initiates translation at an alternate start codon,
            compared to variant 1. The encoded isoform (2, also referred to as
            S)  has a shorter and distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.63543.1,
                                           SRR1803615.80055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC099341.4         43651-43703
            54-777              AK308993.1         2-725
            778-806             BC150304.1         1022-1050
            807-807             HY037545.1         166-166
            808-872             BC150304.1         1052-1116
            873-873             AC024239.7         66465-66465
            874-2045            BC150304.1         1118-2289
            2046-2153           DA156107.1         189-296
            2154-2994           BC150304.1         2398-3238
            2995-4553           AC073336.6         133332-134890
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.2"
     gene            1..4553
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="dipeptidyl peptidase like 6"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
     exon            1..393
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2748
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dipeptidyl aminopeptidase IV-related protein; dipeptidyl
                     peptidase IV-related protein; dipeptidyl
                     aminopeptidase-like protein 6; DPP VI; dipeptidyl
                     peptidase VI; dipeptidyl-peptidase 6; A-type potassium
                     channel modulatory protein DPP6"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein DPP6
                     isoform 2"
                     /protein_id="NP_001927.3"
                     /db_xref="CCDS:CCDS75684.1"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
                     /translation="MTTAKEPSASGKSVQQQEQELVGSNPPQRNWKGIAIALLVILVI
                     CSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKGT
                     VRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVLS
                     KIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGK
                     EGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYPT
                     VKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAV
                     TWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQ
                     GGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRR
                     QLYSANTVGNFNRQCLSCDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDK
                     KKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPLLLVV
                     DGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEK
                     DQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITD
                     FKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAE
                     LITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAKE
                     DEEED"
     exon            394..508
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..607
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..702
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..777
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..830
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..912
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1033
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1188
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1286
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1410
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1449
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1557
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1649
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1697
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1816
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1864
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1963
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2033
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2228
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2283
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2395
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2454
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2527
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2601
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..4553
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4534..4539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="hexamer: AATAAA"
     polyA_site      4553
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="major polyA site"
ORIGIN      
        1 actcgggtcc ccttcctgca cccagccgcc acttgccggt tgctaagcag ttatcattgt
       61 ttctgtggcg attgcagagg ctgttgctaa ttggagaagc cccactaagc agcggcagct
      121 tcctgcttcg gatcctctct ctgctgcttg catttaaaga gcaaactcgt cttgtctacc
      181 caccctccct cccccatcct ccccaaaata gccttgtgat ttcggaagta tggactaaaa
      241 tcacactcct ccttacctta ccgcttggac tctggtggct cccaactcgc cgtcagaccc
      301 cacctgcccc ggtggtggga agcgcctgga cagaccatga ccacagccaa ggagccaagc
      361 gcttcgggga aatccgtgca gcagcaggaa caggagctgg tggggagtaa ccctccgcag
      421 aggaattgga aaggaatagc aattgcactg cttgtcattc tggtcatctg ctccttgatc
      481 gtcacctcgg tcatacttct gacaccagcg gaagataata gtctgtctca aaagaagaag
      541 gtcactgtag aagatctctt cagtgaagac ttcaaaattc atgaccccga ggctaagtgg
      601 ataagtgata cagaattcat ctacagagaa cagaaaggaa cagtgagact gtggaatgtt
      661 gaaacaaata cttctactgt cttaatagaa ggcaaaaaaa ttgaatcatt aagagccatc
      721 agatatgaaa tatctccaga tagagagtat gcactttttt catacaatgt ggaacccata
      781 tatcaacact cgtatactgg atattacgtc ctgagcaaaa ttcctcatgg ggatcctcaa
      841 agtctggacc caccagaagt cagcaatgca aaacttcagt atgcaggatg gggccctaaa
      901 ggccaacagc tgatatttat ttttgaaaac aatatctact actgtgcaca tgtcgggaaa
      961 caggccatcc gtgtggtctc cactggcaag gaaggtgtga tttacaatgg cctcagtgac
     1021 tggctgtatg aagaggagat tttgaagaca cacatcgcac actggtggtc tccggatggc
     1081 acgagactcg cctacgccgc catcaatgat tcccgtgtcc ccatcatgga gctcccaact
     1141 tacaccggct ccatctaccc caccgtgaag ccctaccact atcccaaggc tggaagtgag
     1201 aaccccagca tttccctaca cgttattggc ttaaatggac ccacccatga tctggagatg
     1261 atgccgcctg atgatccacg gatgagggag tactacatca ccatggtgaa gtgggccacc
     1321 agcaccaagg tcgccgtgac ctggctgaac cgggcgcaga acgtgtccat cctcaccctc
     1381 tgcgacgcca ccacgggggt ctgcacgaag aaacacgagg atgaaagtga ggcctggctc
     1441 cacagacaga atgaagaacc tgtgttctcc aaggatggcc gaaagttttt cttcatcaga
     1501 gccatccccc agggaggacg agggaaattc tatcacatca cggtgtcctc gtcccagccc
     1561 aacagcagca acgacaacat ccagtccatc acctccgggg actgggacgt gaccaagatc
     1621 ctagcctacg atgagaaggg gaataagatc tacttcctga gcacggagga cctgcctcgg
     1681 agacgacaac tctacagtgc caacacggtg ggcaacttca acaggcagtg cctctcctgt
     1741 gacctggttg agaactgcac ctacttcagc gcttccttca gccatagcat ggacttcttc
     1801 ctgctcaagt gcgaaggtcc tggtgttcct atggtgacgg tgcacaacac aacagataag
     1861 aaaaaaatgt ttgacctaga aacaaatgaa catgtcaaga aggccataaa tgaccgacag
     1921 atgcctaaag tggaatacag ggacattgag attgatgatt acaacctgcc catgcagata
     1981 ctgaagccag caaccttcac cgacaccacc cactaccctc tgctcctggt ggtggatggc
     2041 accccaggca gccagagtgt ggctgagaag ttcgaggtga gctgggagac ggtgatggtg
     2101 agcagccacg gcgcggtggt ggtaaagtgt gacggccgtg gcagcggctt ccaagggacc
     2161 aagctcctgc acgaagtgag gcggcggctg ggcttgctgg aggagaagga ccagatggag
     2221 gccgtgcgga cgatgctgaa ggagcagtac attgacagga cgcgcgtggc cgtgtttggg
     2281 aaggattacg gtggctacct gagcacctac atcctcccag caaagggaga aaatcaaggc
     2341 cagacattca cctgcggctc tgctctctct ccaataacag acttcaaact ctatgcctct
     2401 gcgttttccg agaggtactt gggcctccat ggacttgaca acagagcata cgagatgacc
     2461 aaggtagccc atcgagtctc cgcgctggaa gaacagcagt tcctgatcat tcatcccact
     2521 gccgatgaaa aaattcattt ccagcacaca gcagaactca ttacacaact aattagggga
     2581 aaggctaatt acagcttaca gatttacccg gacgaaagcc attactttac cagctccagc
     2641 ctcaaacagc atctgtaccg gtccatcatc aacttcttcg tggaatgctt caggatccag
     2701 gacaaactgc tgacagtcac agcgaaagag gacgaggagg aggactaagc tcaggtcgct
     2761 ctaagcacaa acgtggctct ttctacaacc agatgcaacc gagggatttc cctgccctcc
     2821 ctcttccctc ggaggggcgg ggcggggcgg ggccgggtgt tccatagcat gtgtgtctcg
     2881 gatgcggaag gcagttttgc ttgggaaaca agctccttcc ccggggtcat cactcacggc
     2941 ctccatggca ccagggacaa cgctgtcccc gcagcagcgc ctcctcccgg cgcccgagag
     3001 accggcacgc cacggcccct cccccaagga acagagcaaa ggatggtggc cgcaggcccc
     3061 acgcgagccc acaggacacc ggcccctaga ttccagccac caagcggaag catgagaccc
     3121 gcccacacta gcctctgtgt tcccgttagg gacatcacac cctgtctcac gtcgcagtgc
     3181 catggacgca gcagttacag caccattgtt ttagcagtgc gtgttcatat atgggcttgc
     3241 tacttcctgt aatgaggacg ttcaacatgg tgaggggcta caagaaaacg cttttctgta
     3301 cagagtctta ctgtagctac gctaatggtt aacctgatag aattaactcg tatttttcta
     3361 tggttttaac ctgatgctcc actgtctccg tcatggggtt gttttgctgt ttggggttgg
     3421 gccttgtttc cctttccttt ctccagtcca cgtgtagact ttgcgcttga tgaagaagca
     3481 gatcggaagt aactgctccc tcctcaaggt tgtcttcaga cgtcttgggg acgttcctaa
     3541 acactgaggg ggaagacagc caatagcacc cattaaaaga aatacctaaa taaaacctct
     3601 ctcccactca gctatgctag ggcttggctg taggtgtgca ctgtctattt acatccgtcc
     3661 ttacaaccat ccttgtcctc cttggtaccg tatcaagctc tttcccatga catttggttt
     3721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaca gaaaaaagac aaagcgtcaa ctccacccac
     3781 aggcccgctg tgtgtgctcg ggccacggga gtcctgaggg ttctgtgggc ctgcgcgcat
     3841 ccctctccca tcgtgggggt ggctccgtga ccttcctgcc acgagcagga ggttgatgat
     3901 gtgctacgtt agccttgtaa gatacacccc caccaaatgt gcagccggtg ttcccagtgt
     3961 atatttcatt ctcttgtata taaaggaagc aatgtgtgtc aggcctctgt gcagtcaacc
     4021 cagcctcctc ccgccagtgc taaccccgtg ttgagcctgc atgctgacac tgtggccgat
     4081 ctggactcta gaagtgctag tttgaaatat atccattact gtcatttcct tttgagcttg
     4141 tggacaagct gaatgtcagg actgacttcg ccagctccca gccctgcggg ggtgtccttg
     4201 gcatcccatc agcagaggag atgcgtccct gttgcatttt ggcgtttggg gctttgggtt
     4261 tatccacatg agctctgaac gtccgttata gttagggtga ttggaaggtc tccatcactg
     4321 ggtgttttaa aggtgattca ccaccatttg tgaaaggacc aacgtgctga taaacaggac
     4381 cgatccgagt gctacatgac tgtgcgtttg ctatttcaat gggcctgaac gactacaaag
     4441 ccagctaggt ctggaagggg aagccagctc tggccacgac atctggtcgg agggaagtgg
     4501 ggatgtggca tggtagcgtc tgttcatcca tggaataaaa cattatttta cca
//
