LOCUS       NM_001399850            6408 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 17, mRNA.
ACCESSION   NM_001399850
VERSION     NM_001399850.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6408)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6408)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 6408)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 6408)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 6408)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6408)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 6408)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 6408)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 6408)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 6408)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066593.4, AC067947.6, AC017040.7, AC105422.3 and AC016721.11.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803614.104720.1, SRR1660803.35833.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03267754, SAMN03267761 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               AC066593.4         68158-68769
            613-727             AC067947.6         2377-2491
            728-823             AC067947.6         36955-37050
            824-918             AC017040.7         55391-55485
            919-993             AC017040.7         81779-81853
            994-1046            AC105422.3         8821-8873
            1047-1128           AC105422.3         8974-9055
            1129-1249           AC016721.11        7295-7415
            1250-1434           AC016721.11        19188-19372
            1435-1532           AC016721.11        25565-25662
            1533-1656           AC016721.11        32653-32776
            1657-1695           AC016721.11        42051-42089
            1696-1803           AC016721.11        47776-47883
            1804-1895           AC016721.11        56687-56778
            1896-1943           AC016721.11        57266-57313
            1944-2065           AC016721.11        60353-60474
            2066-2113           AC016721.11        61831-61878
            2114-2212           AC016721.11        70560-70658
            2213-2282           AC016721.11        70766-70835
            2283-2477           AC016721.11        94272-94466
            2478-2532           AC016721.11        95154-95208
            2533-2632           AC016721.11        115636-115735
            2633-2691           AC016721.11        115986-116044
            2692-2764           AC016721.11        116153-116225
            2765-2838           AC016721.11        120229-120302
            2839-6408           AC016721.11        121690-125259
FEATURES             Location/Qualifiers
     source          1..6408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..6408
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..612
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..727
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            728..823
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..918
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..993
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1046
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1128
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1249
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1434
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1345..2973
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform i is encoded by transcript variant 17;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform i"
                     /protein_id="NP_001386779.1"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVN
                     LYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGAC
                     SKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQIT
                     VRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMK
                     EQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKI
                     GKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVL
                     IDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLS
                     IFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQA
                     ASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVS
                     EKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE"
     exon            1435..1532
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1656
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1695
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1803
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1895
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1943
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2065
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2113
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2212
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2282
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2477
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2532
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2632
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2691
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2764
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2838
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..6408
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3960
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4989
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      5045..5050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      5069
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
     regulatory      6387..6392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATAAA"
     polyA_site      6408
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcggaa gccggcggcc gtgggcgcgc gggttggggg ctctcgcgcc gctccgggct
       61 ctcccccccc ccggctgcgg ttgccgaaga gaggccggag cgcggcgccc ggctgctcca
      121 cctggcgcgc tgagcaccgc gcggggagcc cccgggggcg ggcggtgggg ggcgcggact
      181 gcgggaagaa ggcacgaggc gtcgccgcag ctcggtcagg ggccggggcc ccgccgctcg
      241 ccgctgcact aacttgccgc ttggtctcgc ctcgccgccg cggctcgctg cgctttgggt
      301 ggcggggggc ggggagagcg gggagtcaga gggtctgcgg tggccgaggg agggacccta
      361 cgacggggag cccgcccggt gccgctcttc ttcccctccc cgcccctccg ctccccccac
      421 cccgtccctt ccgccgattc cgggagcgac gggcgcccgt gacctgcgaa cgctgccaag
      481 tgacggtccc cgagtctgaa gcgcccgcga ggaagcgagc gccagcgcgg gccgccggcg
      541 atgacggccg cgaagcagga gccgcagccc accccggggg ccagggcgag ccaggcgcag
      601 ccggcggacc aggaactggg aagtaacagc cctccacaga gaaactggaa gggaattgct
      661 attgctctgc tggtgatttt agttgtatgc tcactcatca ctatgtcagt catcctctta
      721 accccagatg aactcacaaa ttcgtcagaa accagattgt ctttggaaga cctctttagg
      781 aaagactttg tgcttcacga tccagaggct cggtggatca atgatacaga tgtggtgtat
      841 aaaagcgaga atggacatgt cattaaactg aatatagaaa caaatgctac cacattatta
      901 ttggaaaaca caacttttgt aaccttcaaa gcatcaagac attcagtttc accagattta
      961 aaatatgtcc ttctggcata tgatgtcaaa cagatttttc attattcgta tactgcttca
     1021 tatgtgattt acaacataca cactagggaa gtttgggagt taaatcctcc agaagtagag
     1081 gactccgtct tgcagtacgc ggcctggggt gtccaagggc agcagctgat ttatattttt
     1141 gaaaataata tctactatca acctgatata aagagcagtt cattgcgact gacatcttct
     1201 ggaaaagaag aaataatttt taatgggatt gctgactggt tatatgaagt tggtctcaaa
     1261 taacactcat ttattctaga ggaactcctg cattctcaca tcgcccactg gtggtcacca
     1321 gatggagaaa gacttgcctt cctgatgata aatgactctt tggtacccac catggttatc
     1381 cctcggttta ctggagcgtt gtatcccaaa ggaaagcagt atccgtatcc taaggcaggt
     1441 caagtgaacc caacaataaa attatatgtt gtaaacctgt atggaccaac tcacactttg
     1501 gagctcatgc cacctgacag ctttaaatca agagaatact atatcactat ggttaaatgg
     1561 gtaagcaata ccaagactgt ggtaagatgg ttaaaccgag ctcagaacat ctccatcctc
     1621 acagtctgtg agaccactac aggtgcttgt agtaaaaaat atgagatgac atcagatacg
     1681 tggctctctc agcagaatga ggagcccgtg ttttctagag acggcagcaa attctttatg
     1741 acagtgcctg ttaagcaagg gggacgtgga gaatttcacc acgtagctat gttcctcatc
     1801 cagagtaaaa gtgagcaaat taccgtgcgg catctgacat caggaaactg ggaagtgata
     1861 aagatcttgg catacgatga aactactcaa aaaatttact ttctgagcac tgaatcttct
     1921 cccagaggaa ggcagctgta cagtgcttct actgaaggat tattgaatcg ccaatgcatt
     1981 tcatgtaatt tcatgaaaga acaatgtaca tattttgatg ccagttttag tcccatgaat
     2041 caacatttct tattattctg tgaaggtcca agggtcccag tggtcagcct acatagtacg
     2101 gacaacccag caaaatattt tatattggaa agcaattcta tgctgaagga agctatcctg
     2161 aagaagaaga taggaaagcc agaaattaaa atccttcata ttgacgacta tgaacttcct
     2221 ttacagttgt cccttcccaa agattttatg gaccgaaacc agtatgctct tctgttaata
     2281 atggatgaag aaccaggagg ccagctggtt acagataagt tccatattga ctgggattcc
     2341 gtactcattg acatggataa tgtcattgta gcaagatttg atggcagagg aagtggattc
     2401 cagggtctga aaattttgca ggagattcat cgaagattag gttcagtaga agtaaaggac
     2461 caaataacag ctgtgaaatt tttgctgaaa ctgccttaca ttgactccaa aagattaagc
     2521 atttttggaa agggttatgg tggctatatt gcatcaatga tcttaaaatc agatgaaaag
     2581 ctttttaaat gtggatccgt ggttgcacct atcacagact tgaaattgta tgcctcagct
     2641 ttctctgaaa gataccttgg gatgccatct aaggaagaaa gcacttacca ggcagccagt
     2701 gtgctacata atgttcatgg cttgaaagaa gaaaatatat taataattca tggaactgct
     2761 gacacaaaag ttcatttcca acactcagca gaattaatca agcacctaat aaaagctgga
     2821 gtgaattata ctatgcaggt ctacccagat gaaggtcata acgtatctga gaagagcaag
     2881 tatcatctct acagcacaat cctcaaattc ttcagtgatt gtttgaagga agaaatatct
     2941 gtgctaccac aggaaccaga agaagatgaa taatggactg tatttataca gaactgaagg
     3001 gaatattgag gctcaatgaa acctgacaaa gagactgtaa tattgtagtt gctccagaat
     3061 gtcaagggca gcttacggag atgtcactgg agcagcacgc tcagagacag tgaactagca
     3121 tttgaataca caagtccaag tctactgtgt tgctaggggt gcagaacccg tttctttgta
     3181 tgagagaggt caaagggttg gtttcctggg agaaattagt tttgcattaa agtaggagta
     3241 gtgcatgttt tcttctgtta tccccctgtt tgttctgtaa ctagttgctc tcattttaat
     3301 ttcactggcc accatcatct ttgcatataa tgcacaatct atcatctgtc ctacagtccc
     3361 tgatctttca tggctgagct gcaatctaac actttactgt acctttataa taagtgcaat
     3421 tctttcattg tctattatta tgcttaagaa aatattcagt taataaaaaa cagagtattt
     3481 tatgtaattt ctgtttttaa aaagacatta ttaaatgggt caaaggacat atagaaatgt
     3541 ggatttcagc accttccaaa gttcagccag ttatcagtag atacaatatc tttaaatgaa
     3601 cacacgagtg tatgtctcac aatatatata cacaagtgtg catatacagt taatgaaact
     3661 atctttaaat gttattcatg ctataaagag taaacgtttg atgaattaga agagatgctc
     3721 ttttccaagc tataatggat gctttgttta atgagccaaa tatgatgaaa cattttttcc
     3781 aattcaaatt ctagctattg ctttcctata aatgtttggg ttgtgtttgg tattgttttt
     3841 agtggttaat agttttccag ttgcatttaa ttttttgaat atgatacctt gtcacatgta
     3901 aattagatac ttaaatatta aattatagtt tctgataaag aaattttgtt aacaatgcaa
     3961 tgccactgag tgctattttg ctcttttggt ggagaaggct tttttcaaaa ctcttggtcc
     4021 ttttacttct ttctctcagt gcagaatcaa ttctcatttt catcgtaaaa gcaaatagct
     4081 ggattatttc atttgccagt ttctatttag tattccatgc ctgcccaatt catctgttac
     4141 tgtttaattt caattcttct ggtgagaatt agaaatgaaa tattttttat tcattggcca
     4201 aaaagttcac agacagcagt gtttgctatt tactttgaat tgaaggcaca aaatgcatca
     4261 attcctgtgc tgtgttgact tgcagtagta agtaactgag agcataaaat aaacctgact
     4321 gtatgaagtc aatttaagtg atgagaacat ttaactttgg tgactaaagt cagaatatct
     4381 tctcacttca cttaagggat cttccagaag atatctaaaa gtctgtaata agcttagaag
     4441 ttcagataaa tctaggcagg atactgcatt tttgtggttt taaaaaagtc cttaggacag
     4501 actgaattat cataacttat ggcatcagga ggaaacttta aaatatcaag gaatcactca
     4561 gtcaccctcc tgttttgttg aaggatcaac cccaaattct gggtatttga gtacatgtga
     4621 atcatggatt tggtattcaa ctttttccct ggatgctttg gaatcgtgtc ttccatgctc
     4681 cactgggttc aatttaaaat aggagaggct ttctcttctg aaagatccat tttaggtctt
     4741 tttcaagaat agtgaacaca ttttttaaca aaataagttg taattttaaa aggaaagttt
     4801 tgcctatttt attaagatgg aaatttcttt ttaggctaat ttgaaatcca actgaagctt
     4861 tttaaccaat attttaaatt tgaaccacta gagtttttta tgatgcaaat gattatgttg
     4921 tctgaaaggt gtggttttat tgaatgtcta tttgagtatc atttaaaaag tatttgcctt
     4981 ttactgtcat catttctctt gttttattat tattatcaat gtttatctat ttttcaatta
     5041 atttaataca gtttctaatg tgaaagacat ttttctggaa cccgttttcc ccttaaacac
     5101 taaagagacc tcaagtgaaa gcatattgct tagtaggaag gtagaaaatg ttaatccctg
     5161 cgattctttg agttttaatg acagggtcat tttcagtaaa ggaaatgctc accaacacat
     5221 agtcaccaac tattaaagga atcatgtgat tggattttcc cctgtataca tgtacccttg
     5281 gtcataatcc cactatttca tacatattta tgcattgcta gattttccta ggactccaat
     5341 agcatgcttt ccaagtgtta ttattccctt aatgttaaag aaaaaaatca atatattgaa
     5401 ttctttaatt aaataggtaa gcagtattaa atcatccaca gagataaaca atctcttgaa
     5461 actcttttga aagagaaaag tgtttgttca ctttcattgc cttcattaag atctccaaat
     5521 actcagagac taagcaggct attctcatct ctttgagttt cctgacagaa ctaaaggaag
     5581 gaatcactct tcaaaagatg gatctcactt cactctgaaa atgtgccttt ttttaattgg
     5641 gtgtttagca taaaaatcac tattggggat cttacagatg tctgttgtag atctattaca
     5701 atgaggtgac ttagacattg ggctttacca tattagagaa ttacttaagc cattgtcctt
     5761 caaatgttgg gcttggagac agaagtacct tggactgaat tgctttcaag tctctagaat
     5821 cactgacagc acatagcttc tatgaggagt tatatatgaa ataccacttg tgtccctcct
     5881 caagttctct gaccaccttc acatcctgcg gccaccaaca ctgtatggat acaatctggc
     5941 ctctcagctc tgctcacttt cactttctgt tctggggatt ctctgatact aattttggct
     6001 acttggtaga accaagagac aaatcgctta catgctgcaa accgatgtga aggtgttact
     6061 aacccgctaa aacacaatta atgaaagact gtagcaggta actgatcttt ccctcagata
     6121 ttctacatgg tccatggaag actctgtggg ccgcagaagc ccatagctgc atacccttct
     6181 attttcctct tccccatttc actcttttaa gctccctact cctattccct atgatcactt
     6241 tccaaaataa acggcaggtg tgctagctgt tgtcttagac tctgctttct ggaaactatt
     6301 tttcccctcc acaagaaatt atcactgtga atattacagg aggagaaata aaataagaat
     6361 aaatcagtgg tttattttca ggttcgaata aactctttct aatgaaaa
//
