LOCUS       NM_022355               1728 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens dipeptidase 2 (DPEP2), transcript variant 1, mRNA.
ACCESSION   NM_022355
VERSION     NM_022355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Wang,Y., Zhang,T., Du,H., Yang,M., Xie,G., Liu,T., Deng,S.,
            Yuan,W., He,S., Wu,D. and Xu,Y.
  TITLE     Dipeptidase-2 is a prognostic marker in lung adenocarcinoma that is
            correlated with its sensitivity to cisplatin
  JOURNAL   Oncol Rep 50 (2) (2023)
   PUBMED   37449493
  REMARK    GeneRIF: Dipeptidase-2 is a prognostic marker in lung
            adenocarcinoma that is correlated with its sensitivity to
            cisplatin.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Hayashi,K., Longenecker,K.L., Koenig,P., Prashar,A., Hampl,J.,
            Stoll,V. and Vivona,S.
  TITLE     Structure of human DPEP3 in complex with the SC-003 antibody Fab
            fragment reveals basis for lack of dipeptidase activity
  JOURNAL   J Struct Biol 211 (1), 107512 (2020)
   PUBMED   32325220
REFERENCE   3  (bases 1 to 1728)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Willer,C.J., Sanna,S., Jackson,A.U., Scuteri,A., Bonnycastle,L.L.,
            Clarke,R., Heath,S.C., Timpson,N.J., Najjar,S.S., Stringham,H.M.,
            Strait,J., Duren,W.L., Maschio,A., Busonero,F., Mulas,A., Albai,G.,
            Swift,A.J., Morken,M.A., Narisu,N., Bennett,D., Parish,S., Shen,H.,
            Galan,P., Meneton,P., Hercberg,S., Zelenika,D., Chen,W.M., Li,Y.,
            Scott,L.J., Scheet,P.A., Sundvall,J., Watanabe,R.M., Nagaraja,R.,
            Ebrahim,S., Lawlor,D.A., Ben-Shlomo,Y., Davey-Smith,G.,
            Shuldiner,A.R., Collins,R., Bergman,R.N., Uda,M., Tuomilehto,J.,
            Cao,A., Collins,F.S., Lakatta,E., Lathrop,G.M., Boehnke,M.,
            Schlessinger,D., Mohlke,K.L. and Abecasis,G.R.
  TITLE     Newly identified loci that influence lipid concentrations and risk
            of coronary artery disease
  JOURNAL   Nat Genet 40 (2), 161-169 (2008)
   PUBMED   18193043
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP299049.1, AJ295149.1 and CB528462.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022355.3.
            
            Summary: DPEP2 belongs to the membrane-bound dipeptidase (EC
            3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides,
            including leukotriene D4, the beta-lactam ring of some antibiotics,
            and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione
            degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by
            OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ295149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393847.6/ ENSP00000377430.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BP299049.1         36-66
            32-1701             AJ295149.1         1-1670
            1702-1728           CB528462.1         20-46               c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1728
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="dipeptidase 2"
                     /db_xref="GeneID:64174"
                     /db_xref="HGNC:HGNC:23028"
                     /db_xref="MIM:609925"
     exon            1..110
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            111..418
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1616
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /EC_number="3.4.13.19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="dipeptidase 2 isoform 1 precursor"
                     /protein_id="NP_071750.1"
                     /db_xref="CCDS:CCDS10857.1"
                     /db_xref="GeneID:64174"
                     /db_xref="HGNC:HGNC:23028"
                     /db_xref="MIM:609925"
                     /translation="MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALT
                     TLGAPRAHTMPGTYAPSTTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQK
                     GLQDVNLRNFSYGQTSLDRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMC
                     ASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCN
                     TPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQA
                     PVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHF
                     DHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGN
                     LLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPI
                     HWTAKLPAKWSVSESSPHMAPVLAVVATFPVLILWL"
     exon            419..545
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..675
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..817
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..887
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1064
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1149
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1225
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1361
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1728
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="hexamer: AATAAA"
     polyA_site      1728
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="major polyA site"
ORIGIN      
        1 acacactagt gaaatcttgt cttagtgtgt ccggaattgg tgggttcttg gtctcactga
       61 gttctagaat gaagctgcag accctcgcag tgagtgttac agctcttaag gctctctgac
      121 tgccacccct gcctgcctgc ccggccctgc acaacatgca gccctccggc ctcgagggtc
      181 ccggcacgtt tggtcggtgg cctctgctga gtctgctgct cctgctgctg ctgctccagc
      241 ctgtaacctg tgcctacacc acgccaggcc cccccagagc cctcaccacg ctgggcgccc
      301 ccagagccca caccatgccg ggcacctacg ctccctcgac cacactcagt agtcccagca
      361 cccagggcct gcaagagcag gcacgggccc tgatgcggga cttcccgctc gtggacggcc
      421 acaacgacct gcccctggtc ctaaggcagg tttaccagaa agggctacag gatgttaacc
      481 tgcgcaattt cagctacggc cagaccagcc tggacaggct tagagatggc ctcgtgggcg
      541 cccagttctg gtcagcctat gtgccatgcc agacccagga ccgggatgcc ctgcgcctca
      601 ccctggagca gattgacctc atacgccgca tgtgtgcctc ctattctgag ctggagcttg
      661 tgacctcggc taaagctctg aacgacactc agaaattggc ctgcctcatc ggtgtagagg
      721 gtggccactc gctggacaat agcctctcca tcttacgtac cttctacatg ctgggagtgc
      781 gctacctgac gctcacccac acctgcaaca caccctgggc agagagctcc gctaagggcg
      841 tccactcctt ctacaacaac atcagcgggc tgactgactt tggtgagaag gtggtggcag
      901 aaatgaaccg cctgggcatg atggtagact tatcccatgt ctcagatgct gtggcacggc
      961 gggccctgga agtgtcacag gcacctgtga tcttctccca ctcggctgcc cggggtgtgt
     1021 gcaacagtgc tcggaatgtt cctgatgaca tcctgcagct tctgaagaag aacggtggcg
     1081 tcgtgatggt gtctttgtcc atgggagtaa tacagtgcaa cccatcagcc aatgtgtcca
     1141 ctgtggcaga tcacttcgac cacatcaagg ctgtcattgg atccaagttc atcgggattg
     1201 gtggagatta tgatggggcc ggcaaattcc ctcaggggct ggaagacgtg tccacatacc
     1261 cggtcctgat agaggagttg ctgagtcgtg gctggagtga ggaagagctt cagggtgtcc
     1321 ttcgtggaaa cctgctgcgg gtcttcagac aagtggaaaa ggtacaggaa gaaaacaaat
     1381 ggcaaagccc cttggaggac aagttcccgg atgagcagct gagcagttcc tgccactccg
     1441 acctctcacg tctgcgtcag agacagagtc tgacttcagg ccaggaactc actgagattc
     1501 ccatacactg gacagccaag ttaccagcca agtggtcagt ctcagagtcc tccccccaca
     1561 tggccccagt ccttgcagtt gtggccacct tcccagtcct tattctgtgg ctctgatgac
     1621 ccagttagtc ctgccagatg tcactgtagc aagccacaga caccccacaa agttcccctg
     1681 ttgtgcaggc acaaatattt cctgaaataa atgttttgga catagaaa
//
