LOCUS       NM_001308236            3588 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens docking protein 3 (DOK3), transcript variant 5, mRNA.
ACCESSION   NM_001308236 XM_005265984
VERSION     NM_001308236.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Loh,J.T., Teo,J.K.H., Kannan,S., Verma,C.S., Andiappan,A.K.,
            Lim,H.H. and Lam,K.P.
  TITLE     DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to
            inhibit the T cell signaling mediator CARD11
  JOURNAL   Sci Signal 16 (809), eadg5171 (2023)
   PUBMED   37906628
  REMARK    GeneRIF: DOK3 promotes atopic dermatitis by enabling the
            phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
REFERENCE   2  (bases 1 to 3588)
  AUTHORS   Wang,Y.F., Hu,Y.Q., Hu,Y.N., Bai,Y.C., Wang,H. and Zhang,Q.
  TITLE     Expression and clinical significance of DOK3 in renal clear cell
            carcinoma
  JOURNAL   J Int Med Res 51 (5), 3000605231174974 (2023)
   PUBMED   37235715
  REMARK    GeneRIF: Expression and clinical significance of DOK3 in renal
            clear cell carcinoma.
REFERENCE   3  (bases 1 to 3588)
  AUTHORS   Li,C.X., Su,Y., Gong,Z.C. and Liu,H.
  TITLE     Porphyromonas gingivalis Activation of Tumor-Associated Macrophages
            via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 28, e937126 (2022)
   PUBMED   36210538
  REMARK    GeneRIF: Porphyromonas gingivalis Activation of Tumor-Associated
            Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3588)
  AUTHORS   Loh,J.T., Teo,J.K.H. and Lam,K.P.
  TITLE     Dok3 restrains neutrophil production of calprotectin during TLR4
            sensing of SARS-CoV-2 spike protein
  JOURNAL   Front Immunol 13, 996637 (2022)
   PUBMED   36172386
  REMARK    GeneRIF: Dok3 restrains neutrophil production of calprotectin
            during TLR4 sensing of SARS-CoV-2 spike protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3588)
  AUTHORS   Honma,M., Higuchi,O., Shirakata,M., Yasuda,T., Shibuya,H.,
            Iemura,S., Natsume,T. and Yamanashi,Y.
  TITLE     Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream
            of protein-tyrosine kinases
  JOURNAL   Genes Cells 11 (2), 143-151 (2006)
   PUBMED   16436051
  REMARK    GeneRIF: findings indicate that Dok-3 sequesters Grb2 from Shc and
            inhibits the Ras-Erk pathway downstream of PTKs
REFERENCE   6  (bases 1 to 3588)
  AUTHORS   Robson,J.D., Davidson,D. and Veillette,A.
  TITLE     Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1,
            a lipid phosphatase that interacts with the adaptor molecule Dok-3
  JOURNAL   Mol Cell Biol 24 (6), 2332-2343 (2004)
   PUBMED   14993273
REFERENCE   7  (bases 1 to 3588)
  AUTHORS   Favre,C., Gerard,A., Clauzier,E., Pontarotti,P., Olive,D. and
            Nunes,J.A.
  TITLE     DOK4 and DOK5: new Dok-related genes expressed in human T cells
  JOURNAL   Genes Immun 4 (1), 40-45 (2003)
   PUBMED   12595900
REFERENCE   8  (bases 1 to 3588)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
REFERENCE   9  (bases 1 to 3588)
  AUTHORS   Lemay,S., Davidson,D., Latour,S. and Veillette,A.
  TITLE     Dok-3, a novel adapter molecule involved in the negative regulation
            of immunoreceptor signaling
  JOURNAL   Mol Cell Biol 20 (8), 2743-2754 (2000)
   PUBMED   10733577
REFERENCE   10 (bases 1 to 3588)
  AUTHORS   Cong,F., Yuan,B. and Goff,S.P.
  TITLE     Characterization of a novel member of the DOK family that binds and
            modulates Abl signaling
  JOURNAL   Mol Cell Biol 19 (12), 8314-8325 (1999)
   PUBMED   10567556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145098.2.
            
            On Jun 1, 2020 this sequence version replaced NM_001308236.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2717448.1,
                                           SRR14038194.654016.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000510898.7/ ENSP00000424726.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC145098.2         146938-147006       c
            70-252              AC145098.2         146655-146837       c
            253-558             AC145098.2         145417-145722       c
            559-658             AC145098.2         142191-142290       c
            659-831             AC145098.2         141923-142095       c
            832-3588            AC145098.2         139084-141840       c
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3588
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /note="docking protein 3"
                     /db_xref="GeneID:79930"
                     /db_xref="HGNC:HGNC:24583"
                     /db_xref="MIM:611435"
     exon            1..69
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     exon            70..252
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1509
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /note="isoform 1 is encoded by transcript variant 5;
                     Dok-like protein; downstream of tyrosine kinase 3"
                     /codon_start=1
                     /product="docking protein 3 isoform 1"
                     /protein_id="NP_001295165.1"
                     /db_xref="CCDS:CCDS78098.1"
                     /db_xref="GeneID:79930"
                     /db_xref="HGNC:HGNC:24583"
                     /db_xref="MIM:611435"
                     /translation="MDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLE
                     SWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTER
                     SHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGE
                     FPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVF
                     SFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLP
                     SLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASG
                     PPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDST
                     LEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP"
     exon            253..558
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     exon            559..658
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     exon            659..831
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     exon            832..3588
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3566..3571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /note="hexamer: AATAAA"
     polyA_site      3588
                     /gene="DOK3"
                     /gene_synonym="DOKL"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgcgt gcccagctga accaggtgcg tgagaaggct gccttcaggt ggccgggggc
       61 tccctccagc tgtctctaga cggagggacg ggaagtggcc agaaggggaa gtgtgaggag
      121 ttcccgtcca gcctgtcatc agtctcccca ggtcttgaag cggcggccct gctcctggcc
      181 gtgaccatgg accctctgga gacccctatc aaggatggca tcctctacca gcagcatgtc
      241 aagtttggca agaagtgctg gcggaaggtg tgggctctgc tgtatgcagg aggcccatca
      301 ggcgtggcac ggctggagag ctgggaggtc cgggatggtg gcctgggagc agcgggtgac
      361 aggtcggcag ggcctggccg gcgaggggag cgacgggtca tccgcctggc tgactgtgtg
      421 tccgtgctgc cggctgacgg cgagagctgc ccccgggaca ccggtgcctt cctgctcacc
      481 accaccgagc gaagccatct actggctgct cagcaccgcc aggcctggat gggccccatc
      541 tgccagctgg ccttcccggg gacaggggag gcctcctcag gatccacaga tgcccagtct
      601 cccaagaggg gcctggtccc catggaggaa aactccatct actcctcctg gcaggaagtg
      661 ggcgagtttc ccgtggtggt gcagaggact gaggccgcca cccgctgcca gctgaagggg
      721 ccggccctgc tggtgctggg cccagacgcc atccagctga gggaggccaa gggcacccag
      781 gccctctaca gctggcccta ccacttcctg cgcaagttcg gctccgacaa gggcgtgttc
      841 tcctttgagg ccggccgtcg ctgccactcg ggtgagggcc tctttgcctt cagcaccccc
      901 tgtgcccctg acctgtgcag ggctgtggcc ggggccatcg cccgccagcg ggagcggctg
      961 ccagagctga ccaggcccca gccctgcccc ctgccacggg ccacctctct gccctccctg
     1021 gacacccccg gagagcttcg ggagatgcca ccaggacctg agccacccac gtccaggaaa
     1081 atgcacctgg ccgagcccgg accccagagc ctgccgctac tgctaggccc ggagcccaac
     1141 gatctggcgt ccgggctcta cgcttcagtg tgcaagcgtg ccagtgggcc cccaggcaat
     1201 gagcacctct atgagaacct gtgtgtgctg gaggccagcc ccacgctgca cggtggggaa
     1261 cctgagccgc acgagggccc cggcagccgc agccccacaa ccagtcccat ctaccacaac
     1321 ggccaggact tgagctggcc cggcccggcc aacgacagta ccctggaggc ccagtaccgg
     1381 cggctgctgg agctggatca ggtggagggc acaggccgcc ctgaccctca ggcaggtttc
     1441 aaggccaagc tggtgaccct gctgagtcgt gagcggagga agggcccagc cccttgtgac
     1501 cggccctgaa cgcccagcag agtggtggcc agaggggaga ggtgctcccc ctgggacagg
     1561 agggtgggct ggtgggcaaa cattgggccc atgcagacac acgcctgtgt ccaccctggc
     1621 ctgcaggaac aaggcaggcc gcctgtggag gacctcagcc ctgccctgcc ctcctcatga
     1681 atagtgtgca gactcacaga taataaagct cagagcagct cccggcaggg gcactcacgg
     1741 cacacgcccc tgcccacgtt cattgcggcc aacacaagca ccctgtgccg gttccagggg
     1801 cacaggtgac ctgggcctta cctgccaccc gtgggctcaa acccactgca gcagacagac
     1861 gggatggaaa tcattaggac tccatgttgc tctgcacggc cgagtgacac gaagaggcag
     1921 gcggagggag ctgtgaggct tacttgtcag actcaggaag gagcaacatg agggcccaac
     1981 tggagacccg gaggcccgag ctgggaggag gcagtggggg cggggtgcag gtggaaggga
     2041 tttcagagac accctcgtcc aaaacacttg ttccctgctg aaactccaac aatttgcaga
     2101 tacttctggg aaccccaggc gtcagtctcc tcatctgtaa aggagagaga accgatgacg
     2161 tatcaggcat aatccttgat gagagtttgc tgcgtgccta ctcagtgcca ggcgctgggg
     2221 gacacagccg tgttcaggac agccttggtc ctgttctccg ggagccgaca ttccaggggg
     2281 agagaagttt cctgaagact tccatgctgc gttccctcct ctgctcctgc tcctggcgcc
     2341 atcctaggag ccagccacgc acgcaagcgt catgcctcca gggctctgac tgcccagccc
     2401 ctcaccgcaa ctccacctca gctgcacaca cccttggcac atcctgaacc tcattttcat
     2461 gacggacaca caatttttgc tctctcctgt ccaagcctca tcctctggcc gccacctcct
     2521 tccagctcac ttcctttagt gcggccagta ccgcccctgc ctaggcatgt cgacctgcag
     2581 ggaccctttt ctggctcttc gaggcctctg cccaccatcc cctctttgtt ctccatagtc
     2641 ccttccccct gttctctctc gtttcatctt actggtctgg caaagtcccc ggccttgggc
     2701 gagcccagac ctcctcagtg cctgcacaca gctgcccaca gccagagaaa tccatttaag
     2761 cagactgcct gcatccttct taacagtgca aggcaggcac tccctgccac aagagaccct
     2821 gttccctagt agggcagctt ttctcctccc cagaacctcc tgtctatccc cacccaatgt
     2881 ctcctcacag gcatattggg gaaacaggtc gggctctccc accgtatctg caagtgtact
     2941 ggcatccatc tgtcttcttc ctacccctac agtagaaaca gtgtctgtcc ccagctgtgc
     3001 tctgatcccg gctcctttca cctcagagct tggaaaattg agctgtcccc actctctcct
     3061 gcgcccattc atcctaccag cagcttttcc agccacacgc aaacatgctc tgtaatttca
     3121 cattttaaac cttcccttga cctcacattc ctcttcggcc acctctgttt ctctgttcct
     3181 cttcacagca aaaactgttc aaaagagttg ttgattactt tcatttccac tttctcaccc
     3241 ccattctccc ctcaattaac tctccttcat ccccatgatg ccattatgtg gcttttatta
     3301 gagtcaccaa ccttattctc caaaacaaaa gcaacaagga ctttgacttc tcagcagcac
     3361 tcggctctgg ttcttgaaac acccccgtta cttgctattc ctcctacctc ataacaatct
     3421 ccttcccagc ctctactgct gccttctctg agttcttccc agggtcctag gctcagatgt
     3481 agtgtagctc aaccctgcta cacaaagaat ctcctgaaag cctgtaaaaa tgtccatgca
     3541 tgttctgtga gtgatctacc aagaaaataa aaaattttaa aaatcaaa
//
