LOCUS       NM_018431               1965 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens docking protein 5 (DOK5), transcript variant 1, mRNA.
ACCESSION   NM_018431
VERSION     NM_018431.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1965)
  AUTHORS   Xu,L., Wu,J., Yu,Y., Li,H., Sun,S., Zhang,T. and Wang,M.
  TITLE     Dok5 regulates proliferation and differentiation of osteoblast via
            canonical Wnt/beta-catenin signaling
  JOURNAL   J Musculoskelet Neuronal Interact 22 (1), 113-122 (2022)
   PUBMED   35234166
  REMARK    GeneRIF: Dok5 regulates proliferation and differentiation of
            osteoblast via canonical Wnt/beta-catenin signaling.
REFERENCE   2  (bases 1 to 1965)
  AUTHORS   Luo,F., Wang,Z., Chen,S., Luo,Z., Wang,G., Yang,H. and Tang,L.
  TITLE     DOK5 as a Prognostic Biomarker of Gastric Cancer Immunoinvasion: A
            Bioinformatics Analysis
  JOURNAL   Biomed Res Int 2022, 9914778 (2022)
   PUBMED   35036444
  REMARK    GeneRIF: DOK5 as a Prognostic Biomarker of Gastric Cancer
            Immunoinvasion: A Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1965)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1965)
  AUTHORS   Yasuoka,H., Yamaguchi,Y. and Feghali-Bostwick,C.A.
  TITLE     The membrane-associated adaptor protein DOK5 is upregulated in
            systemic sclerosis and associated with IGFBP-5-induced fibrosis
  JOURNAL   PLoS One 9 (2), e87754 (2014)
   PUBMED   24551065
  REMARK    GeneRIF: IGFBP-5 induces its pro-fibrotic effects, at least in
            part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic
            sclerosis fibroblasts and tissues and may thus be acting in concert
            to promote fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1965)
  AUTHORS   Pan,Y., Zhang,J., Liu,W., Shu,P., Yin,B., Yuan,J., Qiang,B. and
            Peng,X.
  TITLE     Dok5 is involved in the signaling pathway of neurotrophin-3 against
            TrkC-induced apoptosis
  JOURNAL   Neurosci Lett 553, 46-51 (2013)
   PUBMED   23954828
REFERENCE   6  (bases 1 to 1965)
  AUTHORS   Shi,L., Yue,J., You,Y., Yin,B., Gong,Y., Xu,C., Qiang,B., Yuan,J.,
            Liu,Y. and Peng,X.
  TITLE     Dok5 is substrate of TrkB and TrkC receptors and involved in
            neurotrophin induced MAPK activation
  JOURNAL   Cell Signal 18 (11), 1995-2003 (2006)
   PUBMED   16647839
REFERENCE   7  (bases 1 to 1965)
  AUTHORS   Cai,D., Dhe-Paganon,S., Melendez,P.A., Lee,J. and Shoelson,S.E.
  TITLE     Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5
  JOURNAL   J Biol Chem 278 (28), 25323-25330 (2003)
   PUBMED   12730241
  REMARK    GeneRIF: IRS5/DOK4 and IRS6/DOK5 represent two new signaling
            proteins with potential roles in insulin and IGF-1 action
REFERENCE   8  (bases 1 to 1965)
  AUTHORS   Favre,C., Gerard,A., Clauzier,E., Pontarotti,P., Olive,D. and
            Nunes,J.A.
  TITLE     DOK4 and DOK5: new Dok-related genes expressed in human T cells
  JOURNAL   Genes Immun 4 (1), 40-45 (2003)
   PUBMED   12595900
  REMARK    GeneRIF: DOK5 expression in human T cells, its genomic structure
            characterized, and its regulation upon T cell activation has been
            demonstrated.
REFERENCE   9  (bases 1 to 1965)
  AUTHORS   Shi,N., Zhou,W., Tang,K., Gao,Y., Jin,J., Gao,F., Peng,X.,
            Bartlam,M., Qiang,B., Yuan,J. and Rao,Z.
  TITLE     Expression, crystallization and preliminary X-ray studies of the
            recombinant PTB domain of human dok-5 protein
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 12), 2170-2172 (2002)
   PUBMED   12454490
REFERENCE   10 (bases 1 to 1965)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA161365.1, AF466368.1,
            AF132732.1 and CN427887.1.
            
            On May 17, 2019 this sequence version replaced NM_018431.4.
            
            Summary: The protein encoded by this gene is a member of the DOK
            family of membrane proteins, which are adapter proteins involved in
            signal transduction. The encoded protein interacts with
            phosphorylated receptor tyrosine kinases to mediate neurite
            outgrowth and activation of the MAP kinase pathway. Unlike other
            DOK family proteins, this protein does not interact with RASGAP.
            This protein is up-regulated in patients with systemic sclerosis
            and is associated with fibrosis induced by insulin-like growth
            factor binding protein 5. Alternative splicing of this gene results
            in multiple transcript variants. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.679472.1,
                                           SRR7410570.679471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262593.10/ ENSP00000262593.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               DA161365.1         122-475
            355-1275            AF466368.1         1-921
            1276-1838           AF132732.1         1119-1681
            1839-1963           CN427887.1         289-413
            1964-1965           AF132732.1         1807-1808
FEATURES             Location/Qualifiers
     source          1..1965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..1965
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /note="docking protein 5"
                     /db_xref="GeneID:55816"
                     /db_xref="HGNC:HGNC:16173"
                     /db_xref="MIM:608334"
     exon            1..420
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1275
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /note="isoform a is encoded by transcript variant 1;
                     downstream of tyrosine kinase 5; insulin receptor
                     substrate 6"
                     /codon_start=1
                     /product="docking protein 5 isoform a"
                     /protein_id="NP_060901.2"
                     /db_xref="CCDS:CCDS13446.1"
                     /db_xref="GeneID:55816"
                     /db_xref="HGNC:HGNC:16173"
                     /db_xref="MIM:608334"
                     /translation="MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEK
                     FSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADE
                     WCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQIT
                     YEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEA
                     IYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQH
                     STGQLYRLQDVSSPLKLHRTETFPAYRSEH"
     exon            421..528
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            529..643
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            644..763
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            764..953
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1089
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1210
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1965
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /note="hexamer: AATAAA"
     polyA_site      1965
                     /gene="DOK5"
                     /gene_synonym="C20orf180; IRS-6; IRS6"
                     /note="major polyA site"
ORIGIN      
        1 cttcttctcc tccttctcgg ccgggaggag gcagggctgg atccctcagc cgccgccgct
       61 cctcctcctg gcaggccggc cgcggagtca gctgacgccg gcgctccagc ctcgcctccc
      121 cgcgccgcgc tctgcgctcc ccgaaagtgg ctgcaagccg gccgcccact gtcagggttg
      181 gggggacaga gaaagtgatg tgcgccttct aaagcctcgc ccagcgccgc cgaagcagct
      241 tcacctctcc aactttctcc caccgactgc ttgtcttgac cctgccctcc accctcccca
      301 gagccacttc gggtgcgcgc tcttgggtaa agggggggtc accggctgtc tgggatggct
      361 tccaatttta atgacatagt gaagcaaggg tacgtgagga tccggagcag acgcctcggg
      421 atttatcagc gatgctggtt agtattcaag aaagcttcaa gcaaaggtcc aaaaagactg
      481 gagaaatttt ctgatgaacg tgctgcatat ttcaggtgtt atcataaggt tacagaactc
      541 aataatgtga agaacgtagc tcgattgcca aaaagcacca agaaacatgc catagggatt
      601 tatttcaatg acgatacctc caagactttt gcttgcgaat cagatcttga ggctgatgag
      661 tggtgcaaag tactccagat ggagtgtgta ggaacacgga tcaatgacat cagccttgga
      721 gagcctgact tactggccac tggggttgag agagaacaga gtgagagatt caatgtgtat
      781 ttgatgccat ctcctaactt agatgtacat ggcgaatgtg ccttgcagat tacatatgag
      841 tatatctgtc tttgggacgt ccagaatccc agagtcaaac tcatctcttg gccgctaagc
      901 gccctgcggc ggtatggacg tgatactacg tggttcactt ttgaggcagg gaggatgtgt
      961 gagactggtg aagggctgtt tatctttcag acccgagacg gggaggccat ctatcagaaa
     1021 gtccactctg ctgccttggc catagccgag cagcacgagc gcttgctaca gagtgtgaaa
     1081 aactcgatgc tccagatgaa gatgagtgag cgggccgcct cgctgagcac catggtgccc
     1141 ctgcctcgca gcgcctactg gcagcacatc acacggcagc acagcacggg acagctctac
     1201 cgcttgcaag atgtttccag ccctctgaag cttcatcgaa cagagacttt tccagcctac
     1261 agatctgagc actgacagta actgccaaga attgttaaca cacttgtgat gtgtcagcca
     1321 cagattcacc caggaggtca cagaatgaca gcaagggaaa tgacgaccaa gagaagaagc
     1381 ttaaagtcct ggctaattgt gtggtcattg gaaaactctg caatacaata attttcttta
     1441 ttttcttttt cttttttaaa ttcttagtgt aattgaaacg tgctctatag atattgactc
     1501 tgtgttccct cttttacagc tggacagaaa gaagtcaatg tcacgaaatg attttctatt
     1561 gtagatactt tgtcccttgc acttctctga atctgtcctt ttgtggattc ttgtgatttt
     1621 ccttccaagt gtttcagttg tatgacagtc agtattgaca ataaaatggc ttttaattat
     1681 ttgttatttg tttacaccct attcctcagt tattattact gtggttctga ttaactactg
     1741 gaaattatat ttgattatat caccaattag ttaaatcagt gcttcgactc actcttatct
     1801 gttctgttca aaactatttg ttcaaagaac ccgttagtgt tgtttacagg gttacagttt
     1861 ctctcacatg ctttcctcac ccctttaccc ccctttttga aagcctttat tttgttcgga
     1921 gtctcttcat aaaacatttg aaaataaaag atcattcttc accca
//
