LOCUS       NP_001357127             488 aa            linear   PRI 27-APR-2025
DEFINITION  dipeptidase 3 isoform c precursor [Homo sapiens].
ACCESSION   NP_001357127
VERSION     NP_001357127.1
DBSOURCE    REFSEQ: accession NM_001370198.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Hayashi,K., Longenecker,K.L., Koenig,P., Prashar,A., Hampl,J.,
            Stoll,V. and Vivona,S.
  TITLE     Structure of human DPEP3 in complex with the SC-003 antibody Fab
            fragment reveals basis for lack of dipeptidase activity
  JOURNAL   J Struct Biol 211 (1), 107512 (2020)
   PUBMED   32325220
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Schiza,C., Korbakis,D., Panteleli,E., Jarvi,K., Drabovich,A.P. and
            Diamandis,E.P.
  TITLE     Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3
            and Selection of Its Disrupting Antibodies
  JOURNAL   Mol Cell Proteomics 17 (12), 2480-2495 (2018)
   PUBMED   30097533
REFERENCE   3  (residues 1 to 488)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Sabatti,C., Service,S.K., Hartikainen,A.L., Pouta,A., Ripatti,S.,
            Brodsky,J., Jones,C.G., Zaitlen,N.A., Varilo,T., Kaakinen,M.,
            Sovio,U., Ruokonen,A., Laitinen,J., Jakkula,E., Coin,L.,
            Hoggart,C., Collins,A., Turunen,H., Gabriel,S., Elliot,P.,
            McCarthy,M.I., Daly,M.J., Jarvelin,M.R., Freimer,N.B. and
            Peltonen,L.
  TITLE     Genome-wide association analysis of metabolic traits in a birth
            cohort from a founder population
  JOURNAL   Nat Genet 41 (1), 35-46 (2009)
   PUBMED   19060910
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
  REMARK    GeneRIF: This paper describes differences in substrate specificity
            and tissue distribution of membrane-bound dipeptidase 3 from mouse
            in comparison to other mouse members of this family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057401.1 and AY358390.1.
            
            Summary: This gene encodes a membrane-bound glycoprotein from the
            family of dipeptidases involved in hydrolytic metabolism of various
            dipeptides, including penem and carbapenem beta-lactam antibiotics.
            This gene is located on chromosome 16 in a cluster with another
            member of this family. Alternatively spliced transcript variants
            that encode different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000268793.6/
                                                ENSP00000268793.5
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     Protein         1..488
                     /product="dipeptidase 3 isoform c precursor"
                     /EC_number="3.4.13.19"
                     /note="membrane-bound dipeptidase 3; metallopeptidase
                     (family M19); testis secretory sperm-binding protein Li
                     211a"
                     /calculated_mol_wt=49546
     sig_peptide     1..35
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H4B8.2)"
                     /calculated_mol_wt=4160
     mat_peptide     36..463
                     /product="Dipeptidase 3. /id=PRO_0000231609"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H4B8.2)"
                     /calculated_mol_wt=46942
     Region          87..407
                     /region_name="Peptidase_M19"
                     /note="Membrane dipeptidase (Peptidase family M19);
                     pfam01244"
                     /db_xref="CDD:395996"
     Site            order(97,99,143,196,269,290,301,359,362)
                     /site_type="active"
                     /db_xref="CDD:238626"
     Site            order(145,154..156,158..159,162,166,206..207,209..210,
                     213..214)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238626"
     Site            334
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H4B8.2)"
     CDS             1..488
                     /gene="DPEP3"
                     /gene_synonym="MBD3"
                     /coded_by="NM_001370198.1:120..1586"
                     /note="isoform c precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS10856.2"
                     /db_xref="GeneID:64180"
                     /db_xref="HGNC:HGNC:23029"
                     /db_xref="MIM:609926"
ORIGIN      
        1 mqptgregsr alsrrylrrl lllllllllr qpvtraettp gapralstlg spslfttpgv
       61 psalttpglt tpgtpktldl rgraqalmrs fplvdghndl pqvlrqrykn vlqdvnlrnf
      121 shgqtsldrl rdglvgaqfw sasvscqsqd qtavrlaleq idlihrmcas yselelvtsa
      181 eglnssqkla cligvegghs ldsslsvlrs fyvlgvrylt ltftcstpwa esstkfrhhm
      241 ytnvsgltsf gekvveelnr lgmmidlsya sdtlirrvle vsqapvifsh saaravcdnl
      301 lnvpddilql lkknggivmv tlsmgvlqcn llanvstvad hfdhiravig sefigiggny
      361 dgtgrfpqgl edvstypvli eellsrswse eelqgvlrgn llrvfrqvek vreesraqsp
      421 veaefpygql stschshlvp qnghqathle vtkqptnrvp wrssnaspyl vpglvaaati
      481 ptftqwlc
//
