LOCUS       NM_203447               7448 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant
            1, mRNA.
ACCESSION   NM_203447 XM_036307 XM_372073
VERSION     NM_203447.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7448)
  AUTHORS   Wilkie,H., Das,M., Pelovitz,T., Bainter,W., Woods,B., Alasharee,M.,
            Sobh,A., Baris,S., Eltan,S.B., Al-Herz,W., Barbouche,M.R.,
            Ben-Mustapha,I., Ben-Ali,M., Sallam,M.T.H., Awad,A., Lotfy,S., El
            Marsafy,A., Ezzelarab,M., Farrar,M., Schmidt,B.A.R.,
            NandyMazumdar,M., Guttman-Yassky,E., Sheets,A., Vidic,K.M.,
            Murphy,G., Schlievert,P.M., Chou,J., Leyva-Castillo,J.M.,
            Janssen,E., Timilshina,M. and Geha,R.S.
  TITLE     Regulatory T-cell dysfunction and cutaneous exposure to
            Staphylococcus aureus underlie eczema in DOCK8 deficiency
  JOURNAL   J Allergy Clin Immunol 154 (1), 143-156 (2024)
   PUBMED   38185418
  REMARK    GeneRIF: Regulatory T-cell dysfunction and cutaneous exposure to
            Staphylococcus aureus underlie eczema in DOCK8 deficiency.
REFERENCE   2  (bases 1 to 7448)
  AUTHORS   Guo,M., Ma,Y., Cai,K., Liu,X., Liu,W., Wang,F., Qu,N. and Liu,S.
  TITLE     A novel hemizygous CD40L mutation of X-linked hyper IgM syndromes
            and compound heterozygous DOCK8 mutations of hyper IgE syndromes in
            two Chinese families
  JOURNAL   Immunogenetics 76 (3), 165-173 (2024)
   PUBMED   38587548
  REMARK    GeneRIF: A novel hemizygous CD40L mutation of X-linked hyper IgM
            syndromes and compound heterozygous DOCK8 mutations of hyper IgE
            syndromes in two Chinese families.
REFERENCE   3  (bases 1 to 7448)
  AUTHORS   Kumar Jindal,A., Sil,A., Aggarwal,R., Tyagi,R., Mondal,S.,
            Singh,A., Barman,P., Chawla,S., Loganathan,S.K., Gupta,K.,
            Vinay,K., Mahajan,R., Saikia,B., Kaur,G., Sharma,R., Saka,R.,
            Bhatia,A., Sankhyan,N., Pandiarajan,V., Pilania,R., Dhaliwal,M.,
            Sharma,S., Vyas,S., Suri,D., Rawat,A. and Singh,S.
  TITLE     Clinical, immunological and molecular profiles of DOCK8 deficiency
            in six patients from a tertiary care centre in North India
  JOURNAL   Clin Exp Dermatol 49 (3), 226-234 (2024)
   PUBMED   37815217
  REMARK    GeneRIF: Clinical, immunological and molecular profiles of DOCK8
            deficiency in six patients from a tertiary care centre in North
            India.
REFERENCE   4  (bases 1 to 7448)
  AUTHORS   Liquidano-Perez,E., Maza-Ramos,G., Perez Arias,B.A., Lugo
            Reyes,S.O., Barragan Arevalo,T., Solorzano-Morales,S.A., Venegas
            Montoya,E., Staines-Boone,A.T., Guzman Cotaya,R., Okada,S.,
            Picard,C., Patin,E., Ramirez-Uribe,N., Bustamante-Ogando,J.C.,
            Scheffler-Mendoza,S.C., Yamazaki-Nakashimada,M.A.,
            Saez-de-Ocariz,M., Espinosa Padilla,S.E. and Gonzalez-Serrano,M.E.
  TITLE     Clinical, immunological, and genetic description of a Mexican
            cohort of patients with DOCK8 deficiency
  JOURNAL   Pediatr Allergy Immunol 35 (2), e14073 (2024)
   PUBMED   38351896
  REMARK    GeneRIF: Clinical, immunological, and genetic description of a
            Mexican cohort of patients with DOCK8 deficiency.
REFERENCE   5  (bases 1 to 7448)
  AUTHORS   Gutierrez-Ruiz,O.L., Johnson,K.M., Krueger,E.W., Nooren,R.E.,
            Cruz-Reyes,N., Heppelmann,C.J., Hogenson,T.L.,
            Fernandez-Zapico,M.E., McNiven,M.A. and Razidlo,G.L.
  TITLE     Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic
            tumor cell invasion
  JOURNAL   Cell Rep 42 (9), 113042 (2023)
   PUBMED   37651233
  REMARK    GeneRIF: Ectopic expression of DOCK8 regulates lysosome-mediated
            pancreatic tumor cell invasion.
REFERENCE   6  (bases 1 to 7448)
  AUTHORS   Saelee,P., Wongkham,S., Puapairoj,A., Khuntikeo,N., Petmitr,S.,
            Chariyalertsak,S., Sumethchotimaytha,W. and Karalak,A.
  TITLE     Novel PNLIPRP3 and DOCK8 gene expression and prognostic
            implications of DNA loss on chromosome 10q25.3 in hepatocellular
            carcinoma
  JOURNAL   Asian Pac J Cancer Prev 10 (3), 501-506 (2009)
   PUBMED   19640199
  REMARK    GeneRIF: Under-expression of DOCK8 is associated with
            hepatocellular carcinoma.
REFERENCE   7  (bases 1 to 7448)
  AUTHORS   Griggs,B.L., Ladd,S., Saul,R.A., DuPont,B.R. and Srivastava,A.K.
  TITLE     Dedicator of cytokinesis 8 is disrupted in two patients with mental
            retardation and developmental disabilities
  JOURNAL   Genomics 91 (2), 195-202 (2008)
   PUBMED   18060736
  REMARK    GeneRIF: rare mutations in the DOCK8 gene may contribute to some
            cases of autosomal dominant mental retardation
REFERENCE   8  (bases 1 to 7448)
  AUTHORS   Takahashi,K., Kohno,T., Ajima,R., Sasaki,H., Minna,J.D.,
            Fujiwara,T., Tanaka,N. and Yokota,J.
  TITLE     Homozygous deletion and reduced expression of the DOCK8 gene in
            human lung cancer
  JOURNAL   Int J Oncol 28 (2), 321-328 (2006)
   PUBMED   16391785
REFERENCE   9  (bases 1 to 7448)
  AUTHORS   Ruusala,A. and Aspenstrom,P.
  TITLE     Isolation and characterisation of DOCK8, a member of the
            DOCK180-related regulators of cell morphology
  JOURNAL   FEBS Lett 572 (1-3), 159-166 (2004)
   PUBMED   15304341
  REMARK    GeneRIF: involvement of DOCK8 in processes that affect the
            organisation of filamentous actin.
REFERENCE   10 (bases 1 to 7448)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB191037.1, DR004867.1,
            AK090429.1 and AL161725.13.
            
            On Feb 24, 2020 this sequence version replaced NM_203447.3.
            
            Summary: This gene encodes a member of the DOCK180 family of
            guanine nucleotide exchange factors. Guanine nucleotide exchange
            factors interact with Rho GTPases and are components of
            intracellular signaling networks. Mutations in this gene result in
            the autosomal recessive form of the hyper-IgE syndrome.
            Alternatively spliced transcript variants encoding different
            isoforms have been described.[provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB191037.1, SRR14038194.4025885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432829.7/ ENSP00000394888.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AB191037.1         1-176
            177-514             DR004867.1         264-601
            515-1923            AB191037.1         515-1923
            1924-4218           AK090429.1         913-3207
            4219-4602           AB191037.1         4219-4602
            4603-4603           AL161725.13        63582-63582
            4604-7448           AB191037.1         4604-7448
FEATURES             Location/Qualifiers
     source          1..7448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.3"
     gene            1..7448
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /note="dedicator of cytokinesis 8"
                     /db_xref="GeneID:81704"
                     /db_xref="HGNC:HGNC:19191"
                     /db_xref="MIM:611432"
     exon            1..165
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..6412
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     1200017A24Rik; dedicator of cytokinesis protein 8;
                     epididymis luminal protein 205"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 8 isoform 1"
                     /protein_id="NP_982272.2"
                     /db_xref="CCDS:CCDS6440.2"
                     /db_xref="GeneID:81704"
                     /db_xref="HGNC:HGNC:19191"
                     /db_xref="MIM:611432"
                     /translation="MATLPSAERRAFALKINRYSSAEIRKQFTLPPNLGQYHRQSIST
                     SGFPSLQLPQFYDPVEPVDFEGLLMTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRT
                     LQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPK
                     QTFESETLECSEPAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVS
                     AEDFEKQNEEARRTNRQAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLK
                     FEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVF
                     SVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQ
                     RLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGERRTLAQSRRLSERAL
                     SLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLL
                     RLEISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVY
                     PQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHNKS
                     PDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTG
                     SYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLE
                     KFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDK
                     LFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVF
                     RLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSA
                     ADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVST
                     GMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSE
                     IAALLVKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPT
                     LISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASM
                     FDLTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVK
                     PEVKVKIAALYLPLVGIILDALPQLCDFTVADTRRYRTSGSDEEQEGAGAINQNVALA
                     IAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLP
                     STQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEM
                     MRRRAPGNDRFPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATEAHLI
                     ILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGD
                     LLFEEEVEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVT
                     MSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLNSILYDT
                     VKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHA
                     AALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTES
                     GLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVN
                     KDHKRMFGTYFRVGFFGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFV
                     EVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFT
                     LEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPIEVAIEDMKKKTLQ
                     LAVAINQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLC
                     FKEFIMRCGEAVEKNKRLITADQREYQQELKKNYNKLKENLRPMIERKIPELYKPIFR
                     VESQKRDSFHRSSFRKCETQLSQGS"
     exon            166..268
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            269..444
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            445..516
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            517..640
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            641..853
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            854..939
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1006
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1156
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1237
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1397
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1534
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1628
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1791
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1909
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1980
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2119
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2221
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2317
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2552
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2717
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2890
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2986
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3082
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3232
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3346
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3502
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3642
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3812
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3952
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4135
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4265
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4353
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4450
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4585
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4738
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4739..4897
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..4998
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5191
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5335
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5467
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5468..5602
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5692
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5693..5929
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            5930..6073
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            6074..6180
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            6181..6351
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            6352..7448
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7418..7423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /note="hexamer: AATAAA"
     regulatory      7429..7434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /note="hexamer: AATAAG"
     polyA_site      7442
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
     polyA_site      7448
                     /gene="DOCK8"
                     /gene_synonym="HEL-205; HIES2; MRD2; ZIR8"
                     /note="major polyA site"
ORIGIN      
        1 gacagacgag gtttgcgctt ggctgggcat gttccgcggc tactctgcgg cgcgccaggc
       61 ccccgctttc cgcaccccgc gaccctagaa gccaccgaac cgccggcggg ccatggccac
      121 tctgccgagc gcagagcgcc gcgcgttcgc gctcaagatc aacaggtatt cttcagcgga
      181 aataaggaaa cagtttactc tcccaccaaa ccttggccag taccatcgac agagcataag
      241 tacctctggc ttcccctctc ttcaactacc tcagttttat gaccctgtgg agccagtgga
      301 ctttgaagga cttctgatga cacacctgaa cagcctggat gtgcagcttg cccaggagct
      361 cggggacttc actgatgacg acttggacgt ggtgttcacg ccaaaggaat gtaggacttt
      421 gcagccctct ttgccggagg aaggggttga actggaccct catgtcaggg actgtgttca
      481 gacctacatc cgtgagtggc taatcgtgaa ccggaaaaac caaggaagtc cagaaatctg
      541 tggctttaaa aagactggat ctcgaaaaga ttttcacaag acgcttccga aacagacgtt
      601 tgagtcggaa accttggagt gcagtgaacc cgctgctcag gcaggccccc gccacttaaa
      661 cgtgctgtgc gacgtgtctg ggaaaggccc cgtcactgcc tgtgactttg acctccgcag
      721 cctgcagcct gacaagcggc tagaaaacct cctgcagcaa gtgagtgccg aggactttga
      781 gaagcagaac gaggaggccc ggaggaccaa taggcaggcc gagctctttg ccctttaccc
      841 atcagtggac gaggaggatg ctgtggaaat acgtccagta ccagaatgtc ccaaggaaca
      901 cctgggcaac agaatattgg tcaagttgct gaccttgaag ttcgagattg aaattgagcc
      961 cctgtttgcc agcattgccc tctacgatgt taaagaaagg aaaaagatct cagaaaattt
     1021 tcactgtgac ctgaactctg accagttcaa aggatttctg cgagctcaca cgccttcagt
     1081 ggccgcatca agtcaggcga gatctgcagt cttctcagtc acctacccgt cctcagacat
     1141 ctacctggta gtcaagattg aaaaagtcct gcagcaggga gagattggag actgtgcaga
     1201 gccctacacg gttatcaaag aaagtgatgg tggaaagagt aaagaaaaga ttgaaaaact
     1261 aaaactccaa gctgaatcct tctgccagcg tttggggaaa taccggatgc cctttgcctg
     1321 ggcacccata agcttatcaa gcttcttcaa tgtctccacc cttgagaggg aggtaactga
     1381 tgtggactct gtggttggga gaagctcagt gggtgaacgg aggacattgg cccaatctag
     1441 aaggctttct gaaagagccc tctccttgga ggaaaatggg gttggatcca acttcaaaac
     1501 ctccactctg agcgttagca gctttttcaa gcaggaagga gatcgcctta gcgatgaaga
     1561 cttattcaag tttttagctg actacaaaag atcatcatcc ttacagagac gagtcaagtc
     1621 aattccaggc ttgctaagac tggagatttc tacagctcca gagatcatca attgctgtct
     1681 gactcctgaa atgctgcccg tgaaaccctt tcctgaaaac cggacacgcc cgcacaaaga
     1741 gattttggaa tttccaacac gagaagtata tgtccctcac actgtgtaca gaaaccttct
     1801 ctatgtctac ccacagaggc tgaactttgt aaacaaacta gcatcagccc ggaacattac
     1861 aataaagatc cagtttatgt gtggagaaga tgctagcaat gcgatgccgg tcatctttgg
     1921 aaaatccagc gggcctgaat ttctgcagga agtgtacaca gctgttacat accataataa
     1981 gtctcctgac ttttatgaag aagtgaaaat taagctcccc gctaagctca cagtaaatca
     2041 ccacctcctg ttcaccttct accatatcag ctgtcagcag aagcaaggag cctccgtgga
     2101 aactctcctg ggatattcat ggctgccaat tctcttaaat gaacgtcttc aaactggatc
     2161 ctactgtctc ccagttgcct tggaaaaatt gccacccaac tactccatgc attctgctga
     2221 gaaagtccca ttacagaatc ctcccattaa gtgggctgaa ggacataagg gagtatttaa
     2281 tattgaagtg caagctgttt cttctgtaca cacccaggac aaccacctgg agaagttctt
     2341 caccctctgc cactccctgg agagccaggt gaccttcccc atccgcgtgc tggatcagaa
     2401 aatcagcgag atggcgctgg agcatgagct gaagctcagc atcatctgcc tgaactcctc
     2461 ccgcctggag ccgctcgtgc tcttcctgca cctggtgctg gacaagctct tccagctgtc
     2521 cgtgcagccc atggtcatcg ctggccagac agccaacttc tcccagtttg ccttcgagtc
     2581 cgtggtggcc atcgccaaca gtctgcacaa cagcaaggac ctgagcaagg accagcatgg
     2641 gaggaactgc ctgctggctt cctacgtgca ctacgtcttc cgcctgccag aggtgcaaag
     2701 ggatgtgccc aagtcaggcg ctcccactgc cctcctagac cctcggagct accacacgta
     2761 tggccgcaca tcagctgctg ctgtgagttc aaagctgctg caggcccggg tgatgagcag
     2821 cagtaaccca gacctcgcgg ggacacactc cgcagcagac gaggaagtga agaacatcat
     2881 gtcttcaaag atcgccgatc gcaactgcag ccgaatgtct tactattgct ctggcagtag
     2941 tgatgctcca agttcacctg cagccccaag gccagccagc aaaaagcatt tccatgagga
     3001 gcttgccctt cagatggtgg tcagcaccgg aatggtgaga gaaacagtct tcaagtatgc
     3061 ctggttcttc tttgagcttc tggtgaaaag catggcccag cacgtacata acatggacaa
     3121 acgggacagt tttcggagga ctcgtttttc tgaccgtttc atggatgaca taactactat
     3181 tgttaatgtg gtcacctcgg aaattgcagc ccttttagta aaaccacaga aggaaaatga
     3241 acaggcggaa aagatgaaca tcagcctggc tttcttcttg tatgaccttc tctccctcat
     3301 ggatcggggc tttgtgttta acctcatcag acattattgc agccagctgt cagccaagct
     3361 cagtaacctt ccaacgctca tttccatgag gctagagttc ctgagaatcc tctgtagcca
     3421 tgagcattac ctcaatctga accttttttt tatgaatgct gatactgctc caacatctcc
     3481 ttgtccttcc atatcttccc agaactcaag ctcctgctcc agcttccagg accagaagat
     3541 cgccagcatg ttcgatctga cttccgagta ccgccagcag cacttcctca ccgggctcct
     3601 cttcacagaa ctggctgctg ccctggatgc cgaaggggaa ggaatcagca aagtacaaag
     3661 gaaagctgtc agtgcaattc acagcctgct aagttctcac gacctggacc cacgctgtgt
     3721 caaaccagag gtgaaggtca aaatcgccgc cctttaccta cctttagttg gcatcatttt
     3781 ggatgctttg ccacagctct gtgactttac agttgcagat actcgcagat accgcaccag
     3841 tggctcggat gaagaacaag aaggagccgg tgccattaac cagaatgtgg ctctggccat
     3901 agcagggaat aatttcaatt tgaaaacaag tggaatagtg ctgtcttcct tgccctataa
     3961 gcagtacaac atgctgaacg cggacactac tcgcaacctc atgatctgct tcctctggat
     4021 catgaaaaat gctgatcaga gcctcattag gaagtggatt gctgacctgc catcaacgca
     4081 gctcaacagg attttagatc tacttttcat ctgtgtgtta tgttttgagt ataagggaaa
     4141 acagagttct gacaaagtca gtacccaagt cctgcagaag tcaagggatg tcaaggcccg
     4201 gctggaagag gctttgctcc gtggggaagg ggccagaggg gagatgatgc gccgccgggc
     4261 tccagggaac gaccgatttc caggcctaaa tgaaaatttg agatggaaga aagagcagac
     4321 acattggcgg caagctaatg agaagctaga taaaacaaag gccgagttag atcaagaagc
     4381 cttgatcagt ggcaatctgg ctacagaagc acatttaatc atcctggata tgcaggaaaa
     4441 cattatccag gcgagctcgg ctctggactg taaagacagc ctgctgggag gtgttctgag
     4501 ggtgctggtg aattctctga actgtgatca gagtaccacc tacctgactc actgctttgc
     4561 aacactccgt gctctcatcg ccaagtttgg agacttactc tttgaagagg aggtggaaca
     4621 gtgtttcgac ctatgtcacc aagtcctgca ccactgcagc agcagcatgg atgtcacccg
     4681 gagccaagcc tgtgccaccc tttacctcct catgaggttc agttttggag ccaccagtaa
     4741 ttttgcaaga gtaaagatgc aagtaaccat gtccctggca tctttggtgg gaagagcacc
     4801 agactttaat gaagagcacc tgagaagatc cttgaggaca attttggcct attcagaaga
     4861 ggacacagcc atgcagatga ctccttttcc cacccaggtg gaggaacttc tctgtaatct
     4921 gaatagcatc ttatatgaca cagtgaaaat gagggaattt caggaagatc ctgagatgct
     4981 tatggatctc atgtacagaa ttgccaagag ttaccaggca tctcctgatc tgcggctgac
     5041 ctggctccag aacatggcag agaaacacac caagaagaag tgctacacgg aggctgccat
     5101 gtgcctggtg cacgccgctg cgttagtggc tgagtatctg agcatgctgg aggaccacag
     5161 ctacctgccc gtgggcagtg tcagcttcca gaatatttct tccaatgtgc tggaggagtc
     5221 tgtggtctct gaggacaccc tgtcacctga cgaggatggg gtgtgcgcag gccagtactt
     5281 caccgagagt ggcctggtag gcctcctgga gcaggccgcg gagctcttca gcacgggagg
     5341 cttatatgag acagttaatg aggtctacaa gctggtcatc cccatcctag aagcgcatcg
     5401 agaattccgg aagctgacac tcactcacag caagctgcag agagccttcg acagcatcgt
     5461 taacaaggat cataagagaa tgtttggaac ctacttccga gttggtttct ttggatccaa
     5521 atttggggat ttggatgaac aggagtttgt ctacaaagag cctgcaatta ccaagcttcc
     5581 tgagatctca catagactag aggcatttta tggtcaatgt tttggtgcag aatttgtgga
     5641 agtgattaaa gactccactc ctgtggacaa aaccaagttg gatcctaaca aggcctacat
     5701 acagatcact tttgtggagc cctactttga tgagtatgag atgaaagaca gggtcacata
     5761 ctttgagaag aatttcaacc tccggaggtt catgtacacc accccgttca ccctggaggg
     5821 gcggcctcgg ggagagctgc atgagcagta cagaaggaac acagtcctga ccactatgca
     5881 cgccttcccc tacatcaaga ccaggatcag cgtcatccag aaggaggagt ttgttttgac
     5941 accgattgaa gttgccattg aagacatgaa gaagaagacc ctgcagttag cagttgccat
     6001 taaccaggag ccgcctgatg caaagatgct tcagatggtg ctgcaaggct ctgtgggagc
     6061 tactgtaaat cagggaccac tggaagtagc ccaagtgttt ttggctgaaa ttcctgctga
     6121 tccaaaactc tatcgacatc acaacaagtt gaggttatgc tttaaggaat tcatcatgag
     6181 atgtggtgaa gctgtagaga aaaacaagcg tctcatcacg gcagaccaga gggaatatca
     6241 gcaggaactc aaaaagaact ataacaagct aaaagagaac ctcaggccaa tgatcgagcg
     6301 gaaaattcca gaactgtaca agccaatatt cagagttgag agtcaaaaga gggactcctt
     6361 ccacagatct agtttcagga aatgtgaaac ccagttgtca cagggcagct aagaaaagcc
     6421 atcttcattc gtggagactg tggccctgca accctggaga aggacttgct ggtacttaaa
     6481 aaatgggaca tttgccaccc aggactgact gtacactccc tgatcagcca gcactctgga
     6541 agctttggga tcccaggaac catggaatta ttcccaaatg gactctgacc agatttttgc
     6601 catactgggg ggtggcggga tggaggatgg gtactcaggc atgactgcgt atttattaaa
     6661 gtgtgttttt ccacaatgta ccaaacaagg cataagcagc ttctcctgct gactggccaa
     6721 tcactgccca tctgagagat gatttcctct ggcccatatt tgaatttatt ggagtaactc
     6781 aaattgcctg aggaaaaatg gaaaaattat ccaccagtcg attcaaactg aatttcactc
     6841 tttataggaa ggcagggcaa acttgtagga gtacgaaaca ttttcaataa atctacaaag
     6901 ggaagcctta ctacaattcc aaaaatcatc atggttggaa atttgggagg agattatttg
     6961 tgaacttgtt acccttttgg taatggtgga ctaattgctg tatagttatt tttgttttat
     7021 tattactgtt acattaattt aacatgcatt tatagaagaa tacattcaaa gcactgatgt
     7081 aggagataca cggtacttgg agcagtcagc cagaaatcac agatactgct ttcacttaaa
     7141 tggaaacaat tctccgataa tgctttgctt tttttcttat gtcactcttg tgtactatct
     7201 atttttctcc tctctgggac caagtttctt tttataaagc aataatatct ctgttttcat
     7261 ttcagaacat tgtgctgtct gtcagcatat gtatatcagc tacaaaatat attcaacttt
     7321 gacttctttt gacaaaggac tttaggaaaa agaggaacaa agacattatt tgagaattaa
     7381 attatatatt tttaatatga ctgtgacctt gactgataat aaagatgtaa taagaattgc
     7441 aagctaaa
//
