LOCUS       NP_569710                737 aa            linear   PRI 29-APR-2025
DEFINITION  dipeptidyl peptidase 3 isoform 1 [Homo sapiens].
ACCESSION   NP_569710
VERSION     NP_569710.2
DBSOURCE    REFSEQ: accession NM_130443.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 737)
  AUTHORS   Tong,R., Meng,J., Wu,T., Wu,Z., Yin,Y. and Yu,L.
  TITLE     [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of gastric
            cancer cells through down-regulation of major histocompatibility
            complex class I chain-related gene B (MICB) expression]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 40 (10), 894-900 (2024)
   PUBMED   39442988
  REMARK    GeneRIF: [Dipeptidyl peptidase 3 (DPP3) inhibits immune escape of
            gastric cancer cells through down-regulation of major
            histocompatibility complex class I chain-related gene B (MICB)
            expression].
REFERENCE   2  (residues 1 to 737)
  AUTHORS   Fu,X., Li,X., Wang,W. and Li,J.
  TITLE     DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and
            promoting lipid synthesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (5), 805-818 (2024)
   PUBMED   38655619
  REMARK    GeneRIF: DPP3 promotes breast cancer tumorigenesis by stabilizing
            FASN and promoting lipid synthesis.
REFERENCE   3  (residues 1 to 737)
  AUTHORS   Staudner,S.T., Leininger,S.B., Vogel,M.J., Mustroph,J., Hubauer,U.,
            Meindl,C., Wallner,S., Lehn,P., Burkhardt,R., Hanses,F.,
            Zimmermann,M., Scharf,G., Hamer,O.W., Maier,L.S., Hupf,J. and
            Jungbauer,C.G.
  TITLE     Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for
            diagnostics in COVID-19 and association with pulmonary infiltrates
  JOURNAL   Clin Exp Med 23 (8), 4919-4935 (2023)
   PUBMED   37733154
  REMARK    GeneRIF: Dipeptidyl-peptidase 3 and IL-6: potential biomarkers for
            diagnostics in COVID-19 and association with pulmonary infiltrates.
REFERENCE   4  (residues 1 to 737)
  AUTHORS   Arora,M., Kumari,S., Kadian,L., Anupa,G., Singh,J., Kumar,A.,
            Verma,D., Pramanik,R., Kumar,S., Yadav,R., Chopra,A. and
            Chauhan,S.S.
  TITLE     Involvement of DPP3 in modulating oncological features and
            oxidative stress response in esophageal squamous cell carcinoma
  JOURNAL   Biosci Rep 43 (9) (2023)
   PUBMED   37531267
  REMARK    GeneRIF: Involvement of DPP3 in modulating oncological features and
            oxidative stress response in esophageal squamous cell carcinoma.
REFERENCE   5  (residues 1 to 737)
  AUTHORS   Matic,A., Supljika,F., Brkic,H., Jurasovic,J., Karacic,Z. and
            Tomic,S.
  TITLE     Identification of an Additional Metal-Binding Site in Human
            Dipeptidyl Peptidase III
  JOURNAL   Int J Mol Sci 24 (16), 12747 (2023)
   PUBMED   37628928
  REMARK    GeneRIF: Identification of an Additional Metal-Binding Site in
            Human Dipeptidyl Peptidase III.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 737)
  AUTHORS   Grdisa,M. and Vitale,L.
  TITLE     Types and localization of aminopeptidases in different human blood
            cells
  JOURNAL   Int J Biochem 23 (3), 339-345 (1991)
   PUBMED   2044841
REFERENCE   7  (residues 1 to 737)
  AUTHORS   Shimamori,Y., Watanabe,Y. and Fujimoto,Y.
  TITLE     Human placental dipeptidyl aminopeptidase III: hydrolysis of
            enkephalins and its stimulation by cobaltous ion
  JOURNAL   Biochem Med Metab Biol 40 (3), 305-310 (1988)
   PUBMED   3233187
REFERENCE   8  (residues 1 to 737)
  AUTHORS   Vanha-Perttula,T.
  TITLE     Dipeptidyl peptidase III and alanyl aminopeptidase in the human
            seminal plasma: origin and biochemical properties
  JOURNAL   Clin Chim Acta 177 (2), 179-195 (1988)
   PUBMED   2906822
REFERENCE   9  (residues 1 to 737)
  AUTHORS   Swanson,A.A., Davis,R.M. and Meinhardt,N.C.
  TITLE     Proteases in human lenses and their possible significance
  JOURNAL   Curr Eye Res 4 (1), 43-48 (1985)
   PUBMED   2858361
REFERENCE   10 (residues 1 to 737)
  AUTHORS   Kar,N.C. and Pearson,C.M.
  TITLE     Dipeptidyl peptidases in human muscle disease
  JOURNAL   Clin Chim Acta 82 (1-2), 185-192 (1978)
   PUBMED   618680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC407885.1, BC024271.1,
            AL833475.1 and CD366941.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 7, 2006 this sequence version replaced NP_569710.1.
            
            Summary: This gene encodes a protein that is a member of the M49
            family of metallopeptidases. This cytoplasmic protein binds a
            single zinc ion with its zinc-binding motif (HELLGH) and has
            post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro
            dipeptides from the N-termini of proteins. Increased activity of
            this protein is associated with endometrial and ovarian cancers.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site at a 5' non-coding exon compared to variant 1. Variants
            1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222566.1, AJ271216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531863.6/ ENSP00000432782.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     Protein         1..737
                     /product="dipeptidyl peptidase 3 isoform 1"
                     /EC_number="3.4.14.4"
                     /note="dipeptidyl aminopeptidase III; dipeptidyl
                     arylamidase III; DPP III; dipeptidyl peptidase III;
                     enkephalinase B"
                     /calculated_mol_wt=82458
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22223895,
                     ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9NY33.2)"
     Region          143..704
                     /region_name="Peptidase_M49"
                     /note="Peptidase family M49; pfam03571"
                     /db_xref="CDD:460976"
     CDS             1..737
                     /gene="DPP3"
                     /gene_synonym="DPPIII"
                     /coded_by="NM_130443.4:41..2254"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS8141.1"
                     /db_xref="GeneID:10072"
                     /db_xref="HGNC:HGNC:3008"
                     /db_xref="MIM:606818"
ORIGIN      
        1 madtqyilpn digvssldcr eafrllspte rlyayhlsra awygglavll qtspeapyiy
       61 allsrlfraq dpdqlrqhal aeglteeeyq aflvyaagvy snmgnyksfg dtkfvpnlpk
      121 eklervilgs eaaqqhpeev rglwqtcgel mfsleprlrh lglgkegitt yfsgnctmed
      181 aklaqdflds qnlsayntrl fkevdgegkp yyevrlasvl gsepsldsev tsklksyefr
      241 gspfqvtrgd yapilqkvve qlekakayaa nshqgqmlaq yiesftqgsi eahkrgsrfw
      301 iqdkgpives yigfiesyrd pfgsrgefeg fvavvnkams akferlvasa eqllkelpwp
      361 ptfekdkflt pdftsldvlt fagsgipagi nipnyddlrq tegfknvslg nvlavayatq
      421 rekltfleed dkdlyilwkg psfdvqvglh ellghgsgkl fvqdekgafn fdqetvinpe
      481 tgeqiqswyr sgetwdskfs tiassyeecr aesvglylcl hpqvleifgf egadaedviy
      541 vnwlnmvrag llalefytpe afnwrqahmq arfvilrvll eageglvtit pttgsdgrpd
      601 arvrldrski rsvgkpaler flrrlqvlks tgdvaggral yegyatvtda ppecfltlrd
      661 tvllrkesrk livqpntrle gsdvqlleye asaaglirsf serfpedgpe leeiltqlat
      721 adarfwkgps eapsgqa
//
