LOCUS       NM_001394655            2826 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens docking protein 4 (DOK4), transcript variant 10, mRNA.
ACCESSION   NM_001394655
VERSION     NM_001394655.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Heidarizadi,A., Salimi,M. and Mozdarani,H.
  TITLE     Study of DOK4 gene expression and promoter methylation in sporadic
            breast cancer
  JOURNAL   Neoplasma 67 (4), 916-921 (2020)
   PUBMED   32386480
  REMARK    GeneRIF: Study of DOK4 gene expression and promoter methylation in
            sporadic breast cancer.
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Petko,J., Justice-Bitner,S., Jin,J., Wong,V., Kittanakom,S.,
            Ferraro,T.N., Stagljar,I. and Levenson,R.
  TITLE     MOR is not enough: identification of novel mu-opioid receptor
            interacting proteins using traditional and modified membrane yeast
            two-hybrid screens
  JOURNAL   PLoS One 8 (6), e67608 (2013)
   PUBMED   23840749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Hooker,E., Baldwin,C. and Lemay,S.
  TITLE     New insights into Dok-4 PTB domain structure and function
  JOURNAL   Biochem Biophys Res Commun 427 (1), 67-72 (2012)
   PUBMED   22982678
  REMARK    GeneRIF: the current study have explored in more detail the
            structure and function of the Dok-4 PTB domain.
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Jones,R.B., Gordus,A., Krall,J.A. and MacBeath,G.
  TITLE     A quantitative protein interaction network for the ErbB receptors
            using protein microarrays
  JOURNAL   Nature 439 (7073), 168-174 (2006)
   PUBMED   16273093
REFERENCE   7  (bases 1 to 2826)
  AUTHORS   Cai,D., Dhe-Paganon,S., Melendez,P.A., Lee,J. and Shoelson,S.E.
  TITLE     Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5
  JOURNAL   J Biol Chem 278 (28), 25323-25330 (2003)
   PUBMED   12730241
  REMARK    GeneRIF: IRS5/DOK4 and IRS6/DOK5 represent two new signaling
            proteins with potential roles in insulin and IGF-1 action
REFERENCE   8  (bases 1 to 2826)
  AUTHORS   Favre,C., Gerard,A., Clauzier,E., Pontarotti,P., Olive,D. and
            Nunes,J.A.
  TITLE     DOK4 and DOK5: new Dok-related genes expressed in human T cells
  JOURNAL   Genes Immun 4 (1), 40-45 (2003)
   PUBMED   12595900
  REMARK    GeneRIF: DOK4 expression in human T cells has been demonstrated,
            and its genomic structure has been predicted.
REFERENCE   9  (bases 1 to 2826)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
REFERENCE   10 (bases 1 to 2826)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009052.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1452617.1,
                                           SRR14038192.3165751.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC009052.8         178012-178106       c
            96-339              AC009052.8         177159-177402       c
            340-447             AC009052.8         173567-173674       c
            448-562             AC009052.8         173223-173337       c
            563-682             AC009052.8         172817-172936       c
            683-872             AC009052.8         172510-172699       c
            873-1011            AC009052.8         171618-171756       c
            1012-2826           AC009052.8         169639-171453       c
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2826
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="docking protein 4"
                     /db_xref="GeneID:55715"
                     /db_xref="HGNC:HGNC:19868"
                     /db_xref="MIM:608333"
     exon            1..95
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            96..339
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1371
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="isoform 2 is encoded by transcript variant 10;
                     downstream of tyrosine kinase 4; insulin receptor
                     substrate 5"
                     /codon_start=1
                     /product="docking protein 4 isoform 2"
                     /protein_id="NP_001381584.1"
                     /db_xref="CCDS:CCDS81986.1"
                     /db_xref="GeneID:55715"
                     /db_xref="HGNC:HGNC:19868"
                     /db_xref="MIM:608333"
                     /translation="MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEK
                     YPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEE
                     WYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQIT
                     HENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQ
                     IYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITG
                     SQNIAEASSYAGESLPCPTPTCQEALWRMRPIGQGSFDLALSSEPASVPTGEGYGAAQ
                     ASSETDLLNRFILLKPKPSQGDSSEAKTPSQ"
     exon            340..447
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..562
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            563..682
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            683..872
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1011
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2826
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2768..2773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="hexamer: AATAAA"
     polyA_site      2787
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="major polyA site"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
                     /note="hexamer: AATAAA"
     polyA_site      2826
                     /gene="DOK4"
                     /gene_synonym="IRS-5; IRS5"
ORIGIN      
        1 acccagagct gcgtgcggaa gagttgcagg gcctgggaac aggccctgcg tgagctcgag
       61 gtagtgattc ttagcctggg gctggagaga aacaggcgcg gggcgaagga gctgctagaa
      121 caatgctgag gcgggtgagg tgaggagcag cccctcgcgg cagccccgac agagtgtctg
      181 gaacaggtga ttggaggagc cggagaccca ggcacctggg catccttccc ctcgcctctg
      241 ccaggccccg cgcccctaaa aggtgggaaa accatggcga ccaatttcag tgacatcgtc
      301 aagcaaggct acgtgaagat gaagagcagg aagctcggga tctaccggag gtgctggctg
      361 gtgttccgga aatcctccag caaggggccc cagcggctgg agaagtatcc agatgagaag
      421 tcggtgtgcc tccggggctg ccccaaggtg actgagatca gcaacgtcaa gtgtgttacg
      481 cggctcccca aggagaccaa gcggcaggcg gtggccatca tattcactga tgactcggca
      541 cgtaccttca cctgcgactc agagctagag gcagaggagt ggtacaagac actatctgtg
      601 gagtgtctgg ggtcccgcct caacgacatc agtctgggag aacctgacct cctggcccca
      661 ggggtgcagt gtgaacagac agatcgcttc aatgtcttcc tgctgccctg ccccaacctg
      721 gacgtgtatg gcgagtgcaa gctgcagatc acccacgaga acatctacct ctgggacatc
      781 cacaaccccc gtgtgaagct cgtctcgtgg cccctctgct cactgcgccg ctatggccgg
      841 gatgccacac gctttacctt cgaggctggc cggatgtgtg atgctgggga aggactctat
      901 accttccaga cacaagaggg ggagcagatt taccagcgcg tccacagtgc caccctggcc
      961 atcgcagagc agcacaagcg ggtcctgctg gaaatggaga agaacgtgag gctgctgaac
     1021 aagggcacgg aacattactc gtatccctgc acacccacga ccatgctgcc gcgcagtgcc
     1081 tactggcacc acatcactgg ttcccagaac atcgccgaag cctccagcta tgctggtgag
     1141 tcgcttccat gccccacacc cacctgccag gaggctttgt ggaggatgag gcctattggg
     1201 caggggtctt ttgacctagc tctgagttct gagcctgctt ctgtgcccac aggtgagggg
     1261 tatggggcag cccaggccag ctcggaaaca gacctcctca acagattcat cctgctaaag
     1321 ccaaagccca gccaggggga cagcagtgag gccaagaccc catcccagtg accacagtgc
     1381 tggcgagcac cgatgactgc tgggggctgc ctgctgcggg gctggctgca gtgtaccgtg
     1441 gacagcctca gggggctgtc ggccaagagc ctggagaaag ggagcaagct gccccctcct
     1501 tgcccccaag gatgaggctg gactgaggca aagggctggc cacaccacct gagcatgtgt
     1561 gaggggttgg agctaccgtg ggactatata ctgttaatga ttttaatata tatggcttat
     1621 gacatactct gtatcaatga gatcccctca ccctcacccc atccttcccc accaatacac
     1681 acaaattttt taatcccatg accaggccac ggtcaaggct gtttttgagt atgagtgcag
     1741 tcgtgtccat cctccatggc acagccctcc tgctgccagg acctgcttga actaccaggg
     1801 ccacaggagg gggataatca gagcttgagg ctggcactct gactgctggc ttttcccaga
     1861 cagcccaagg gccggaacag caggtggctt ctcagttcct ctgggcctgg agtgacacag
     1921 gaaggatctg cacttcctct gtgctgcttg ccagccttgc agttggagtt ttaagcagag
     1981 gtgacatctg gttgacgcct caggtgaaaa tctggtttta aaatgtaact tctgcacagg
     2041 ctccttcctg ctttgtaggc tgggaagatg cccctggggt aggggtgctg attacctcag
     2101 ccatgtggag gaaggctgga gcttgttcct gccccaggaa taggccagga gggaaggccg
     2161 cagcaggact gccgtgggga gcacccctgc tgcccccctc tcactgacca ggggtggaca
     2221 atgcccaagc agagggagcc cccttgccct gtttggccac cctctggcca gccaaaagca
     2281 ctctgaaacc aagaccttcc catttcctcc tccccacatg gtgctgaggc tccctgctgc
     2341 aatgcaatta aagcaattga ttttctagtg ctggtatttg ttgactacca tgcagaaggg
     2401 ctatctttct attcacgtca aacttttggt tgtgtggggt tttttgttgt tttttgggtt
     2461 ttgtttttta atactttagg gtcctgattt gtgggaacag accttcttgt aaataaccac
     2521 tatttgagtt gtggcaggag gatgataaag cacgcggccc ctcccaaagg agcccttgag
     2581 ctagggaggt ggtgcagtca gcctcgctct caacgtgacc cggggaatga ccacccagag
     2641 ggatgagcta gcctgtagag gggaactggg gtccaaaggt ctttggggag ggaggcagag
     2701 ctggctggct cagctaagtg gcacgatgac gcatgaagga gattatgttg tgctctttat
     2761 tgccaaaaat aaacactttt aaaaagacaa cttctgttaa tcaataaata tcctttcctt
     2821 tctgta
//
