LOCUS       NM_001329744             860 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens deleted in primary ciliary dyskinesia homolog (mouse)
            (DPCD), transcript variant 4, mRNA.
ACCESSION   NM_001329744
VERSION     NM_001329744.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Dos Santos Morais,R., Santo,P.E., Ley,M., Schelcher,C., Abel,Y.,
            Plassart,L., Desligniere,E., Chagot,M.E., Quinternet,M.,
            Paiva,A.C.F., Hessmann,S., Morellet,N., M F Sousa,P.,
            Vandermoere,F., Bertrand,E., Charpentier,B., Bandeiras,T.M.,
            Plisson-Chastang,C., Verheggen,C., Cianferani,S. and Manival,X.
  TITLE     Deciphering cellular and molecular determinants of human DPCD
            protein in complex with RUVBL1/RUVBL2 AAA-ATPases
  JOURNAL   J Mol Biol 434 (19), 167760 (2022)
   PUBMED   35901867
  REMARK    GeneRIF: Deciphering cellular and molecular determinants of human
            DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases.
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Zariwala,M., O'Neal,W.K., Noone,P.G., Leigh,M.W., Knowles,M.R. and
            Ostrowski,L.E.
  TITLE     Investigation of the possible role of a novel gene, DPCD, in
            primary ciliary dyskinesia
  JOURNAL   Am J Respir Cell Mol Biol 30 (4), 428-434 (2004)
   PUBMED   14630615
  REMARK    GeneRIF: a novel candidate gene for primary ciliary dyskinesia
            GeneRIF: The mouse homolog of this gene (named Dpcd, for Deleted in
            a mouse model of Primary Ciliary Dyskinesia) appears to be
            responsible for an inner arm defect in cilia.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627424.8, BM782340.1 and
            BU681755.1.
            
            On May 31, 2019 this sequence version replaced NM_001329744.1.
            
            Summary: This gene in mouse encodes a protein that may be involved
            in the generation and maintenance of ciliated cells. In mouse,
            expression of this gene increases during ciliated cell
            differentiation, and disruption of this gene has been linked to
            primary ciliary dyskinesia. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM782340.1, BM782007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL627424.8         57978-57981
            5-581               BM782340.1         1-577
            582-851             BU681755.1         18-287              c
            852-860             AL627424.8         79311-79319
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..860
                     /gene="DPCD"
                     /note="deleted in primary ciliary dyskinesia homolog
                     (mouse)"
                     /db_xref="GeneID:25911"
                     /db_xref="HGNC:HGNC:24542"
                     /db_xref="MIM:616467"
     exon            1..80
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..529
                     /gene="DPCD"
                     /note="isoform 4 is encoded by transcript variant 4;
                     protein DPCD; deleted in a mouse model of primary ciliary
                     dyskinesia; RP11-529I10.4"
                     /codon_start=1
                     /product="protein DPCD isoform 4"
                     /protein_id="NP_001316673.1"
                     /db_xref="CCDS:CCDS86141.1"
                     /db_xref="GeneID:25911"
                     /db_xref="HGNC:HGNC:24542"
                     /db_xref="MIM:616467"
                     /translation="MAVTGWLESLRTAQKTALLQDGRRKVHYLFPDGKEMAEEYDEKT
                     SELLVRKWRVKSALGAMGQWQLEVGDPAPLGAGNLGPELIKESNANPIFMRKDTKMSF
                     QWRIRNLPYPKDVYSVSVDQKERCIIVRTTNKKRTGWRLLWTPLAMRCAGVHGTPSEI
                     DTSYLWMTPC"
     exon            81..161
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     exon            162..286
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     exon            287..420
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     exon            421..493
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     exon            494..564
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     exon            565..860
                     /gene="DPCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      832..837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DPCD"
                     /note="hexamer: AGTAAA"
     polyA_site      860
                     /gene="DPCD"
                     /note="major polyA site"
ORIGIN      
        1 gcttagcagg ggaaagatgg cggtgacggg ctggttggag agtctgcgga cagcccagaa
       61 gactgcgctg ctgcaggacg ggagaaggaa ggttcactat ttattcccag acggcaagga
      121 aatggctgaa gaatatgacg agaagacgag tgaactactt gtgagaaagt ggcgtgtgaa
      181 aagtgccctg ggagccatgg gccagtggca gcttgaagta ggagacccag cgcccctagg
      241 agcagggaac ctggggcctg aactcatcaa ggaaagcaat gccaatccta tcttcatgcg
      301 caaggacacc aagatgagtt tccagtggcg gattcgaaac ctcccctatc ctaaggatgt
      361 ctatagtgtc tctgtggacc agaaggagcg ctgcatcatt gtcagaacaa ccaacaagaa
      421 gcggactggt tggaggcttc tctggacccc tctggccatg cggtgtgcag gtgtgcatgg
      481 caccccctct gagatagaca ccagctacct ctggatgacg ccttgctgag ctttgcccac
      541 gccaactgca ccctgatcat ctcttaccag aagccaaagg aggttgtggt ggccgagtct
      601 gagctacaga aggaactaaa gaaggtgaag acagcccaca gcaacgatgg ggactgcaag
      661 acccagtagt tggcccctga gccttatacc tccaccacag ggggtgccgt gagacttcaa
      721 ggcttggccc ttcttgacca cggcagcctc ctgtcttcta ggagctatca agggtctcta
      781 agaactgggc atggggcact cctagccagt gagtcatggt catatttcct gagtaaagtc
      841 attctgagtt acttactgca
//
