LOCUS       NP_001267471             378 aa            linear   PRI 30-APR-2025
DEFINITION  zinc finger protein DPF3 isoform 2 [Homo sapiens].
ACCESSION   NP_001267471
VERSION     NP_001267471.1
DBSOURCE    REFSEQ: accession NM_001280542.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Liu,C., Chen,M., Xu,J., Yi,F., Li,X., Zhang,H., Wang,Y., He,S. and
            Jin,T.
  TITLE     DPF3 polymorphisms increased the risk of pulmonary tuberculosis in
            the Northwest Chinese Han population
  JOURNAL   Gene 927, 148617 (2024)
   PUBMED   38795855
  REMARK    GeneRIF: DPF3 polymorphisms increased the risk of pulmonary
            tuberculosis in the Northwest Chinese Han population.
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Verrillo,G., Obeid,A.M., Genco,A., Scrofani,J., Orange,F.,
            Hanache,S., Mignon,J., Leyder,T., Michaux,C., Kempeneers,C.,
            Bricmont,N., Herkenne,S., Vernos,I., Martin,M. and Mottet,D.
  TITLE     Non-canonical role for the BAF complex subunit DPF3 in mitosis and
            ciliogenesis
  JOURNAL   J Cell Sci 137 (9) (2024)
   PUBMED   38661008
  REMARK    GeneRIF: Non-canonical role for the BAF complex subunit DPF3 in
            mitosis and ciliogenesis.
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Cui,H., Yi,H., Bao,H., Tan,Y., Tian,C., Shi,X., Gan,D., Zhang,B.,
            Liang,W., Chen,R., Zhu,Q., Fang,L., Gao,X., Huang,H., Tian,R.,
            Sperling,S.R., Hu,Y. and Chen,W.
  TITLE     The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis
            of ccRCC by modulating TGF-beta signaling
  JOURNAL   Nat Commun 13 (1), 4680 (2022)
   PUBMED   35945219
  REMARK    GeneRIF: The SWI/SNF chromatin remodeling factor DPF3 regulates
            metastasis of ccRCC by modulating TGF-beta signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 378)
  AUTHORS   Protze,J., Naas,S., Kruger,R., Stohr,C., Kraus,A., Grampp,S.,
            Wiesener,M., Schiffer,M., Hartmann,A., Wullich,B. and Schodel,J.
  TITLE     The renal cancer risk allele at 14q24.2 activates a novel
            hypoxia-inducible transcription factor-binding enhancer of DPF3
            expression
  JOURNAL   J Biol Chem 298 (3), 101699 (2022)
   PUBMED   35148991
  REMARK    GeneRIF: The renal cancer risk allele at 14q24.2 activates a novel
            hypoxia-inducible transcription factor-binding enhancer of DPF3
            expression.
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Colli,L.M., Jessop,L., Myers,T.A., Camp,S.Y., Machiela,M.J.,
            Choi,J., Cunha,R., Onabajo,O., Mills,G.C., Schmid,V., Brodie,S.A.,
            Delattre,O., Mole,D.R., Purdue,M.P., Yu,K., Brown,K.M. and
            Chanock,S.J.
  TITLE     Altered regulation of DPF3, a member of the SWI/SNF complexes,
            underlies the 14q24 renal cancer susceptibility locus
  JOURNAL   Am J Hum Genet 108 (9), 1590-1610 (2021)
   PUBMED   34390653
  REMARK    GeneRIF: Altered regulation of DPF3, a member of the SWI/SNF
            complexes, underlies the 14q24 renal cancer susceptibility locus.
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Lange,M., Kaynak,B., Forster,U.B., Tonjes,M., Fischer,J.J.,
            Grimm,C., Schlesinger,J., Just,S., Dunkel,I., Krueger,T., Mebus,S.,
            Lehrach,H., Lurz,R., Gobom,J., Rottbauer,W., Abdelilah-Seyfried,S.
            and Sperling,S.
  TITLE     Regulation of muscle development by DPF3, a novel histone
            acetylation and methylation reader of the BAF chromatin remodeling
            complex
  JOURNAL   Genes Dev 22 (17), 2370-2384 (2008)
   PUBMED   18765789
  REMARK    GeneRIF: DPF3 adds a further layer of complexity to the BAF complex
            by representing a tissue-specific anchor between histone
            acetylations as well as methylations and chromatin remodeling.
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Chestkov,A.V., Baka,I.D., Kost,M.V., Georgiev,G.P. and Buchman,V.L.
  TITLE     The d4 gene family in the human genome
  JOURNAL   Genomics 36 (1), 174-177 (1996)
   PUBMED   8812431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007160.3, AC006360.2,
            AL392024.3 and AC004828.2.
            
            Summary: This gene encodes a member of the D4 protein family. The
            encoded protein is a transcription regulator that binds acetylated
            histones and is a component of the BAF chromatin remodeling
            complex. Alternate splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 3' CDS and the
            3' UTR compared to variant 1. The encoded isoform (2, also known as
            DPF3b) has a distinct C-terminus and is longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1921676.1,
                                           SRR14038193.109214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556509.6/ ENSP00000450518.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     Protein         1..378
                     /product="zinc finger protein DPF3 isoform 2"
                     /note="D4, zinc and double PHD fingers, family 3; zinc
                     finger protein DPF3; BRG1-associated factor 45C; zinc
                     finger protein cer-d4"
                     /calculated_mol_wt=42953
     Region          13..79
                     /region_name="DPF1-3_N"
                     /note="DPF1-3, N-terminal; pfam14051"
                     /db_xref="CDD:464074"
     Region          145..193
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92784.3)"
     Region          <195..222
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          225..254
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92784.3)"
     Region          261..317
                     /region_name="PHD1_DPF3"
                     /note="PHD finger 1 found in D4, zinc and double PHD
                     fingers family 3 (DPF3); cd15692"
                     /db_xref="CDD:277162"
     Site            order(261,263..264,266,284,289..291,296..298,302,311,
                     313..315)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277162"
     Site            order(298..299,301..302,305..306,309,311..312,314,316)
                     /site_type="other"
                     /note="PHD2 interface [polypeptide binding]"
                     /db_xref="CDD:277162"
     Region          317..332
                     /region_name="Interaction with HDGFL2.
                     /evidence=ECO:0000269|PubMed:32459350"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92784.3)"
     Region          318..363
                     /region_name="PHD2_d4"
                     /note="PHD finger 2 found in d4 gene family proteins;
                     cd15530"
                     /db_xref="CDD:277005"
     Site            order(318,333..339)
                     /site_type="other"
                     /note="PHD1 interface [polypeptide binding]"
                     /db_xref="CDD:277005"
     Site            323
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:32459350; propagated from
                     UniProtKB/Swiss-Prot (Q92784.3)"
     Site            order(325,328..335,343,353..358)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277005"
     CDS             1..378
                     /gene="DPF3"
                     /gene_synonym="BAF45C; CERD4; SMARCG3"
                     /coded_by="NM_001280542.3:14..1150"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS61497.1"
                     /db_xref="GeneID:8110"
                     /db_xref="HGNC:HGNC:17427"
                     /db_xref="MIM:601672"
ORIGIN      
        1 matvihnplk algdqfykea iehcrsynsr lcaersvrlp fldsqtgvaq nncyiwmekr
       61 hrgpglapgq lytyparcwr kkrrlhpped pklrlleikp evelplkkdg ftsesttlea
      121 llrgegvekk vdareeesiq eiqrvlende nveegneeed leedipkrkn rtrgrargsa
      181 ggrrrhdaas qedhdkpyvc dicgkryknr pglsyhyaht hlaseegdea qdqetrsppn
      241 hrnenhrpqk gpdgtvipnn ycdfclggsn mnkksgrpee lvscadcgrs ghptclqftl
      301 nmteavktyk wqciecksci lcgtsenddq llfcddcdrg yhmyclnppv aeppegswsc
      361 hlcwellkek asafgcqa
//
