LOCUS       NM_001364500            4698 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 6 (DPP6), transcript variant
            9, mRNA.
ACCESSION   NM_001364500 XM_017011811
VERSION     NM_001364500.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4698)
  AUTHORS   Miah,M.M., Zinnia,M.A., Tabassum,N. and Islam,A.B.M.M.K.
  TITLE     Association between DPP6 gene rs10260404 polymorphism and increased
            risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis
  JOURNAL   Neurol Sci 45 (7), 3225-3243 (2024)
   PUBMED   38381392
  REMARK    GeneRIF: Association between DPP6 gene rs10260404 polymorphism and
            increased risk of sporadic amyotrophic lateral sclerosis (sALS): a
            meta-analysis.
REFERENCE   2  (bases 1 to 4698)
  AUTHORS   Naujock,M., Speidel,A., Fischer,S., Kizner,V., Dorner-Ciossek,C.
            and Gillardon,F.
  TITLE     Neuronal Differentiation of Induced Pluripotent Stem Cells from
            Schizophrenia Patients in Two-Dimensional and in Three-Dimensional
            Cultures Reveals Increased Expression of the Kv4.2 Subunit DPP6
            That Contributes to Decreased Neuronal Activity
  JOURNAL   Stem Cells Dev 29 (24), 1577-1587 (2020)
   PUBMED   33143549
  REMARK    GeneRIF: Neuronal Differentiation of Induced Pluripotent Stem Cells
            from Schizophrenia Patients in Two-Dimensional and in
            Three-Dimensional Cultures Reveals Increased Expression of the
            Kv4.2 Subunit DPP6 That Contributes to Decreased Neuronal Activity.
REFERENCE   3  (bases 1 to 4698)
  AUTHORS   Zhao,X., Cao,D., Ren,Z., Liu,Z., Lv,S., Zhu,J., Li,L., Lang,R. and
            He,Q.
  TITLE     Dipeptidyl peptidase like 6 promoter methylation is a potential
            prognostic biomarker for pancreatic ductal adenocarcinoma
  JOURNAL   Biosci Rep 40 (7) (2020)
   PUBMED   32701143
  REMARK    GeneRIF: Dipeptidyl peptidase like 6 promoter methylation is a
            potential prognostic biomarker for pancreatic ductal
            adenocarcinoma.
REFERENCE   4  (bases 1 to 4698)
  AUTHORS   Ji,C.C., Yao,F.J., Cheng,Y.J., Yao,H., Fan,J., Chen,X.M.,
            Zheng,Z.H., Dong,Y.G. and Wu,S.H.
  TITLE     A novel DPP6 variant in Chinese families causes early
            repolarization syndrome
  JOURNAL   Exp Cell Res 384 (1), 111561 (2019)
   PUBMED   31476289
  REMARK    GeneRIF: The slope of the activation curve of DPP6-L747P was
            slightly decreased.
REFERENCE   5  (bases 1 to 4698)
  AUTHORS   Cacace,R., Heeman,B., Van Mossevelde,S., De Roeck,A.,
            Hoogmartens,J., De Rijk,P., Gossye,H., De Vos,K., De Coster,W.,
            Strazisar,M., De Baets,G., Schymkowitz,J., Rousseau,F., Geerts,N.,
            De Pooter,T., Peeters,K., Sieben,A., Martin,J.J., Engelborghs,S.,
            Salmon,E., Santens,P., Vandenberghe,R., Cras,P., P De Deyn,P., C
            van Swieten,J., M van Duijn,C., van der Zee,J., Sleegers,K. and Van
            Broeckhoven,C.
  CONSRTM   BELNEU Consortium
  TITLE     Loss of DPP6 in neurodegenerative dementia: a genetic player in the
            dysfunction of neuronal excitability
  JOURNAL   Acta Neuropathol 137 (6), 901-918 (2019)
   PUBMED   30874922
  REMARK    GeneRIF: In an unresolved autosomal dominant dementia family
            significantly linked to 7q36, there was a chromosomal inversion of
            ca. 4 Mb, segregating on the disease haplotype and disrupting the
            coding sequence of DPP6. The missense variants found in patients
            destabilize DPP6 and reduce its membrane expression. DPP6 loss
            plays a in dementia.
REFERENCE   6  (bases 1 to 4698)
  AUTHORS   Nadal,M.S., Ozaita,A., Amarillo,Y., Vega-Saenz de Miera,E., Ma,Y.,
            Mo,W., Goldberg,E.M., Misumi,Y., Ikehara,Y., Neubert,T.A. and
            Rudy,B.
  TITLE     The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a
            critical component of neuronal A-type K+ channels
  JOURNAL   Neuron 37 (3), 449-461 (2003)
   PUBMED   12575952
REFERENCE   7  (bases 1 to 4698)
  AUTHORS   Kin,Y., Misumi,Y. and Ikehara,Y.
  TITLE     Biosynthesis and characterization of the brain-specific membrane
            protein DPPX, a dipeptidyl peptidase IV-related protein
  JOURNAL   J Biochem 129 (2), 289-295 (2001)
   PUBMED   11173531
REFERENCE   8  (bases 1 to 4698)
  AUTHORS   Zhu,X.R., Wulf,A., Schwarz,M., Isbrandt,D. and Pongs,O.
  TITLE     Characterization of human Kv4.2 mediating a rapidly-inactivating
            transient voltage-sensitive K+ current
  JOURNAL   Recept Channels 6 (5), 387-400 (1999)
   PUBMED   10551270
REFERENCE   9  (bases 1 to 4698)
  AUTHORS   Yokotani,N., Doi,K., Wenthold,R.J. and Wada,K.
  TITLE     Non-conservation of a catalytic residue in a dipeptidyl
            aminopeptidase IV-related protein encoded by a gene on human
            chromosome 7
  JOURNAL   Hum Mol Genet 2 (7), 1037-1039 (1993)
   PUBMED   8103397
REFERENCE   10 (bases 1 to 4698)
  AUTHORS   Wada,K., Yokotani,N., Hunter,C., Doi,K., Wenthold,R.J. and
            Shimasaki,S.
  TITLE     Differential expression of two distinct forms of mRNA encoding
            members of a dipeptidyl aminopeptidase family
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 197-201 (1992)
   PUBMED   1729689
  REMARK    GeneRIF: Analysis of the differential expression of two distinct
            forms of mRNA for the cow and rat orthologs. Names the variants S
            and L.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005998.3, AC024730.7,
            AC024239.7 and AC073336.6.
            
            On May 31, 2019 this sequence version replaced NM_001364500.1.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the peptidase S9B family of serine proteases.
            This protein has no detectable protease activity, most likely due
            to the absence of the conserved serine residue normally present in
            the catalytic domain of serine proteases. However, it does bind
            specific voltage-gated potassium channels and alters their
            expression and biophysical properties. Variations in this gene may
            be associated with susceptibility to amyotrophic lateral sclerosis
            and with idiopathic ventricular fibrillation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (9), as well as variants 6, 7, and
            8, encodes isoform 6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2155974,
                              SAMN03465421 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC005998.3         48450-48733         c
            285-538             AC005998.3         47858-48111         c
            539-653             AC024730.7         127222-127336       c
            654-752             AC024730.7         98513-98611         c
            753-847             AC024730.7         32924-33018         c
            848-922             AC024730.7         6634-6708           c
            923-975             AC024239.7         34884-34936
            976-1057            AC024239.7         66423-66504
            1058-1178           AC024239.7         124830-124950
            1179-1333           AC073336.6         10022-10176
            1334-1431           AC073336.6         13450-13547
            1432-1555           AC073336.6         34684-34807
            1556-1594           AC073336.6         36450-36488
            1595-1702           AC073336.6         41960-42067
            1703-1794           AC073336.6         44469-44560
            1795-1842           AC073336.6         45522-45569
            1843-1961           AC073336.6         47599-47717
            1962-2009           AC073336.6         94385-94432
            2010-2108           AC073336.6         108600-108698
            2109-2178           AC073336.6         113229-113298
            2179-2373           AC073336.6         116511-116705
            2374-2428           AC073336.6         121493-121547
            2429-2540           AC073336.6         126238-126349
            2541-2599           AC073336.6         128281-128339
            2600-2672           AC073336.6         129877-129949
            2673-2746           AC073336.6         130062-130135
            2747-4698           AC073336.6         132939-134890
FEATURES             Location/Qualifiers
     source          1..4698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.2"
     gene            1..4698
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="dipeptidyl peptidase like 6"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
     exon            1..284
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..538
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             479..2893
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="isoform 6 is encoded by transcript variant 9;
                     dipeptidyl aminopeptidase IV-related protein; dipeptidyl
                     peptidase IV-related protein; dipeptidyl
                     aminopeptidase-like protein 6; DPP VI; dipeptidyl
                     peptidase VI; dipeptidyl-peptidase 6; A-type potassium
                     channel modulatory protein DPP6"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein DPP6
                     isoform 6"
                     /protein_id="NP_001351429.1"
                     /db_xref="CCDS:CCDS94238.1"
                     /db_xref="GeneID:1804"
                     /db_xref="HGNC:HGNC:3010"
                     /db_xref="MIM:126141"
                     /translation="MNQTAGVSNSVRCPPGKGHKELVGSNPPQRNWKGIAIALLVILV
                     ICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKG
                     TVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVL
                     SKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTG
                     KEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYP
                     TVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVA
                     VTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIP
                     QGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRR
                     RQLYSANTVGNFNRQCLSCDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTD
                     KKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPLLLV
                     VDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEE
                     KDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPIT
                     DFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTA
                     ELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAK
                     EDEEED"
     exon            539..653
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..752
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..847
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..922
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..975
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1057
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1178
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1333
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1431
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1555
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1594
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1702
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1794
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1842
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1961
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2009
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2108
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2178
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2373
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2428
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2540
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2599
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2672
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2746
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..4698
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4679..4684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="hexamer: AATAAA"
     polyA_site      4698
                     /gene="DPP6"
                     /gene_synonym="DPL1; DPPX; MRD33; VF2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgctcg catccctcag ctgtagctcg tgcagcctgt gctaacgagc ccgggtgccg
       61 tcccagctcc tcctccgccc actccactgt ctctctttcg cctgtgcagt ggttcctggc
      121 aaaacctctt atgccacctc ccgaccatcc cgggaagatt tggcggctgg agccctgcgc
      181 aggagctgta ggcaagagtg ggcgccagtc cctccttaac ccctgctggg tgggtggggt
      241 gccggagtcc gcactgatga ccgctccagc ctgagctttt gaggctctgg gctgcggatt
      301 ttaccgcccc tgcacagaag cctgcagcgt ggaggctccc ctcgcgctcg cccagactcg
      361 gctgcagaag gaggacccac ctcgcgtctc ccccgaggcg cgcacctctg tcgccaccct
      421 ccacgcgcct aggaagtttt gaaggtagag aatctgggcc cctcaacttc ctctggacat
      481 gaatcaaacc gcaggagtct ccaatagcgt caggtgtccc ccggggaaag gccacaagga
      541 gctggtgggg agtaaccctc cgcagaggaa ttggaaagga atagcaattg cactgcttgt
      601 cattctggtc atctgctcct tgatcgtcac ctcggtcata cttctgacac cagcggaaga
      661 taatagtctg tctcaaaaga agaaggtcac tgtagaagat ctcttcagtg aagacttcaa
      721 aattcatgac cccgaggcta agtggataag tgatacagaa ttcatctaca gagaacagaa
      781 aggaacagtg agactgtgga atgttgaaac aaatacttct actgtcttaa tagaaggcaa
      841 aaaaattgaa tcattaagag ccatcagata tgaaatatct ccagatagag agtatgcact
      901 tttttcatac aatgtggaac ccatatatca acactcgtat actggatatt acgtcctgag
      961 caaaattcct catggggatc ctcaaagtct ggacccacca gaagtcagca atgcaaaact
     1021 tcagtatgca ggatggggcc ctaaaggcca acagctgata tttatttttg aaaacaatat
     1081 ctactactgt gcacatgtcg ggaaacaggc catccgtgtg gtctccactg gcaaggaagg
     1141 tgtgatttac aatggcctca gtgactggct gtatgaagag gagattttga agacacacat
     1201 cgcacactgg tggtctccgg atggcacgag actcgcctac gccgccatca atgattcccg
     1261 tgtccccatc atggagctcc caacttacac cggctccatc taccccaccg tgaagcccta
     1321 ccactatccc aaggctggaa gtgagaaccc cagcatttcc ctacacgtta ttggcttaaa
     1381 tggacccacc catgatctgg agatgatgcc gcctgatgat ccacggatga gggagtacta
     1441 catcaccatg gtgaagtggg ccaccagcac caaggtcgcc gtgacctggc tgaaccgggc
     1501 gcagaacgtg tccatcctca ccctctgcga cgccaccacg ggggtctgca cgaagaaaca
     1561 cgaggatgaa agtgaggcct ggctccacag acagaatgaa gaacctgtgt tctccaagga
     1621 tggccgaaag tttttcttca tcagagccat cccccaggga ggacgaggga aattctatca
     1681 catcacggtg tcctcgtccc agcccaacag cagcaacgac aacatccagt ccatcacctc
     1741 cggggactgg gacgtgacca agatcctagc ctacgatgag aaggggaata agatctactt
     1801 cctgagcacg gaggacctgc ctcggagacg acaactctac agtgccaaca cggtgggcaa
     1861 cttcaacagg cagtgcctct cctgtgacct ggttgagaac tgcacctact tcagcgcttc
     1921 cttcagccat agcatggact tcttcctgct caagtgcgaa ggtcctggtg ttcctatggt
     1981 gacggtgcac aacacaacag ataagaaaaa aatgtttgac ctagaaacaa atgaacatgt
     2041 caagaaggcc ataaatgacc gacagatgcc taaagtggaa tacagggaca ttgagattga
     2101 tgattacaac ctgcccatgc agatactgaa gccagcaacc ttcaccgaca ccacccacta
     2161 ccctctgctc ctggtggtgg atggcacccc aggcagccag agtgtggctg agaagttcga
     2221 ggtgagctgg gagacggtga tggtgagcag ccacggcgcg gtggtggtaa agtgtgacgg
     2281 ccgtggcagc ggcttccaag ggaccaagct cctgcacgaa gtgaggcggc ggctgggctt
     2341 gctggaggag aaggaccaga tggaggccgt gcggacgatg ctgaaggagc agtacattga
     2401 caggacgcgc gtggccgtgt ttgggaagga ttacggtggc tacctgagca cctacatcct
     2461 cccagcaaag ggagaaaatc aaggccagac attcacctgc ggctctgctc tctctccaat
     2521 aacagacttc aaactctatg cctctgcgtt ttccgagagg tacttgggcc tccatggact
     2581 tgacaacaga gcatacgaga tgaccaaggt agcccatcga gtctccgcgc tggaagaaca
     2641 gcagttcctg atcattcatc ccactgccga tgaaaaaatt catttccagc acacagcaga
     2701 actcattaca caactaatta ggggaaaggc taattacagc ttacagattt acccggacga
     2761 aagccattac tttaccagct ccagcctcaa acagcatctg taccggtcca tcatcaactt
     2821 cttcgtggaa tgcttcagga tccaggacaa actgctgaca gtcacagcga aagaggacga
     2881 ggaggaggac taagctcagg tcgctctaag cacaaacgtg gctctttcta caaccagatg
     2941 caaccgaggg atttccctgc cctccctctt ccctcggagg ggcggggcgg ggcggggccg
     3001 ggtgttccat agcatgtgtg tctcggatgc ggaaggcagt tttgcttggg aaacaagctc
     3061 cttccccggg gtcatcactc acggcctcca tggcaccagg gacaacgctg tccccgcagc
     3121 agcgcctcct cccggcgccc gagagaccgg cacgccacgg cccctccccc aaggaacaga
     3181 gcaaaggatg gtggccgcag gccccacgcg agcccacagg acaccggccc ctagattcca
     3241 gccaccaagc ggaagcatga gacccgccca cactagcctc tgtgttcccg ttagggacat
     3301 cacaccctgt ctcacgtcgc agtgccatgg acgcagcagt tacagcacca ttgttttagc
     3361 agtgcgtgtt catatatggg cttgctactt cctgtaatga ggacgttcaa catggtgagg
     3421 ggctacaaga aaacgctttt ctgtacagag tcttactgta gctacgctaa tggttaacct
     3481 gatagaatta actcgtattt ttctatggtt ttaacctgat gctccactgt ctccgtcatg
     3541 gggttgtttt gctgtttggg gttgggcctt gtttcccttt cctttctcca gtccacgtgt
     3601 agactttgcg cttgatgaag aagcagatcg gaagtaactg ctccctcctc aaggttgtct
     3661 tcagacgtct tggggacgtt cctaaacact gagggggaag acagccaata gcacccatta
     3721 aaagaaatac ctaaataaaa cctctctccc actcagctat gctagggctt ggctgtaggt
     3781 gtgcactgtc tatttacatc cgtccttaca accatccttg tcctccttgg taccgtatca
     3841 agctctttcc catgacattt ggtttaaaaa aaaaaaaaaa aaaaaaaaaa aaacagaaaa
     3901 aagacaaagc gtcaactcca cccacaggcc cgctgtgtgt gctcgggcca cgggagtcct
     3961 gagggttctg tgggcctgcg cgcatccctc tcccatcgtg ggggtggctc cgtgaccttc
     4021 ctgccacgag caggaggttg atgatgtgct acgttagcct tgtaagatac acccccacca
     4081 aatgtgcagc cggtgttccc agtgtatatt tcattctctt gtatataaag gaagcaatgt
     4141 gtgtcaggcc tctgtgcagt caacccagcc tcctcccgcc agtgctaacc ccgtgttgag
     4201 cctgcatgct gacactgtgg ccgatctgga ctctagaagt gctagtttga aatatatcca
     4261 ttactgtcat ttccttttga gcttgtggac aagctgaatg tcaggactga cttcgccagc
     4321 tcccagccct gcgggggtgt ccttggcatc ccatcagcag aggagatgcg tccctgttgc
     4381 attttggcgt ttggggcttt gggtttatcc acatgagctc tgaacgtccg ttatagttag
     4441 ggtgattgga aggtctccat cactgggtgt tttaaaggtg attcaccacc atttgtgaaa
     4501 ggaccaacgt gctgataaac aggaccgatc cgagtgctac atgactgtgc gtttgctatt
     4561 tcaatgggcc tgaacgacta caaagccagc taggtctgga aggggaagcc agctctggcc
     4621 acgacatctg gtcggaggga agtggggatg tggcatggta gcgtctgttc atccatggaa
     4681 taaaacatta ttttacca
//
