LOCUS       NM_001004360            5884 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dipeptidyl peptidase like 10 (DPP10), transcript
            variant 2, mRNA.
ACCESSION   NM_001004360
VERSION     NM_001004360.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5884)
  AUTHORS   Lee-Sarwar,K.A., Fischer-Rasmussen,K., Bonnelykke,K., Bisgaard,H.,
            Chawes,B., Kelly,R.S., Lasky-Su,J., Zeiger,R.S., O'Connor,G.T.,
            Bacharier,L.B., Carey,V.J., Laranjo,N., Litonjua,A.A. and
            Weiss,S.T.
  TITLE     Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy
  JOURNAL   Nutrients 15 (10), 2416 (2023)
   PUBMED   37242299
  REMARK    GeneRIF: Omega-3 Fatty Acids Interact with DPP10 Region Genotype in
            Association with Childhood Atopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5884)
  AUTHORS   Sim,S., Choi,Y., Lee,D.H., Lee,H.R., Seob Shin,Y. and Park,H.S.
  TITLE     Contribution of dipeptidyl peptidase 10 to airway dysfunction in
            patients with NSAID-exacerbated respiratory disease
  JOURNAL   Clin Exp Allergy 52 (1), 115-126 (2022)
   PUBMED   34431147
  REMARK    GeneRIF: Contribution of dipeptidyl peptidase 10 to airway
            dysfunction in patients with NSAID-exacerbated respiratory disease.
REFERENCE   3  (bases 1 to 5884)
  AUTHORS   Belau,F., Metzner,K., Christ,T., Ravens,U., Schaefer,M., Kunzel,S.,
            Li,W., Wettwer,E., Dobrev,D., El-Armouche,A. and Kammerer,S.
  TITLE     DPP10 is a new regulator of Nav1.5 channels in human heart
  JOURNAL   Int J Cardiol 284, 68-73 (2019)
   PUBMED   30638748
  REMARK    GeneRIF: increased ventricular DPP10 expression in heart failure
            might promote arrhythmias by decreasing peak Na(+) current, while
            increasing window Na(+) current and channel re-openings due to
            accelerated recovery from inactivation
REFERENCE   4  (bases 1 to 5884)
  AUTHORS   Xu,J., Gaddis,N.C., Bartz,T.M., Hou,R., Manichaikul,A.W.,
            Pankratz,N., Smith,A.V., Sun,F., Terzikhan,N., Markunas,C.A.,
            Patchen,B.K., Schu,M., Beydoun,M.A., Brusselle,G.G.,
            Eiriksdottir,G., Zhou,X., Wood,A.C., Graff,M., Harris,T.B.,
            Ikram,M.A., Jacobs,D.R. Jr., Launer,L.J., Lemaitre,R.N.,
            O'Connor,G.T., Oelsner,E.C., Psaty,B.M., Vasan,R.S., Rohde,R.R.,
            Rich,S.S., Rotter,J.I., Seshadri,S., Smith,L.J., Tiemeier,H.,
            Tsai,M.Y., Uitterlinden,A.G., Voruganti,V.S., Xu,H., Zilhao,N.R.,
            Fornage,M., Zillikens,M.C., London,S.J., Barr,R.G., Dupuis,J.,
            Gharib,S.A., Gudnason,V., Lahousse,L., North,K.E., Steffen,L.M.,
            Cassano,P.A. and Hancock,D.B.
  TITLE     Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal
            DPP10-Pulmonary Function Association
  JOURNAL   Am J Respir Crit Care Med 199 (5), 631-642 (2019)
   PUBMED   30199657
  REMARK    GeneRIF: SNP rs11693320 associated with pulmonary function when
            incorporating an interaction with docosahexaenoic acid
REFERENCE   5  (bases 1 to 5884)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5884)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   7  (bases 1 to 5884)
  AUTHORS   Jerng,H.H., Qian,Y. and Pfaffinger,P.J.
  TITLE     Modulation of Kv4.2 channel expression and gating by dipeptidyl
            peptidase 10 (DPP10)
  JOURNAL   Biophys J 87 (4), 2380-2396 (2004)
   PUBMED   15454437
REFERENCE   8  (bases 1 to 5884)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   9  (bases 1 to 5884)
  AUTHORS   Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
  TITLE     Cloning and characterization of dipeptidyl peptidase 10, a new
            member of an emerging subgroup of serine proteases
  JOURNAL   Biochem J 373 (Pt 1), 179-189 (2003)
   PUBMED   12662155
  REMARK    GeneRIF: cloning, characterization and mapping to chromosome 2
REFERENCE   10 (bases 1 to 5884)
  AUTHORS   Chen,T., Ajami,K., McCaughan,G.W., Gorrell,M.D. and Abbott,C.A.
  TITLE     Dipeptidyl peptidase IV gene family. The DPIV family
  JOURNAL   Adv Exp Med Biol 524, 79-86 (2003)
   PUBMED   12675227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC066593.4, AC067947.6, AC017040.7, AC105422.3 and AC016721.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001004360.4.
            
            Summary: This gene encodes a single-pass type II membrane protein
            that is a member of the S9B family in clan SC of the serine
            proteases. This protein has no detectable protease activity, most
            likely due to the absence of the conserved serine residue normally
            present in the catalytic domain of serine proteases. However, it
            does bind specific voltage-gated potassium channels and alters
            their expression and biophysical properties. Mutations in this gene
            have been associated with asthma. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an alternate 5' exon, as
            compared to variant 3. The resulting isoform (short, also referred
            to as DPL2-s and d) has a shorter and distinct N-terminus when
            compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040925.2, SRR1803614.54258.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC066593.4         68896-69013
            119-233             AC067947.6         2377-2491
            234-329             AC067947.6         36955-37050
            330-424             AC017040.7         55391-55485
            425-499             AC017040.7         81779-81853
            500-552             AC105422.3         8821-8873
            553-634             AC105422.3         8974-9055
            635-755             AC016721.11        7295-7415
            756-910             AC016721.11        19218-19372
            911-1008            AC016721.11        25565-25662
            1009-1132           AC016721.11        32653-32776
            1133-1171           AC016721.11        42051-42089
            1172-1279           AC016721.11        47776-47883
            1280-1371           AC016721.11        56687-56778
            1372-1419           AC016721.11        57266-57313
            1420-1541           AC016721.11        60353-60474
            1542-1589           AC016721.11        61831-61878
            1590-1688           AC016721.11        70560-70658
            1689-1758           AC016721.11        70766-70835
            1759-1953           AC016721.11        94272-94466
            1954-2008           AC016721.11        95154-95208
            2009-2108           AC016721.11        115636-115735
            2109-2167           AC016721.11        115986-116044
            2168-2240           AC016721.11        116153-116225
            2241-2314           AC016721.11        120229-120302
            2315-5884           AC016721.11        121690-125259
FEATURES             Location/Qualifiers
     source          1..5884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..5884
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="dipeptidyl peptidase like 10"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
     exon            1..118
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2449
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="isoform short is encoded by transcript variant 2;
                     dipeptidyl peptidase IV-related protein 3; dipeptidyl
                     peptidase X; inactive dipeptidyl peptidase 10; DPP X;
                     dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase
                     10 (non-functional); dipeptidyl-peptidase 10 (inactive)"
                     /codon_start=1
                     /product="inactive dipeptidyl peptidase 10 isoform short"
                     /protein_id="NP_001004360.3"
                     /db_xref="CCDS:CCDS33278.1"
                     /db_xref="GeneID:57628"
                     /db_xref="HGNC:HGNC:20823"
                     /db_xref="MIM:608209"
                     /translation="MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITM
                     SVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIE
                     TNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREV
                     WELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNG
                     IADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYP
                     KAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQ
                     NISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFH
                     HVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSAST
                     EGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFIL
                     ESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGG
                     QLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAV
                     KFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSE
                     RYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGV
                     NYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE"
     exon            119..233
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            234..329
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..424
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..499
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..552
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..634
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..755
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..910
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1008
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1132
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1171
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1279
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1371
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1419
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1541
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1589
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1688
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1758
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1953
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2008
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2108
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2167
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2240
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2314
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..5884
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3414..3419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AAGAAA"
     polyA_site      3436
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     polyA_site      4465
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
     regulatory      4521..4526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATACA"
     polyA_site      4545
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
     regulatory      5863..5868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="hexamer: AATAAA"
     polyA_site      5884
                     /gene="DPP10"
                     /gene_synonym="DPL2; DPPY; DPRP-3; DPRP3"
                     /note="major polyA site"
ORIGIN      
        1 agttccaggc tctcctgctt ctccacggac tctgcgggaa gttagagcct ctgcgtgcgc
       61 tccggggccc ggcgagagga tgcgcaaggt ggagagccgc ggggaagggg gcagagagga
      121 actgggaagt aacagccctc cacagagaaa ctggaaggga attgctattg ctctgctggt
      181 gattttagtt gtatgctcac tcatcactat gtcagtcatc ctcttaaccc cagatgaact
      241 cacaaattcg tcagaaacca gattgtcttt ggaagacctc tttaggaaag actttgtgct
      301 tcacgatcca gaggctcggt ggatcaatga tacagatgtg gtgtataaaa gcgagaatgg
      361 acatgtcatt aaactgaata tagaaacaaa tgctaccaca ttattattgg aaaacacaac
      421 ttttgtaacc ttcaaagcat caagacattc agtttcacca gatttaaaat atgtccttct
      481 ggcatatgat gtcaaacaga tttttcatta ttcgtatact gcttcatatg tgatttacaa
      541 catacacact agggaagttt gggagttaaa tcctccagaa gtagaggact ccgtcttgca
      601 gtacgcggcc tggggtgtcc aagggcagca gctgatttat atttttgaaa ataatatcta
      661 ctatcaacct gatataaaga gcagttcatt gcgactgaca tcttctggaa aagaagaaat
      721 aatttttaat gggattgctg actggttata tgaagaggaa ctcctgcatt ctcacatcgc
      781 ccactggtgg tcaccagatg gagaaagact tgccttcctg atgataaatg actctttggt
      841 acccaccatg gttatccctc ggtttactgg agcgttgtat cccaaaggaa agcagtatcc
      901 gtatcctaag gcaggtcaag tgaacccaac aataaaatta tatgttgtaa acctgtatgg
      961 accaactcac actttggagc tcatgccacc tgacagcttt aaatcaagag aatactatat
     1021 cactatggtt aaatgggtaa gcaataccaa gactgtggta agatggttaa accgagctca
     1081 gaacatctcc atcctcacag tctgtgagac cactacaggt gcttgtagta aaaaatatga
     1141 gatgacatca gatacgtggc tctctcagca gaatgaggag cccgtgtttt ctagagacgg
     1201 cagcaaattc tttatgacag tgcctgttaa gcaaggggga cgtggagaat ttcaccacgt
     1261 agctatgttc ctcatccaga gtaaaagtga gcaaattacc gtgcggcatc tgacatcagg
     1321 aaactgggaa gtgataaaga tcttggcata cgatgaaact actcaaaaaa tttactttct
     1381 gagcactgaa tcttctccca gaggaaggca gctgtacagt gcttctactg aaggattatt
     1441 gaatcgccaa tgcatttcat gtaatttcat gaaagaacaa tgtacatatt ttgatgccag
     1501 ttttagtccc atgaatcaac atttcttatt attctgtgaa ggtccaaggg tcccagtggt
     1561 cagcctacat agtacggaca acccagcaaa atattttata ttggaaagca attctatgct
     1621 gaaggaagct atcctgaaga agaagatagg aaagccagaa attaaaatcc ttcatattga
     1681 cgactatgaa cttcctttac agttgtccct tcccaaagat tttatggacc gaaaccagta
     1741 tgctcttctg ttaataatgg atgaagaacc aggaggccag ctggttacag ataagttcca
     1801 tattgactgg gattccgtac tcattgacat ggataatgtc attgtagcaa gatttgatgg
     1861 cagaggaagt ggattccagg gtctgaaaat tttgcaggag attcatcgaa gattaggttc
     1921 agtagaagta aaggaccaaa taacagctgt gaaatttttg ctgaaactgc cttacattga
     1981 ctccaaaaga ttaagcattt ttggaaaggg ttatggtggc tatattgcat caatgatctt
     2041 aaaatcagat gaaaagcttt ttaaatgtgg atccgtggtt gcacctatca cagacttgaa
     2101 attgtatgcc tcagctttct ctgaaagata ccttgggatg ccatctaagg aagaaagcac
     2161 ttaccaggca gccagtgtgc tacataatgt tcatggcttg aaagaagaaa atatattaat
     2221 aattcatgga actgctgaca caaaagttca tttccaacac tcagcagaat taatcaagca
     2281 cctaataaaa gctggagtga attatactat gcaggtctac ccagatgaag gtcataacgt
     2341 atctgagaag agcaagtatc atctctacag cacaatcctc aaattcttca gtgattgttt
     2401 gaaggaagaa atatctgtgc taccacagga accagaagaa gatgaataat ggactgtatt
     2461 tatacagaac tgaagggaat attgaggctc aatgaaacct gacaaagaga ctgtaatatt
     2521 gtagttgctc cagaatgtca agggcagctt acggagatgt cactggagca gcacgctcag
     2581 agacagtgaa ctagcatttg aatacacaag tccaagtcta ctgtgttgct aggggtgcag
     2641 aacccgtttc tttgtatgag agaggtcaaa gggttggttt cctgggagaa attagttttg
     2701 cattaaagta ggagtagtgc atgttttctt ctgttatccc cctgtttgtt ctgtaactag
     2761 ttgctctcat tttaatttca ctggccacca tcatctttgc atataatgca caatctatca
     2821 tctgtcctac agtccctgat ctttcatggc tgagctgcaa tctaacactt tactgtacct
     2881 ttataataag tgcaattctt tcattgtcta ttattatgct taagaaaata ttcagttaat
     2941 aaaaaacaga gtattttatg taatttctgt ttttaaaaag acattattaa atgggtcaaa
     3001 ggacatatag aaatgtggat ttcagcacct tccaaagttc agccagttat cagtagatac
     3061 aatatcttta aatgaacaca cgagtgtatg tctcacaata tatatacaca agtgtgcata
     3121 tacagttaat gaaactatct ttaaatgtta ttcatgctat aaagagtaaa cgtttgatga
     3181 attagaagag atgctctttt ccaagctata atggatgctt tgtttaatga gccaaatatg
     3241 atgaaacatt ttttccaatt caaattctag ctattgcttt cctataaatg tttgggttgt
     3301 gtttggtatt gtttttagtg gttaatagtt ttccagttgc atttaatttt ttgaatatga
     3361 taccttgtca catgtaaatt agatacttaa atattaaatt atagtttctg ataaagaaat
     3421 tttgttaaca atgcaatgcc actgagtgct attttgctct tttggtggag aaggcttttt
     3481 tcaaaactct tggtcctttt acttctttct ctcagtgcag aatcaattct cattttcatc
     3541 gtaaaagcaa atagctggat tatttcattt gccagtttct atttagtatt ccatgcctgc
     3601 ccaattcatc tgttactgtt taatttcaat tcttctggtg agaattagaa atgaaatatt
     3661 ttttattcat tggccaaaaa gttcacagac agcagtgttt gctatttact ttgaattgaa
     3721 ggcacaaaat gcatcaattc ctgtgctgtg ttgacttgca gtagtaagta actgagagca
     3781 taaaataaac ctgactgtat gaagtcaatt taagtgatga gaacatttaa ctttggtgac
     3841 taaagtcaga atatcttctc acttcactta agggatcttc cagaagatat ctaaaagtct
     3901 gtaataagct tagaagttca gataaatcta ggcaggatac tgcatttttg tggttttaaa
     3961 aaagtcctta ggacagactg aattatcata acttatggca tcaggaggaa actttaaaat
     4021 atcaaggaat cactcagtca ccctcctgtt ttgttgaagg atcaacccca aattctgggt
     4081 atttgagtac atgtgaatca tggatttggt attcaacttt ttccctggat gctttggaat
     4141 cgtgtcttcc atgctccact gggttcaatt taaaatagga gaggctttct cttctgaaag
     4201 atccatttta ggtctttttc aagaatagtg aacacatttt ttaacaaaat aagttgtaat
     4261 tttaaaagga aagttttgcc tattttatta agatggaaat ttctttttag gctaatttga
     4321 aatccaactg aagcttttta accaatattt taaatttgaa ccactagagt tttttatgat
     4381 gcaaatgatt atgttgtctg aaaggtgtgg ttttattgaa tgtctatttg agtatcattt
     4441 aaaaagtatt tgccttttac tgtcatcatt tctcttgttt tattattatt atcaatgttt
     4501 atctattttt caattaattt aatacagttt ctaatgtgaa agacattttt ctggaacccg
     4561 ttttcccctt aaacactaaa gagacctcaa gtgaaagcat attgcttagt aggaaggtag
     4621 aaaatgttaa tccctgcgat tctttgagtt ttaatgacag ggtcattttc agtaaaggaa
     4681 atgctcacca acacatagtc accaactatt aaaggaatca tgtgattgga ttttcccctg
     4741 tatacatgta cccttggtca taatcccact atttcataca tatttatgca ttgctagatt
     4801 ttcctaggac tccaatagca tgctttccaa gtgttattat tcccttaatg ttaaagaaaa
     4861 aaatcaatat attgaattct ttaattaaat aggtaagcag tattaaatca tccacagaga
     4921 taaacaatct cttgaaactc ttttgaaaga gaaaagtgtt tgttcacttt cattgccttc
     4981 attaagatct ccaaatactc agagactaag caggctattc tcatctcttt gagtttcctg
     5041 acagaactaa aggaaggaat cactcttcaa aagatggatc tcacttcact ctgaaaatgt
     5101 gccttttttt aattgggtgt ttagcataaa aatcactatt ggggatctta cagatgtctg
     5161 ttgtagatct attacaatga ggtgacttag acattgggct ttaccatatt agagaattac
     5221 ttaagccatt gtccttcaaa tgttgggctt ggagacagaa gtaccttgga ctgaattgct
     5281 ttcaagtctc tagaatcact gacagcacat agcttctatg aggagttata tatgaaatac
     5341 cacttgtgtc cctcctcaag ttctctgacc accttcacat cctgcggcca ccaacactgt
     5401 atggatacaa tctggcctct cagctctgct cactttcact ttctgttctg gggattctct
     5461 gatactaatt ttggctactt ggtagaacca agagacaaat cgcttacatg ctgcaaaccg
     5521 atgtgaaggt gttactaacc cgctaaaaca caattaatga aagactgtag caggtaactg
     5581 atctttccct cagatattct acatggtcca tggaagactc tgtgggccgc agaagcccat
     5641 agctgcatac ccttctattt tcctcttccc catttcactc ttttaagctc cctactccta
     5701 ttccctatga tcactttcca aaataaacgg caggtgtgct agctgttgtc ttagactctg
     5761 ctttctggaa actatttttc ccctccacaa gaaattatca ctgtgaatat tacaggagga
     5821 gaaataaaat aagaataaat cagtggttta ttttcaggtt cgaataaact ctttctaatg
     5881 aaaa
//
