LOCUS       NM_152721               9057 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens docking protein 6 (DOK6), mRNA.
ACCESSION   NM_152721
VERSION     NM_152721.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9057)
  AUTHORS   Lan,C., Wu,Y., Wang,N., Luo,Y., Zhao,J., Zheng,Y., Zhang,Y.,
            Huang,L., Zhu,Y., Lu,L., Zhong,W., Zeng,J. and Xia,H.
  TITLE     Association between ABHD1 and DOK6 polymorphisms and susceptibility
            to Hirschsprung disease in Southern Chinese children
  JOURNAL   J Cell Mol Med 25 (20), 9609-9616 (2021)
   PUBMED   34545688
  REMARK    GeneRIF: Association between ABHD1 and DOK6 polymorphisms and
            susceptibility to Hirschsprung disease in Southern Chinese
            children.
REFERENCE   2  (bases 1 to 9057)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9057)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9057)
  AUTHORS   Li,Wq., Shi,L., You,Yg., Gong,Yh., Yin,B., Yuan,Jg. and Peng,Xz.
  TITLE     Downstream of tyrosine kinase/docking protein 6, as a novel
            substrate of tropomyosin-related kinase C receptor, is involved in
            neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons
  JOURNAL   BMC Biol 8, 86 (2010)
   PUBMED   20565848
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9057)
  AUTHORS   Hsu,Y.H., Zillikens,M.C., Wilson,S.G., Farber,C.R., Demissie,S.,
            Soranzo,N., Bianchi,E.N., Grundberg,E., Liang,L., Richards,J.B.,
            Estrada,K., Zhou,Y., van Nas,A., Moffatt,M.F., Zhai,G., Hofman,A.,
            van Meurs,J.B., Pols,H.A., Price,R.I., Nilsson,O., Pastinen,T.,
            Cupples,L.A., Lusis,A.J., Schadt,E.E., Ferrari,S.,
            Uitterlinden,A.G., Rivadeneira,F., Spector,T.D., Karasik,D. and
            Kiel,D.P.
  TITLE     An integration of genome-wide association study and gene expression
            profiling to prioritize the discovery of novel susceptibility Loci
            for osteoporosis-related traits
  JOURNAL   PLoS Genet 6 (6), e1000977 (2010)
   PUBMED   20548944
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9057)
  AUTHORS   Kurotsuchi,A., Murakumo,Y., Jijiwa,M., Kurokawa,K., Itoh,Y.,
            Kodama,Y., Kato,T., Enomoto,A., Asai,N., Terasaki,H. and
            Takahashi,M.
  TITLE     Analysis of DOK-6 function in downstream signaling of RET in human
            neuroblastoma cells
  JOURNAL   Cancer Sci 101 (5), 1147-1155 (2010)
   PUBMED   20210798
  REMARK    GeneRIF: DOK-6 is involved in RET signaling with less influence
            when compared with DOK-1, DOK-4, and SHC.
REFERENCE   7  (bases 1 to 9057)
  AUTHORS   Jones,R.B., Gordus,A., Krall,J.A. and MacBeath,G.
  TITLE     A quantitative protein interaction network for the ErbB receptors
            using protein microarrays
  JOURNAL   Nature 439 (7073), 168-174 (2006)
   PUBMED   16273093
REFERENCE   8  (bases 1 to 9057)
  AUTHORS   Crowder,R.J., Enomoto,H., Yang,M., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite
            outgrowth
  JOURNAL   J Biol Chem 279 (40), 42072-42081 (2004)
   PUBMED   15286081
  REMARK    GeneRIF: Dok-6 binds to the phosphorylated Ret Tyr(1062) residue
            resulting in phosphorylation of tyrosine residue(s) located within
            the unique C terminus of Dok-6 predominantly through a
            Src-dependent mechanism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026585.9, DB480182.1, AY599248.1, BC008583.1, BX280184.1,
            BC019045.2 and AC090231.7.
            
            On Nov 22, 2018 this sequence version replaced NM_152721.5.
            
            Summary: DOK6 is a member of the DOK (see DOK1; MIM 602919) family
            of intracellular adaptors that play a role in the RET (MIM 164761)
            signaling cascade (Crowder et al., 2004 [PubMed
            15286081]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.154678.1,
                                           SRR1803612.137908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382713.10/ ENSP00000372160.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC026585.9         121227-121386
            161-167             DB480182.1         1-7
            168-698             AY599248.1         6-536
            699-710             BC008583.1         121-132
            711-888             BX280184.1         325-502
            889-938             AY599248.1         727-776
            939-1951            BC008583.1         361-1373
            1952-2011           AY599248.1         1790-1849
            2012-2127           BC008583.1         1442-1557
            2128-2129           BC019045.2         1593-1594
            2130-9057           AC090231.7         42545-49472         c
FEATURES             Location/Qualifiers
     source          1..9057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.2"
     gene            1..9057
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="docking protein 6"
                     /db_xref="GeneID:220164"
                     /db_xref="HGNC:HGNC:28301"
                     /db_xref="MIM:611402"
     exon            1..423
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1353
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="downstream of tyrosine kinase 6"
                     /codon_start=1
                     /product="docking protein 6"
                     /protein_id="NP_689934.2"
                     /db_xref="CCDS:CCDS32841.1"
                     /db_xref="GeneID:220164"
                     /db_xref="HGNC:HGNC:28301"
                     /db_xref="MIM:611402"
                     /translation="MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEK
                     FPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEE
                     WCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQIT
                     HENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEM
                     IYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQN
                     SVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ"
     exon            424..531
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            532..646
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            647..766
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            767..956
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1095
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1213
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..9057
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4999..5004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="hexamer: ATTAAA"
     polyA_site      5019
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="major polyA site"
     regulatory      8946..8951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="hexamer: AACAAA"
     polyA_site      8966
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="major polyA site"
     regulatory      9024..9029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="hexamer: AATAAA"
     polyA_site      9057
                     /gene="DOK6"
                     /gene_synonym="DOK5L; HsT3226"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgccgcc gagcgaggcg ccagcccgtg ggtgctgccg ggggcggcgg cgcggtgggg
       61 gctcccgcag ctggcggagg cgcgggccgc ggcgctgggc tcgcggcggg gagcgaaggt
      121 gagcgccaga acgcggaggg ctggcgcggc tcgcggcgcc gggccccgtt ccccgtccgc
      181 ggcggccctg caggcgaccc cgcgtcccca ccggcgggag ctcggggaag agcgggcggc
      241 ggcgctgctg ctggcggcgg ccggctggat gcgagacccg cgcagacccg gcggcggacg
      301 gcggctctcg actccggaga gcggatcgcg gggcgcagga gcccgatcgc gctggccatg
      361 gcctccaact ttaacgacat agtcaagcag ggctacgtga aaatccgcag caggaagctt
      421 gggattttca gacgatgctg gttggttttc aagaaggctt ctagcaaagg acccagaagg
      481 ttagaaaaat ttccagatga aaaggcagct tatttcagaa actttcataa ggtaactgaa
      541 ctgcacaata tcaaaaatat aaccagactg ccccgagaga caaagaagca tgcggtggca
      601 atcatctttc acgatgaaac atcgaagaca tttgcctgtg agtcagagct ggaggccgag
      661 gagtggtgca agcacctctg catggagtgt ctggggacca ggctcaatga tatcagcctt
      721 ggggagcccg accttctggc cgcaggagtg cagcgggaac agaatgagag attcaacgtg
      781 tatcttatgc ctacaccaaa cctggatatt tatggtgaat gcacaatgca gatcactcat
      841 gaaaatatct atctctggga tatccacaat gccaaggtca aactggtgat gtggcctctc
      901 agctcactga ggagatacgg tcgggactca acgtggttca cgtttgagtc aggaagaatg
      961 tgtgacacag gagaaggact attcactttt caaacaaggg aaggagaaat gatctatcag
     1021 aaggttcatt ctgcgacact ggccatagct gagcaacatg aaagattaat gctagaaatg
     1081 gaacagaagg cccggcttca gacaagcttg actgaaccaa tgacattatc caaatcaata
     1141 tctcttcctc gcagcgcgta ctggcatcac atcactcgtc agaacagcgt tggtgaaatc
     1201 tacagtttgc aaggtcatgg gtttggttcg tcaaagatgt ctcgtgcaca gacatttccc
     1261 agctacgccc cagaacagag tgaagaggcc cagcagccgt tgtcgcggtc cagcagctat
     1321 ggattcagct acagctccag cctcatccaa tgacacacag agagccgctg ttgactagag
     1381 agacagtctg tcctggaccc gtctgtgggg tcattaccct ctgcctcctg gaagaccaat
     1441 tgcagtacaa attgaaatgg gtcggctcta gccccagtcc cattggaagg ttaaaaactg
     1501 gagttctgct tccttgattc agtggctaag tcctttattt attgaatttc tttgggggaa
     1561 tctatgtttt acataaatag aatccaaatc gtatgaacag ttatttaaat aaacaaaatt
     1621 ctttgggtct gacagtaaca gaaacctcag cactgggaaa agttgcccac actggggtat
     1681 gcctgggtga tgggcacctc tcactgacct cacagcgcag tccgcccatc tgagcacagg
     1741 gtctgtcctt agacataatg gtgaccctcc acaagctctg tggcttttaa agttctgaca
     1801 gggataaata cagtaagctc tgcaaatgac atcgtagctg catataaata aacccagtga
     1861 caattaaagg aacatgaaat tcagaacaca ctattaagca gggccctgta gctctactcg
     1921 tgtgtgtgtg tgcgtgtgtg tgtgtgtgtg tagacaaatg gatattgcta tatccatcta
     1981 tatataacaa gtatatatca aacatgtgct gagggtgaca ggatatgctc acttaaattg
     2041 ttgaaaacca taatttggtg cattaaagtt aagattgtta tgttgaatag ctatttttaa
     2101 aatagtgctg taaaaaaaaa aaaaaaaaag gcttcttatt agcaaaagta tatgtaatcc
     2161 agtctgttcc taacaagtgt aagcaaaaat gtgagaaggg gaacattcag aagcaaaaga
     2221 accagtctag ctgtcctaca catcatgtca taccctgtct ttctggtgag cgtttccttg
     2281 ttgctgacaa tgttgctccc tgtggccatc catctgagct acgtgaggag gattccatgt
     2341 gaacgccgat cagcttccat ttaaccttga gagaaaagag aggttctaaa tgaagaactc
     2401 tttaagaaag aaagaataca cccataaaga actcagctat tttgcagtaa agagaagaac
     2461 aaaatgggta caggattgtg gatatcatag atgctgttct cacacaacca ctgggggctt
     2521 gtaatttact gtgtaaccag aacttgcagg gctttatttt ttcttttact ggacacaggt
     2581 tgtctgagat tataagaaat aaaatagatc aataattttc atcatccctg acactgatta
     2641 caaacctaca gtgtttaaag ggaggtagtg aattccacgg aaactgagtt tggctaattc
     2701 aggtcaacaa agatatattt gcccttaatt ctggagttaa gtaaaaataa aaattatcct
     2761 gcctgaatca tctgatgctt tgtgcctaag atggttatct ctcaaatact ctagggtggg
     2821 tttaaagaac agtgagctca ggtcacgcaa gatgaaaacc caggtttttt ttttcttaat
     2881 aggaaaattt tttaaactat ccaaattagt ctgttgaaag ggtacctttt ttgctgatct
     2941 ctgatgagtt gtcttttcat ccctatctgt agcttgagtg cagattgaca attcatttca
     3001 gtgaattact accgaataaa agtggttccg gatccctcct agataaatgt gcacttacag
     3061 caactaccta ggctctccaa atcactccac tcggtatgaa aaccccatca agatactaat
     3121 cgtaagagtt aatgtggctg caaaaaataa ttatcctaag ctttcaggga taaaaagaaa
     3181 attacccagg ttctctgcac tgtgaatttt gctgacacag cggaggagca gatgactggt
     3241 tcctacaact gtacagcctt ccttgaaatc atagcttttg gggttaaaca cttgtgaatt
     3301 tcttttgcac atggcatttg cttttgaaat gcctttagtc aaatacacca gagcaactcc
     3361 cagctgagac catttgagca cagttcctag tggggccaca ttcagagcaa gcctctcgcc
     3421 ggctcactca gttgagctgt tgcttagaca ccacaagttt ctacaaggga cttatgggga
     3481 acggccctca ggggtcctgg ttcacatctc agctttattc atgtgctgga agcacaaaca
     3541 gcgagtccag ggagggattc tgctaatcag atgagtctgc tcttgtgtct ctttcttagg
     3601 agacaaatac ctgtatgtaa ttgcttcaag aactccattt ggttctgatc attaccaatg
     3661 aatataactg aaggagcacc aaagatcagg cataacctcg ggccagttca ttctgaaaat
     3721 gatgtcgtaa aaagagtatg tgtgagagaa atctccttcc caagttttta accagatctc
     3781 gtcacaatga ggagaatgct ataatctatc tcatggtaca tttttggagc ttaattctag
     3841 catactcctc caagtacact cacaattgta gctgagtcaa gactgctaaa tgaacagata
     3901 ggagaactta tattagacta atatccttga cacgaagcag ggttcattgt aataaaaacg
     3961 gcaaacagat aaatcttcta ccaaaaccaa agatggaaag tcactgcacc agtctcctgg
     4021 aacttcataa aatcaatttc actggagcaa ccagaagggt catggagatg tataccactc
     4081 gcttgggctc gtaggttttt gactggggat gcctctacac tttgtaagtc atttctccct
     4141 tcaaaaattg tattatatct ttaatatatg tgtatttttc aatgcgaggg aggaattact
     4201 atgaaccaaa gatatctttt ggctccttct gaaagtgact cagtttgaat tccattcaga
     4261 tttgtacaga taaatagatg gtcaccattt ctgcatcagg ttggaagaga ccaatgataa
     4321 aggaacccaa cgtaaggaat agcagttctg aaaatagaca aagcctagag gaggtatcta
     4381 tttcactgag agattacacg aggggactta ttttttatgt tcccaatttt ttcttctgat
     4441 aatattaatc aatgtacaca tgattgatgc atgatattac acttaaaatg caggagagta
     4501 caaaacaacc ttgatccaat agtttcctat tctggggggt gggggcagag gcggaaaaga
     4561 aaacacatct ttcacttact tattgaacaa acaataagca ctcagaacta atttatttat
     4621 gcaggttgca aatatgtatg aagcaatagg ttctggccac tgccacaatt tgaaatcaat
     4681 aaaataagaa atatatattt atatatgagg gaagatgctg tttgatagag catgtgaaat
     4741 caatggaaac atatttatta aaagtaaacc tcaccttttt caccaaatag taactagaga
     4801 actagtccta gtatcttgcg taattcttct ctgtcttcat tgggaaatta tgtttgaaaa
     4861 tctttcatca cctataaaat ggtgagcctc ttgtactttc tattcagtgt agaaagagtg
     4921 gactgataaa taactttaca ttgttggtag tagtttctac agatccagtt tattgcatgt
     4981 cgtatcttta ttgtagatat taaaaacaca tgataaaaat tgatgtgtgc ccctccttgt
     5041 ttggccagta tcacagaaaa ctttgtaaaa aagcatgggg accctactcc ctagattatt
     5101 tgagccattt actaaaattg gccattagtg atacagtgaa aacaagctaa ggaaatgata
     5161 ttctcctaaa aagttatatt ccagttttga ttattataac acagcacaat aaatgggcag
     5221 tatacgtcta atggaactga gatttaaggc tttaacaatt cgtgttttaa aatattatat
     5281 tgaagactgc acaaagagaa aattatacat gtttctccaa tcctgtgatc atgtctgtaa
     5341 ataccttgca atttcaaatt acttcatccg tcattaacta tatgatctcc caaacacagc
     5401 cttctcaaaa tcgataaaaa tttgccactg aatatgcatt aatagctata acaatgggtg
     5461 acatgccaca caaatttagc ttatgcaatt tatggggtgt gtgtttgcag actatgaaat
     5521 gtatgaagtg cagtctccca tggagagaat agagaggcag gatggcaact agtcatgaac
     5581 gcaacaattt aggttaaatg ataaagaata caatgaaatg tccagagtaa cacttggtct
     5641 ctacctttct aacattctaa cccaaggcca gtgtcatggg cttggctttc ttccctgtcg
     5701 cctcatactg agtatgcaat ttacagagga catctgttgc tttatgtctt aaggccacta
     5761 gaggaagtca ctacattccc aacaaagatg tgtctttcgg cttagtgaaa aacatttaac
     5821 aagaaacaat gtgtaaccaa gtccccacag taaaatgtgt cttcagaaac atgagaatca
     5881 cttttatata gccaacctca tttgaatttt atcatgaaca taaattatcg gtgagactgg
     5941 tgtgcggggc tggatctgtg agacaagctc acactctcat gtgtgcattc tctattaaca
     6001 tatttggaag attgcccaca ttttctctgc agacctgcca caaatcctta ccttcttact
     6061 gaagaatgtg actattgtag cattcgtgca attatgccag cagaggaggc actagacagt
     6121 ttatagactc ttatggaagt tgggcacatt tcccaggcag gtggaatgct agctagatct
     6181 agaagcaccc ttaaaggtca tgtagaatca aggtcccact ttatgtttcc cttgggagaa
     6241 aactgaaacc catggatgct gtaatttgtt taacggcaaa gaaagagcca agaattgttt
     6301 ctcgtagttc cagggtcctg atctaggaat gtttccttgg ctccatggca tctcccagtt
     6361 tgacatagtg ggagctgaga aatgccatat ggcctcaaaa taaataaacc cttgtacatt
     6421 taagtgtttt cccagatttt cagatgcctc tactcttgct gaactcatca ccagctgtat
     6481 cagtagagag gtgttatggg gcaattcatt agatttctgg taggtcatga atggttggta
     6541 taagctttat ttactcatat attgtcatcc agttctttga aattcaatct tatcctaaag
     6601 tggtagtcaa agtaaaacac attaagtagg tgtttgtgtt tagcagtcct actaattcat
     6661 cacaatcaca tagtaattgt gattataatt tttggaatct ttatcacttt ctagcacttt
     6721 acggtgtcat tatttatggc atttttaaca actttgttgc ataattgata acatcagggc
     6781 tacatttttt tcatgtgagc ctcaagaagc ttccattatc aacaagaatt ggggaaatga
     6841 cttttttaca ttataatacc ttatatatta ggtttttcct gataatcttc agtagacaat
     6901 gatttaaatt aactgaagtt taaataagaa atatgttaaa attactaaat aatatgaaaa
     6961 ccacattata cttgtaattt tcagacactt ttctcctacc ttaagatttt aacatcttgt
     7021 aaatattaat atttgaaggg gagaggaaaa atacatttgt agtagaaata ttccctctaa
     7081 caattctgtt taactagtaa gtttttttta agttatcttc catgcctgct tccctagtct
     7141 gaactccaca ttccagttgt cagaagaatg aatggattta aattttctaa tcattatttt
     7201 gggcccatgt tagcagttga aacaattaag ttcctcactc tttcctgctt ttaggatgat
     7261 tttagactgt gagcataaaa tcaacccttt ctgtcagcac agaattgaac atcgaatgga
     7321 gcaaggtcta cactctcagc ctgtagctgt gctaatgtta ggattgaatt gttctattaa
     7381 ttccctcaag agacccacag cctcaaaaga gttgcttatt atcagatgtc cgaaattcag
     7441 aaacccaaag tcaggcaaag aaggaaactg agataatgat ttaatttttt taagtcactg
     7501 caggatttct ctcaaagaaa acatctgaaa atggttgaga aagtagttcc agatcattaa
     7561 ctattttaca gagggactga aagccaggga aaataaagaa cagaatgata gtagtatctt
     7621 gatattaaat ttgcatcaga aatgagcaaa atatgtcaat atgaaataat ttgaaatcaa
     7681 attcagattc acatgtatag tgcatagttc aagaaataat gcttactctt gtaaaaaaaa
     7741 aaaatatata tatatgtatc agcaggtaga gtgtgggagc tccaactttg ttgtgaaagc
     7801 tgataacaga gtatgattct ttccagttac aaaatactgt attactttag ttatagcaag
     7861 cagtacataa atgacatcaa caactcaggc tgctccctga cataaaagcc agttccatct
     7921 ttactgcaga tgacaggaga ctttccaaga cctgcagagg ccccctccac cccaacctta
     7981 gtgcatgctc acacacacac acacacacac acacacacac acacacacac acatttttgg
     8041 cttttgaccc actctgtgtg ttccactgaa gttatctttt ccttaataga ttcacacaga
     8101 attaccccat cctgcaaaat ccttatccct atgaatctct aaaatatatt aaataatgtg
     8161 ttatatattt gctttttgta aatctttatt taattaattt atatatactt tgtgaagtct
     8221 tatactgtac atcataaagc gatgtcatct gtagttggtt caatataatg tttatgatca
     8281 ttttgataag aaataacttt ggacattagg cccttgttaa gaaataaaac acccattata
     8341 aatttgcttc tgttggaaaa tacatgattt ggcatacttc atttttagta acaatctatt
     8401 ctagataaat gataatttgg ggacatctgt acttaaaaac tagctgaact acgttttggg
     8461 atgagatgca aagcaacagc tgtccctgga actgaaatgt gaatttctag cagaacagaa
     8521 aatattataa taatgaggca ataataaaat taggaaatta aattattttt aaatctgtct
     8581 gtgtgatttt tccccttggt aaaaatacat gaaatacata attgaaaaat taccttcttc
     8641 tgaagtcgta gtttttaatc ttaaccatca ataaataaac ctattgttaa caatgtctta
     8701 ttcataattc taaaaaattt acaaatgata ttgctatgag gttgtgcact attaaagttt
     8761 gctccatcac ttaaaggtaa agcagttcaa aaatactact ttacatcaca actttgcatg
     8821 gctgagattt tgaacaacta aattgatggt tttacccaca agttatttca taaagctaac
     8881 actgtaatat tacttggttt tcttatactt ttgttatcat gtgatgaaat gtaactatgt
     8941 aattaaacaa aattctgaca atcatattct gctaatgttt aaaatgttac ttattccttc
     9001 acttattagc ttgctatttt gaaaataaag tgaaagaagg ccctttatta aatgaaa
//
