LOCUS       NM_001379606            3519 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 4 (DPP4), transcript variant 4,
            mRNA.
ACCESSION   NM_001379606
VERSION     NM_001379606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3519)
  AUTHORS   Wesley,U.V. and Dempsey,R.J.
  TITLE     Neuro-molecular perspectives on long COVID-19 impacted
            cerebrovascular diseases - a role for dipeptidyl peptidase IV
  JOURNAL   Exp Neurol 380, 114890 (2024)
   PUBMED   39038507
  REMARK    GeneRIF: Neuro-molecular perspectives on long COVID-19 impacted
            cerebrovascular diseases - a role for dipeptidyl peptidase IV.
            Review article
REFERENCE   2  (bases 1 to 3519)
  AUTHORS   Shi,J., Hu,S., Wei,H., Zhang,L., Lan,Y., Guan,J., Zhao,K., Gao,F.,
            He,W. and Li,Z.
  TITLE     Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV
            spikes and mediates host range expansion
  JOURNAL   J Virol 98 (7), e0075324 (2024)
   PUBMED   38829136
  REMARK    GeneRIF: Dipeptidyl peptidase 4 interacts with porcine coronavirus
            PHEV spikes and mediates host range expansion.
REFERENCE   3  (bases 1 to 3519)
  AUTHORS   Hu,X., Jiang,C., Gu,Y. and Xue,X.
  TITLE     Exploring the conformational dynamics and key amino acids in the
            CD26-caveolin-1 interaction and potential therapeutic interventions
  JOURNAL   Medicine (Baltimore) 103 (22), e38367 (2024)
   PUBMED   39259075
  REMARK    GeneRIF: Exploring the conformational dynamics and key amino acids
            in the CD26-caveolin-1 interaction and potential therapeutic
            interventions.
REFERENCE   4  (bases 1 to 3519)
  AUTHORS   Gnoth,K., Bar,J.W., Rosche,F., Rahfeld,J.U. and Demuth,H.U.
  TITLE     Contribution of amino acids in the active site of dipeptidyl
            peptidase 4 to the catalytic action of the enzyme
  JOURNAL   PLoS One 19 (4), e0289239 (2024)
   PUBMED   38625918
  REMARK    GeneRIF: Contribution of amino acids in the active site of
            dipeptidyl peptidase 4 to the catalytic action of the enzyme.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3519)
  AUTHORS   Iacobellis,G.
  TITLE     COVID-19 and diabetes: Can DPP4 inhibition play a role?
  JOURNAL   Diabetes Res Clin Pract 162, 108125 (2020)
   PUBMED   32224164
REFERENCE   6  (bases 1 to 3519)
  AUTHORS   Vankadari,N. and Wilce,J.A.
  TITLE     Emerging WuHan (COVID-19) coronavirus: glycan shield and structure
            prediction of spike glycoprotein and its interaction with human
            CD26
  JOURNAL   Emerg Microbes Infect 9 (1), 601-604 (2020)
   PUBMED   32178593
  REMARK    GeneRIF: highlights the key finding that the S1 domain of COVID-19
            spike glycoprotein potentially interacts with the human CD26
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3519)
  AUTHORS   Imai,K., Maeda,M., Fujiwara,H., Kariya,M., Takakura,K., Kanzaki,H.
            and Mori,T.
  TITLE     Dipeptidyl peptidase IV as a differentiation marker of the human
            endometrial glandular cells
  JOURNAL   Hum Reprod 7 (9), 1189-1194 (1992)
   PUBMED   1362202
REFERENCE   8  (bases 1 to 3519)
  AUTHORS   Misumi,Y., Hayashi,Y., Arakawa,F. and Ikehara,Y.
  TITLE     Molecular cloning and sequence analysis of human dipeptidyl
            peptidase IV, a serine proteinase on the cell surface
  JOURNAL   Biochim Biophys Acta 1131 (3), 333-336 (1992)
   PUBMED   1352704
REFERENCE   9  (bases 1 to 3519)
  AUTHORS   Tanaka,T., Camerini,D., Seed,B., Torimoto,Y., Dang,N.H.,
            Kameoka,J., Dahlberg,H.N., Schlossman,S.F. and Morimoto,C.
  TITLE     Cloning and functional expression of the T cell activation antigen
            CD26
  JOURNAL   J Immunol 149 (2), 481-486 (1992)
   PUBMED   1352530
  REMARK    Erratum:[J Immunol. 1993 Mar 1;150(5):2090.. PMID: 8094732]
REFERENCE   10 (bases 1 to 3519)
  AUTHORS   Darmoul,D., Lacasa,M., Baricault,L., Marguet,D., Sapin,C.,
            Trotot,P., Barbat,A. and Trugnan,G.
  TITLE     Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like
            colon cancer cell lines HT-29 and Caco-2. Cloning of the complete
            human coding sequence and changes of dipeptidyl peptidase IV mRNA
            levels during cell differentiation
  JOURNAL   J Biol Chem 267 (7), 4824-4833 (1992)
   PUBMED   1347043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008063.2.
            
            Summary: The DPP4 gene encodes dipeptidyl peptidase 4, which is
            identical to adenosine deaminase complexing protein-2, and to the
            T-cell activation antigen CD26. It is an intrinsic type II
            transmembrane glycoprotein and a serine exopeptidase that cleaves
            X-proline dipeptides from the N-terminus of polypeptides.
            Dipeptidyl peptidase 4 is highly involved in glucose and insulin
            metabolism, as well as in immune regulation. This protein was shown
            to be a functional receptor for Middle East respiratory syndrome
            coronavirus (MERS-CoV), and protein modeling suggests that it may
            play a similar role with SARS-CoV-2, the virus responsible for
            COVID-19. [provided by RefSeq, Apr 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.902975.1,
                                           SRR14038197.2506172.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in SARS-CoV-2 infection
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC008063.2         94371-94610         c
            241-328             AC008063.2         93794-93881         c
            329-427             AC008063.2         67798-67896         c
            428-519             AC008063.2         67310-67401         c
            520-600             AC008063.2         65927-66007         c
            601-653             AC008063.2         59527-59579         c
            654-726             AC008063.2         59344-59416         c
            727-847             AC008063.2         58697-58817         c
            848-1008            AC008063.2         55559-55719         c
            1009-1121           AC008063.2         53936-54048         c
            1122-1257           AC008063.2         45199-45334         c
            1258-1302           AC008063.2         43150-43194         c
            1303-1410           AC008063.2         40976-41083         c
            1411-1478           AC008063.2         40624-40691         c
            1479-1600           AC008063.2         39124-39245         c
            1601-1648           AC008063.2         37503-37550         c
            1649-1747           AC008063.2         37163-37261         c
            1748-1817           AC008063.2         34791-34860         c
            1818-2012           AC008063.2         32188-32382         c
            2013-2067           AC008063.2         29636-29690         c
            2068-2167           AC008063.2         28957-29056         c
            2168-2232           AC008063.2         26140-26204         c
            2233-2305           AC008063.2         15695-15767         c
            2306-2379           AC008063.2         15356-15429         c
            2380-3519           AC008063.2         12640-13779         c
FEATURES             Location/Qualifiers
     source          1..3519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..3519
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="dipeptidyl peptidase 4"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:HGNC:3009"
                     /db_xref="MIM:102720"
     exon            1..240
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2481
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /EC_number="3.4.14.5"
                     /note="isoform 4 is encoded by transcript variant 4;
                     dipeptidylpeptidase IV (CD26, adenosine deaminase
                     complexing protein 2); T-cell activation antigen CD26;
                     dipeptidylpeptidase 4; ADCP-2; DPP IV; dipeptidyl
                     peptidase IV; Gly-Pro naphthylamidase;
                     Xaa-Pro-dipeptidylaminopeptidase; Post-proline dipeptidyl
                     aminopeptidase IV"
                     /codon_start=1
                     /product="dipeptidyl peptidase 4 isoform 4"
                     /protein_id="NP_001366535.1"
                     /db_xref="GeneID:1803"
                     /db_xref="HGNC:HGNC:3009"
                     /db_xref="MIM:102720"
                     /translation="MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYT
                     LTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSI
                     NDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPV
                     GHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSP
                     NGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL
                     SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESS
                     GRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKK
                     DCTFITKGTWEVIGIEALTSDYLIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYY
                     QLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY
                     QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSG
                     YQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGS
                     GSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEY
                     LLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHF
                     IKQCFSLP"
     exon            241..328
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            329..427
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            428..519
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            520..600
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            601..653
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            654..726
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            727..847
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1008
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1121
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1257
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1302
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1410
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1478
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1600
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1648
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1747
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1817
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2012
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2067
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2167
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2232
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2305
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2379
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..3519
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="hexamer: AATAAA"
     polyA_site      3519
                     /gene="DPP4"
                     /gene_synonym="ADABP; ADCP2; CD26; DPPIV; TP103"
                     /note="major polyA site"
ORIGIN      
        1 agtgccccgc gccacgcgcg cctgctcccg cgccgcctgc cctgcagcct gcccgcggcg
       61 cctttatacc cagcgggctc ggcgctcact aatgtttaac tcggggccga aacttgccag
      121 cggcgagtga ctccaccgcc cggagcagcg gtgcaggacg cgcgtctccg ccgcccgcgg
      181 tgacttctgc ctgcgctcct tctctgaacg ctcacttccg aggagacgcc gacgatgaag
      241 acaccgtgga aggttcttct gggactgctg ggtgctgctg cgcttgtcac catcatcacc
      301 gtgcccgtgg ttctgctgaa caaaggcaca gatgatgcta cagctgacag tcgcaaaact
      361 tacactctaa ctgattactt aaaaaatact tatagactga agttatactc cttaagatgg
      421 atttcagatc atgaatatct ctacaaacaa gaaaataata tcttggtatt caatgctgaa
      481 tatggaaaca gctcagtttt cttggagaac agtacatttg atgagtttgg acattctatc
      541 aatgattatt caatatctcc tgatgggcag tttattctct tagaatacaa ctacgtgaag
      601 caatggaggc attcctacac agcttcatat gacatttatg atttaaataa aaggcagctg
      661 attacagaag agaggattcc aaacaacaca cagtgggtca catggtcacc agtgggtcat
      721 aaattggcat atgtttggaa caatgacatt tatgttaaaa ttgaaccaaa tttaccaagt
      781 tacagaatca catggacggg gaaagaagat ataatatata atggaataac tgactgggtt
      841 tatgaagagg aagtcttcag tgcctactct gctctgtggt ggtctccaaa cggcactttt
      901 ttagcatatg cccaatttaa cgacacagaa gtcccactta ttgaatactc cttctactct
      961 gatgagtcac tgcagtaccc aaagactgta cgggttccat atccaaaggc aggagctgtg
     1021 aatccaactg taaagttctt tgttgtaaat acagactctc tcagctcagt caccaatgca
     1081 acttccatac aaatcactgc tcctgcttct atgttgatag gggatcacta cttgtgtgat
     1141 gtgacatggg caacacaaga aagaatttct ttgcagtggc tcaggaggat tcagaactat
     1201 tcggtcatgg atatttgtga ctatgatgaa tccagtggaa gatggaactg cttagtggca
     1261 cggcaacaca ttgaaatgag tactactggc tgggttggaa gatttaggcc ttcagaacct
     1321 cattttaccc ttgatggtaa tagcttctac aagatcatca gcaatgaaga aggttacaga
     1381 cacatttgct atttccaaat agataaaaaa gactgcacat ttattacaaa aggcacctgg
     1441 gaagtcatcg ggatagaagc tctaaccagt gattatctaa tccaacttag tgactataca
     1501 aaagtgacat gcctcagttg tgagctgaat ccggaaaggt gtcagtacta ttctgtgtca
     1561 ttcagtaaag aggcgaagta ttatcagctg agatgttccg gtcctggtct gcccctctat
     1621 actctacaca gcagcgtgaa tgataaaggg ctgagagtcc tggaagacaa ttcagctttg
     1681 gataaaatgc tgcagaatgt ccagatgccc tccaaaaaac tggacttcat tattttgaat
     1741 gaaacaaaat tttggtatca gatgatcttg cctcctcatt ttgataaatc caagaaatat
     1801 cctctactat tagatgtgta tgcaggccca tgtagtcaaa aagcagacac tgtcttcaga
     1861 ctgaactggg ccacttacct tgcaagcaca gaaaacatta tagtagctag ctttgatggc
     1921 agaggaagtg gttaccaagg agataagatc atgcatgcaa tcaacagaag actgggaaca
     1981 tttgaagttg aagatcaaat tgaagcagcc agacaatttt caaaaatggg atttgtggac
     2041 aacaaacgaa ttgcaatttg gggctggtca tatggagggt acgtaacctc aatggtcctg
     2101 ggatcgggaa gtggcgtgtt caagtgtgga atagccgtgg cgcctgtatc ccggtgggag
     2161 tactatgact cagtgtacac agaacgttac atgggtctcc caactccaga agacaacctt
     2221 gaccattaca gaaattcaac agtcatgagc agagctgaaa attttaaaca agttgagtac
     2281 ctccttattc atggaacagc agatgataac gttcactttc agcagtcagc tcagatctcc
     2341 aaagccctgg tcgatgttgg agtggatttc caggcaatgt ggtatactga tgaagaccat
     2401 ggaatagcta gcagcacagc acaccaacat atatataccc acatgagcca cttcataaaa
     2461 caatgtttct ctttacctta gcacctcaaa ataccatgcc atttaaagct tattaaaact
     2521 catttttgtt ttcattatct caaaactgca ctgtcaagat gatgatgatc tttaaaatac
     2581 acactcaaat caagaaactt aaggttacct ttgttcccaa atttcatacc tatcatctta
     2641 agtagggact tctgtcttca caacagatta ttaccttaca gaagtttgaa ttatccggtc
     2701 gggttttatt gtttaaaatc atttctgcat cagctgctga aacaacaaat aggaattgtt
     2761 tttatggagg ctttgcatag attccctgag caggatttta atctttttct aactggactg
     2821 gttcaaatgt tgttctcttc tttaaaggga tggcaagatg tgggcagtga tgtcactagg
     2881 gcagggacag gataagaggg attagggaga gaagatagca gggcatggct gggaacccaa
     2941 gtccaagcat accaacacga gcaggctact gtcagctccc ctcggagaag agctgttcac
     3001 agccagactg gcacagtttt ctgagaaaga ctattcaaac agtctcagga aatcaaatat
     3061 gcaaagcact gacttctaag taaaaccaca gcagttgaaa agactccaaa gaaatgtaag
     3121 ggaaactgcc agcaacgcag gcccccaggt gccagttatg gctataggtg ctacaaaaac
     3181 acagcaaggg tgatgggaaa gcattgtaaa tgtgctttta aaaaaaaata ctgatgttcc
     3241 tagtgaaaga ggcagcttga aactgagatg tgaacacatc agcttgccct gttaaaagat
     3301 gaaaatattt gtatcacaaa tcttaacttg aaggagtcct tgcatcaatt tttcttattt
     3361 catttctttg agtgtcttaa ttaaaagaat attttaactt ccttggactc attttaaaaa
     3421 atggaacata aaatacaatg ttatgtatta ttattcccat tctacatact atggaatttc
     3481 tcccagtcat ttaataaatg tgccttcatt ttttcagaa
//
