LOCUS       NM_020868               5964 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 1, mRNA.
ACCESSION   NM_020868
VERSION     NM_020868.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5964)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5964)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 5964)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 5964)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 5964)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5964)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 5964)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 5964)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 5964)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 5964)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010885.8, AC067947.6, AC017040.7, AC105422.3 and AC016721.11.
            
            On Aug 31, 2019 this sequence version replaced NM_020868.5.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) has an alternate 5' exon, as
            compared to variant 3. The resulting isoform (long, also referred
            to as DPL2-l) is slightly shorter and has a distinct N-terminus
            when compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030832.1, SRR1660805.85760.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410059.6/ ENSP00000386565.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC010885.8         24858-25055
            199-313             AC067947.6         2377-2491
            314-409             AC067947.6         36955-37050
            410-504             AC017040.7         55391-55485
            505-579             AC017040.7         81779-81853
            580-632             AC105422.3         8821-8873
            633-714             AC105422.3         8974-9055
            715-835             AC016721.11        7295-7415
            836-990             AC016721.11        19218-19372
            991-1088            AC016721.11        25565-25662
            1089-1212           AC016721.11        32653-32776
            1213-1251           AC016721.11        42051-42089
            1252-1359           AC016721.11        47776-47883
            1360-1451           AC016721.11        56687-56778
            1452-1499           AC016721.11        57266-57313
            1500-1621           AC016721.11        60353-60474
            1622-1669           AC016721.11        61831-61878
            1670-1768           AC016721.11        70560-70658
            1769-1838           AC016721.11        70766-70835
            1839-2033           AC016721.11        94272-94466
            2034-2088           AC016721.11        95154-95208
            2089-2188           AC016721.11        115636-115735
            2189-2247           AC016721.11        115986-116044
            2248-2320           AC016721.11        116153-116225
            2321-2394           AC016721.11        120229-120302
            2395-5964           AC016721.11        121690-125259
FEATURES             Location/Qualifiers
     source          1..5964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..5964
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..198
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2529
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform long is encoded by transcript variant 1;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform long"
                     /protein_id="NP_065919.3"
                     /db_xref="CCDS:CCDS46400.1"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILV
                     VCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGH
                     VIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIY
                     NIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGK
                     EEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPK
                     GKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVV
                     RWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQ
                     GGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGR
                     QLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDN
                     PAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLI
                     MDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEV
                     KDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKL
                     YASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK
                     HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE"
     exon            199..313
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            314..409
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            410..504
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..579
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..632
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            633..714
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..835
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            836..990
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1088
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1212
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1251
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1359
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1451
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1499
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1621
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1669
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1768
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1838
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2033
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2088
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2188
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2247
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2320
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2394
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..5964
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3516
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4545
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      4601..4606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      4625
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
     regulatory      5943..5948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATAAA"
     polyA_site      5964
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
ORIGIN      
        1 agaagcagca gaagcaacag cagtagcagc ggcagcagca acagcagcag cccctactga
       61 agtccaatag aggagacttg atctctagtt cattctggaa ctccgcctgg gattgtgcac
      121 tgtccagggt cctgaaacat gaaccaaact gccagcgtgt cccatcacat caagtgtcaa
      181 ccctcaaaaa caatcaagga actgggaagt aacagccctc cacagagaaa ctggaaggga
      241 attgctattg ctctgctggt gattttagtt gtatgctcac tcatcactat gtcagtcatc
      301 ctcttaaccc cagatgaact cacaaattcg tcagaaacca gattgtcttt ggaagacctc
      361 tttaggaaag actttgtgct tcacgatcca gaggctcggt ggatcaatga tacagatgtg
      421 gtgtataaaa gcgagaatgg acatgtcatt aaactgaata tagaaacaaa tgctaccaca
      481 ttattattgg aaaacacaac ttttgtaacc ttcaaagcat caagacattc agtttcacca
      541 gatttaaaat atgtccttct ggcatatgat gtcaaacaga tttttcatta ttcgtatact
      601 gcttcatatg tgatttacaa catacacact agggaagttt gggagttaaa tcctccagaa
      661 gtagaggact ccgtcttgca gtacgcggcc tggggtgtcc aagggcagca gctgatttat
      721 atttttgaaa ataatatcta ctatcaacct gatataaaga gcagttcatt gcgactgaca
      781 tcttctggaa aagaagaaat aatttttaat gggattgctg actggttata tgaagaggaa
      841 ctcctgcatt ctcacatcgc ccactggtgg tcaccagatg gagaaagact tgccttcctg
      901 atgataaatg actctttggt acccaccatg gttatccctc ggtttactgg agcgttgtat
      961 cccaaaggaa agcagtatcc gtatcctaag gcaggtcaag tgaacccaac aataaaatta
     1021 tatgttgtaa acctgtatgg accaactcac actttggagc tcatgccacc tgacagcttt
     1081 aaatcaagag aatactatat cactatggtt aaatgggtaa gcaataccaa gactgtggta
     1141 agatggttaa accgagctca gaacatctcc atcctcacag tctgtgagac cactacaggt
     1201 gcttgtagta aaaaatatga gatgacatca gatacgtggc tctctcagca gaatgaggag
     1261 cccgtgtttt ctagagacgg cagcaaattc tttatgacag tgcctgttaa gcaaggggga
     1321 cgtggagaat ttcaccacgt agctatgttc ctcatccaga gtaaaagtga gcaaattacc
     1381 gtgcggcatc tgacatcagg aaactgggaa gtgataaaga tcttggcata cgatgaaact
     1441 actcaaaaaa tttactttct gagcactgaa tcttctccca gaggaaggca gctgtacagt
     1501 gcttctactg aaggattatt gaatcgccaa tgcatttcat gtaatttcat gaaagaacaa
     1561 tgtacatatt ttgatgccag ttttagtccc atgaatcaac atttcttatt attctgtgaa
     1621 ggtccaaggg tcccagtggt cagcctacat agtacggaca acccagcaaa atattttata
     1681 ttggaaagca attctatgct gaaggaagct atcctgaaga agaagatagg aaagccagaa
     1741 attaaaatcc ttcatattga cgactatgaa cttcctttac agttgtccct tcccaaagat
     1801 tttatggacc gaaaccagta tgctcttctg ttaataatgg atgaagaacc aggaggccag
     1861 ctggttacag ataagttcca tattgactgg gattccgtac tcattgacat ggataatgtc
     1921 attgtagcaa gatttgatgg cagaggaagt ggattccagg gtctgaaaat tttgcaggag
     1981 attcatcgaa gattaggttc agtagaagta aaggaccaaa taacagctgt gaaatttttg
     2041 ctgaaactgc cttacattga ctccaaaaga ttaagcattt ttggaaaggg ttatggtggc
     2101 tatattgcat caatgatctt aaaatcagat gaaaagcttt ttaaatgtgg atccgtggtt
     2161 gcacctatca cagacttgaa attgtatgcc tcagctttct ctgaaagata ccttgggatg
     2221 ccatctaagg aagaaagcac ttaccaggca gccagtgtgc tacataatgt tcatggcttg
     2281 aaagaagaaa atatattaat aattcatgga actgctgaca caaaagttca tttccaacac
     2341 tcagcagaat taatcaagca cctaataaaa gctggagtga attatactat gcaggtctac
     2401 ccagatgaag gtcataacgt atctgagaag agcaagtatc atctctacag cacaatcctc
     2461 aaattcttca gtgattgttt gaaggaagaa atatctgtgc taccacagga accagaagaa
     2521 gatgaataat ggactgtatt tatacagaac tgaagggaat attgaggctc aatgaaacct
     2581 gacaaagaga ctgtaatatt gtagttgctc cagaatgtca agggcagctt acggagatgt
     2641 cactggagca gcacgctcag agacagtgaa ctagcatttg aatacacaag tccaagtcta
     2701 ctgtgttgct aggggtgcag aacccgtttc tttgtatgag agaggtcaaa gggttggttt
     2761 cctgggagaa attagttttg cattaaagta ggagtagtgc atgttttctt ctgttatccc
     2821 cctgtttgtt ctgtaactag ttgctctcat tttaatttca ctggccacca tcatctttgc
     2881 atataatgca caatctatca tctgtcctac agtccctgat ctttcatggc tgagctgcaa
     2941 tctaacactt tactgtacct ttataataag tgcaattctt tcattgtcta ttattatgct
     3001 taagaaaata ttcagttaat aaaaaacaga gtattttatg taatttctgt ttttaaaaag
     3061 acattattaa atgggtcaaa ggacatatag aaatgtggat ttcagcacct tccaaagttc
     3121 agccagttat cagtagatac aatatcttta aatgaacaca cgagtgtatg tctcacaata
     3181 tatatacaca agtgtgcata tacagttaat gaaactatct ttaaatgtta ttcatgctat
     3241 aaagagtaaa cgtttgatga attagaagag atgctctttt ccaagctata atggatgctt
     3301 tgtttaatga gccaaatatg atgaaacatt ttttccaatt caaattctag ctattgcttt
     3361 cctataaatg tttgggttgt gtttggtatt gtttttagtg gttaatagtt ttccagttgc
     3421 atttaatttt ttgaatatga taccttgtca catgtaaatt agatacttaa atattaaatt
     3481 atagtttctg ataaagaaat tttgttaaca atgcaatgcc actgagtgct attttgctct
     3541 tttggtggag aaggcttttt tcaaaactct tggtcctttt acttctttct ctcagtgcag
     3601 aatcaattct cattttcatc gtaaaagcaa atagctggat tatttcattt gccagtttct
     3661 atttagtatt ccatgcctgc ccaattcatc tgttactgtt taatttcaat tcttctggtg
     3721 agaattagaa atgaaatatt ttttattcat tggccaaaaa gttcacagac agcagtgttt
     3781 gctatttact ttgaattgaa ggcacaaaat gcatcaattc ctgtgctgtg ttgacttgca
     3841 gtagtaagta actgagagca taaaataaac ctgactgtat gaagtcaatt taagtgatga
     3901 gaacatttaa ctttggtgac taaagtcaga atatcttctc acttcactta agggatcttc
     3961 cagaagatat ctaaaagtct gtaataagct tagaagttca gataaatcta ggcaggatac
     4021 tgcatttttg tggttttaaa aaagtcctta ggacagactg aattatcata acttatggca
     4081 tcaggaggaa actttaaaat atcaaggaat cactcagtca ccctcctgtt ttgttgaagg
     4141 atcaacccca aattctgggt atttgagtac atgtgaatca tggatttggt attcaacttt
     4201 ttccctggat gctttggaat cgtgtcttcc atgctccact gggttcaatt taaaatagga
     4261 gaggctttct cttctgaaag atccatttta ggtctttttc aagaatagtg aacacatttt
     4321 ttaacaaaat aagttgtaat tttaaaagga aagttttgcc tattttatta agatggaaat
     4381 ttctttttag gctaatttga aatccaactg aagcttttta accaatattt taaatttgaa
     4441 ccactagagt tttttatgat gcaaatgatt atgttgtctg aaaggtgtgg ttttattgaa
     4501 tgtctatttg agtatcattt aaaaagtatt tgccttttac tgtcatcatt tctcttgttt
     4561 tattattatt atcaatgttt atctattttt caattaattt aatacagttt ctaatgtgaa
     4621 agacattttt ctggaacccg ttttcccctt aaacactaaa gagacctcaa gtgaaagcat
     4681 attgcttagt aggaaggtag aaaatgttaa tccctgcgat tctttgagtt ttaatgacag
     4741 ggtcattttc agtaaaggaa atgctcacca acacatagtc accaactatt aaaggaatca
     4801 tgtgattgga ttttcccctg tatacatgta cccttggtca taatcccact atttcataca
     4861 tatttatgca ttgctagatt ttcctaggac tccaatagca tgctttccaa gtgttattat
     4921 tcccttaatg ttaaagaaaa aaatcaatat attgaattct ttaattaaat aggtaagcag
     4981 tattaaatca tccacagaga taaacaatct cttgaaactc ttttgaaaga gaaaagtgtt
     5041 tgttcacttt cattgccttc attaagatct ccaaatactc agagactaag caggctattc
     5101 tcatctcttt gagtttcctg acagaactaa aggaaggaat cactcttcaa aagatggatc
     5161 tcacttcact ctgaaaatgt gccttttttt aattgggtgt ttagcataaa aatcactatt
     5221 ggggatctta cagatgtctg ttgtagatct attacaatga ggtgacttag acattgggct
     5281 ttaccatatt agagaattac ttaagccatt gtccttcaaa tgttgggctt ggagacagaa
     5341 gtaccttgga ctgaattgct ttcaagtctc tagaatcact gacagcacat agcttctatg
     5401 aggagttata tatgaaatac cacttgtgtc cctcctcaag ttctctgacc accttcacat
     5461 cctgcggcca ccaacactgt atggatacaa tctggcctct cagctctgct cactttcact
     5521 ttctgttctg gggattctct gatactaatt ttggctactt ggtagaacca agagacaaat
     5581 cgcttacatg ctgcaaaccg atgtgaaggt gttactaacc cgctaaaaca caattaatga
     5641 aagactgtag caggtaactg atctttccct cagatattct acatggtcca tggaagactc
     5701 tgtgggccgc agaagcccat agctgcatac ccttctattt tcctcttccc catttcactc
     5761 ttttaagctc cctactccta ttccctatga tcactttcca aaataaacgg caggtgtgct
     5821 agctgttgtc ttagactctg ctttctggaa actatttttc ccctccacaa gaaattatca
     5881 ctgtgaatat tacaggagga gaaataaaat aagaataaat cagtggttta ttttcaggtt
     5941 cgaataaact ctttctaatg aaaa
//
