LOCUS       NM_001369657            1759 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dipeptidase 2 (DPEP2), transcript variant 4, mRNA.
ACCESSION   NM_001369657
VERSION     NM_001369657.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Wang,Y., Zhang,T., Du,H., Yang,M., Xie,G., Liu,T., Deng,S.,
            Yuan,W., He,S., Wu,D. and Xu,Y.
  TITLE     Dipeptidase-2 is a prognostic marker in lung adenocarcinoma that is
            correlated with its sensitivity to cisplatin
  JOURNAL   Oncol Rep 50 (2) (2023)
   PUBMED   37449493
  REMARK    GeneRIF: Dipeptidase-2 is a prognostic marker in lung
            adenocarcinoma that is correlated with its sensitivity to
            cisplatin.
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Hayashi,K., Longenecker,K.L., Koenig,P., Prashar,A., Hampl,J.,
            Stoll,V. and Vivona,S.
  TITLE     Structure of human DPEP3 in complex with the SC-003 antibody Fab
            fragment reveals basis for lack of dipeptidase activity
  JOURNAL   J Struct Biol 211 (1), 107512 (2020)
   PUBMED   32325220
REFERENCE   3  (bases 1 to 1759)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Willer,C.J., Sanna,S., Jackson,A.U., Scuteri,A., Bonnycastle,L.L.,
            Clarke,R., Heath,S.C., Timpson,N.J., Najjar,S.S., Stringham,H.M.,
            Strait,J., Duren,W.L., Maschio,A., Busonero,F., Mulas,A., Albai,G.,
            Swift,A.J., Morken,M.A., Narisu,N., Bennett,D., Parish,S., Shen,H.,
            Galan,P., Meneton,P., Hercberg,S., Zelenika,D., Chen,W.M., Li,Y.,
            Scott,L.J., Scheet,P.A., Sundvall,J., Watanabe,R.M., Nagaraja,R.,
            Ebrahim,S., Lawlor,D.A., Ben-Shlomo,Y., Davey-Smith,G.,
            Shuldiner,A.R., Collins,R., Bergman,R.N., Uda,M., Tuomilehto,J.,
            Cao,A., Collins,F.S., Lakatta,E., Lathrop,G.M., Boehnke,M.,
            Schlessinger,D., Mohlke,K.L. and Abecasis,G.R.
  TITLE     Newly identified loci that influence lipid concentrations and risk
            of coronary artery disease
  JOURNAL   Nat Genet 40 (2), 161-169 (2008)
   PUBMED   18193043
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040162.5 and KC877614.1.
            
            Summary: DPEP2 belongs to the membrane-bound dipeptidase (EC
            3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides,
            including leukotriene D4, the beta-lactam ring of some antibiotics,
            and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione
            degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by
            OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315090.1, AY358454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC040162.5         22483-22927
            446-572             AC040162.5         23241-23367
            573-617             AC040162.5         23684-23728
            618-702             KC877614.1         407-491             c
            703-844             KC877614.1         181-322             c
            845-914             AC040162.5         24693-24762
            915-1091            AC040162.5         24880-25056
            1092-1176           AC040162.5         25746-25830
            1177-1252           AC040162.5         26479-26554
            1253-1388           AC040162.5         27890-28025
            1389-1759           AC040162.5         28117-28487
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1759
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="dipeptidase 2"
                     /db_xref="GeneID:64174"
                     /db_xref="HGNC:HGNC:23028"
                     /db_xref="MIM:609925"
     exon            1..445
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1643
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /EC_number="3.4.13.19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="dipeptidase 2 isoform 1 precursor"
                     /protein_id="NP_001356586.1"
                     /db_xref="CCDS:CCDS10857.1"
                     /db_xref="GeneID:64174"
                     /db_xref="HGNC:HGNC:23028"
                     /db_xref="MIM:609925"
                     /translation="MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALT
                     TLGAPRAHTMPGTYAPSTTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQK
                     GLQDVNLRNFSYGQTSLDRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMC
                     ASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCN
                     TPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQA
                     PVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHF
                     DHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGN
                     LLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPI
                     HWTAKLPAKWSVSESSPHMAPVLAVVATFPVLILWL"
     exon            446..572
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..702
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..844
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..914
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1091
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1176
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1252
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1388
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1759
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="hexamer: AATAAA"
     polyA_site      1755
                     /gene="DPEP2"
                     /gene_synonym="MBD2"
                     /note="major polyA site"
ORIGIN      
        1 ggtgccgccg ctctccgcac atccttcgcg gggccctgtg acttcgttac cctcctcttg
       61 aggccacgcc gccaggtggc ctgaatcgag ggtcgggact ccatcgtcgc gctctgcccc
      121 tcgcccgccc ctctcaggct ctctgactgc cacccctgcc tgcctgcccg gccctgcaca
      181 acatgcagcc ctccggcctc gagggtcccg gcacgtttgg tcggtggcct ctgctgagtc
      241 tgctgctcct gctgctgctg ctccagcctg taacctgtgc ctacaccacg ccaggccccc
      301 ccagagccct caccacgctg ggcgccccca gagcccacac catgccgggc acctacgctc
      361 cctcgaccac actcagtagt cccagcaccc agggcctgca agagcaggca cgggccctga
      421 tgcgggactt cccgctcgtg gacggccaca acgacctgcc cctggtccta aggcaggttt
      481 accagaaagg gctacaggat gttaacctgc gcaatttcag ctacggccag accagcctgg
      541 acaggcttag agatggcctc gtgggcgccc agttctggtc agcctatgtg ccatgccaga
      601 cccaggaccg ggatgccctg cgcctcaccc tggagcagat tgacctcata cgccgcatgt
      661 gtgcctccta ttctgagctg gagcttgtga cctcggctaa agctctgaac gacactcaga
      721 aattggcctg cctcatcggt gtagagggtg gccactcgct ggacaatagc ctctccatct
      781 tacgtacctt ctacatgctg ggagtgcgct acctgacgct cacccacacc tgcaacacac
      841 cctgggcaga gagctccgct aagggcgtcc actccttcta caacaacatc agcgggctga
      901 ctgactttgg tgagaaggtg gtggcagaaa tgaaccgcct gggcatgatg gtagacttat
      961 cccatgtctc agatgctgtg gcacggcggg ccctggaagt gtcacaggca cctgtgatct
     1021 tctcccactc ggctgcccgg ggtgtgtgca acagtgctcg gaatgttcct gatgacatcc
     1081 tgcagcttct gaagaagaac ggtggcgtcg tgatggtgtc tttgtccatg ggagtaatac
     1141 agtgcaaccc atcagccaat gtgtccactg tggcagatca cttcgaccac atcaaggctg
     1201 tcattggatc caagttcatc gggattggtg gagattatga tggggccggc aaattccctc
     1261 aggggctgga agacgtgtcc acatacccgg tcctgataga ggagttgctg agtcgtggct
     1321 ggagtgagga agagcttcag ggtgtccttc gtggaaacct gctgcgggtc ttcagacaag
     1381 tggaaaaggt acaggaagaa aacaaatggc aaagcccctt ggaggacaag ttcccggatg
     1441 agcagctgag cagttcctgc cactccgacc tctcacgtct gcgtcagaga cagagtctga
     1501 cttcaggcca ggaactcact gagattccca tacactggac agccaagtta ccagccaagt
     1561 ggtcagtctc agagtcctcc ccccacatgg ccccagtcct tgcagttgtg gccaccttcc
     1621 cagtccttat tctgtggctc tgatgaccca gttagtcctg ccagatgtca ctgtagcaag
     1681 ccacagacac cccacaaagt tcccctgttg tgcaggcaca aatatttcct gaaataaatg
     1741 ttttggacat agaaacaga
//
