LOCUS       NM_130443               2660 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens dipeptidyl peptidase 3 (DPP3), transcript variant 2,
            mRNA.
ACCESSION   NM_130443
VERSION     NM_130443.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Tong,R., Meng,J., Wu,T., Wu,Z., Yin,Y. and Yu,L.
  TITLE     [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric
            cancer cells through down-regulation of major histocompatibility
            complex class I chain-related gene B (MICB) expression]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (10), 894-900 (2024)
   PUBMED   39442988
  REMARK    GeneRIF: [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of
            gastric cancer cells through down-regulation of major
            histocompatibility complex class I chain-related gene B (MICB)
            expression].
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Fu,X., Li,X., Wang,W. and Li,J.
  TITLE     DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and
            promoting lipid synthesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (5), 805-818 (2024)
   PUBMED   38655619
  REMARK    GeneRIF: DPP3 promotes breast cancer tumorigenesis by stabilizing
            FASN and promoting lipid synthesis.
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Staudner,S.T., Leininger,S.B., Vogel,M.J., Mustroph,J., Hubauer,U.,
            Meindl,C., Wallner,S., Lehn,P., Burkhardt,R., Hanses,F.,
            Zimmermann,M., Scharf,G., Hamer,O.W., Maier,L.S., Hupf,J. and
            Jungbauer,C.G.
  TITLE     Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for
            diagnostics in COVID-19 and association with pulmonary infiltrates
  JOURNAL   Clin Exp Med 23 (8), 4919-4935 (2023)
   PUBMED   37733154
  REMARK    GeneRIF: Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for
            diagnostics in COVID-19 and association with pulmonary infiltrates.
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Arora,M., Kumari,S., Kadian,L., Anupa,G., Singh,J., Kumar,A.,
            Verma,D., Pramanik,R., Kumar,S., Yadav,R., Chopra,A. and
            Chauhan,S.S.
  TITLE     Involvement of DPP3 in modulating oncological features and
            oxidative stress response in esophageal squamous cell carcinoma
  JOURNAL   Biosci Rep 43 (9) (2023)
   PUBMED   37531267
  REMARK    GeneRIF: Involvement of DPP3 in modulating oncological features and
            oxidative stress response in esophageal squamous cell carcinoma.
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Matic,A., Supljika,F., Brkic,H., Jurasovic,J., Karacic,Z. and
            Tomic,S.
  TITLE     Identification of an Additional Metal-Binding Site in Human
            Dipeptidyl Peptidase III
  JOURNAL   Int J Mol Sci 24 (16), 12747 (2023)
   PUBMED   37628928
  REMARK    GeneRIF: Identification of an Additional Metal-Binding Site in
            Human Dipeptidyl Peptidase III.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Grdisa,M. and Vitale,L.
  TITLE     Types and localization of aminopeptidases in different human blood
            cells
  JOURNAL   Int J Biochem 23 (3), 339-345 (1991)
   PUBMED   2044841
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Shimamori,Y., Watanabe,Y. and Fujimoto,Y.
  TITLE     Human placental dipeptidyl aminopeptidase III: hydrolysis of
            enkephalins and its stimulation by cobaltous ion
  JOURNAL   Biochem Med Metab Biol 40 (3), 305-310 (1988)
   PUBMED   3233187
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Vanha-Perttula,T.
  TITLE     Dipeptidyl peptidase III and alanyl aminopeptidase in the human
            seminal plasma: origin and biochemical properties
  JOURNAL   Clin Chim Acta 177 (2), 179-195 (1988)
   PUBMED   2906822
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Swanson,A.A., Davis,R.M. and Meinhardt,N.C.
  TITLE     Proteases in human lenses and their possible significance
  JOURNAL   Curr Eye Res 4 (1), 43-48 (1985)
   PUBMED   2858361
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   Kar,N.C. and Pearson,C.M.
  TITLE     Dipeptidyl peptidases in human muscle disease
  JOURNAL   Clin Chim Acta 82 (1-2), 185-192 (1978)
   PUBMED   618680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC407885.1, BC024271.1,
            AL833475.1 and CD366941.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2019 this sequence version replaced NM_130443.3.
            
            Summary: This gene encodes a protein that is a member of the M49
            family of metallopeptidases. This cytoplasmic protein binds a
            single zinc ion with its zinc-binding motif (HELLGH) and has
            post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro
            dipeptides from the N-termini of proteins. Increased activity of
            this protein is associated with endometrial and ovarian cancers.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site at a 5' non-coding exon compared to variant 1. Variants
            1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222566.1, AJ271216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531863.6/ ENSP00000432782.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DC407885.1         375-397
            24-1977             BC024271.1         1-1954
            1978-2658           AL833475.1         2001-2681
            2659-2660           CD366941.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2660
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /note="dipeptidyl peptidase 3"
                     /db_xref="GeneID:10072"
                     /db_xref="HGNC:HGNC:3008"
                     /db_xref="MIM:606818"
     exon            1..32
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            33..310
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2254
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /EC_number="3.4.14.4"
                     /note="isoform 1 is encoded by transcript variant 2;
                     dipeptidyl aminopeptidase III; dipeptidyl arylamidase III;
                     DPP III; dipeptidyl peptidase III; enkephalinase B"
                     /codon_start=1
                     /product="dipeptidyl peptidase 3 isoform 1"
                     /protein_id="NP_569710.2"
                     /db_xref="CCDS:CCDS8141.1"
                     /db_xref="GeneID:10072"
                     /db_xref="HGNC:HGNC:3008"
                     /db_xref="MIM:606818"
                     /translation="MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYG
                     GLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSN
                     MGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRH
                     LGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLAS
                     VLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQ
                     MLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAV
                     VNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINI
                     PNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLH
                     ELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEE
                     CRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQ
                     AHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRR
                     LQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGS
                     DVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA"
     exon            311..400
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            401..538
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            539..613
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            614..707
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            708..838
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            839..969
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1028
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1223
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1336
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1429
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1492
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1617
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1738
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1918
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2081
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2660
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2637..2642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /note="major polyA site"
ORIGIN      
        1 aagtgagttt gcgaacggag cagctgctgc agcagggccc atggcggaca cccagtacat
       61 cctgcccaat gacatcggcg tgtctagcct ggactgccgt gaggccttcc gcctgctgtc
      121 acccacagag cgcctctatg cctaccacct gtcccgtgcc gcctggtacg gaggcctggc
      181 tgtgctgctt cagacctccc ctgaggcccc ctacatctat gctctgctca gccgcctctt
      241 ccgcgcccag gaccccgacc agctgcgcca acatgccctg gctgaaggcc ttaccgagga
      301 ggagtatcag gcgttcctgg tctatgccgc gggtgtttac tccaacatgg gcaactacaa
      361 gtcctttggt gacaccaagt ttgttcccaa cttgcccaag gaaaagctgg aacgggtgat
      421 cctagggagt gaggctgctc agcagcaccc agaagaagtc aggggcctct ggcagacctg
      481 cggggagctt atgttctctc tggagccaag gcttcgacac ctcggactgg ggaaggaggg
      541 aatcaccacc tatttctctg ggaattgtac catggaagat gccaaattgg cccaggactt
      601 tctggactca cagaacctca gtgcctacaa cacccggctc ttcaaagagg tcgatggaga
      661 agggaagccc tactacgagg tgcggctggc ttctgtgctt ggctcagagc cttccctgga
      721 ctctgaggtg acttccaagc tgaagagcta tgaattccgg ggaagccctt tccaggtgac
      781 ccggggggac tacgcgccca tcctccagaa ggtggtggag cagctggaga aagccaaggc
      841 ctatgcagcc aacagccacc aggggcagat gctggcccag tatatagaga gcttcaccca
      901 gggctccatc gaggcccaca agaggggctc ccgcttctgg atccaggaca aaggccccat
      961 cgtggagagt tacatcgggt tcatcgagag ctaccgcgac ccctttggtt cccgaggaga
     1021 atttgaaggt ttcgtagctg tggtgaacaa ggccatgagt gccaagtttg agcggctggt
     1081 ggcgagcgca gagcagctgc tgaaggagct gccctggccc ccaacctttg agaaggacaa
     1141 gttcctcacc cctgacttca cctccctgga tgttctcacc ttcgctggct ccggcatccc
     1201 tgccggcatc aacatcccca actacgatga tctgaggcag acggaaggct ttaagaacgt
     1261 gtcgctgggg aatgtgctgg ctgtggccta cgccacgcag cgggagaagc ttacctttct
     1321 ggaggaggat gacaaggacc tgtacatcct ctggaagggg ccctccttcg atgtgcaggt
     1381 gggcctgcac gagctgctgg gccatggcag tggcaagctc ttcgtacagg acgaaaaagg
     1441 agcattcaac tttgaccagg aaacagtgat caacccagag acgggcgagc agattcagag
     1501 ctggtatcgg agcggggaga cctgggatag caagttcagc accatcgcct ccagctacga
     1561 agagtgccgg gctgagagcg tgggtctcta cctctgtctc cacccgcaag tgctggagat
     1621 ctttggcttt gagggggctg atgcggagga cgtgatctac gtgaactggc tcaacatggt
     1681 tcgggccggg ctgctcgctc tggagttcta cacacctgag gccttcaact ggcgacaggc
     1741 ccatatgcag gcccggtttg tgatcctgag agtcttgctg gaggctggcg agggactcgt
     1801 taccatcact cccaccacag gctccgatgg gcgcccagat gcccgggtcc gcctcgaccg
     1861 cagcaagatc cggtctgtgg gcaagcctgc tctagagcgc ttcctgcgga gacttcaggt
     1921 gctgaagtcc acaggggatg tggccggagg gcgggccctg tacgaggggt atgcaacagt
     1981 cactgatgcg ccccccgagt gcttcctcac cctcagggac acggtgctgc tgcgtaagga
     2041 atctcggaag ctcattgttc agcccaacac tcgccttgaa ggctcagacg tgcagcttct
     2101 ggaatacgag gcgtcagctg ctggcctcat ccgatccttc tctgagcgtt tcccagagga
     2161 tggacccgag ttggaggaga tcctcacaca gctggccaca gccgatgccc gattctggaa
     2221 gggccccagt gaggccccat ctggccaagc ttgaggaaga tgtgtggcct tgcccccaat
     2281 tccatcagac caaggctgca agtggccctc cattcgtgtg tgtatttagg ggctggggag
     2341 ggggaggggc aggagcttgg accttggtac tacctcagct gagggtggtg acacaacccc
     2401 ttccatttgt cagcactttc cagcctgcca attgcttccc ctctgtgatc tcatttcatc
     2461 tgcactgcca tacgtggagt gagcaagaca gggcttacca tcctgtctac cagatgagga
     2521 aatggcagtt ctgagaagtc actggtctag atcccgcagg tggcacgtga cagctagggt
     2581 tcaaaacgtt ctcaccaaat ccaatgctcc tcacatatta attttataac cagacaaata
     2641 aatattagag acaaccacca
//
