LOCUS       NM_001370198            1688 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dipeptidase 3 (DPEP3), transcript variant 3, mRNA.
ACCESSION   NM_001370198
VERSION     NM_001370198.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1688)
  AUTHORS   Hayashi,K., Longenecker,K.L., Koenig,P., Prashar,A., Hampl,J.,
            Stoll,V. and Vivona,S.
  TITLE     Structure of human DPEP3 in complex with the SC-003 antibody Fab
            fragment reveals basis for lack of dipeptidase activity
  JOURNAL   J Struct Biol 211 (1), 107512 (2020)
   PUBMED   32325220
REFERENCE   2  (bases 1 to 1688)
  AUTHORS   Schiza,C., Korbakis,D., Panteleli,E., Jarvi,K., Drabovich,A.P. and
            Diamandis,E.P.
  TITLE     Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3
            and Selection of Its Disrupting Antibodies
  JOURNAL   Mol Cell Proteomics 17 (12), 2480-2495 (2018)
   PUBMED   30097533
REFERENCE   3  (bases 1 to 1688)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1688)
  AUTHORS   Sabatti,C., Service,S.K., Hartikainen,A.L., Pouta,A., Ripatti,S.,
            Brodsky,J., Jones,C.G., Zaitlen,N.A., Varilo,T., Kaakinen,M.,
            Sovio,U., Ruokonen,A., Laitinen,J., Jakkula,E., Coin,L.,
            Hoggart,C., Collins,A., Turunen,H., Gabriel,S., Elliot,P.,
            McCarthy,M.I., Daly,M.J., Jarvelin,M.R., Freimer,N.B. and
            Peltonen,L.
  TITLE     Genome-wide association analysis of metabolic traits in a birth
            cohort from a founder population
  JOURNAL   Nat Genet 41 (1), 35-46 (2009)
   PUBMED   19060910
REFERENCE   5  (bases 1 to 1688)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 1688)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
  REMARK    GeneRIF: This paper describes differences in substrate specificity
            and tissue distribution of membrane-bound dipeptidase 3 from mouse
            in comparison to other mouse members of this family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057401.1 and AY358390.1.
            
            Summary: This gene encodes a membrane-bound glycoprotein from the
            family of dipeptidases involved in hydrolytic metabolism of various
            dipeptides, including penem and carbapenem beta-lactam antibiotics.
            This gene is located on chromosome 16 in a cluster with another
            member of this family. Alternatively spliced transcript variants
            that encode different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000268793.6/
                                                ENSP00000268793.5
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              AK057401.1         51-1737
            1688-1688           AY358390.1         1658-1658
FEATURES             Location/Qualifiers
     source          1..1688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1688
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /note="dipeptidase 3"
                     /db_xref="GeneID:64180"
                     /db_xref="HGNC:HGNC:23029"
                     /db_xref="MIM:609926"
     exon            1..406
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1586
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /EC_number="3.4.13.19"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; membrane-bound dipeptidase 3; metallopeptidase
                     (family M19); testis secretory sperm-binding protein Li
                     211a"
                     /codon_start=1
                     /product="dipeptidase 3 isoform c precursor"
                     /protein_id="NP_001357127.1"
                     /db_xref="CCDS:CCDS10856.2"
                     /db_xref="GeneID:64180"
                     /db_xref="HGNC:HGNC:23029"
                     /db_xref="MIM:609926"
                     /translation="MQPTGREGSRALSRRYLRRLLLLLLLLLLRQPVTRAETTPGAPR
                     ALSTLGSPSLFTTPGVPSALTTPGLTTPGTPKTLDLRGRAQALMRSFPLVDGHNDLPQ
                     VLRQRYKNVLQDVNLRNFSHGQTSLDRLRDGLVGAQFWSASVSCQSQDQTAVRLALEQ
                     IDLIHRMCASYSELELVTSAEGLNSSQKLACLIGVEGGHSLDSSLSVLRSFYVLGVRY
                     LTLTFTCSTPWAESSTKFRHHMYTNVSGLTSFGEKVVEELNRLGMMIDLSYASDTLIR
                     RVLEVSQAPVIFSHSAARAVCDNLLNVPDDILQLLKKNGGIVMVTLSMGVLQCNLLAN
                     VSTVADHFDHIRAVIGSEFIGIGGNYDGTGRFPQGLEDVSTYPVLIEELLSRSWSEEE
                     LQGVLRGNLLRVFRQVEKVREESRAQSPVEAEFPYGQLSTSCHSHLVPQNGHQATHLE
                     VTKQPTNRVPWRSSNASPYLVPGLVAAATIPTFTQWLC"
     exon            407..533
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            534..663
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..805
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            806..875
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1052
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1137
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1213
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1349
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1688
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /note="hexamer: AATAAA"
     polyA_site      1688
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgcgt gacttcaacc ccctcttcgg gaggctgggt cgtcatgatc cggaccccat
       61 tgtcggcctc tgcccatcgc ctgctcctcc caggctcccg cggccgaccc ccgcgcaaca
      121 tgcagcccac gggccgcgag ggttcccgcg cgctcagccg gcggtatctg cggcgtctgc
      181 tgctcctgct actgctgctg ctgctgcggc agcccgtaac ccgcgcggag accacgccgg
      241 gcgcccccag agccctctcc acgctgggct cccccagcct cttcaccacg ccgggtgtcc
      301 ccagcgccct cactacccca ggcctcacta cgccaggcac ccccaaaacc ctggaccttc
      361 ggggtcgcgc gcaggccctg atgcggagtt tcccactcgt ggacggccac aatgacctgc
      421 cccaggtcct gagacagcgt tacaagaatg tgcttcagga tgttaacctg cgaaatttca
      481 gccatggtca gaccagcctg gacaggctta gagacggcct cgtgggtgcc cagttctggt
      541 cagcctccgt ctcatgccag tcccaggacc agactgccgt gcgcctcgcc ctggagcaga
      601 ttgacctcat tcaccgcatg tgtgcctcct actctgaact cgagcttgtg acctcagctg
      661 aaggtctgaa cagctctcaa aagctggcct gcctcattgg cgtggagggt ggtcactcac
      721 tggacagcag cctctctgtg ctgcgcagtt tctatgtgct gggggtgcgc tacctgacac
      781 ttaccttcac ctgcagtaca ccatgggcag agagttccac caagttcaga caccacatgt
      841 acaccaacgt cagcggattg acaagctttg gtgagaaagt agtagaggag ttgaaccgcc
      901 tgggcatgat gatagatttg tcctatgcat cggacacctt gataagaagg gtcctggaag
      961 tgtctcaggc tcctgtgatc ttctcccact cagctgccag agctgtgtgt gacaatttgt
     1021 tgaatgttcc cgatgatatc ctgcagcttc tgaagaagaa cggtggcatc gtgatggtga
     1081 cactgtccat gggggtgctg cagtgcaacc tgcttgctaa cgtgtccact gtggcagatc
     1141 actttgacca catcagggca gtcattggat ctgagttcat cgggattggt ggaaattatg
     1201 acgggactgg ccggttccct caggggctgg aggatgtgtc cacataccca gtcctgatag
     1261 aggagttgct gagtcgtagc tggagcgagg aagagcttca aggtgtcctt cgtggaaacc
     1321 tgctgcgggt cttcagacaa gtggaaaagg tgagagagga gagcagggcg cagagccccg
     1381 tggaggctga gtttccatat gggcaactga gcacatcctg ccactcccac ctcgtgcctc
     1441 agaatggaca ccaggctact catctggagg tgaccaagca gccaaccaat cgggtcccct
     1501 ggaggtcctc aaatgcctcc ccataccttg ttccaggcct tgtggctgct gccaccatcc
     1561 caaccttcac ccagtggctc tgctgacaca gtcggtcccc gcagaggtca ctgtggcaaa
     1621 gcctcacaaa gccccctctc ctagttcatt cacaagcata tgctgagaat aaacatgtta
     1681 cacatgga
//
