LOCUS       NM_001321912            6288 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 13, mRNA.
ACCESSION   NM_001321912
VERSION     NM_001321912.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6288)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6288)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 6288)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 6288)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 6288)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6288)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 6288)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 6288)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 6288)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 6288)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010885.8, AC067947.6, AC017040.7, AC105422.3 and AC016721.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001321912.2.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.262344.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145743,
                                           SAMEA2154665 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-564               AC010885.8         43794-44357
            565-596             AC010885.8         45612-45643
            597-711             AC067947.6         2377-2491
            712-807             AC067947.6         36955-37050
            808-902             AC017040.7         55391-55485
            903-977             AC017040.7         81779-81853
            978-1030            AC105422.3         8821-8873
            1031-1112           AC105422.3         8974-9055
            1113-1233           AC016721.11        7295-7415
            1234-1388           AC016721.11        19218-19372
            1389-1486           AC016721.11        25565-25662
            1487-1610           AC016721.11        32653-32776
            1611-1649           AC016721.11        42051-42089
            1650-1757           AC016721.11        47776-47883
            1758-1849           AC016721.11        56687-56778
            1850-1897           AC016721.11        57266-57313
            1898-2019           AC016721.11        60353-60474
            2020-2067           AC016721.11        61831-61878
            2068-2166           AC016721.11        70560-70658
            2167-2236           AC016721.11        70766-70835
            2237-2431           AC016721.11        94272-94466
            2432-2486           AC016721.11        95154-95208
            2487-2586           AC016721.11        115636-115735
            2587-2645           AC016721.11        115986-116044
            2646-2718           AC016721.11        116153-116225
            2719-6288           AC016721.11        121690-125259
FEATURES             Location/Qualifiers
     source          1..6288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..6288
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..564
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..596
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..711
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             687..2732
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform h is encoded by transcript variant 13;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform h"
                     /protein_id="NP_001308841.2"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDV
                     VYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYS
                     YTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSS
                     LRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPR
                     FTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKW
                     VSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKF
                     FMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLS
                     TESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV
                     VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDR
                     NQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIH
                     RRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVV
                     APITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADSLPR"
     exon            712..807
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..902
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..977
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1030
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1112
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1233
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1388
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1486
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1610
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1649
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1757
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1849
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1897
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2019
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2067
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2166
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2236
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2431
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2486
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2586
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2645
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2718
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..6288
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3818..3823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3840
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4869
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      4949
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
     regulatory      6267..6272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATAAA"
     polyA_site      6288
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
ORIGIN      
        1 atattgcatt aaacacttga tgaaagaaga cctagaaggc tttaagaaag acagggtaat
       61 attttgctgg tgtagagggc ctgctcttcg gagacaaata cttgcttttc attttgatca
      121 gccgtctgca cttaaaagcc tcctagccag ggacatgtta attaaacagt ctggggctca
      181 gtgctgccat ccgtaaattg gaggattaga gaaataatat acacaagtac ctggtacata
      241 ccaaatatga tagaagatat cttcaacctt tagctataag aagaatggaa aatgaaaaag
      301 agacaggtgg agagagggag ggagatgaga gctgcgtgga gctggtatgc tggttaggag
      361 gtaggaaata atgaggcctc gaccatctaa gatacagaag tctccctgct gaatcgaaag
      421 gaagtgctac aatattcttt caaattcatc gcagttgaga gaaaactgga gcagagtgtg
      481 atatcaagaa agggcttcac caggatgatc aatgcaaatg gatatggagc tttcttggaa
      541 tgaaacatta tcccgtaaca ccaggtatac atacatgaag agtggcttca ggactggaac
      601 tgggaagtaa cagccctcca cagagaaact ggaagggaat tgctattgct ctgctggtga
      661 ttttagttgt atgctcactc atcactatgt cagtcatcct cttaacccca gatgaactca
      721 caaattcgtc agaaaccaga ttgtctttgg aagacctctt taggaaagac tttgtgcttc
      781 acgatccaga ggctcggtgg atcaatgata cagatgtggt gtataaaagc gagaatggac
      841 atgtcattaa actgaatata gaaacaaatg ctaccacatt attattggaa aacacaactt
      901 ttgtaacctt caaagcatca agacattcag tttcaccaga tttaaaatat gtccttctgg
      961 catatgatgt caaacagatt tttcattatt cgtatactgc ttcatatgtg atttacaaca
     1021 tacacactag ggaagtttgg gagttaaatc ctccagaagt agaggactcc gtcttgcagt
     1081 acgcggcctg gggtgtccaa gggcagcagc tgatttatat ttttgaaaat aatatctact
     1141 atcaacctga tataaagagc agttcattgc gactgacatc ttctggaaaa gaagaaataa
     1201 tttttaatgg gattgctgac tggttatatg aagaggaact cctgcattct cacatcgccc
     1261 actggtggtc accagatgga gaaagacttg ccttcctgat gataaatgac tctttggtac
     1321 ccaccatggt tatccctcgg tttactggag cgttgtatcc caaaggaaag cagtatccgt
     1381 atcctaaggc aggtcaagtg aacccaacaa taaaattata tgttgtaaac ctgtatggac
     1441 caactcacac tttggagctc atgccacctg acagctttaa atcaagagaa tactatatca
     1501 ctatggttaa atgggtaagc aataccaaga ctgtggtaag atggttaaac cgagctcaga
     1561 acatctccat cctcacagtc tgtgagacca ctacaggtgc ttgtagtaaa aaatatgaga
     1621 tgacatcaga tacgtggctc tctcagcaga atgaggagcc cgtgttttct agagacggca
     1681 gcaaattctt tatgacagtg cctgttaagc aagggggacg tggagaattt caccacgtag
     1741 ctatgttcct catccagagt aaaagtgagc aaattaccgt gcggcatctg acatcaggaa
     1801 actgggaagt gataaagatc ttggcatacg atgaaactac tcaaaaaatt tactttctga
     1861 gcactgaatc ttctcccaga ggaaggcagc tgtacagtgc ttctactgaa ggattattga
     1921 atcgccaatg catttcatgt aatttcatga aagaacaatg tacatatttt gatgccagtt
     1981 ttagtcccat gaatcaacat ttcttattat tctgtgaagg tccaagggtc ccagtggtca
     2041 gcctacatag tacggacaac ccagcaaaat attttatatt ggaaagcaat tctatgctga
     2101 aggaagctat cctgaagaag aagataggaa agccagaaat taaaatcctt catattgacg
     2161 actatgaact tcctttacag ttgtcccttc ccaaagattt tatggaccga aaccagtatg
     2221 ctcttctgtt aataatggat gaagaaccag gaggccagct ggttacagat aagttccata
     2281 ttgactggga ttccgtactc attgacatgg ataatgtcat tgtagcaaga tttgatggca
     2341 gaggaagtgg attccagggt ctgaaaattt tgcaggagat tcatcgaaga ttaggttcag
     2401 tagaagtaaa ggaccaaata acagctgtga aatttttgct gaaactgcct tacattgact
     2461 ccaaaagatt aagcattttt ggaaagggtt atggtggcta tattgcatca atgatcttaa
     2521 aatcagatga aaagcttttt aaatgtggat ccgtggttgc acctatcaca gacttgaaat
     2581 tgtatgcctc agctttctct gaaagatacc ttgggatgcc atctaaggaa gaaagcactt
     2641 accaggcagc cagtgtgcta cataatgttc atggcttgaa agaagaaaat atattaataa
     2701 ttcatggaac tgctgacagt ctacccagat gaaggtcata acgtatctga gaagagcaag
     2761 tatcatctct acagcacaat cctcaaattc ttcagtgatt gtttgaagga agaaatatct
     2821 gtgctaccac aggaaccaga agaagatgaa taatggactg tatttataca gaactgaagg
     2881 gaatattgag gctcaatgaa acctgacaaa gagactgtaa tattgtagtt gctccagaat
     2941 gtcaagggca gcttacggag atgtcactgg agcagcacgc tcagagacag tgaactagca
     3001 tttgaataca caagtccaag tctactgtgt tgctaggggt gcagaacccg tttctttgta
     3061 tgagagaggt caaagggttg gtttcctggg agaaattagt tttgcattaa agtaggagta
     3121 gtgcatgttt tcttctgtta tccccctgtt tgttctgtaa ctagttgctc tcattttaat
     3181 ttcactggcc accatcatct ttgcatataa tgcacaatct atcatctgtc ctacagtccc
     3241 tgatctttca tggctgagct gcaatctaac actttactgt acctttataa taagtgcaat
     3301 tctttcattg tctattatta tgcttaagaa aatattcagt taataaaaaa cagagtattt
     3361 tatgtaattt ctgtttttaa aaagacatta ttaaatgggt caaaggacat atagaaatgt
     3421 ggatttcagc accttccaaa gttcagccag ttatcagtag atacaatatc tttaaatgaa
     3481 cacacgagtg tatgtctcac aatatatata cacaagtgtg catatacagt taatgaaact
     3541 atctttaaat gttattcatg ctataaagag taaacgtttg atgaattaga agagatgctc
     3601 ttttccaagc tataatggat gctttgttta atgagccaaa tatgatgaaa cattttttcc
     3661 aattcaaatt ctagctattg ctttcctata aatgtttggg ttgtgtttgg tattgttttt
     3721 agtggttaat agttttccag ttgcatttaa ttttttgaat atgatacctt gtcacatgta
     3781 aattagatac ttaaatatta aattatagtt tctgataaag aaattttgtt aacaatgcaa
     3841 tgccactgag tgctattttg ctcttttggt ggagaaggct tttttcaaaa ctcttggtcc
     3901 ttttacttct ttctctcagt gcagaatcaa ttctcatttt catcgtaaaa gcaaatagct
     3961 ggattatttc atttgccagt ttctatttag tattccatgc ctgcccaatt catctgttac
     4021 tgtttaattt caattcttct ggtgagaatt agaaatgaaa tattttttat tcattggcca
     4081 aaaagttcac agacagcagt gtttgctatt tactttgaat tgaaggcaca aaatgcatca
     4141 attcctgtgc tgtgttgact tgcagtagta agtaactgag agcataaaat aaacctgact
     4201 gtatgaagtc aatttaagtg atgagaacat ttaactttgg tgactaaagt cagaatatct
     4261 tctcacttca cttaagggat cttccagaag atatctaaaa gtctgtaata agcttagaag
     4321 ttcagataaa tctaggcagg atactgcatt tttgtggttt taaaaaagtc cttaggacag
     4381 actgaattat cataacttat ggcatcagga ggaaacttta aaatatcaag gaatcactca
     4441 gtcaccctcc tgttttgttg aaggatcaac cccaaattct gggtatttga gtacatgtga
     4501 atcatggatt tggtattcaa ctttttccct ggatgctttg gaatcgtgtc ttccatgctc
     4561 cactgggttc aatttaaaat aggagaggct ttctcttctg aaagatccat tttaggtctt
     4621 tttcaagaat agtgaacaca ttttttaaca aaataagttg taattttaaa aggaaagttt
     4681 tgcctatttt attaagatgg aaatttcttt ttaggctaat ttgaaatcca actgaagctt
     4741 tttaaccaat attttaaatt tgaaccacta gagtttttta tgatgcaaat gattatgttg
     4801 tctgaaaggt gtggttttat tgaatgtcta tttgagtatc atttaaaaag tatttgcctt
     4861 ttactgtcat catttctctt gttttattat tattatcaat gtttatctat ttttcaatta
     4921 atttaataca gtttctaatg tgaaagacat ttttctggaa cccgttttcc ccttaaacac
     4981 taaagagacc tcaagtgaaa gcatattgct tagtaggaag gtagaaaatg ttaatccctg
     5041 cgattctttg agttttaatg acagggtcat tttcagtaaa ggaaatgctc accaacacat
     5101 agtcaccaac tattaaagga atcatgtgat tggattttcc cctgtataca tgtacccttg
     5161 gtcataatcc cactatttca tacatattta tgcattgcta gattttccta ggactccaat
     5221 agcatgcttt ccaagtgtta ttattccctt aatgttaaag aaaaaaatca atatattgaa
     5281 ttctttaatt aaataggtaa gcagtattaa atcatccaca gagataaaca atctcttgaa
     5341 actcttttga aagagaaaag tgtttgttca ctttcattgc cttcattaag atctccaaat
     5401 actcagagac taagcaggct attctcatct ctttgagttt cctgacagaa ctaaaggaag
     5461 gaatcactct tcaaaagatg gatctcactt cactctgaaa atgtgccttt ttttaattgg
     5521 gtgtttagca taaaaatcac tattggggat cttacagatg tctgttgtag atctattaca
     5581 atgaggtgac ttagacattg ggctttacca tattagagaa ttacttaagc cattgtcctt
     5641 caaatgttgg gcttggagac agaagtacct tggactgaat tgctttcaag tctctagaat
     5701 cactgacagc acatagcttc tatgaggagt tatatatgaa ataccacttg tgtccctcct
     5761 caagttctct gaccaccttc acatcctgcg gccaccaaca ctgtatggat acaatctggc
     5821 ctctcagctc tgctcacttt cactttctgt tctggggatt ctctgatact aattttggct
     5881 acttggtaga accaagagac aaatcgctta catgctgcaa accgatgtga aggtgttact
     5941 aacccgctaa aacacaatta atgaaagact gtagcaggta actgatcttt ccctcagata
     6001 ttctacatgg tccatggaag actctgtggg ccgcagaagc ccatagctgc atacccttct
     6061 attttcctct tccccatttc actcttttaa gctccctact cctattccct atgatcactt
     6121 tccaaaataa acggcaggtg tgctagctgt tgtcttagac tctgctttct ggaaactatt
     6181 tttcccctcc acaagaaatt atcactgtga atattacagg aggagaaata aaataagaat
     6241 aaatcagtgg tttattttca ggttcgaata aactctttct aatgaaaa
//
