LOCUS       NM_015018               7957 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens DOP1 leucine zipper like protein A (DOP1A), transcript
            variant 1, mRNA.
ACCESSION   NM_015018
VERSION     NM_015018.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7957)
  AUTHORS   Lend,A.K., Kazantseva,A., Kivil,A., Valvere,V. and Palm,K.
  TITLE     Diagnostic significance of alternative splice variants of REST and
            DOPEY1 in the peripheral blood of patients with breast cancer
  JOURNAL   Tumour Biol 36 (4), 2473-2480 (2015)
   PUBMED   25424701
  REMARK    GeneRIF: Assessment of REST-N50 and DOPEY1v2 may prove useful in
            diagnostic blood tests of breast cancer. REST-N50 shows a high
            potential as a blood biomarker for evaluating the effectiveness of
            therapy in the neoadjuvant setting.
REFERENCE   2  (bases 1 to 7957)
  AUTHORS   Gillingham,A.K., Whyte,J.R., Panic,B. and Munro,S.
  TITLE     Mon2, a relative of large Arf exchange factors, recruits Dop1 to
            the Golgi apparatus
  JOURNAL   J Biol Chem 281 (4), 2273-2280 (2006)
   PUBMED   16301316
REFERENCE   3  (bases 1 to 7957)
  AUTHORS   Pascon,R.C. and Miller,B.L.
  TITLE     Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a
            member of a novel family of leucine zipper-like proteins conserved
            from yeast to humans
  JOURNAL   Mol Microbiol 36 (6), 1250-1264 (2000)
   PUBMED   10931277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139333.10 and AL121716.16.
            
            On Jul 29, 2020 this sequence version replaced NM_015018.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349129.7/ ENSP00000195654.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL139333.10        45276-45384
            110-202             AL139333.10        74336-74428
            203-393             AL139333.10        74530-74720
            394-575             AL139333.10        78310-78491
            576-746             AL139333.10        86515-86685
            747-936             AL139333.10        87730-87919
            937-1035            AL139333.10        90928-91026
            1036-1135           AL139333.10        96493-96592
            1136-1245           AL139333.10        97353-97462
            1246-1354           AL139333.10        98288-98396
            1355-1475           AL121716.16        64504-64624         c
            1476-1595           AL121716.16        63572-63691         c
            1596-1710           AL121716.16        61735-61849         c
            1711-1740           AL121716.16        61359-61388         c
            1741-1974           AL121716.16        60821-61054         c
            1975-2596           AL121716.16        57046-57667         c
            2597-2871           AL121716.16        56157-56431         c
            2872-3024           AL121716.16        54226-54378         c
            3025-3125           AL121716.16        52267-52367         c
            3126-3385           AL121716.16        50676-50935         c
            3386-5375           AL121716.16        47392-49381         c
            5376-5487           AL121716.16        46443-46554         c
            5488-5670           AL121716.16        46151-46333         c
            5671-5796           AL121716.16        44508-44633         c
            5797-5931           AL121716.16        40896-41030         c
            5932-5987           AL121716.16        39263-39318         c
            5988-6092           AL121716.16        37691-37795         c
            6093-6159           AL121716.16        34895-34961         c
            6160-6304           AL121716.16        34527-34671         c
            6305-6384           AL121716.16        34187-34266         c
            6385-6494           AL121716.16        32934-33043         c
            6495-6644           AL121716.16        32511-32660         c
            6645-6706           AL121716.16        32313-32374         c
            6707-6859           AL121716.16        30451-30603         c
            6860-6996           AL121716.16        29236-29372         c
            6997-7052           AL121716.16        27932-27987         c
            7053-7217           AL121716.16        26594-26758         c
            7218-7347           AL121716.16        23635-23764         c
            7348-7957           AL121716.16        18083-18692         c
FEATURES             Location/Qualifiers
     source          1..7957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..7957
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /note="DOP1 leucine zipper like protein A"
                     /db_xref="GeneID:23033"
                     /db_xref="HGNC:HGNC:21194"
                     /db_xref="MIM:616823"
     exon            1..109
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            110..202
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            203..393
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..7653
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /note="isoform a is encoded by transcript variant 1;
                     homolog of yeast DOP1; protein dopey-1; dopey family
                     member 1; protein DOP1A"
                     /codon_start=1
                     /product="protein DOP1A isoform a"
                     /protein_id="NP_055833.2"
                     /db_xref="CCDS:CCDS4996.1"
                     /db_xref="GeneID:23033"
                     /db_xref="HGNC:HGNC:21194"
                     /db_xref="MIM:616823"
                     /translation="MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKL
                     NKVLQNNAKYQVVPKKLTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKD
                     LFLYSSGLFPLLANAAMSVKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSE
                     YYERTNMLLEKVAAAVDQSAFYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLY
                     IIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHV
                     VLRRDMSLNRRLYAWLLGFDNNGAIIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVG
                     ILQVNGFGEENTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAELDL
                     QTEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYVARWFEECCRRTL
                     HVRLQIGPGDSNDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQ
                     LLLRMISALTSHLQTLHLSELTDSLRLCSKILSKVQPPLLSASTGGVLQFPSGQNNSV
                     KEWEDKKVSSVSHENPTEVFEDGENPPSSRSSESGFTEFIQYQADRTDDIDRELSEGQ
                     GAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQGTATRSRKTAQKTAMQCCLEYVQ
                     QFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSKWDRNSQGDVKEKNISKQKTS
                     KEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLETDCEHVQPPQWLQTLMNAC
                     SQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQPLSPNQGRVAVVIRPPL
                     TQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQLHNLVPSSSICEDVI
                     SQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLFIMLDSLNSLDGS
                     TSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWNKSPCYPGEE
                     SDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLSLLSTSSET
                     IPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMPKESSPD
                     DDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDSIQQS
                     QNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKSRQ
                     RSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
                     TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDS
                     SRTLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFY
                     SHIPVDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILT
                     LLFTELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNL
                     VAVEEGFSEDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFV
                     VSDLEHISPHQPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTL
                     PYMGKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEG
                     ITAIIHYCLLDPTTQYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADS
                     SEKMTIAASASLTTINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKT
                     TTRTKVIPAASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVC
                     MLQFFYAYIQRIPVPNLVDSWASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSL
                     ENKKDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVE
                     DMLSPAMETANITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVP
                     YLRNHSAHNAPSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWR
                     AIMDNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRDVELEQRAMLLKRLAFAIFSSEI
                     DQYQKYLPDIQERLVESLRLPQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELV
                     QVFLLMEQELTADEDISRTSGPSVAGLETTYTGGNGFSTSYNSQRWLNLYLSACKFLD
                     LALALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQREFKPYVVRLAKLLRKRAK
                     KNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSP
                     ILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLEGMIKT"
     exon            394..575
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            576..746
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            747..936
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1035
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1135
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1245
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1354
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1475
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1595
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1710
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1740
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1974
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2596
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2871
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3024
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3125
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3385
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..5375
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5487
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5670
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5796
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5931
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..5987
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            5988..6092
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6093..6159
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6160..6304
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6305..6384
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6385..6494
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6495..6644
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6645..6706
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6707..6859
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..6996
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            6997..7052
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7217
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            7218..7347
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     exon            7348..7957
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7932..7937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /note="hexamer: AATATA"
     polyA_site      7957
                     /gene="DOP1A"
                     /gene_synonym="dJ202D23.2; DOP1; DOPEY1; KIAA1117"
                     /note="major polyA site"
ORIGIN      
        1 acggtgcact ctgggagctg tcactaggcc cttcggctcc cggtctcggt gtagctgccg
       61 tggttgccag gagagctgcg ccggcgagaa gcggccgagc cagcagcagg aaggaacaca
      121 caagtagtta tctttcaggc tgtctttgaa tacttccatg accctgaaca ctagctgagg
      181 agagtttcaa ccactgctaa cagtaatgac tttacatgag tttggaactg gtctctagtg
      241 ggaagttgtg ggaggatgaa cacagaagag ctggagttat tgagtgactc caaatacaga
      301 aactatgtag cagcaattga caaagcacta aagaattttg aatactccag tgaatgggca
      361 gatttgatat cagcacttgg aaaacttaat aaggttttac aaaataatgc aaagtaccaa
      421 gtagtaccca aaaagctgac cataggcaaa cgcctagctc aatgtctaca tccagcatta
      481 ccaggtggag ttcatcggaa ggcgcttgaa acatatgaaa ttatcttcaa aataattgga
      541 cctaagcgac ttgccaaaga tcttttttta tatagttctg gattatttcc tcttcttgca
      601 aatgctgcca tgtctgtgaa accaacattg ctcagtttgt atgagatata ttatctgcct
      661 ttgggtaaaa cactgaaacc tggtctacag ggattgctta ctggtattct tcctggctta
      721 gaagaaggat cagagtacta tgagagaaca aatatgttgt tggaaaaggt tgctgctgct
      781 gtggaccagt cagcattcta cagtgccctg tggggtagtc ttctcaccag tcctgctgtg
      841 cgtttacctg gaatcacgta tgttcttgcc catttaaaca ggaagctttc tatggaagat
      901 caactttata taattggcag tgatattgag ctaatggtag aagcagtaag tacttcagtg
      961 caggactcaa gtgtacttgt acagagaagc acactggacc tcatactctt ctgttttcca
     1021 ttccacatga gtcaggccac tcgaccggat atgatcagga tcttgtcagc agcccttcat
     1081 gtagtgctaa ggagggatat gtctctgaat cgaagacttt atgcatggct tcttggtttt
     1141 gataacaacg gtgctatcat aggacccaga agcacaagac acagtaatcc tgaagaacat
     1201 gccacttact atttcactac cttttcaaaa gaattattag tccaggcaat ggtgggaatc
     1261 ttacaagtga atggatttgg agaagagaac actctaatgc aggatctaaa gccttttcgc
     1321 attttaatca gtttactgga caaacctgag ctaggacctg taattctaga agatgtcctg
     1381 attgaagtgt ttagaacatt atattctcaa tgcaaagcag agttggatct tcaaactgaa
     1441 ccacccttca gcaaggatca tgctcagtta agcagtaaat taagagaaaa taagaaaaca
     1501 gcagagctga ttaaaactgc taaccttctc tttaattcct tcgaacctta ttatatgtgg
     1561 gattatgttg cacgctggtt tgaagaatgt tgtaggagga cactgcatgt gagacttcag
     1621 attggacctg gagatagtaa tgactcatct gaattacagc tgaccaattt ctgcttactg
     1681 gtggattttt tgttggacat agtttctttg cctactagaa gtatgagggt gctgtgtcag
     1741 gagacttaca ttgaaatcca gacagaacac ttgccccagt tgctgctcag aatgatttct
     1801 gccttgacaa gccatctcca gacattgcac ttatctgaac tcacagattc tctcagactc
     1861 tgctcaaaga tccttagcaa ggttcagcct ccactgttat ctgctagcac tggaggtgtt
     1921 ttgcagtttc caagtgggca gaacaattca gtcaaagagt gggaagacaa aaaggtatca
     1981 tcagtttctc atgaaaatcc tactgaagtg tttgaagatg gagaaaatcc accaagtagt
     2041 cgatcatcag agagtggatt cactgagttt atacaatatc aagcagaccg aactgatgat
     2101 attgacagag aactgagtga gggccagggg gcagctgcca tcccaattgg tagcacatcc
     2161 tctgagacag aaacagcatc cactgtggga tctgaagaaa ccatcatcca gaccccttcc
     2221 gtagtcactc aggggacagc aacccgaagt aggaagacag cccaaaagac tgcaatgcag
     2281 tgctgcttgg agtatgtcca acagtttctt accagactta tcaacctcta catcattcag
     2341 aataactctt tttctcagtc tttggctaca gaacatcaag gggatcttgg tcgagaacaa
     2401 ggagagactt caaaatggga cagaaattca caaggagatg taaaagagaa aaacataagt
     2461 aaacaaaaaa cttctaaaga atacctgtct gccttccttg ctgcctgtca gctcttccta
     2521 gagtgctcaa gtttcccagt ttacattgct gaggggaacc atacatcaga gttacgttct
     2581 gaaaaattgg agactgactg tgagcatgtg cagcctccac agtggctcca gactctgatg
     2641 aatgcttgca gccaagcaag tgatttcagt gttcagagtg ttgctatttc actagttatg
     2701 gacctggtgg gactgacaca gtctgtggcc atggtcactg gggaaaacat caacagtgta
     2761 gagcctgcac aacccttaag tccaaaccag ggaagagtag ctgtggttat tagacctccc
     2821 ctcactcagg gcaatctgag gtacatagct gagaagactg aatttttcaa gcatgtagct
     2881 ttaacattgt gggaccagtt gggagatggg acacctcagc atcaccagaa gagtgtggaa
     2941 ctattttatc aattacataa cttagttcct tcttctagca tctgtgagga tgttataagt
     3001 cagcagttaa cccataaaga taagaaaata aggatggaag cacatgccaa gtttgcagtt
     3061 ctttggcatc taacgagaga tctccatata aataaatctt catcttttgt acgttctttt
     3121 gacaggtcac tgttcatcat gttagatagc cttaacagtc tcgatggttc tactagctct
     3181 gtgggacaag cctggctgaa ccaagtccta caaagacatg atattgcacg agttttggaa
     3241 ccattgctat tgctcctgct tcatccaaaa actcagaggg tttcagtaca gcgtgtacaa
     3301 gcagaacgtt attggaataa gtctccctgt tatccaggag aggagagtga caagcatttc
     3361 atgcaaaatt ttgcctgcag caatgtgagc caagtacaac tcatcacatc aaaaggaaat
     3421 ggtgaaaagc cacttaccat ggatgaaata gagaacttta gtctcactgt gaatccatta
     3481 agtgacagac tttccctcct aagtaccagc agtgagacaa ttccaatggt tgtgtctgat
     3541 tttgatcttc cagaccaaca gatagaaata cttcagagtt ctgactcggg atgttcacag
     3601 tcctctgctg gggacaactt gagttacgaa gttgatcctg aaaccgtgaa tgcccaagag
     3661 gattctcaaa tgcccaagga aagctcccca gatgatgatg ttcaacaggt agtatttgac
     3721 ctgatatgta aagttgtaag tggcctcgaa gtggaatctg catcagttac atctcaatta
     3781 gaaattgaag ctatgccccc aaagtgcagt gatatagatc cagatgaaga gacgattaaa
     3841 attgaagatg actccattca acagagtcag aatgctttgc tgagtaatga aagttctcag
     3901 tttctgtctg tgtctgcaga gggaggccat gagtgtgtgg caaatggaat ctccaggaat
     3961 agctcctcac cttgtatttc aggaaccaca cacactcttc atgactcttc tgttgcttcc
     4021 atagaaacca aatctagaca aaggagtcac agtagtattc aattcagctt caaagaaaaa
     4081 ttatcagaaa aagtttcgga gaaggaaaca atagttaagg agtcaggtaa acaaccagga
     4141 gcaaaaccta aagtaaaact tgccagaaaa aaggatgatg acaagaaaaa atcttcaaat
     4201 gaaaaactca aacaaaccag tgtattcttc agtgatggtc tggatttaga gaactggtat
     4261 agctgtggag agggagacat ttctgaaatt gagagtgaca tgggttctcc aggatctcga
     4321 aaatctccca atttcaacat tcatcctctc tatcaacatg tgctcctgta tctccagttg
     4381 tatgattcat ccaggacttt gtatgctttc tctgccatca aagccatctt gaaaactaac
     4441 cctatagctt ttgtaaatgc catttcaact actagtgtaa ataatgcata tactcctcag
     4501 ttgtctctcc ttcagaatct attggccaga caccggattt ctgttatggg caaagatttt
     4561 tatagtcaca ttccagtgga ctcaaatcat aacttccgga gttctatgta catagaaatt
     4621 cttatttctc tctgcttata ttacatgcgt agccattacc caactcatgt caaggttact
     4681 gcacaagatt taataggcaa tcgaaacatg caaatgatga gcatagaaat tctgacacta
     4741 ctcttcactg agctggcaaa agtaatagaa agctcagcga agggtttccc tagttttatt
     4801 tctgatatgt tatctaagtg caaagttcag aaagtgattc ttcattgttt gctgtcatct
     4861 atctttagtg ctcagaaatg gcatagtgaa aaaatggcag gtaagaacct ggttgctgtg
     4921 gaagaaggtt tctcagagga cagccttatt aatttctcag aggatgaatt tgacaatggc
     4981 agcacgttgc agtcacaact tcttaaggtg cttcagaggc tgattgttct agaacacaga
     5041 gtaatgacta ttcctgaaga gaatgaaaca ggttttgatt ttgttgtatc tgacttagaa
     5101 cacatcagtc cccatcaacc catgacttct cttcagtatt tgcatgctca gccaatcaca
     5161 tgtcaaggca tgttcctctg tgcagtgata cgagctttgc atcagcactg tgcatgtaag
     5221 atgcacccac aatggattgg tttaatcaca tctactctgc cttacatggg aaaagttctg
     5281 cagagagtgg ttgtttctgt gacactacaa ctgtgcagaa atttagataa tctaattcag
     5341 cagtacaaat acgaaacagg attatctgat agtaggcctc tgtggatggc atcaattatt
     5401 ccaccagata tgattcttac tcttttggaa gggattacag ccattatcca ttactgtttg
     5461 ttggatccaa ctacacagta tcaccaactt ttggtcagtg tagaccagaa acacttgttt
     5521 gaagcacgca gtggaatcct ctcaatcctt catatgatca tgtcctctgt gacactgctt
     5581 tggagcatac tgcatcaagc tgattcttca gaaaagatga ctattgccgc atccgcatct
     5641 cttaccacta ttaatcttgg agctacaaag aacttgagac aacagattct tgaattgttg
     5701 ggccccattt caatgaatca tggtgttcac tttatggctg ccattgcatt tgtgtggaat
     5761 gaaagaagac agaataaaac aaccaccagg accaaggtca ttcctgcagc cagtgaagaa
     5821 cagcttttat tagtggaatt ggttcgttca atcagtgtca tgagagcaga aactgttatc
     5881 cagactgtaa aagaagtttt aaagcagcca ccagccatag ccaaggacaa gaaacatctt
     5941 tctttggaag tctgcatgct tcagtttttc tatgcttata ttcaaagaat tccagtgccc
     6001 aatttagtgg atagctgggc gtcactgttg atacttctga aagactctat acaactgagt
     6061 cttccagctc cagggcagtt tcttatactt ggggttctga atgagtttat tatgaaaaac
     6121 cctagtttgg aaaataaaaa agaccaaaga gaccttcagg atgtaactca caaaatagtg
     6181 gatgcaattg gtgcaattgc tggttcttct ctggaacaga caacatggct gcgacgaaat
     6241 cttgaagtta agccttctcc caaaataatg gtagatggaa ccaatttgga atctgatgtt
     6301 gaagatatgt tatcacctgc aatggaaacc gcaaacataa ctccttctgt atatagtgtc
     6361 catgcattga cattactctc tgaggttttg gctcatcttt tggatatggt tttctatagt
     6421 gatgaaaagg agcgggttat tcctttactt gtaaatatta tgcattatgt tgtgccctac
     6481 ctcagaaatc acagtgcaca taatgcccct agttatcgag cttgtgtcca gctgctcagc
     6541 agtcttagtg ggtatcagta cacacggaga gcttggaaaa aagaagcttt tgacctcttt
     6601 atggatccca gtttctttca gatggatgcc tcttgtgtta atcattggag agcaattatg
     6661 gacaatctga tgacacatga taaaacaaca tttagagatt tgatgactcg tgtagcagtg
     6721 gctcaaagca gttcacttaa tctctttgca aaccgtgatg tggagctaga acagagagct
     6781 atgcttctta aaagattagc atttgctatt tttagcagtg aaattgacca gtaccagaaa
     6841 tatcttccag atatacaaga gagattggtt gagagtctcc gtttgccaca ggtgccaact
     6901 ctccattctc aagtgttcct gtttttcaga gtgttacttt taagaatgtc tccccaacat
     6961 cttacctcac tctggcctac catgattaca gaacttgtac aagtattttt actgatggag
     7021 caggaactca ctgctgatga agatatttca cggacttcag ggccctctgt ggctggtctg
     7081 gagacaacgt acacaggagg taatggcttc tctacttcat ataacagcca gcggtggtta
     7141 aacctctatc tctctgcttg caaatttttg gatttggctc tcgcattgcc ctctgaaaac
     7201 cttcctcagt ttcagatgta ccgatgggcc tttattccag aagcctcaga tgattcaggt
     7261 ttggaagtca gaaggcaggg tatacatcaa cgagaattta aaccttacgt ggtacgacta
     7321 gcaaaacttc ttcggaaaag agcaaagaaa aatccagagg aagacaactc agggagaaca
     7381 ttgggttggg agccagggca cttgctgctc accatctgca ccgtgcgcag tatggagcag
     7441 ctcctgccgt tcttcaatgt gctcagtcaa gtcttcaaca gcaaagtcac aagccgatgt
     7501 ggaggacact cagggagtcc tatcctctac tcaaatgcct tccctaataa ggacatgaaa
     7561 ctggagaacc acaaaccatg ttccagcaaa gccaggcaaa aaatagaaga gatggtagaa
     7621 aaagattttc tggaagggat gataaaaact tgagcaccat tgctggttcc atttagctta
     7681 catgtaaatg taattattta aaacacacac actgctctgc gttgtatagt ttttcctttt
     7741 ttgtatgtaa cagaacacat ttcagattgt atttaattta aatatttgta tataagagca
     7801 aatgtctgaa tgtggcctga atcaagttta aatattgttg gctcatactg attatggtgc
     7861 ctaagagagc tatatatata cacatgtaaa gtccattgtt tttattgtcc tgagttgtct
     7921 taaacctgca aaatatacac tacccatttt ttttttc
//
