LOCUS       NM_001178034            4829 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 3, mRNA.
ACCESSION   NM_001178034
VERSION     NM_001178034.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 4829)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 4829)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 4829)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066593.4, DQ857322.1 and AC016721.11.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.274718.1,
                                           SRR1660803.87487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC066593.4         68677-68708
            33-2424             DQ857322.1         12-2403
            2425-4829           AC016721.11        121825-124229
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..4829
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..93
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2424
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform c is encoded by transcript variant 3;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform c"
                     /protein_id="NP_001171505.1"
                     /db_xref="CCDS:CCDS54388.1"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MTAAKQEPQPTPGARASQAQPADQELGSNSPPQRNWKGIAIALL
                     VILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKS
                     ENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTAS
                     YVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLT
                     SSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGA
                     LYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNT
                     KTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTV
                     PVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESS
                     PRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLH
                     STDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYA
                     LLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG
                     SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPIT
                     DLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSA
                     ELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEE
                     DE"
     exon            94..208
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            209..304
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..399
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..474
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..527
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..609
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..730
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..885
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..983
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1107
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1146
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1254
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1346
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1394
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1516
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1564
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1663
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1733
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1928
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..1983
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2083
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2142
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2215
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2289
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..4829
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3389..3394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3411
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4440
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      4496..4501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      4520
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
ORIGIN      
        1 cgccagcgcg ggccgccggc gatgacggcc gcgaagcagg agccgcagcc caccccgggg
       61 gccagggcga gccaggcgca gccggcggac caggaactgg gaagtaacag ccctccacag
      121 agaaactgga agggaattgc tattgctctg ctggtgattt tagttgtatg ctcactcatc
      181 actatgtcag tcatcctctt aaccccagat gaactcacaa attcgtcaga aaccagattg
      241 tctttggaag acctctttag gaaagacttt gtgcttcacg atccagaggc tcggtggatc
      301 aatgatacag atgtggtgta taaaagcgag aatggacatg tcattaaact gaatatagaa
      361 acaaatgcta ccacattatt attggaaaac acaacttttg taaccttcaa agcatcaaga
      421 cattcagttt caccagattt aaaatatgtc cttctggcat atgatgtcaa acagattttt
      481 cattattcgt atactgcttc atatgtgatt tacaacatac acactaggga agtttgggag
      541 ttaaatcctc cagaagtaga ggactccgtc ttgcagtacg cggcctgggg tgtccaaggg
      601 cagcagctga tttatatttt tgaaaataat atctactatc aacctgatat aaagagcagt
      661 tcattgcgac tgacatcttc tggaaaagaa gaaataattt ttaatgggat tgctgactgg
      721 ttatatgaag aggaactcct gcattctcac atcgcccact ggtggtcacc agatggagaa
      781 agacttgcct tcctgatgat aaatgactct ttggtaccca ccatggttat ccctcggttt
      841 actggagcgt tgtatcccaa aggaaagcag tatccgtatc ctaaggcagg tcaagtgaac
      901 ccaacaataa aattatatgt tgtaaacctg tatggaccaa ctcacacttt ggagctcatg
      961 ccacctgaca gctttaaatc aagagaatac tatatcacta tggttaaatg ggtaagcaat
     1021 accaagactg tggtaagatg gttaaaccga gctcagaaca tctccatcct cacagtctgt
     1081 gagaccacta caggtgcttg tagtaaaaaa tatgagatga catcagatac gtggctctct
     1141 cagcagaatg aggagcccgt gttttctaga gacggcagca aattctttat gacagtgcct
     1201 gttaagcaag ggggacgtgg agaatttcac cacatagcta tgttcctcat ccagagtaaa
     1261 agtgagcaaa ttaccgtgcg gcatctgaca tcaggaaact gggaagtgat aaagatcttg
     1321 gcatacgatg aaactactca aaaaatttac tttctgagca ctgaatcttc tcccagagga
     1381 aggcagctgt acagtgcttc tactgaagga ttattgaatc gccaatgcat ttcatgtaat
     1441 ttcatgaaag aacaatgtac atattttgat gccagtttta gtcccatgaa tcaacatttc
     1501 ttattattct gtgaaggtcc aagggtccca gtggtcagcc tacatagtac ggacaaccca
     1561 gcaaaatatt ttatattgga aagcaattct atgctgaagg aagctatcct gaagaagaag
     1621 ataggaaagc cagaaattaa aatccttcat attgacgact atgaacttcc tttacagttg
     1681 tcccttccca aagattttat ggaccgaaac cagtatgctc ttctgttaat aatggatgaa
     1741 gaaccaggag gccagctggt tacagataag ttccatattg actgggattc cgtactcatt
     1801 gacatggata atgtcattgt agcaagattt gatggcagag gaagtggatt ccagggtctg
     1861 aaaattttgc aggagattca tcgaagatta ggttcagtag aagtaaagga ccaaataaca
     1921 gctgtgaaat ttttgctgaa actgccttac attgactcca aaagattaag catttttgga
     1981 aagggttatg gtggctatat tgcatcaatg atcttaaaat cagatgaaaa gctttttaaa
     2041 tgtggatccg tggttgcacc tatcacagac ttgaaattgt atgcctcagc tttctctgaa
     2101 agataccttg ggatgccatc taaggaagaa agcacttacc aggcagccag tgtgctacat
     2161 aatgttcatg gcttgaaaga agaaaatata ttaataattc atggaactgc tgacacaaaa
     2221 gttcatttcc aacactcagc agaattaatc aagcacctaa taaaagctgg agtgaattat
     2281 actatgcagg tctacccaga tgaaggtcat aacgtatctg agaagagcaa gtatcatctc
     2341 tacagcacaa tcctcaaatt cttcagtgat tgtttgaagg aagaaatatc tgtgctacca
     2401 caggaaccag aagaagatga ataatggact gtatttatac agaactgaag ggaatattga
     2461 ggctcaatga aacctgacaa agagactgta atattgtagt tgctccagaa tgtcaagggc
     2521 agcttacgga gatgtcactg gagcagcacg ctcagagaca gtgaactagc atttgaatac
     2581 acaagtccaa gtctactgtg ttgctagggg tgcagaaccc gtttctttgt atgagagagg
     2641 tcaaagggtt ggtttcctgg gagaaattag ttttgcatta aagtaggagt agtgcatgtt
     2701 ttcttctgtt atccccctgt ttgttctgta actagttgct ctcattttaa tttcactggc
     2761 caccatcatc tttgcatata atgcacaatc tatcatctgt cctacagtcc ctgatctttc
     2821 atggctgagc tgcaatctaa cactttactg tacctttata ataagtgcaa ttctttcatt
     2881 gtctattatt atgcttaaga aaatattcag ttaataaaaa acagagtatt ttatgtaatt
     2941 tctgttttta aaaagacatt attaaatggg tcaaaggaca tatagaaatg tggatttcag
     3001 caccttccaa agttcagcca gttatcagta gatacaatat ctttaaatga acacacgagt
     3061 gtatgtctca caatatatat acacaagtgt gcatatacag ttaatgaaac tatctttaaa
     3121 tgttattcat gctataaaga gtaaacgttt gatgaattag aagagatgct cttttccaag
     3181 ctataatgga tgctttgttt aatgagccaa atatgatgaa acattttttc caattcaaat
     3241 tctagctatt gctttcctat aaatgtttgg gttgtgtttg gtattgtttt tagtggttaa
     3301 tagttttcca gttgcattta attttttgaa tatgatacct tgtcacatgt aaattagata
     3361 cttaaatatt aaattatagt ttctgataaa gaaattttgt taacaatgca atgccactga
     3421 gtgctatttt gctcttttgg tggagaaggc ttttttcaaa actcttggtc cttttacttc
     3481 tttctctcag tgcagaatca attctcattt tcatcgtaaa agcaaatagc tggattattt
     3541 catttgccag tttctattta gtattccatg cctgcccaat tcatctgtta ctgtttaatt
     3601 tcaattcttc tggtgagaat tagaaatgaa atatttttta ttcattggcc aaaaagttca
     3661 cagacagcag tgtttgctat ttactttgaa ttgaaggcac aaaatgcatc aattcctgtg
     3721 ctgtgttgac ttgcagtagt aagtaactga gagcataaaa taaacctgac tgtatgaagt
     3781 caatttaagt gatgagaaca tttaactttg gtgactaaag tcagaatatc ttctcacttc
     3841 acttaaggga tcttccagaa gatatctaaa agtctgtaat aagcttagaa gttcagataa
     3901 atctaggcag gatactgcat ttttgtggtt ttaaaaaagt ccttaggaca gactgaatta
     3961 tcataactta tggcatcagg aggaaacttt aaaatatcaa ggaatcactc agtcaccctc
     4021 ctgttttgtt gaaggatcaa ccccaaattc tgggtatttg agtacatgtg aatcatggat
     4081 ttggtattca actttttccc tggatgcttt ggaatcgtgt cttccatgct ccactgggtt
     4141 caatttaaaa taggagaggc tttctcttct gaaagatcca ttttaggtct ttttcaagaa
     4201 tagtgaacac attttttaac aaaataagtt gtaattttaa aaggaaagtt ttgcctattt
     4261 tattaagatg gaaatttctt tttaggctaa tttgaaatcc aactgaagct ttttaaccaa
     4321 tattttaaat ttgaaccact agagtttttt atgatgcaaa tgattatgtt gtctgaaagg
     4381 tgtggtttta ttgaatgtct atttgagtat catttaaaaa gtatttgcct tttactgtca
     4441 tcatttctct tgttttatta ttattatcaa tgtttatcta tttttcaatt aatttaatac
     4501 agtttctaat gtgaaagaca tttttctgga acccgttttc cccttaaaca ctaaagagac
     4561 ctcaagtgaa agcatattgc ttagtaggaa ggtagaaaat gttaatccct gcgattcttt
     4621 gagttttaat gacagggtca ttttcagtaa aggaaatgct caccaacaca tagtcaccaa
     4681 ctattaaagg aatcatgtga ttggattttc ccctgtatac atgtaccctt ggtcataatc
     4741 ccactatttc atacatattt atgcattgct agattttcct aggactccaa tagcatgctt
     4801 tccaagtgtt attattccct taatgttaa
//
