LOCUS       NM_001178037            5999 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 4, mRNA.
ACCESSION   NM_001178037
VERSION     NM_001178037.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5999)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5999)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 5999)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 5999)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 5999)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5999)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 5999)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 5999)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 5999)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 5999)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093610.2, AC067947.6, AC017040.7, AC105422.3 and AC016721.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001178037.2.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) has an alternate 5' exon, as
            compared to variant 3. The resulting isoform (b) has a shorter and
            distinct N-terminus when compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ857321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267752 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC093610.2         112618-112850
            234-348             AC067947.6         2377-2491
            349-444             AC067947.6         36955-37050
            445-539             AC017040.7         55391-55485
            540-614             AC017040.7         81779-81853
            615-667             AC105422.3         8821-8873
            668-749             AC105422.3         8974-9055
            750-870             AC016721.11        7295-7415
            871-1025            AC016721.11        19218-19372
            1026-1123           AC016721.11        25565-25662
            1124-1247           AC016721.11        32653-32776
            1248-1286           AC016721.11        42051-42089
            1287-1394           AC016721.11        47776-47883
            1395-1486           AC016721.11        56687-56778
            1487-1534           AC016721.11        57266-57313
            1535-1656           AC016721.11        60353-60474
            1657-1704           AC016721.11        61831-61878
            1705-1803           AC016721.11        70560-70658
            1804-1873           AC016721.11        70766-70835
            1874-2068           AC016721.11        94272-94466
            2069-2123           AC016721.11        95154-95208
            2124-2223           AC016721.11        115636-115735
            2224-2282           AC016721.11        115986-116044
            2283-2355           AC016721.11        116153-116225
            2356-2429           AC016721.11        120229-120302
            2430-5999           AC016721.11        121690-125259
FEATURES             Location/Qualifiers
     source          1..5999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..5999
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..233
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2564
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform b is encoded by transcript variant 4;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform b"
                     /protein_id="NP_001171508.2"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MVITEVAEGPVDGSEKELGSNSPPQRNWKGIAIALLVILVVCSL
                     ITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKL
                     NIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHT
                     REVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEII
                     FNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQY
                     PYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLN
                     RAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRG
                     EFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYS
                     ASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKY
                     FILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEE
                     PGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQI
                     TAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASA
                     FSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIK
                     AGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE"
     exon            234..348
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..444
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..539
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..614
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..667
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..749
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..870
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1025
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1123
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1247
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1286
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1394
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1486
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1534
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1656
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1704
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1803
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1873
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2068
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2123
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2223
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2282
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2355
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2429
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..5999
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3551
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4580
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      4636..4641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      4660
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
     regulatory      5978..5983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATAAA"
     polyA_site      5999
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
ORIGIN      
        1 acacatattt cggttggaca taggtgggca ctgacgtaga ttctttgctt cctgtactta
       61 tatgtgaata gcaaagtgtt gagaactgga agcatgagtg agtgacatgc aaggaactga
      121 cattgaagta agattctgtg agggtgaggt tgcatttgta gaaagtggtt atagtccact
      181 tagcaatggt catcacagag gtggctgagg gaccagtaga tggttctgaa aaggaactgg
      241 gaagtaacag ccctccacag agaaactgga agggaattgc tattgctctg ctggtgattt
      301 tagttgtatg ctcactcatc actatgtcag tcatcctctt aaccccagat gaactcacaa
      361 attcgtcaga aaccagattg tctttggaag acctctttag gaaagacttt gtgcttcacg
      421 atccagaggc tcggtggatc aatgatacag atgtggtgta taaaagcgag aatggacatg
      481 tcattaaact gaatatagaa acaaatgcta ccacattatt attggaaaac acaacttttg
      541 taaccttcaa agcatcaaga cattcagttt caccagattt aaaatatgtc cttctggcat
      601 atgatgtcaa acagattttt cattattcgt atactgcttc atatgtgatt tacaacatac
      661 acactaggga agtttgggag ttaaatcctc cagaagtaga ggactccgtc ttgcagtacg
      721 cggcctgggg tgtccaaggg cagcagctga tttatatttt tgaaaataat atctactatc
      781 aacctgatat aaagagcagt tcattgcgac tgacatcttc tggaaaagaa gaaataattt
      841 ttaatgggat tgctgactgg ttatatgaag aggaactcct gcattctcac atcgcccact
      901 ggtggtcacc agatggagaa agacttgcct tcctgatgat aaatgactct ttggtaccca
      961 ccatggttat ccctcggttt actggagcgt tgtatcccaa aggaaagcag tatccgtatc
     1021 ctaaggcagg tcaagtgaac ccaacaataa aattatatgt tgtaaacctg tatggaccaa
     1081 ctcacacttt ggagctcatg ccacctgaca gctttaaatc aagagaatac tatatcacta
     1141 tggttaaatg ggtaagcaat accaagactg tggtaagatg gttaaaccga gctcagaaca
     1201 tctccatcct cacagtctgt gagaccacta caggtgcttg tagtaaaaaa tatgagatga
     1261 catcagatac gtggctctct cagcagaatg aggagcccgt gttttctaga gacggcagca
     1321 aattctttat gacagtgcct gttaagcaag ggggacgtgg agaatttcac cacgtagcta
     1381 tgttcctcat ccagagtaaa agtgagcaaa ttaccgtgcg gcatctgaca tcaggaaact
     1441 gggaagtgat aaagatcttg gcatacgatg aaactactca aaaaatttac tttctgagca
     1501 ctgaatcttc tcccagagga aggcagctgt acagtgcttc tactgaagga ttattgaatc
     1561 gccaatgcat ttcatgtaat ttcatgaaag aacaatgtac atattttgat gccagtttta
     1621 gtcccatgaa tcaacatttc ttattattct gtgaaggtcc aagggtccca gtggtcagcc
     1681 tacatagtac ggacaaccca gcaaaatatt ttatattgga aagcaattct atgctgaagg
     1741 aagctatcct gaagaagaag ataggaaagc cagaaattaa aatccttcat attgacgact
     1801 atgaacttcc tttacagttg tcccttccca aagattttat ggaccgaaac cagtatgctc
     1861 ttctgttaat aatggatgaa gaaccaggag gccagctggt tacagataag ttccatattg
     1921 actgggattc cgtactcatt gacatggata atgtcattgt agcaagattt gatggcagag
     1981 gaagtggatt ccagggtctg aaaattttgc aggagattca tcgaagatta ggttcagtag
     2041 aagtaaagga ccaaataaca gctgtgaaat ttttgctgaa actgccttac attgactcca
     2101 aaagattaag catttttgga aagggttatg gtggctatat tgcatcaatg atcttaaaat
     2161 cagatgaaaa gctttttaaa tgtggatccg tggttgcacc tatcacagac ttgaaattgt
     2221 atgcctcagc tttctctgaa agataccttg ggatgccatc taaggaagaa agcacttacc
     2281 aggcagccag tgtgctacat aatgttcatg gcttgaaaga agaaaatata ttaataattc
     2341 atggaactgc tgacacaaaa gttcatttcc aacactcagc agaattaatc aagcacctaa
     2401 taaaagctgg agtgaattat actatgcagg tctacccaga tgaaggtcat aacgtatctg
     2461 agaagagcaa gtatcatctc tacagcacaa tcctcaaatt cttcagtgat tgtttgaagg
     2521 aagaaatatc tgtgctacca caggaaccag aagaagatga ataatggact gtatttatac
     2581 agaactgaag ggaatattga ggctcaatga aacctgacaa agagactgta atattgtagt
     2641 tgctccagaa tgtcaagggc agcttacgga gatgtcactg gagcagcacg ctcagagaca
     2701 gtgaactagc atttgaatac acaagtccaa gtctactgtg ttgctagggg tgcagaaccc
     2761 gtttctttgt atgagagagg tcaaagggtt ggtttcctgg gagaaattag ttttgcatta
     2821 aagtaggagt agtgcatgtt ttcttctgtt atccccctgt ttgttctgta actagttgct
     2881 ctcattttaa tttcactggc caccatcatc tttgcatata atgcacaatc tatcatctgt
     2941 cctacagtcc ctgatctttc atggctgagc tgcaatctaa cactttactg tacctttata
     3001 ataagtgcaa ttctttcatt gtctattatt atgcttaaga aaatattcag ttaataaaaa
     3061 acagagtatt ttatgtaatt tctgttttta aaaagacatt attaaatggg tcaaaggaca
     3121 tatagaaatg tggatttcag caccttccaa agttcagcca gttatcagta gatacaatat
     3181 ctttaaatga acacacgagt gtatgtctca caatatatat acacaagtgt gcatatacag
     3241 ttaatgaaac tatctttaaa tgttattcat gctataaaga gtaaacgttt gatgaattag
     3301 aagagatgct cttttccaag ctataatgga tgctttgttt aatgagccaa atatgatgaa
     3361 acattttttc caattcaaat tctagctatt gctttcctat aaatgtttgg gttgtgtttg
     3421 gtattgtttt tagtggttaa tagttttcca gttgcattta attttttgaa tatgatacct
     3481 tgtcacatgt aaattagata cttaaatatt aaattatagt ttctgataaa gaaattttgt
     3541 taacaatgca atgccactga gtgctatttt gctcttttgg tggagaaggc ttttttcaaa
     3601 actcttggtc cttttacttc tttctctcag tgcagaatca attctcattt tcatcgtaaa
     3661 agcaaatagc tggattattt catttgccag tttctattta gtattccatg cctgcccaat
     3721 tcatctgtta ctgtttaatt tcaattcttc tggtgagaat tagaaatgaa atatttttta
     3781 ttcattggcc aaaaagttca cagacagcag tgtttgctat ttactttgaa ttgaaggcac
     3841 aaaatgcatc aattcctgtg ctgtgttgac ttgcagtagt aagtaactga gagcataaaa
     3901 taaacctgac tgtatgaagt caatttaagt gatgagaaca tttaactttg gtgactaaag
     3961 tcagaatatc ttctcacttc acttaaggga tcttccagaa gatatctaaa agtctgtaat
     4021 aagcttagaa gttcagataa atctaggcag gatactgcat ttttgtggtt ttaaaaaagt
     4081 ccttaggaca gactgaatta tcataactta tggcatcagg aggaaacttt aaaatatcaa
     4141 ggaatcactc agtcaccctc ctgttttgtt gaaggatcaa ccccaaattc tgggtatttg
     4201 agtacatgtg aatcatggat ttggtattca actttttccc tggatgcttt ggaatcgtgt
     4261 cttccatgct ccactgggtt caatttaaaa taggagaggc tttctcttct gaaagatcca
     4321 ttttaggtct ttttcaagaa tagtgaacac attttttaac aaaataagtt gtaattttaa
     4381 aaggaaagtt ttgcctattt tattaagatg gaaatttctt tttaggctaa tttgaaatcc
     4441 aactgaagct ttttaaccaa tattttaaat ttgaaccact agagtttttt atgatgcaaa
     4501 tgattatgtt gtctgaaagg tgtggtttta ttgaatgtct atttgagtat catttaaaaa
     4561 gtatttgcct tttactgtca tcatttctct tgttttatta ttattatcaa tgtttatcta
     4621 tttttcaatt aatttaatac agtttctaat gtgaaagaca tttttctgga acccgttttc
     4681 cccttaaaca ctaaagagac ctcaagtgaa agcatattgc ttagtaggaa ggtagaaaat
     4741 gttaatccct gcgattcttt gagttttaat gacagggtca ttttcagtaa aggaaatgct
     4801 caccaacaca tagtcaccaa ctattaaagg aatcatgtga ttggattttc ccctgtatac
     4861 atgtaccctt ggtcataatc ccactatttc atacatattt atgcattgct agattttcct
     4921 aggactccaa tagcatgctt tccaagtgtt attattccct taatgttaaa gaaaaaaatc
     4981 aatatattga attctttaat taaataggta agcagtatta aatcatccac agagataaac
     5041 aatctcttga aactcttttg aaagagaaaa gtgtttgttc actttcattg ccttcattaa
     5101 gatctccaaa tactcagaga ctaagcaggc tattctcatc tctttgagtt tcctgacaga
     5161 actaaaggaa ggaatcactc ttcaaaagat ggatctcact tcactctgaa aatgtgcctt
     5221 tttttaattg ggtgtttagc ataaaaatca ctattgggga tcttacagat gtctgttgta
     5281 gatctattac aatgaggtga cttagacatt gggctttacc atattagaga attacttaag
     5341 ccattgtcct tcaaatgttg ggcttggaga cagaagtacc ttggactgaa ttgctttcaa
     5401 gtctctagaa tcactgacag cacatagctt ctatgaggag ttatatatga aataccactt
     5461 gtgtccctcc tcaagttctc tgaccacctt cacatcctgc ggccaccaac actgtatgga
     5521 tacaatctgg cctctcagct ctgctcactt tcactttctg ttctggggat tctctgatac
     5581 taattttggc tacttggtag aaccaagaga caaatcgctt acatgctgca aaccgatgtg
     5641 aaggtgttac taacccgcta aaacacaatt aatgaaagac tgtagcaggt aactgatctt
     5701 tccctcagat attctacatg gtccatggaa gactctgtgg gccgcagaag cccatagctg
     5761 catacccttc tattttcctc ttccccattt cactctttta agctccctac tcctattccc
     5821 tatgatcact ttccaaaata aacggcaggt gtgctagctg ttgtcttaga ctctgctttc
     5881 tggaaactat ttttcccctc cacaagaaat tatcactgtg aatattacag gaggagaaat
     5941 aaaataagaa taaatcagtg gtttattttc aggttcgaat aaactctttc taatgaaaa
//
