LOCUS       NM_018110               2806 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens docking protein 4 (DOK4), transcript variant 1, mRNA.
ACCESSION   NM_018110
VERSION     NM_018110.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2806)
  AUTHORS   Heidarizadi,A., Salimi,M. and Mozdarani,H.
  TITLE     Study of DOK4 gene expression and promoter methylation in sporadic
            breast cancer
  JOURNAL   Neoplasma 67 (4), 916-921 (2020)
   PUBMED   32386480
  REMARK    GeneRIF: Study of DOK4 gene expression and promoter methylation in
            sporadic breast cancer.
REFERENCE   2  (bases 1 to 2806)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2806)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2806)
  AUTHORS   Petko,J., Justice-Bitner,S., Jin,J., Wong,V., Kittanakom,S.,
            Ferraro,T.N., Stagljar,I. and Levenson,R.
  TITLE     MOR is not enough: identification of novel mu-opioid receptor
            interacting proteins using traditional and modified membrane yeast
            two-hybrid screens
  JOURNAL   PLoS One 8 (6), e67608 (2013)
   PUBMED   23840749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2806)
  AUTHORS   Hooker,E., Baldwin,C. and Lemay,S.
  TITLE     New insights into Dok-4 PTB domain structure and function
  JOURNAL   Biochem Biophys Res Commun 427 (1), 67-72 (2012)
   PUBMED   22982678
  REMARK    GeneRIF: the current study have explored in more detail the
            structure and function of the Dok-4 PTB domain.
REFERENCE   6  (bases 1 to 2806)
  AUTHORS   Jones,R.B., Gordus,A., Krall,J.A. and MacBeath,G.
  TITLE     A quantitative protein interaction network for the ErbB receptors
            using protein microarrays
  JOURNAL   Nature 439 (7073), 168-174 (2006)
   PUBMED   16273093
REFERENCE   7  (bases 1 to 2806)
  AUTHORS   Cai,D., Dhe-Paganon,S., Melendez,P.A., Lee,J. and Shoelson,S.E.
  TITLE     Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5
  JOURNAL   J Biol Chem 278 (28), 25323-25330 (2003)
   PUBMED   12730241
  REMARK    GeneRIF: IRS5/DOK4 and IRS6/DOK5 represent two new signaling
            proteins with potential roles in insulin and IGF-1 action
REFERENCE   8  (bases 1 to 2806)
  AUTHORS   Favre,C., Gerard,A., Clauzier,E., Pontarotti,P., Olive,D. and
            Nunes,J.A.
  TITLE     DOK4 and DOK5: new Dok-related genes expressed in human T cells
  JOURNAL   Genes Immun 4 (1), 40-45 (2003)
   PUBMED   12595900
  REMARK    GeneRIF: DOK4 expression in human T cells has been demonstrated,
            and its genomic structure has been predicted.
REFERENCE   9  (bases 1 to 2806)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
REFERENCE   10 (bases 1 to 2806)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009052.8.
            
            On Apr 13, 2019 this sequence version replaced NM_018110.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003541.1, DRR138524.770421.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340099.10/ ENSP00000344277.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC009052.8         184022-184210       c
            190-436             AC009052.8         177159-177405       c
            437-544             AC009052.8         173567-173674       c
            545-659             AC009052.8         173223-173337       c
            660-779             AC009052.8         172817-172936       c
            780-969             AC009052.8         172510-172699       c
            970-1108            AC009052.8         171618-171756       c
            1109-1232           AC009052.8         171330-171453       c
            1233-2806           AC009052.8         169639-171212       c
FEATURES             Location/Qualifiers
     source          1..2806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2806
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="docking protein 4"
                     /db_xref="GeneID:55715"
                     /db_xref="HGNC:HGNC:19868"
                     /db_xref="MIM:608333"
     exon            1..189
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            190..436
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1351
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downstream of tyrosine kinase 4; insulin receptor
                     substrate 5"
                     /codon_start=1
                     /product="docking protein 4 isoform 1"
                     /protein_id="NP_060580.2"
                     /db_xref="CCDS:CCDS10783.1"
                     /db_xref="GeneID:55715"
                     /db_xref="HGNC:HGNC:19868"
                     /db_xref="MIM:608333"
                     /translation="MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEK
                     YPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEE
                     WYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQIT
                     HENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQ
                     IYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITG
                     SQNIAEASSYAGEGYGAAQASSETDLLNRFILLKPKPSQGDSSEAKTPSQ"
     exon            437..544
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..659
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            660..779
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            780..969
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1108
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1232
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..2806
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2748..2753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="hexamer: AATAAA"
     polyA_site      2767
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="major polyA site"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="hexamer: AATAAA"
     polyA_site      2806
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
ORIGIN      
        1 ggagtcccag ccggagcccc agccggagcc cgatccctag ccctgcggcc gcgcctccct
       61 cgccgtcccc gcctggagcc cggcgccgcc gccgccctgc cgcccccgcc agccgcgccg
      121 tgacgcgggc atgagcctgc tccgcggcgc cgctgagcag gcgctcctgg cccgggcctc
      181 ggcgcccagc aggcgcgggg cgaaggagct gctagaacaa tgctgaggcg ggtgaggtga
      241 ggagcagccc ctcgcggcag ccccgacaga gtgtctggaa caggtgattg gaggagccgg
      301 agacccaggc acctgggcat ccttcccctc gcctctgcca ggccccgcgc ccctaaaagg
      361 tgggaaaacc atggcgacca atttcagtga catcgtcaag caaggctacg tgaagatgaa
      421 gagcaggaag ctcgggatct accggaggtg ctggctggtg ttccggaaat cctccagcaa
      481 ggggccccag cggctggaga agtatccaga tgagaagtcg gtgtgcctcc ggggctgccc
      541 caaggtgact gagatcagca acgtcaagtg tgttacgcgg ctccccaagg agaccaagcg
      601 gcaggcggtg gccatcatat tcactgatga ctcggcacgt accttcacct gcgactcaga
      661 gctagaggca gaggagtggt acaagacact atctgtggag tgtctggggt cccgcctcaa
      721 cgacatcagt ctgggagaac ctgacctcct ggccccaggg gtgcagtgtg aacagacaga
      781 tcgcttcaat gtcttcctgc tgccctgccc caacctggac gtgtatggcg agtgcaagct
      841 gcagatcacc cacgagaaca tctacctctg ggacatccac aacccccgtg tgaagctcgt
      901 ctcgtggccc ctctgctcac tgcgccgcta tggccgggat gccacacgct ttaccttcga
      961 ggctggccgg atgtgtgatg ctggggaagg actctatacc ttccagacac aagaggggga
     1021 gcagatttac cagcgcgtcc acagtgccac cctggccatc gcagagcagc acaagcgggt
     1081 cctgctggaa atggagaaga acgtgaggct gctgaacaag ggcacggaac attactcgta
     1141 tccctgcaca cccacgacca tgctgccgcg cagtgcctac tggcaccaca tcactggttc
     1201 ccagaacatc gccgaagcct ccagctatgc tggtgagggg tatggggcag cccaggccag
     1261 ctcggaaaca gacctcctca acagattcat cctgctaaag ccaaagccca gccaggggga
     1321 cagcagtgag gccaagaccc catcccagtg accacagtgc tggcgagcac cgatgactgc
     1381 tgggggctgc ctgctgcggg gctggctgca gtgtaccgtg gacagcctca gggggctgtc
     1441 ggccaagagc ctggagaaag ggagcaagct gccccctcct tgcccccaag gatgaggctg
     1501 gactgaggca aagggctggc cacaccacct gagcatgtgt gaggggttgg agctaccgtg
     1561 ggactatata ctgttaatga ttttaatata tatggcttat gacatactct gtatcaatga
     1621 gatcccctca ccctcacccc atccttcccc accaatacac acaaattttt taatcccatg
     1681 accaggccac ggtcaaggct gtttttgagt atgagtgcag tcgtgtccat cctccatggc
     1741 acagccctcc tgctgccagg acctgcttga actaccaggg ccacaggagg gggataatca
     1801 gagcttgagg ctggcactct gactgctggc ttttcccaga cagcccaagg gccggaacag
     1861 caggtggctt ctcagttcct ctgggcctgg agtgacacag gaaggatctg cacttcctct
     1921 gtgctgcttg ccagccttgc agttggagtt ttaagcagag gtgacatctg gttgacgcct
     1981 caggtgaaaa tctggtttta aaatgtaact tctgcacagg ctccttcctg ctttgtaggc
     2041 tgggaagatg cccctggggt aggggtgctg attacctcag ccatgtggag gaaggctgga
     2101 gcttgttcct gccccaggaa taggccagga gggaaggccg cagcaggact gccgtgggga
     2161 gcacccctgc tgcccccctc tcactgacca ggggtggaca atgcccaagc agagggagcc
     2221 cccttgccct gtttggccac cctctggcca gccaaaagca ctctgaaacc aagaccttcc
     2281 catttcctcc tccccacatg gtgctgaggc tccctgctgc aatgcaatta aagcaattga
     2341 ttttctagtg ctggtatttg ttgactacca tgcagaaggg ctatctttct attcacgtca
     2401 aacttttggt tgtgtggggt tttttgttgt tttttgggtt ttgtttttta atactttagg
     2461 gtcctgattt gtgggaacag accttcttgt aaataaccac tatttgagtt gtggcaggag
     2521 gatgataaag cacgcggccc ctcccaaagg agcccttgag ctagggaggt ggtgcagtca
     2581 gcctcgctct caacgtgacc cggggaatga ccacccagag ggatgagcta gcctgtagag
     2641 gggaactggg gtccaaaggt ctttggggag ggaggcagag ctggctggct cagctaagtg
     2701 gcacgatgac gcatgaagga gattatgttg tgctctttat tgccaaaaat aaacactttt
     2761 aaaaagacaa cttctgttaa tcaataaata tcctttcctt tctgta
//
