LOCUS       NM_020438               2169 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dolichyldiphosphatase 1 (DOLPP1), transcript variant
            1, mRNA.
ACCESSION   NM_020438
VERSION     NM_020438.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Rush,J.S., Cho,S.K., Jiang,S., Hofmann,S.L. and Waechter,C.J.
  TITLE     Identification and characterization of a cDNA encoding a dolichyl
            pyrophosphate phosphatase located in the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Biol Chem 277 (47), 45226-45234 (2002)
   PUBMED   12198133
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Wedgwood,J.F. and Strominger,J.L.
  TITLE     Enzymatic activities in cultured human lymphocytes that
            dephosphorylate dolichyl pyrophosphate and dolichyl phosphate
  JOURNAL   J Biol Chem 255 (3), 1120-1123 (1980)
   PUBMED   6243292
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA590931.1, BC009493.2 and
            BC033686.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020438.4.
            
            Summary: A similar gene has been characterized in mice and encodes
            dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein
            dephosphorylates dolichyl pyrophosphate so that it may be
            re-utilized as a glycosyl carrier lipid by the
            oligosaccharyltransferase multisubunit complex in the ER.
            Alternative splicing results in multiple transcript variants and
            protein isoforms. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.8411.1,
                                           SRR3476690.116041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372546.9/ ENSP00000361625.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA590931.1         8-30
            24-2166             BC009493.2         1-2143
            2167-2169           BC033686.1         2152-2154
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2169
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /note="dolichyldiphosphatase 1"
                     /db_xref="GeneID:57171"
                     /db_xref="HGNC:HGNC:29565"
                     /db_xref="MIM:614516"
     exon            1..97
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..738
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /EC_number="3.6.1.43"
                     /note="isoform a is encoded by transcript variant 1;
                     linked to Surfeit genes in Fugu rubripes 2; dolichyl
                     pyrophosphate phosphatase 1"
                     /codon_start=1
                     /product="dolichyldiphosphatase 1 isoform a"
                     /protein_id="NP_065171.2"
                     /db_xref="CCDS:CCDS6918.1"
                     /db_xref="GeneID:57171"
                     /db_xref="HGNC:HGNC:29565"
                     /db_xref="MIM:614516"
                     /translation="MAADGQCSLPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPVFVI
                     VGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCGGPHTAVGTKYGMPSS
                     HSQFMWFFSVYSFLFLYLRMHQTNNARFLDLLWRHVLSLGLLAVAFLVSYSRVYLLYH
                     TWSQVLYGGIAGGLMAIAWFIFTQEVLTPLFPRIAAWPVSEFFLIRDTSLIPNVLWFE
                     YTVTRAEARNRQRKLGTKLQ"
     exon            98..198
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..283
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..383
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..482
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..611
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..701
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2169
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2148..2153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /note="hexamer: AATAAA"
     polyA_site      2169
                     /gene="DOLPP1"
                     /gene_synonym="LSFR2"
                     /note="major polyA site"
ORIGIN      
        1 gaagcccggt ctccgggtaa gatggcagcg gacggacagt gctcgctccc cgcttcatgg
       61 cggccggtga ccctcaccca cgtcgaatat cctgcaggtg atctctctgg ccacctcctt
      121 gcctacctga gcctcagccc tgtatttgtc atcgtcggtt tcgtgaccct catcatattt
      181 aagcgggagc tgcacacgat ctccttcctt gggggcctgg cactgaacga gggggtcaac
      241 tggctgatca aaaacgtcat ccaggagcca cggccctgtg gaggccccca cacagcagtg
      301 ggcaccaagt acgggatgcc ctccagccat tcccagttta tgtggttctt ctccgtctat
      361 tccttccttt tcctgtattt aagaatgcac caaacaaaca acgccaggtt cctggacttg
      421 ctgtggaggc acgtgctctc cctgggactc ctcgctgtgg ccttcctagt ctcctacagc
      481 agggtctacc tgctgtacca cacctggagc caggtgctct atggaggcat cgctggaggc
      541 ctcatggcca tcgcctggtt catcttcacc caggaggtcc tcaccccgct gttccccagg
      601 atagcagcct ggcctgtctc cgagttcttc ctaatccgag acacaagcct cattcccaac
      661 gtactctggt ttgagtacac ggtaacccgg gcagaagcca ggaacagaca acgcaagctg
      721 gggacgaaac tgcagtgacc agtgggtgtg gctgggtcca gcctccagat ctggcccgca
      781 cgatgccttg caggatggac aggatgacag acagggacga agcagagacc tctacagacc
      841 caagtcacca agtggagcct ttttttttct tattttaatt ttaatgaaca aggtggacca
      901 aagggctgaa ccagcccctc aaccaggacc ctggggggcc tgctgcctgg gggccgtggc
      961 cagagaccct cgctgtgctg ctgccagccc ctggctgggc agaaagtgcc ctcggcatgg
     1021 gcacctgggt gtggggtgga ggaggagggc tcgcgcctct ggtctcgggg ccaggaattc
     1081 caggtggcgt gagaagtaca cactatttat tttttggttt tgtcagaggc aggcaggatt
     1141 ttggagctgg aagaatctgc tctccggtgg ctgccctgtg aacagagggc tcccggtcag
     1201 cttcccaggc ccttcgccct atgcccagag ggcagactgc ctctccctgg gccggggtgg
     1261 cctgggtgcc aggaggaggg gagcataccc cacaccctcc ctgccaccgt tgccgttcca
     1321 gaacctcggt cagtgtttcc ctgtctgggg gcagggccca gagcgagcac gcgtctggcg
     1381 gctgctgtcg ttgtgttcta ccccgtactg acccaacacc acaagggctt tctctggtcc
     1441 cctgtcccta agacaataat cgctttctga caaaggagcc tgcacatttg ggtgagcaga
     1501 cccaagctgt ttacagctct ttcttgtcct gccatccagt agcagttagt cttcatcccc
     1561 acgtgaacaa aatgggaagg agccgtgagg agaggagtga ggcaacaggc acccgaagtc
     1621 cctcgtcctt ccctctgtgt gctctgaata tgtccttgtc cttcctgacc catctctgac
     1681 cagctgggaa cctgcttggg gtccccctca aacctgtgtc tggggtgtgg gctcacagat
     1741 ccctatcagc ctggttcgtg ggagggctct tcctaaaggg acccccatct ctaagtcact
     1801 ctgaaaggga gttgtggaga ggagacgcct ccagactctc agaagttttg aggactgaac
     1861 tgggtcactc gggatctgtg ttcgaatcct ccccacccct ttctttgtgg agtttcctaa
     1921 cctgctgctg aagcacaatg ttttggtgct ttcttttctc atttgttaaa ggcagtgtcc
     1981 aaaagccatt ccagatgcca agaccagggg cttatttcta gggaaggtag gtcggtttcc
     2041 atgtttccct cccgttattt ttatttttta ctttttgcct gagacaagcc gagtatgagg
     2101 tggtttgatt taagaaaaat caatgaaatt gtttactact gttttaaaat aaaaccgtaa
     2161 actctggca
//
