LOCUS       NM_001381               1918 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens docking protein 1 (DOK1), transcript variant 1, mRNA.
ACCESSION   NM_001381
VERSION     NM_001381.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Vish,K.J., Stiegler,A.L. and Boggon,T.J.
  TITLE     Diverse p120RasGAP interactions with doubly phosphorylated partners
            EphB4, p190RhoGAP, and Dok1
  JOURNAL   J Biol Chem 299 (9), 105098 (2023)
   PUBMED   37507023
  REMARK    GeneRIF: Diverse p120RasGAP interactions with doubly phosphorylated
            partners EphB4, p190RhoGAP, and Dok1.
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Ha,X., Cai,X., Cao,H., Li,J., Yang,B., Jiang,R., Li,X., Li,B. and
            Xin,Y.
  TITLE     Docking protein 1 and free fatty acids are associated with insulin
            resistance in patients with type 2 diabetes mellitus
  JOURNAL   J Int Med Res 49 (11), 3000605211048293 (2021)
   PUBMED   34727748
  REMARK    GeneRIF: Docking protein 1 and free fatty acids are associated with
            insulin resistance in patients with type 2 diabetes mellitus.
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Tuna,E., Ersoy,Y.E., Bulut,P., Ozdemir,F. and Buyru,N.
  TITLE     Analysis of the DOK1 gene in breast cancer
  JOURNAL   Mol Biol Rep 47 (3), 1605-1612 (2020)
   PUBMED   31919752
  REMARK    GeneRIF: Analysis of the DOK1 gene in breast cancer.
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Chaki,S.P., Barhoumi,R. and Rivera,G.M.
  TITLE     Nck adapter proteins promote podosome biogenesis facilitating
            extracellular matrix degradation and cancer invasion
  JOURNAL   Cancer Med 8 (17), 7385-7398 (2019)
   PUBMED   31638742
  REMARK    GeneRIF: Nck adapter proteins promote podosome biogenesis
            facilitating extracellular matrix degradation and cancer invasion.
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   He,P.F., Xu,Z.J., Zhou,J.D., Li,X.X., Zhang,W., Wu,D.H.,
            Zhang,Z.H., Lian,X.Y., Yao,X.Y., Deng,Z.Q., Lin,J. and Qian,J.
  TITLE     Methylation-associated DOK1 and DOK2 down-regulation: Potential
            biomarkers for predicting adverse prognosis in acute myeloid
            leukemia
  JOURNAL   J Cell Physiol 233 (9), 6604-6614 (2018)
   PUBMED   29150948
  REMARK    GeneRIF: Decreased DOK1/2 expressions associated with their
            promoter hypermethylations predict adverse prognosis in AML.
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Chen,M., She,H., Davis,E.M., Spicer,C.M., Kim,L., Ren,R., Le
            Beau,M.M. and Li,W.
  TITLE     Identification of Nck family genes, chromosomal localization,
            expression, and signaling specificity
  JOURNAL   J Biol Chem 273 (39), 25171-25178 (1998)
   PUBMED   9737977
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Vuica,M., Desiderio,S. and Schneck,J.P.
  TITLE     Differential effects of B cell receptor and B cell
            receptor-FcgammaRIIB1 engagement on docking of Csk to
            GTPase-activating protein (GAP)-associated p62
  JOURNAL   J Exp Med 186 (2), 259-267 (1997)
   PUBMED   9221755
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Yamanashi,Y. and Baltimore,D.
  TITLE     Identification of the Abl- and rasGAP-associated 62 kDa protein as
            a docking protein, Dok
  JOURNAL   Cell 88 (2), 205-211 (1997)
   PUBMED   9008161
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Carpino,N., Wisniewski,D., Strife,A., Marshak,D., Kobayashi,R.,
            Stillman,B. and Clarkson,B.
  TITLE     p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated
            protein in chronic myelogenous leukemia progenitor cells
  JOURNAL   Cell 88 (2), 197-204 (1997)
   PUBMED   9008160
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   Wisniewski,D., Strife,A., Wojciechowicz,D., Lambek,C. and
            Clarkson,B.
  TITLE     A 62-kilodalton tyrosine phosphoprotein constitutively present in
            primary chronic phase chronic myelogenous leukemia enriched lineage
            negative blast populations
  JOURNAL   Leukemia 8 (4), 688-693 (1994)
   PUBMED   8152267
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK055944.1, AC005033.1 and
            BQ575925.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_001381.4.
            
            Summary: The protein encoded by this gene is part of a signal
            transduction pathway downstream of receptor tyrosine kinases. The
            encoded protein is a scaffold protein that helps form a platform
            for the assembly of multiprotein signaling complexes. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222883.1, AK055944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233668.10/ ENSP00000233668.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AK055944.1         561-818
            259-259             AC005033.1         93625-93625         c
            260-1764            AK055944.1         820-2324
            1765-1918           BQ575925.1         17-170              c
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..1918
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /note="docking protein 1"
                     /db_xref="GeneID:1796"
                     /db_xref="HGNC:HGNC:2990"
                     /db_xref="MIM:602919"
     exon            1..95
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1481
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /note="isoform a is encoded by transcript variant 1;
                     Downstream of tyrosine kinase 1"
                     /codon_start=1
                     /product="docking protein 1 isoform a"
                     /protein_id="NP_001372.1"
                     /db_xref="CCDS:CCDS1954.1"
                     /db_xref="GeneID:1796"
                     /db_xref="HGNC:HGNC:2990"
                     /db_xref="MIM:602919"
                     /translation="MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFD
                     HKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAA
                     DAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQ
                     RTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSF
                     EAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAE
                     GKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKK
                     PLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQAR
                     VKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYS
                     QVQKSGASGSWDCGLSRVGTDKTGVKSEGST"
     exon            96..395
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /inference="alignment:Splign:2.1.0"
     exon            396..489
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /inference="alignment:Splign:2.1.0"
     exon            490..674
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1918
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /note="hexamer: ATTAAA"
     polyA_site      1918
                     /gene="DOK1"
                     /gene_synonym="P62DOK; pp62"
                     /note="major polyA site"
ORIGIN      
        1 agggccagga agcgcggaag gaaccgccgg gggccatgga cggagcagtg atggaagggc
       61 cgcttttttt gcagagtcag cgctttggga ccaagaggtg gaggaagacc tgggccgtgc
      121 tctacccggc cagtccccac ggcgtagcgc ggctcgagtt ctttgaccat aaggggtcga
      181 gctctggggg tggccgaggg agctcgcgcc gcctggactg caaagtgatc cgtctggctg
      241 agtgtgtgag tgtggccccc gtcaccgtgg agaccccccc tgagcccggc gccactgcct
      301 tccgcctgga cactgctcag cgctcgcacc tgctggcggc cgacgcgccg tccagtgcag
      361 cctgggtgca gacgctgtgc cgaaacgcct ttccgaaagg cagctggact ctggcgccta
      421 ccgataaccc acctaagctt tctgccctgg agatgctgga gaactccttg tacagcccta
      481 cctgggaagg atcccaattc tgggtaacgg tgcagaggac tgaggccgcc gagcgctgtg
      541 gcctgcatgg ctcctacgtg ctgagggtgg aggctgaaag gctgactctc ctgaccgtgg
      601 gggcccagag tcagatactg gagccactcc tgtcctggcc ctacactctg ttgcgtcgct
      661 atggccggga caaggtcatg ttctctttcg aggccggccg ccgctgcccc tcaggccctg
      721 gaaccttcac cttccagacg gcacagggaa atgacatctt ccaggcagtt gagactgcca
      781 tccaccggca gaaggcccag ggaaaggccg gacaggggca cgatgttctc agagctgact
      841 cccatgaagg ggaggtggca gaggggaagt tgccttcccc acctggcccc caagagctcc
      901 tcgacagtcc cccagccctg tatgctgagc ccttagactc cctgcgcatt gctccatgcc
      961 cttcccagga ctccctatac tcagacccct tggacagcac gtctgctcag gcaggagagg
     1021 gagtacaacg gaagaaacct ctctattggg acttgtatga gcatgcgcag cagcagttgc
     1081 tgaaggccaa gctgacagac cccaaagagg atcccatcta tgatgaacct gagggcctgg
     1141 ccccagtccc tccccagggc ctttatgatc tgcctcggga gcccaaggat gcatggtggt
     1201 gccaagctcg ggtgaaggag gagggctatg agctccccta caaccctgcc actgatgact
     1261 acgctgtgcc accccctcgg agcacaaagc ccctccttgc tcccaagccc cagggcccag
     1321 ccttccctga acctggtact gcaactggca gtggcatcaa aagccacaac tcagccctgt
     1381 acagccaggt ccagaagagc ggggcctcag ggagctggga ctgtgggctc tctagagtag
     1441 ggactgacaa gactggggtc aagtcagagg gctctacctg agaaggacgg caaggctgag
     1501 gtggctaagg gggaccatgg ggaggtggca ctagggatca aagaagatgg ttagaaccag
     1561 cagaagccag agggtgggag gggccatgct gtgtgagacc aggggaccag agggatggga
     1621 gagtcaaggg aaggacaatc ccaggaagtc ctaagaagtg gggcagatgg cagggctgag
     1681 gatgggctct gcatccccca aagccatccc ttccctactt ccccaaatga agggacggct
     1741 gtgggaccag gtctgtggaa agtggtgcat ggtcagaatg ggtgcagttt gaggggcctg
     1801 tgtggaggcc tcagggagat gttggactgt gcctggatcc ttactcctgc attgttcttt
     1861 gccagagacc tatttaaaaa ttttaaaatt ctcattaaag tcagcttggg tttaagaa
//
