LOCUS       NM_017613               2500 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens DNA replication fork stabilization factor DONSON
            (DONSON), mRNA.
ACCESSION   NM_017613
VERSION     NM_017613.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2500)
  AUTHORS   Evrin,C., Alvarez,V., Ainsworth,J., Fujisawa,R., Alabert,C. and
            Labib,K.P.
  TITLE     DONSON is required for CMG helicase assembly in the mammalian cell
            cycle
  JOURNAL   EMBO Rep 24 (11), e57677 (2023)
   PUBMED   37781960
  REMARK    GeneRIF: DONSON is required for CMG helicase assembly in the
            mammalian cell cycle.
REFERENCE   2  (bases 1 to 2500)
  AUTHORS   Kingsley,G., Skagia,A., Passaretti,P., Fernandez-Cuesta,C.,
            Reynolds-Winczura,A., Koscielniak,K. and Gambus,A.
  TITLE     DONSON facilitates Cdc45 and GINS chromatin association and is
            essential for DNA replication initiation
  JOURNAL   Nucleic Acids Res 51 (18), 9748-9763 (2023)
   PUBMED   37638758
  REMARK    GeneRIF: DONSON facilitates Cdc45 and GINS chromatin association
            and is essential for DNA replication initiation.
REFERENCE   3  (bases 1 to 2500)
  AUTHORS   Hashimoto,Y., Sadano,K., Miyata,N., Ito,H. and Tanaka,H.
  TITLE     Novel role of DONSON in CMG helicase assembly during vertebrate DNA
            replication initiation
  JOURNAL   EMBO J 42 (17), e114131 (2023)
   PUBMED   37458194
  REMARK    GeneRIF: Novel role of DONSON in CMG helicase assembly during
            vertebrate DNA replication initiation.
REFERENCE   4  (bases 1 to 2500)
  AUTHORS   Zhang,J., Bellani,M.A., James,R.C., Pokharel,D., Zhang,Y.,
            Reynolds,J.J., McNee,G.S., Jackson,A.P., Stewart,G.S. and
            Seidman,M.M.
  TITLE     DONSON and FANCM associate with different replisomes distinguished
            by replication timing and chromatin domain
  JOURNAL   Nat Commun 11 (1), 3951 (2020)
   PUBMED   32769987
  REMARK    GeneRIF: DONSON and FANCM associate with different replisomes
            distinguished by replication timing and chromatin domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2500)
  AUTHORS   Zou,Z., Dong,Y.S., Liu,J.M., Zhao,Z.H., Li,G. and Liu,D.D.
  TITLE     Circ-DONSON promotes malignant progression of glioma through
            modulating FOXO3
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (2), 749-757 (2020)
   PUBMED   32016978
  REMARK    GeneRIF: Circ-DONSON promotes malignant progression of glioma
            through modulating FOXO3.
REFERENCE   6  (bases 1 to 2500)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   7  (bases 1 to 2500)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   8  (bases 1 to 2500)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   9  (bases 1 to 2500)
  AUTHORS   Wynn,S.L., Fisher,R.A., Pagel,C., Price,M., Liu,Q.Y., Khan,I.M.,
            Zammit,P., Dadrah,K., Mazrani,W., Kessling,A., Lee,J.S. and
            Buluwela,L.
  TITLE     Organization and conservation of the GART/SON/DONSON locus in mouse
            and human genomes
  JOURNAL   Genomics 68 (1), 57-62 (2000)
   PUBMED   10950926
REFERENCE   10 (bases 1 to 2500)
  AUTHORS   Slavov,D., Hattori,M., Sakaki,Y., Rosenthal,A., Shimizu,N.,
            Minoshima,S., Kudoh,J., Yaspo,M.L., Ramser,J., Reinhardt,R.,
            Reimer,C., Clancy,K., Rynditch,A. and Gardiner,K.
  TITLE     Criteria for gene identification and features of genome
            organization: analysis of 6.5 Mb of DNA sequence from human
            chromosome 21
  JOURNAL   Gene 247 (1-2), 215-232 (2000)
   PUBMED   10773462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463648.1, BC048266.1, BM451848.1, AP000304.1 and BM679236.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017613.3.
            
            Summary: This gene lies downstream of the SON gene and spans 10 kb
            on chromosome 21. The function of this gene is unknown. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.679886.1,
                                           SRR1163658.280858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303071.10/ ENSP00000307143.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BI463648.1         30-55
            27-2144             BC048266.1         1-2118
            2145-2418           BM451848.1         252-525             c
            2419-2441           AP000304.1         17974-17996         c
            2442-2500           BM679236.1         15-73               c
FEATURES             Location/Qualifiers
     source          1..2500
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..2500
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /note="DNA replication fork stabilization factor DONSON"
                     /db_xref="GeneID:29980"
                     /db_xref="HGNC:HGNC:2993"
                     /db_xref="MIM:611428"
     exon            1..364
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1744
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /note="downstream neighbor of SON"
                     /codon_start=1
                     /product="protein downstream neighbor of Son"
                     /protein_id="NP_060083.1"
                     /db_xref="CCDS:CCDS13632.1"
                     /db_xref="GeneID:29980"
                     /db_xref="HGNC:HGNC:2993"
                     /db_xref="MIM:611428"
                     /translation="MALSVPGYSPGFRKPPEVVRLRRKRARSRGAAASPPRELTEPAA
                     RRAALVAGLPLRPFPAAGGRGGGSGGGPAAARRNPFARLDNRPRVAAEPPDGPAREQP
                     EAPVPFLDSNQENDLLWEEKFPERTTVTELPQTSHVSFSEPDIPSSKSTELPVDWSIK
                     TRLLFTSSQPFTWADHLKAQEEAQGLVQHCRATEVTLPKSIQDPKLSSELRCTFQQSL
                     IYWLHPALSWLPLFPRIGADRKMAGKTSPWSNDATLQHVLMSDWSVSFTSLYNLLKTK
                     LCPYFYVCTYQFTVLFRAAGLAGSDLITALISPTTRGLREAMRNEGIEFSLPLIKESG
                     HKKETASGTSLGYGEEQAISDEDEEESFSWLEEMGVQDKIKKPDILSIKLRKEKHEVQ
                     MDHRPESVVLVKGINTFTLLNFLINSKSLVATSGPQAGLPPTLLSPVAFRGATMQMLK
                     ARSVNVKTQALSGYRDQFSLEITGPIMPHSLHSLTMLLKSSQSGSFSAVLYPHEPTAV
                     FNICLQMDKVLDMEVVHKELTNCGLHPNTLEQLSQIPLLGKSSLRNVVLRDYIYNWRS
                     "
     exon            365..445
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            446..649
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            650..828
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1007
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1089
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1194
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1393
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1606
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2500
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /note="major polyA site"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
                     /note="hexamer: AATAAA"
     polyA_site      2500
                     /gene="DONSON"
                     /gene_synonym="B17; C21orf60; MIMIS; MISSLA"
ORIGIN      
        1 aagtctctgt agggcggccg gctaccctca gccgccgcgc gtcatggccc tttcggtgcc
       61 cggctactca ccgggcttcc gaaagccgcc cgaggtagtg cggctccgac ggaaaagggc
      121 ccggagccgt ggagctgccg cctccccgcc ccgtgagctg acggagccgg cggcccgccg
      181 agccgccctg gtggcggggc tgcctcttcg ccctttccct gctgcggggg gcagaggcgg
      241 tggcagcggc ggcggcccgg ccgctgctcg gaggaacccc ttcgcccgcc tggacaaccg
      301 accgcgggtc gccgcggagc cccccgacgg gccggcccgc gagcagccgg aggccccggt
      361 cccgttttta gattctaatc aagaaaatga tttgctatgg gaagagaagt ttcctgaaag
      421 aacaactgtt actgaattac ctcagacttc acatgtatca ttctccgagc ctgatattcc
      481 gtcctcaaaa agtactgagt tacctgtgga ctggagtatt aaaacgcgac tccttttcac
      541 ctcttctcaa ccctttacct gggcagatca tttgaaagca caggaagaag ctcaaggtct
      601 tgtccagcat tgtagggcaa cagaagttac tttgcctaaa agtatacagg atcccaaact
      661 ctcctctgag ctccgttgta ccttccagca gagccttatc tattggctcc accctgcttt
      721 gtcttggcta ccactgttcc ctcgtattgg agctgataga aaaatggctg gaaagacaag
      781 tccttggtca aatgatgcaa ccctgcagca tgttttaatg agtgactggt ctgtgagctt
      841 tacttctcta tataatttgc tgaagacaaa actttgcccc tatttctacg tttgtaccta
      901 tcagtttact gtcctgttcc gagcagcagg attagctgga agtgacttaa tcacagctct
      961 catatctcca acaactcgag gtttaagaga agctatgaga aatgaaggta ttgaattttc
     1021 tctgccttta ataaaagaaa gtggccataa gaaggagaca gcatctggaa caagcttggg
     1081 atatggggag gagcaagcca tcagtgatga ggatgaagag gaaagttttt cctggctgga
     1141 agagatgggt gtgcaagata aaattaaaaa gccagacata ctttctatca agctgcgtaa
     1201 agagaaacat gaagtacaaa tggatcacag acctgaatct gttgtgttgg taaaaggaat
     1261 caacaccttt acattgctca attttttgat taactctaag agtttagttg ctacctcagg
     1321 tccacaggca ggacttcctc caaccctctt gtcccctgtt gctttccgag gtgccacaat
     1381 gcaaatgctt aaggcacgga gtgtgaatgt gaagacacaa gctctttctg gatacagaga
     1441 ccaatttagt ttggagatta caggtcctat catgcctcat tctctgcatt cactgaccat
     1501 gctgctcaaa tcttcacaga gtggatcttt ctctgcagta ctgtatccac acgagccaac
     1561 tgctgtattt aacatctgcc tgcaaatgga caaagtactt gatatggagg ttgttcataa
     1621 ggagcttact aactgtggtt tgcaccctaa cactctggag caacttagtc aaataccgtt
     1681 acttgggaaa tcatctttac ggaatgtggt gctgagagac tacatttata attggagatc
     1741 ctgaacacca aagtaagcct aaaaggaatc tttgaggaaa aaagccttct agcaaggaaa
     1801 ttcaagattc ttgaagttga aggaatatac tgaaatgttt ataaacataa cttttactac
     1861 agtagcatct aaggttttaa atgtgtttta ctattttcag attagatttt tagatataaa
     1921 gatgaaaaac tcagataact caaatgagat atctatatcc ctacaaccta attgtatatt
     1981 gagcagaaac tgaattaata tgcttccttg caaatgggaa atcacatagc agttacccca
     2041 tggcattgtg actaatggca tcagggcaaa aatatgttac tttacgattt acctgttagc
     2101 aggttcttgt ttcataaagg tagaaaataa atacagacaa catctactga gctagttgat
     2161 tggtgatgct tctaccttaa tatctttcct actgatttat aattccttta ttttcacata
     2221 tactaaaact ttttaaatgc atgttaattc agataaaaag gcattttgta ttccacatag
     2281 aatagtgtta agaattgtga agtacactga gctgtcacgg caaagtagta tttaatgtgc
     2341 ttataggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2401 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtaggg ggggactgta
     2461 taattcacat ttttaaaata aaagtgctta aaaatcaaaa
//
