LOCUS       NM_032482               7652 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L),
            transcript variant 1, mRNA.
ACCESSION   NM_032482
VERSION     NM_032482.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7652)
  AUTHORS   Hu,Y., Ye,S., Kong,J., Zhou,Q., Wang,Z., Zhang,Y., Yan,H., Wang,Y.,
            Li,T., Xie,Y., Chen,B., Zhao,Y., Zhang,T., Zheng,X., Niu,J., Hu,B.,
            Wang,S., Chen,Z. and Zheng,C.
  TITLE     DOT1L protects against podocyte injury in diabetic kidney disease
            through phospholipase C-like 1
  JOURNAL   Cell Commun Signal 22 (1), 519 (2024)
   PUBMED   39456056
  REMARK    GeneRIF: DOT1L protects against podocyte injury in diabetic kidney
            disease through phospholipase C-like 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7652)
  AUTHORS   Kanojia,A., Roy,G., Madhubala,R. and Muthuswami,R.
  TITLE     Interplay between DOT1L and HDAC1 regulates Leishmania donovani
            infection in human THP-1 cells
  JOURNAL   Acta Trop 258, 107352 (2024)
   PUBMED   39103111
  REMARK    GeneRIF: Interplay between DOT1L and HDAC1 regulates Leishmania
            donovani infection in human THP-1 cells.
REFERENCE   3  (bases 1 to 7652)
  AUTHORS   Tang,H., Lu,Y.F., Zeng,R., Liu,C., Shu,Y., Wu,Y., Su,J., Di,L.,
            Qian,J., Zhang,J., Tian,Y., Lu,X., Pei,X.H., Zhu,Q. and Zhu,W.G.
  TITLE     DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to
            elicit DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2320804121 (2024)
   PUBMED   39172790
  REMARK    GeneRIF: DOT1L-mediated RAP80 methylation promotes BRCA1
            recruitment to elicit DNA repair.
REFERENCE   4  (bases 1 to 7652)
  AUTHORS   Sudholz,H., Schuster,I.S., Foroutan,M., Sng,X., Andoniou,C.E.,
            Doan,A., Camilleri,T., Shen,Z., Zaph,C., Degli-Esposti,M.A.,
            Huntington,N.D. and Scheer,S.
  TITLE     DOT1L maintains NK cell phenotype and function for optimal tumor
            control
  JOURNAL   Cell Rep 43 (6), 114333 (2024)
   PUBMED   38865244
  REMARK    GeneRIF: DOT1L maintains NK cell phenotype and function for optimal
            tumor control.
REFERENCE   5  (bases 1 to 7652)
  AUTHORS   Adriaanse,F.R.S., Schneider,P., Arentsen-Peters,S.T.C.J.M.,
            Fonseca,A.M.N.D., Stutterheim,J., Pieters,R., Zwaan,C.M. and
            Stam,R.W.
  TITLE     Distinct Responses to Menin Inhibition and Synergy with DOT1L
            Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid
            Leukemia
  JOURNAL   Int J Mol Sci 25 (11), 6020 (2024)
   PUBMED   38892207
  REMARK    GeneRIF: Distinct Responses to Menin Inhibition and Synergy with
            DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and
            Myeloid Leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7652)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 7652)
  AUTHORS   Okada,Y., Feng,Q., Lin,Y., Jiang,Q., Li,Y., Coffield,V.M., Su,L.,
            Xu,G. and Zhang,Y.
  TITLE     hDOT1L links histone methylation to leukemogenesis
  JOURNAL   Cell 121 (2), 167-178 (2005)
   PUBMED   15851025
  REMARK    GeneRIF: mistargeting of hDOT1L to Hoxa9 plays an important role in
            MLL-AF10-mediated leukemogenesis
            Erratum:[Cell. 2005 Jun 3;121(5):809]
REFERENCE   8  (bases 1 to 7652)
  AUTHORS   Min,J., Feng,Q., Li,Z., Zhang,Y. and Xu,R.M.
  TITLE     Structure of the catalytic domain of human DOT1L, a non-SET domain
            nucleosomal histone methyltransferase
  JOURNAL   Cell 112 (5), 711-723 (2003)
   PUBMED   12628190
REFERENCE   9  (bases 1 to 7652)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
REFERENCE   10 (bases 1 to 7652)
  AUTHORS   Feng,Q., Wang,H., Ng,H.H., Erdjument-Bromage,H., Tempst,P.,
            Struhl,K. and Zhang,Y.
  TITLE     Methylation of H3-lysine 79 is mediated by a new family of HMTases
            without a SET domain
  JOURNAL   Curr Biol 12 (12), 1052-1058 (2002)
   PUBMED   12123582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005257.1, AF509504.1,
            AC005263.1 and AL080221.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032482.2.
            
            Summary: The protein encoded by this gene is a histone
            methyltransferase that methylates lysine-79 of histone H3. It is
            inactive against free core histones, but shows significant histone
            methyltransferase activity against nucleosomes. [provided by
            RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF509504.1, KX792913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398665.8/ ENSP00000381657.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC005257.1         23395-23610
            217-5090            AF509504.1         1-4874
            5091-6741           AC005263.1         10908-12558
            6742-7652           AL080221.1         1-911
FEATURES             Location/Qualifiers
     source          1..7652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..7652
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /note="DOT1 like histone lysine methyltransferase"
                     /db_xref="GeneID:84444"
                     /db_xref="HGNC:HGNC:24948"
                     /db_xref="MIM:607375"
     exon            1..333
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..4866
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /EC_number="2.1.1.360"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone methyltransferase DOT1L; histone-lysine
                     N-methyltransferase, H3 lysine-79 specific; H3-K79-HMTase;
                     DOT1-like protein; lysine N-methyltransferase 4; histone
                     H3-K79 methyltransferase; DOT1-like, histone H3
                     methyltransferase; DOT1 like histone H3K79
                     methyltransferase; DOT1-like histone methyltransferase"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase, H3 lysine-79
                     specific isoform 1"
                     /protein_id="NP_115871.1"
                     /db_xref="CCDS:CCDS42460.1"
                     /db_xref="GeneID:84444"
                     /db_xref="HGNC:HGNC:24948"
                     /db_xref="MIM:607375"
                     /translation="MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWV
                     CEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRP
                     STGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFV
                     DLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTL
                     ERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLN
                     FRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKL
                     REEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPS
                     KARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQ
                     DAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYK
                     ASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQ
                     AQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQ
                     ALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRE
                     LEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLA
                     SPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAAS
                     ELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYG
                     SSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTL
                     EKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSG
                     SLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPS
                     DSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGR
                     RKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSP
                     ETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKI
                     ATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQ
                     ASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
                     GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAG
                     LKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPG
                     SLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVL
                     QSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN"
     exon            334..377
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            378..452
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            453..516
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            517..745
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..840
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..903
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            904..959
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1039
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1108
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1215
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1257
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1368
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1603
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1717
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1809
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1911
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2049
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2175
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2660
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2796
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2943
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3058
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3642
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3848
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..3913
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4858
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..7652
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7628..7633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /note="hexamer: AATAAA"
     polyA_site      7652
                     /gene="DOT1L"
                     /gene_synonym="DOT1; KMT4"
                     /note="major polyA site"
ORIGIN      
        1 attgtgctcg cttcacgccg gcccaagatg gcggaggcgc tggaggcccc gggcctgtga
       61 ctacaaagag ggagtcgggg gccgggccgg accggagcgc ggcggcggcg gcggcggcgg
      121 ccgaggccga ggccaggccc cctcccctca gcctcccgcc cctccctccc gcccgccctc
      181 ctccgcccac cggcggcccc gcccctcccc caaccgcccg cctagcatgg tgcggcggcc
      241 gcgcgcgcgg acatggggga gaagctggag ctgagactga agtcgcccgt gggggctgag
      301 cccgccgtct acccgtggcc gctgccggtc tacgataaac atcacgatgc tgctcatgaa
      361 atcatcgaga ccatccgatg ggtctgtgaa gaaatcccgg atctcaagct cgctatggag
      421 aattacgttt taattgacta tgacaccaaa agcttcgaga gcatgcagag gctctgcgac
      481 aagtacaacc gtgccatcga cagcatccac cagctgtgga agggcaccac gcagcccatg
      541 aagctgaaca cgcggccgtc cactggactc ctgcgccata tcctgcagca ggtctacaac
      601 cactcggtga ccgaccccga gaagctcaac aactacgagc ccttctcccc cgaggtgtac
      661 ggggagacct ccttcgacct ggtggcccag atgattgatg agatcaagat gaccgacgac
      721 gacctgtttg tggacttggg gagcggtgtg ggccaggtcg tgctccaggt tgctgctgcc
      781 accaactgca aacatcacta tggcgtcgag aaagcagaca tcccggccaa gtatgcggag
      841 accatggacc gcgagttcag gaagtggatg aaatggtatg gaaaaaagca tgcagaatac
      901 acattggaga gaggcgattt cctctcagaa gagtggaggg agcgaatcgc caacacgagt
      961 gttatatttg tgaataattt tgcctttggt cctgaggtgg atcaccagct gaaggagcgg
     1021 tttgcaaaca tgaaggaagg tggcagaatc gtgtcctcga aaccctttgc acctctgaac
     1081 ttcagaataa acagtagaaa cttgagtgac atcggcacca tcatgcgcgt ggtggagctc
     1141 tcgcccctga agggctcggt gtcgtggacg gggaagccag tctcctacta cctgcacact
     1201 atcgaccgca ccatacttga aaactatttt tctagtctga aaaacccaaa actcagggag
     1261 gaacaggagg cagcccggcg ccgccagcag cgcgagagca agagcaacgc ggccacgccc
     1321 actaagggcc cagagggcaa ggtggccggc cccgccgacg cccccatgga ctctggtgct
     1381 gaggaagaga aggcgggagc agccaccgtg aagaagccgt ctccctccaa agcccgcaag
     1441 aagaagctaa acaagaaggg gaggaagatg gctggccgca agcgcgggcg ccccaagaag
     1501 atgaacactg cgaaccccga gcggaagccc aagaagaacc aaactgcact ggatgccctg
     1561 cacgctcaga ccgtgtctca gacggcggcc tcctcacccc aggatgccta cagatcccct
     1621 cacagcccgt tctaccagct acctccgagc gtgcagcggc actcccccaa cccgctgctg
     1681 gtggcgccca ccccgcccgc gctgcagaag cttctagagt ccttcaagat ccagtacctg
     1741 cagttcctgg catacacaaa gaccccccag tacaaggcca gcctgcagga gctgctgggc
     1801 caggagaagg agaagaacgc ccagctcctg ggtgcggctc agcagctcct cagccactgc
     1861 caggcccaga aggaggagat caggaggctg tttcagcaaa aattggatga gctgggtgtg
     1921 aaggcgctga cctacaacga cctgattcaa gcgcagaagg agatctccgc ccataaccag
     1981 cagctgcggg agcagtcgga gcagctggag caggacaacc gcgcgctccg cggccagagc
     2041 ttgcagctgc tcaaggctcg ctgcgaggag ctgcagctgg actgggccac gctgtcgctg
     2101 gagaagctgt tgaaggagaa gcaggccctg aagagccaga tctcggagaa gcagaggcac
     2161 tgcctggagc tgcagatcag cattgtggag ctagagaaga gccagcggca gcaggagctc
     2221 ctgcagctca agtcctgtgt gccgcctgac gacgccctgt ccctgcacct gcgtgggaag
     2281 ggcgccctgg gccgcgagct ggagcctgac gccagccggc tgcacctgga gctggactgc
     2341 accaagttct cgctgcctca cttgagcagc atgagcccgg agctctccat gaacggccag
     2401 gctgctggct atgagctctg cggtgtgctg agccggcctt cgtcgaagca gaacacgccc
     2461 cagtacctgg cctcacccct ggaccaggag gtggtgccct gtacccctag ccacgtcggc
     2521 cggccgcgcc tggagaagct gtctggccta gccgcacccg actacactag gctgtccccg
     2581 gccaagattg tgctgaggcg gcacctgagc caggaccaca cggtgcccgg caggccggct
     2641 gccagtgagc tgcattcgag agctgagcac accaaggaga acggccttcc ctaccagagc
     2701 cccagcgtgc ctggcagcat gaagctgagc cctcaggacc cgcggcccct gtcccctggg
     2761 gccttgcagc ttgctggaga gaagagcagt gagaagggcc tgagagagcg cgcctacggc
     2821 agcagcgggg agctcatcac cagcctgccc atcagcatcc cgctcagcac cgtgcagccc
     2881 aacaagctcc cggtcagcat tcccctggcc agcgtggtgc tgcccagccg cgccgagagg
     2941 gcgaggagca cccccagtcc cgtgctgcag ccccgtgacc cctcgtccac acttgaaaag
     3001 cagattggtg ctaatgccca cggtgctggg agcagaagcc ttgccctggc ccccgcaggc
     3061 ttctcctacg ctggctcggt ggccatcagc ggggccttgg cgggcagccc ggcctctctc
     3121 acacctggag ccgagccggc caccttggat gagtcctcca gctctgggag cctttttgcc
     3181 accgtggggt cccgcagctc cacgccacag caccccctgc tgctggcaca gccccggaac
     3241 tcgcttcctg cctctcccgc ccaccagctc tcctccagtc cccggcttgg tggggccgcc
     3301 cagggcccgt tgcccgaggc cagcaaggga gacctgccct ccgattccgg cttctcagat
     3361 cctgagagtg aagccaagag gaggattgtg ttcaccatca ccactggtgc gggcagtgcc
     3421 aagcagtcgc cctccagcaa gcacagcccc ctgaccgcca gcgcccgtgg ggactgtgtg
     3481 ccgagccacg ggcaggacag tcgcaggcgc ggccggcgga agcgagcatc tgcggggacg
     3541 cccagcttga gcgcaggcgt gtcccccaag cgccgagccc tgccgtccgt cgctggcctt
     3601 ttcacacagc cttcggggtc tcccctcaac ctcaactcca tggtcagtaa catcaaccag
     3661 cccctggaga ttacagccat ctcgtccccg gagacctccc tgaagagctc ccctgtgccc
     3721 taccaggacc acgaccagcc ccccgtgctc aagaaggagc ggcctctgag ccagaccaat
     3781 ggggcacact actccccact cacctcagac gaggagccag gctctgagga cgagcccagc
     3841 agtgctcgaa ttgagagaaa aattgcaaca atctccttag aaagcaaatc tcccccgaaa
     3901 accttggaaa atggtggtgg cttggcggga aggaagcccg cgcccgccgg cgagccagtc
     3961 aatagcagca agtggaagtc caccttctcg cccatctccg acatcggcct ggccaagtcg
     4021 gcggacagcc cgctgcaggc cagctccgcc ctcagccaga actccctgtt cacgttccgg
     4081 cccgccctgg aggagccctc tgccgatgcc aagctggccg ctcaccccag gaaaggcttt
     4141 cccggctccc tgtcgggggc tgacggactc agcccgggca ccaaccctgc caacggctgc
     4201 accttcggcg ggggcctggc cgcggacctg agtttacaca gcttcagtga tggtgcttct
     4261 cttccccaca agggccccga ggcggccggc ctgagctccc cgctgagctt cccctcgcag
     4321 cgcggcaagg agggctcgga cgccaaccct ttcctgagca agaggcagct ggacggcctg
     4381 gctgggctga agggcgaggg cagccgcggc aaggaggcag gggagggcgg cctaccgctg
     4441 tgcgggccca cggacaagac cccactgctg agcggcaagg ccgccaaggc ccgggaccgc
     4501 gaggtcgacc tcaagaatgg ccacaacctc ttcatctctg cggcggccgt gcctcccgga
     4561 agcctcctca gcggccccgg cctggccccg gcggcgtcct ccgcaggcgg cgcggcgtcc
     4621 tccgcccaga cgcaccggtc cttcctgggc cccttcccgc cgggaccgca gttcgcgctc
     4681 ggccccatgt ccctgcaggc caacctcggc tccgtggccg gctcctccgt gctgcagtcg
     4741 ctgttcagct ctgtgccggc cgccgcaggc ctggtgcacg tgtcgtccgc tgccaccaga
     4801 ctgaccaact cgcacgccat gggcagcttt tccggggtgg caggcggcac agttggaggt
     4861 aactaggatt tctacctcaa ccgcgagacc tatgcaagga cggtgtggac caactcgcgc
     4921 ccgcggcatg gtgcccgccg gcctgccggg ctcccacccc tggacggcag aggcaaggac
     4981 ggacgggagc tccactgtga atcggcggca cgcgccgcag gaggctggga ctggtccagt
     5041 ttgtactgtc gatagtttta gataaagtat ttatcatttt ttaaaaagta taaacaattc
     5101 tgacttattt tattccatct aagtggtaaa aggcaactta ttgagaaata taaatatcta
     5161 tatatgagag ctctatataa agacacgtgt ctgcagggcg ggcccgccag cggattcgcc
     5221 acagcctgcc ccggtgctat ctcgtcccca ggcccgcgcc tgcctccacc cgcttggtgc
     5281 tgactagacg ctgacaacgc cgaaccccgt tctcggaaac gccgcccggc cggctccccc
     5341 gacgcgctgc tcccgtacca aaggcaggcc cgtcgccacc acattcctcg gaggcctccc
     5401 cgcggcctga gccccttcct gagcgccctg gcgcctgccc tgagctcttc acctttaccc
     5461 cggcactgtg aacccccaga ctgttcaccc tccggggcgt gggttgcgcc cttgcatgtg
     5521 aaggggcctg cgcggtgacg cagctggcca tgtgctgcgc gatggtgctg tgaggacggc
     5581 gcgggcacgt tgaacaagtg catttacttt tgtatttctc ggctgtccat ggctcgcagc
     5641 atgccctgcg atgcggggca ggcctgtcgt gggtcccttg gtgtttctgt acaggagaga
     5701 gtcacactaa tgagtggcag tattttatag agatgtgatg agaatttata aatttcatag
     5761 atttgacagc ttttattttt agatggtata atgcacagtg aagaggaaag aaaagcgagg
     5821 ggaaaaaacc ttatttattc aaacagtgca caaaatggcc ccagcgtcag ccccgaccct
     5881 agacccctca gttgcagctc ccagcagccc agacagagct gccggcgccc ctgcctgccc
     5941 cacatccctt cctgtcaggg ccacgcctgg cacccatccc ttggagcctg tgctggttct
     6001 cccagctgct gtgggtgtgc tggggccagg gtgcactgct gaaacctggc ctctctggcc
     6061 ctaggcccca gggtgacgtc ggccccccac tctgcagcct tggcgggtgc ctgggactgg
     6121 gtgtggaagg agaggagctg aggccggggt gtagcaggca ggcagggcca ctccagtgct
     6181 tctggagccc tgagcagtca gggcctgggt tgtctgagca gtggtggctc tgtgccctcc
     6241 ctggaggatg ggatctggga gtctgagctc cccgcatctg gccctgggct gtgtggcact
     6301 tgctgagccc accttctcaa gtgcttgctc ctgtgagatg gcatcgggga gccccttccc
     6361 caaggtgcca cagatccacc ctccagggag ctgccagccc tgtgttctgg ttcccaaggg
     6421 caggatggac acacgtcaca tccctaccac gtggcctcca aagggagcca cggaggaaag
     6481 gcttctgtgg ttgctaggtg ggggagtcct gtgtgggagg gcctgaagac ccctgcttgt
     6541 gcctggtgag gggggtgctg cctcccccag cccccaacaa cctctcagac ccccaccctc
     6601 caacatagct gagttctgaa gatggtgctc cggacctgtc ctcttaagtg gtgcccagtg
     6661 ccctccccac cccacgttgg tgctctcagc tagaaggtgc tgtgcctctg cctgagcccc
     6721 aagccccgag cctggccttc aggacaggca gcctgctctg tgtcgccacg ggccggatac
     6781 gccacagggt tgatggcaga gacggccgag tccctggtct agaacaagac acattcttta
     6841 aacactgtat tacttctgcc tccctctagg tgacagtggc agtccgggtg ccatcacggg
     6901 tcctgcagat ggccatgcag ggctcctgcc cacgcaggcc accgtatgtt caggacacgc
     6961 actgggtctc agagccactg gcccaggcag aagtctcctt gagcccactg ggtcatatgc
     7021 gtgtcaccac acgtgaacta gtgtggtggc tgcctgcgga caccctcctg ttctgagccc
     7081 tgggcctgtg ttcttctcag acactcccag actgaggggt ggtgtgtggc gggtggcagg
     7141 gtggctgtgg agactgggga tctggagcct ggtgctggca cctggcctga gtttccgtgg
     7201 gcagctggcg gggacctgtg ctgctgctgc tgactgtggg tgggcgggcg gcgcctggga
     7261 gtggctcttg ctcaggaatt gataggaacc ctaaaaacta ggataccccc tcctcggccc
     7321 atgaggcacg cacagtgact tatttaagac ttccccctta atttatctgc ccccaggatg
     7381 cgtcagtctg ttcagtggtc agcaggcccc ccaccccccg ccgactgccc tcgccatcgt
     7441 ggtcagaccc ccctcccaac acaacacgct gctggtctgt gtcagccttt gtaacgtggg
     7501 aggctctgcc gtgtcttccg ggtgaactgt atttggattg cgcgcattgt cacggtccgc
     7561 ccctgggctg caggcgcccc ttcctctggg cacccctgca ttctgcatcc ccacctctag
     7621 acgctgtaat aaacagactg ttttcactcg ga
//
