LOCUS       NM_003974               1766 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens docking protein 2 (DOK2), transcript variant 1, mRNA.
ACCESSION   NM_003974
VERSION     NM_003974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1766)
  AUTHORS   Sun,P., Li,R., Meng,Y., Xi,S., Wang,Q., Yang,X., Peng,X. and Cai,J.
  TITLE     Introduction to DOK2 and its potential role in cancer
  JOURNAL   Physiol Res 70 (5), 671-685 (2021)
   PUBMED   34505522
  REMARK    GeneRIF: Introduction to DOK2 and its potential role in cancer.
            Review article
REFERENCE   2  (bases 1 to 1766)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1766)
  AUTHORS   He,P.F., Xu,Z.J., Zhou,J.D., Li,X.X., Zhang,W., Wu,D.H.,
            Zhang,Z.H., Lian,X.Y., Yao,X.Y., Deng,Z.Q., Lin,J. and Qian,J.
  TITLE     Methylation-associated DOK1 and DOK2 down-regulation: Potential
            biomarkers for predicting adverse prognosis in acute myeloid
            leukemia
  JOURNAL   J Cell Physiol 233 (9), 6604-6614 (2018)
   PUBMED   29150948
  REMARK    GeneRIF: Decreased DOK1/2 expressions associated with their
            promoter hypermethylations predict adverse prognosis in AML.
REFERENCE   4  (bases 1 to 1766)
  AUTHORS   Deshpande,R.P., Chandra Sekhar,Y.B.V.K., Panigrahi,M. and Babu,P.P.
  TITLE     Region-Specific Dok2 Overexpression Associates with Poor Prognosis
            in Human Astrocytoma
  JOURNAL   Mol Neurobiol 55 (1), 402-408 (2018)
   PUBMED   27975172
  REMARK    GeneRIF: DOK2 overexpression in different brain regions is
            associated with poor prognosis in astrocytoma clinical cases.
REFERENCE   5  (bases 1 to 1766)
  AUTHORS   Lahmidi,S., Strunk,U., Smiley,J.R., Pearson,A. and Duplay,P.
  TITLE     Herpes simplex virus 1 infection of T cells causes
            VP11/12-dependent phosphorylation and degradation of the cellular
            protein Dok-2
  JOURNAL   Virology 511, 66-73 (2017)
   PUBMED   28841444
  REMARK    GeneRIF: In this report, the authors demonstrated that the cellular
            adaptor proteins Dok-2 and Dok-1 are tyrosine phosphorylated upon
            herpes simplex virus 1 infection. In addition, herpes simplex virus
            1 induced the selective degradation of Dok-2. Finally, Dok-2
            interacts with herpes simplex virus 1 VP11/12, and that herpes
            simplex virus 1-induced tyrosine phosphorylation and degradation of
            Dok-2 require VP11/12.
REFERENCE   6  (bases 1 to 1766)
  AUTHORS   Nemorin,J.G. and Duplay,P.
  TITLE     Evidence that Llck-mediated phosphorylation of p56dok and p62dok
            may play a role in CD2 signaling
  JOURNAL   J Biol Chem 275 (19), 14590-14597 (2000)
   PUBMED   10799545
REFERENCE   7  (bases 1 to 1766)
  AUTHORS   Dunant,N.M., Wisniewski,D., Strife,A., Clarkson,B. and Resh,M.D.
  TITLE     The phosphatidylinositol polyphosphate 5-phosphatase SHIP1
            associates with the dok1 phosphoprotein in bcr-Abl transformed
            cells
  JOURNAL   Cell Signal 12 (5), 317-326 (2000)
   PUBMED   10822173
REFERENCE   8  (bases 1 to 1766)
  AUTHORS   Jones,N. and Dumont,D.J.
  TITLE     Recruitment of Dok-R to the EGF receptor through its PTB domain is
            required for attenuation of Erk MAP kinase activation
  JOURNAL   Curr Biol 9 (18), 1057-1060 (1999)
   PUBMED   10508618
REFERENCE   9  (bases 1 to 1766)
  AUTHORS   Jones,N. and Dumont,D.J.
  TITLE     The Tek/Tie2 receptor signals through a novel Dok-related docking
            protein, Dok-R
  JOURNAL   Oncogene 17 (9), 1097-1108 (1998)
   PUBMED   9764820
REFERENCE   10 (bases 1 to 1766)
  AUTHORS   Di Cristofano,A., Carpino,N., Dunant,N., Friedland,G.,
            Kobayashi,R., Strife,A., Wisniewski,D., Clarkson,B., Pandolfi,P.P.
            and Resh,M.D.
  TITLE     Molecular cloning and characterization of p56dok-2 defines a new
            family of RasGAP-binding proteins
  JOURNAL   J Biol Chem 273 (9), 4827-4830 (1998)
   PUBMED   9478921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC295259.1, BC032623.1 and AK226110.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003974.3.
            
            Summary: The protein encoded by this gene is constitutively
            tyrosine phosphorylated in hematopoietic progenitors isolated from
            chronic myelogenous leukemia (CML) patients in the chronic phase.
            It may be a critical substrate for p210(bcr/abl), a chimeric
            protein whose presence is associated with CML. This encoded protein
            binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032623.1, SRR1163658.407181.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276420.9/ ENSP00000276420.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DC295259.1         19-32
            15-874              BC032623.1         1-860
            875-1766            AK226110.1         493-1384
FEATURES             Location/Qualifiers
     source          1..1766
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1766
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /note="docking protein 2"
                     /db_xref="GeneID:9046"
                     /db_xref="HGNC:HGNC:2991"
                     /db_xref="MIM:604997"
     exon            1..152
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1328
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /note="isoform a is encoded by transcript variant 1;
                     p56(dok-2); downstream of tyrosine kinase 2; docking
                     protein 2, 56kD; docking protein 2, 56kDa"
                     /codon_start=1
                     /product="docking protein 2 isoform a"
                     /protein_id="NP_003965.2"
                     /db_xref="CCDS:CCDS6016.1"
                     /db_xref="GeneID:9046"
                     /db_xref="HGNC:HGNC:2991"
                     /db_xref="MIM:604997"
                     /translation="MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQ
                     EGPEKPRRCEAARKVIRLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAER
                     GDWVQAICLLAFPGQRKELSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEA
                     SERCHLRGSYTLRAGESALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCV
                     SGEGNFEFETRQGNEIFLALEEAISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHD
                     SLPPPSPTTPVPAPRPRGQEGEYAVPFDAVARSLGKNFRGILAVPPQLLADPLYDSIE
                     ETLPPRPDHIYDEPEGVAALSLYDSPQEPRGEAWRRQATADRDPAGLQHVQPAGQDFS
                     ASGWQPGTEYDNVVLKKGPK"
     exon            153..434
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..522
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..707
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1766
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1747..1752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1766
                     /gene="DOK2"
                     /gene_synonym="p56DOK; p56dok-2"
                     /note="major polyA site"
ORIGIN      
        1 agagaaggga aacacacggc taagaagaga gaggcaaggg caggagtgaa ggagagagct
       61 gaagcctggg gctccgagat ggtcagagga tgggagacgg ggcagtgaaa caaggcttct
      121 tgtatcttca gcagcagcag acgtttggaa agaaatggcg ccgcttcggc gcctcactgt
      181 atggagggtc ggactgcgcc ttggcccggc tggagctgca ggagggcccg gagaagcctc
      241 gtcggtgtga ggctgcccgg aaggtcatcc gcctcagtga ctgcctgcgg gtggccgagg
      301 ccggcggaga ggccagcagc ccccgggaca ccagtgcctt cttcctggag accaaggagc
      361 gcctgtacct cctggcggcc cctgcagcgg agcgcggcga ctgggtgcag gccatctgcc
      421 tcctggcctt ccccgggcag aggaaggagc tctcggggcc agagggaaag cagagccggc
      481 cctgcatgga ggaaaatgaa ttgtacagca gcgcagtcac agtcggcccc cacaaggaat
      541 ttgctgtgac catgagacct acagaagcca gtgagaggtg ccacctgcgg gggtcctata
      601 ccctccgggc tggggagagt gccctggagc tgtggggtgg gcccgagcca gggacccagc
      661 tgtacgactg gccctacagg tttctgcggc gctttgggcg ggacaaggta accttttcct
      721 ttgaggcagg ccgtcgctgc gtctctggag agggcaactt tgagttcgaa acccggcaag
      781 gcaatgagat cttcttggcc ctggaagagg ccatctctgc ccagaagaat gctgcacccg
      841 ctacacccca accgcagcca gccacaatcc ccgcgtcgct gccccggcct gatagcccct
      901 actctcggcc gcatgactca ctgccgccgc cttcacccac cacaccggtg cctgctccac
      961 ggcctcgggg ccaggagggg gagtatgccg tgcccttcga tgcggtggcc cgttccttgg
     1021 ggaagaactt caggggcatc ttggcagtcc ctcctcagct cctggccgac cctctgtacg
     1081 acagcattga ggagaccctg ccccctcgac ctgaccacat atacgatgag cccgagggag
     1141 tggctgccct gtccctctat gacagcccgc aggagccccg gggtgaggca tggaggaggc
     1201 aggcgacagc tgacagggac cctgctggcc tccagcatgt ccagccagcc gggcaggatt
     1261 tctctgcttc tggctggcag ccaggaactg agtatgacaa tgttgtacta aagaaaggcc
     1321 caaagtgaca gaggcagcag agggatggtc caccgcccct tggcttctgc tggtgactcc
     1381 tcctggccac tgcatcagaa gaacctcctc tgccccttct ggagcccgag gcctggcctg
     1441 tcttcgttgg ggctgataaa ttgcctctcc cagggcctgc tgggtgagtc accatcccaa
     1501 agcaggaagg gtgccctgga gagaaccacc ctcctcctac tctttttcca cttcctcctc
     1561 tttctttccc cagctgagga ggaacctggg gcatttaggg cagaggacaa aaggatgtca
     1621 gcaattgctt gggctgcttg gctatgcaag cctcctgcct gctgatggcc acttcaggga
     1681 cagcctgggc ccaggcaccc agggggatgg cggcagcttc ctgcaccttt cagatttctt
     1741 ggtggcatta aagcattttc agaaca
//
