LOCUS       NM_001935               3573 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 4 (DPP4), transcript variant 1,
            mRNA.
ACCESSION   NM_001935
VERSION     NM_001935.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Wesley,U.V. and Dempsey,R.J.
  TITLE     Neuro-molecular perspectives on long COVID-19 impacted
            cerebrovascular diseases - a role for dipeptidyl peptidase IV
  JOURNAL   Exp Neurol 380, 114890 (2024)
   PUBMED   39038507
  REMARK    GeneRIF: Neuro-molecular perspectives on long COVID-19 impacted
            cerebrovascular diseases - a role for dipeptidyl peptidase IV.
            Review article
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Shi,J., Hu,S., Wei,H., Zhang,L., Lan,Y., Guan,J., Zhao,K., Gao,F.,
            He,W. and Li,Z.
  TITLE     Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV
            spikes and mediates host range expansion
  JOURNAL   J Virol 98 (7), e0075324 (2024)
   PUBMED   38829136
  REMARK    GeneRIF: Dipeptidyl peptidase 4 interacts with porcine coronavirus
            PHEV spikes and mediates host range expansion.
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Hu,X., Jiang,C., Gu,Y. and Xue,X.
  TITLE     Exploring the conformational dynamics and key amino acids in the
            CD26-caveolin-1 interaction and potential therapeutic interventions
  JOURNAL   Medicine (Baltimore) 103 (22), e38367 (2024)
   PUBMED   39259075
  REMARK    GeneRIF: Exploring the conformational dynamics and key amino acids
            in the CD26-caveolin-1 interaction and potential therapeutic
            interventions.
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Gnoth,K., Bar,J.W., Rosche,F., Rahfeld,J.U. and Demuth,H.U.
  TITLE     Contribution of amino acids in the active site of dipeptidyl
            peptidase 4 to the catalytic action of the enzyme
  JOURNAL   PLoS One 19 (4), e0289239 (2024)
   PUBMED   38625918
  REMARK    GeneRIF: Contribution of amino acids in the active site of
            dipeptidyl peptidase 4 to the catalytic action of the enzyme.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Iacobellis,G.
  TITLE     COVID-19 and diabetes: Can DPP4 inhibition play a role?
  JOURNAL   Diabetes Res Clin Pract 162, 108125 (2020)
   PUBMED   32224164
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Vankadari,N. and Wilce,J.A.
  TITLE     Emerging WuHan (COVID-19) coronavirus: glycan shield and structure
            prediction of spike glycoprotein and its interaction with human
            CD26
  JOURNAL   Emerg Microbes Infect 9 (1), 601-604 (2020)
   PUBMED   32178593
  REMARK    GeneRIF: highlights the key finding that the S1 domain of COVID-19
            spike glycoprotein potentially interacts with the human CD26
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Imai,K., Maeda,M., Fujiwara,H., Kariya,M., Takakura,K., Kanzaki,H.
            and Mori,T.
  TITLE     Dipeptidyl peptidase IV as a differentiation marker of the human
            endometrial glandular cells
  JOURNAL   Hum Reprod 7 (9), 1189-1194 (1992)
   PUBMED   1362202
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Misumi,Y., Hayashi,Y., Arakawa,F. and Ikehara,Y.
  TITLE     Molecular cloning and sequence analysis of human dipeptidyl
            peptidase IV, a serine proteinase on the cell surface
  JOURNAL   Biochim Biophys Acta 1131 (3), 333-336 (1992)
   PUBMED   1352704
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   Tanaka,T., Camerini,D., Seed,B., Torimoto,Y., Dang,N.H.,
            Kameoka,J., Dahlberg,H.N., Schlossman,S.F. and Morimoto,C.
  TITLE     Cloning and functional expression of the T cell activation antigen
            CD26
  JOURNAL   J Immunol 149 (2), 481-486 (1992)
   PUBMED   1352530
  REMARK    Erratum:[J Immunol. 1993 Mar 1;150(5):2090.. PMID: 8094732]
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Darmoul,D., Lacasa,M., Baricault,L., Marguet,D., Sapin,C.,
            Trotot,P., Barbat,A. and Trugnan,G.
  TITLE     Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like
            colon cancer cell lines HT-29 and Caco-2. Cloning of the complete
            human coding sequence and changes of dipeptidyl peptidase IV mRNA
            levels during cell differentiation
  JOURNAL   J Biol Chem 267 (7), 4824-4833 (1992)
   PUBMED   1347043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065265.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001935.3.
            
            Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is
            identical to adenosine deaminase complexing protein-2, and to the
            T-cell activation antigen CD26. It is an intrinsic type II
            transmembrane glycoprotein and a serine exopeptidase that cleaves
            X-proline dipeptides from the N-terminus of polypeptides.
            Dipeptidyl peptidase 4 is highly involved in glucose and insulin
            metabolism, as well as in immune regulation. This protein was shown
            to be a functional receptor for Middle East respiratory syndrome
            coronavirus (MERS-CoV), and protein modeling suggests that it may
            play a similar role with SARS-CoV-2, the virus responsible for
            COVID-19. [provided by RefSeq, Apr 2020].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065265.1, X60708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in SARS-CoV-2 infection
            MANE Ensembl match     :: ENST00000360534.8/ ENSP00000353731.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3573              BC065265.1         328-3900
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..3573
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="dipeptidyl peptidase 4"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:HGNC:3009"
                     /db_xref="MIM:102720"
     exon            1..240
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2535
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /EC_number="3.4.14.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dipeptidylpeptidase IV (CD26, adenosine deaminase
                     complexing protein 2); T-cell activation antigen CD26;
                     dipeptidylpeptidase 4; ADCP-2; DPP IV; dipeptidyl
                     peptidase IV; Gly-Pro naphthylamidase;
                     Xaa-Pro-dipeptidylaminopeptidase; Post-proline dipeptidyl
                     aminopeptidase IV"
                     /codon_start=1
                     /product="dipeptidyl peptidase 4 isoform 1"
                     /protein_id="NP_001926.2"
                     /db_xref="CCDS:CCDS2216.1"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:HGNC:3009"
                     /db_xref="MIM:102720"
                     /translation="MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYT
                     LTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSI
                     NDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPV
                     GHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSP
                     NGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL
                     SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESS
                     GRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKK
                     DCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELN
                     PERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQ
                     MPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATY
                     LASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRI
                     AIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDH
                     YRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDH
                     GIASSTAHQHIYTHMSHFIKQCFSLP"
     exon            241..328
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            329..427
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            428..519
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            520..600
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            601..653
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            654..726
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            727..847
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1008
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1121
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1257
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1302
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1410
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1478
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1532
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1654
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1702
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1801
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1871
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2066
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2121
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2221
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2286
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2359
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2433
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3573
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="hexamer: AATAAA"
     polyA_site      3573
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="major polyA site"
ORIGIN      
        1 agtgccccgc gccacgcgcg cctgctcccg cgccgcctgc cctgcagcct gcccgcggcg
       61 cctttatacc cagcgggctc ggcgctcact aatgtttaac tcggggccga aacttgccag
      121 cggcgagtga ctccaccgcc cggagcagcg gtgcaggacg cgcgtctccg ccgcccgcgg
      181 tgacttctgc ctgcgctcct tctctgaacg ctcacttccg aggagacgcc gacgatgaag
      241 acaccgtgga aggttcttct gggactgctg ggtgctgctg cgcttgtcac catcatcacc
      301 gtgcccgtgg ttctgctgaa caaaggcaca gatgatgcta cagctgacag tcgcaaaact
      361 tacactctaa ctgattactt aaaaaatact tatagactga agttatactc cttaagatgg
      421 atttcagatc atgaatatct ctacaaacaa gaaaataata tcttggtatt caatgctgaa
      481 tatggaaaca gctcagtttt cttggagaac agtacatttg atgagtttgg acattctatc
      541 aatgattatt caatatctcc tgatgggcag tttattctct tagaatacaa ctacgtgaag
      601 caatggaggc attcctacac agcttcatat gacatttatg atttaaataa aaggcagctg
      661 attacagaag agaggattcc aaacaacaca cagtgggtca catggtcacc agtgggtcat
      721 aaattggcat atgtttggaa caatgacatt tatgttaaaa ttgaaccaaa tttaccaagt
      781 tacagaatca catggacggg gaaagaagat ataatatata atggaataac tgactgggtt
      841 tatgaagagg aagtcttcag tgcctactct gctctgtggt ggtctccaaa cggcactttt
      901 ttagcatatg cccaatttaa cgacacagaa gtcccactta ttgaatactc cttctactct
      961 gatgagtcac tgcagtaccc aaagactgta cgggttccat atccaaaggc aggagctgtg
     1021 aatccaactg taaagttctt tgttgtaaat acagactctc tcagctcagt caccaatgca
     1081 acttccatac aaatcactgc tcctgcttct atgttgatag gggatcacta cttgtgtgat
     1141 gtgacatggg caacacaaga aagaatttct ttgcagtggc tcaggaggat tcagaactat
     1201 tcggtcatgg atatttgtga ctatgatgaa tccagtggaa gatggaactg cttagtggca
     1261 cggcaacaca ttgaaatgag tactactggc tgggttggaa gatttaggcc ttcagaacct
     1321 cattttaccc ttgatggtaa tagcttctac aagatcatca gcaatgaaga aggttacaga
     1381 cacatttgct atttccaaat agataaaaaa gactgcacat ttattacaaa aggcacctgg
     1441 gaagtcatcg ggatagaagc tctaaccagt gattatctat actacattag taatgaatat
     1501 aaaggaatgc caggaggaag gaatctttat aaaatccaac ttagtgacta tacaaaagtg
     1561 acatgcctca gttgtgagct gaatccggaa aggtgtcagt actattctgt gtcattcagt
     1621 aaagaggcga agtattatca gctgagatgt tccggtcctg gtctgcccct ctatactcta
     1681 cacagcagcg tgaatgataa agggctgaga gtcctggaag acaattcagc tttggataaa
     1741 atgctgcaga atgtccagat gccctccaaa aaactggact tcattatttt gaatgaaaca
     1801 aaattttggt atcagatgat cttgcctcct cattttgata aatccaagaa atatcctcta
     1861 ctattagatg tgtatgcagg cccatgtagt caaaaagcag acactgtctt cagactgaac
     1921 tgggccactt accttgcaag cacagaaaac attatagtag ctagctttga tggcagagga
     1981 agtggttacc aaggagataa gatcatgcat gcaatcaaca gaagactggg aacatttgaa
     2041 gttgaagatc aaattgaagc agccagacaa ttttcaaaaa tgggatttgt ggacaacaaa
     2101 cgaattgcaa tttggggctg gtcatatgga gggtacgtaa cctcaatggt cctgggatcg
     2161 ggaagtggcg tgttcaagtg tggaatagcc gtggcgcctg tatcccggtg ggagtactat
     2221 gactcagtgt acacagaacg ttacatgggt ctcccaactc cagaagacaa ccttgaccat
     2281 tacagaaatt caacagtcat gagcagagct gaaaatttta aacaagttga gtacctcctt
     2341 attcatggaa cagcagatga taacgttcac tttcagcagt cagctcagat ctccaaagcc
     2401 ctggtcgatg ttggagtgga tttccaggca atgtggtata ctgatgaaga ccatggaata
     2461 gctagcagca cagcacacca acatatatat acccacatga gccacttcat aaaacaatgt
     2521 ttctctttac cttagcacct caaaatacca tgccatttaa agcttattaa aactcatttt
     2581 tgttttcatt atctcaaaac tgcactgtca agatgatgat gatctttaaa atacacactc
     2641 aaatcaagaa acttaaggtt acctttgttc ccaaatttca tacctatcat cttaagtagg
     2701 gacttctgtc ttcacaacag attattacct tacagaagtt tgaattatcc ggtcgggttt
     2761 tattgtttaa aatcatttct gcatcagctg ctgaaacaac aaataggaat tgtttttatg
     2821 gaggctttgc atagattccc tgagcaggat tttaatcttt ttctaactgg actggttcaa
     2881 atgttgttct cttctttaaa gggatggcaa gatgtgggca gtgatgtcac tagggcaggg
     2941 acaggataag agggattagg gagagaagat agcagggcat ggctgggaac ccaagtccaa
     3001 gcataccaac acgagcaggc tactgtcagc tcccctcgga gaagagctgt tcacagccag
     3061 actggcacag ttttctgaga aagactattc aaacagtctc aggaaatcaa atatgcaaag
     3121 cactgacttc taagtaaaac cacagcagtt gaaaagactc caaagaaatg taagggaaac
     3181 tgccagcaac gcaggccccc aggtgccagt tatggctata ggtgctacaa aaacacagca
     3241 agggtgatgg gaaagcattg taaatgtgct tttaaaaaaa aatactgatg ttcctagtga
     3301 aagaggcagc ttgaaactga gatgtgaaca catcagcttg ccctgttaaa agatgaaaat
     3361 atttgtatca caaatcttaa cttgaaggag tccttgcatc aatttttctt atttcatttc
     3421 tttgagtgtc ttaattaaaa gaatatttta acttccttgg actcatttta aaaaatggaa
     3481 cataaaatac aatgttatgt attattattc ccattctaca tactatggaa tttctcccag
     3541 tcatttaata aatgtgcctt cattttttca gaa
//
