LOCUS       NM_001367561            7233 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 7 (DOCK7), transcript variant
            7, mRNA.
ACCESSION   NM_001367561 XM_011542326
VERSION     NM_001367561.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7233)
  AUTHORS   Chen,W., Zhou,M., Guan,B., Xie,B., Liu,Y., He,J., Zhao,J., Zhao,Q.
            and Yan,D.
  TITLE     Tumour-associated macrophage-derived DOCK7-enriched extracellular
            vesicles drive tumour metastasis in colorectal cancer via the
            RAC1/ABCA1 axis
  JOURNAL   Clin Transl Med 14 (2), e1591 (2024)
   PUBMED   38385857
  REMARK    GeneRIF: Tumour-associated macrophage-derived DOCK7-enriched
            extracellular vesicles drive tumour metastasis in colorectal cancer
            via the RAC1/ABCA1 axis.
REFERENCE   2  (bases 1 to 7233)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7233)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7233)
  AUTHORS   Gao,M., Guo,G., Huang,J., Hou,X., Ham,H., Kim,W., Zhao,F., Tu,X.,
            Zhou,Q., Zhang,C., Zhu,Q., Liu,J., Yan,Y., Xu,Z., Yin,P., Luo,K.,
            Weroha,J., Deng,M., Billadeau,D.D. and Lou,Z.
  TITLE     DOCK7 protects against replication stress by promoting RPA
            stability on chromatin
  JOURNAL   Nucleic Acids Res 49 (6), 3322-3337 (2021)
   PUBMED   33704464
  REMARK    GeneRIF: DOCK7 protects against replication stress by promoting RPA
            stability on chromatin.
REFERENCE   5  (bases 1 to 7233)
  AUTHORS   Haberlandt,E., Valovka,T., Janjic,T., Muller,T., Blatsios,G.,
            Karall,D. and Janecke,A.R.
  TITLE     Characteristic facial features and cortical blindness distinguish
            the DOCK7-related epileptic encephalopathy
  JOURNAL   Mol Genet Genomic Med 9 (3), e1607 (2021)
   PUBMED   33471954
  REMARK    GeneRIF: Characteristic facial features and cortical blindness
            distinguish the DOCK7-related epileptic encephalopathy.
REFERENCE   6  (bases 1 to 7233)
  AUTHORS   Nellist,M., Burgers,P.C., van den Ouweland,A.M., Halley,D.J. and
            Luider,T.M.
  TITLE     Phosphorylation and binding partner analysis of the TSC1-TSC2
            complex
  JOURNAL   Biochem Biophys Res Commun 333 (3), 818-826 (2005)
   PUBMED   15963462
REFERENCE   7  (bases 1 to 7233)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 7233)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   9  (bases 1 to 7233)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
REFERENCE   10 (bases 1 to 7233)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103923.2, AL138847.14,
            AL451044.7 and AC096946.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 8, 2018 this sequence version replaced XM_011542326.2.
            
            Summary: The protein encoded by this gene is a guanine nucleotide
            exchange factor (GEF) that plays a role in axon formation and
            neuronal polarization. The encoded protein displays GEF activity
            toward RAC1 and RAC3 Rho small GTPases but not toward CDC42.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000635253.2/ ENSP00000489124.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC103923.2         43941-44100         c
            161-266             AC103923.2         18739-18844         c
            267-442             AC103923.2         9698-9873           c
            443-511             AC103923.2         9439-9507           c
            512-641             AC103923.2         4129-4258           c
            642-854             AC103923.2         3820-4032           c
            855-940             AC103923.2         3405-3490           c
            941-1007            AL138847.14        56924-56990         c
            1008-1157           AL138847.14        55160-55309         c
            1158-1238           AL138847.14        53885-53965         c
            1239-1404           AL138847.14        51627-51792         c
            1405-1547           AL138847.14        45646-45788         c
            1548-1641           AL138847.14        40287-40380         c
            1642-1804           AL138847.14        39093-39255         c
            1805-1922           AL138847.14        6894-7011           c
            1923-1993           AL138847.14        3571-3641           c
            1994-2132           AL451044.7         124586-124724       c
            2133-2234           AL451044.7         123020-123121       c
            2235-2321           AL451044.7         107375-107461       c
            2322-2553           AL451044.7         104747-104978       c
            2554-2718           AL451044.7         101583-101747       c
            2719-2888           AL451044.7         98490-98659         c
            2889-2981           AL451044.7         90705-90797         c
            2982-3071           AL451044.7         89414-89503         c
            3072-3167           AL451044.7         88366-88461         c
            3168-3308           AL451044.7         85510-85650         c
            3309-3422           AL451044.7         85303-85416         c
            3423-3593           AL451044.7         83649-83819         c
            3594-3733           AL451044.7         81251-81390         c
            3734-3903           AL451044.7         75035-75204         c
            3904-4058           AL451044.7         73909-74063         c
            4059-4241           AL451044.7         59474-59656         c
            4242-4404           AL451044.7         59202-59364         c
            4405-4501           AL451044.7         56335-56431         c
            4502-4598           AL451044.7         53720-53816         c
            4599-4733           AL451044.7         51440-51574         c
            4734-4886           AL451044.7         50388-50540         c
            4887-5045           AL451044.7         42097-42255         c
            5046-5146           AL451044.7         41339-41439         c
            5147-5339           AL451044.7         40033-40225         c
            5340-5483           AL451044.7         38462-38605         c
            5484-5615           AL451044.7         34692-34823         c
            5616-5630           AL451044.7         33156-33170         c
            5631-5756           AL451044.7         23458-23583         c
            5757-5846           AL451044.7         21825-21914         c
            5847-6083           AL451044.7         21465-21701         c
            6084-6227           AL451044.7         20966-21109         c
            6228-6334           AL451044.7         19740-19846         c
            6335-6502           AL451044.7         3296-3463           c
            6503-7233           AC096946.2         788-1518
FEATURES             Location/Qualifiers
     source          1..7233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..7233
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="dedicator of cytokinesis 7"
                     /db_xref="GeneID:85440"
                     /db_xref="HGNC:HGNC:19190"
                     /db_xref="MIM:615730"
     exon            1..160
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..6545
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="isoform 7 is encoded by transcript variant 7;
                     dedicator of cytokinesis protein 7"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 7 isoform 7"
                     /protein_id="NP_001354490.1"
                     /db_xref="CCDS:CCDS90964.1"
                     /db_xref="GeneID:85440"
                     /db_xref="HGNC:HGNC:19190"
                     /db_xref="MIM:615730"
                     /translation="MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNIS
                     HHTTVPLTEAVDPVDLEDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSA
                     VPEESEMDPHVRDCIRSYTEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFES
                     DEAPDGNSYQDDQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEE
                     IDRQNDDQRKSNRHKELFALHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEI
                     EIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARSAIFSIT
                     YPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLG
                     KYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSIVGRRSLERT
                     TSGDDACNLTSFRPATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQ
                     LKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYI
                     YPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNR
                     SPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKT
                     GQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKF
                     FALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQLEPVVRFLHLLLDKLIL
                     LVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNSLLASYIHYVFRLP
                     NTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDE
                     VRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFL
                     QTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLE
                     APRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRG
                     FVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPAS
                     PSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEG
                     LFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTET
                     HNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTF
                     SAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVF
                     ERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAF
                     GSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTV
                     SVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCAD
                     LCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQN
                     FNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEM
                     LIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLE
                     DRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAAS
                     FSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTY
                     FRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVD
                     KCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELH
                     EQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPA
                     DPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCED
                     ALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSR
                     MSLRKMDL"
     exon            161..266
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..442
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..511
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..641
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..854
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..940
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1007
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1157
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1238
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1404
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1547
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1641
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1804
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1922
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1993
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2132
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2234
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2321
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2553
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2718
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2888
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2981
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3071
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3167
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3308
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3422
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3593
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3733
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3903
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4058
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4241
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4242..4404
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4501
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4598
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4733
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4734..4886
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5045
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5046..5146
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5339
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5483
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5615
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5616..5630
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5631..5756
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5757..5846
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            5847..6083
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            6084..6227
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            6228..6334
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            6335..6502
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     exon            6503..7233
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6923..6928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="hexamer: ATTAAA"
     polyA_site      6948
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="major polyA site"
     regulatory      7040..7045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="hexamer: AATAAA"
     polyA_site      7064
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
     regulatory      7214..7219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
                     /note="hexamer: ATTAAA"
     polyA_site      7233
                     /gene="DOCK7"
                     /gene_synonym="DEE23; EIEE23; ZIR2"
ORIGIN      
        1 aggtccggag cccggactgg cggaggccgc gagggaggga gcacgagcga ggaggcacgc
       61 gcccgccggt ccgcacccgg cccgccgcag ccgccgccgc cgtcgccgtc gccgcagcag
      121 ccatggccga gcgccgcgcc ttcgcccaga agatcagcag aacggtggca gccgaagtta
      181 ggaagcagat ctccggacaa tatagtggtt ctccccaact gctcaaaaac cttaatattg
      241 ttggcaatat atcccatcac accacagtgc cccttaccga agcagtagat ccagtggatt
      301 tggaagatta cctcattact catcctttgg ctgtggattc tgggccttta cgggatttga
      361 ttgaatttcc tccagatgat attgaagttg tttatagtcc tcgggactgc agaactcttg
      421 tttcagctgt acctgaagaa agtgaaatgg atccacatgt tagagactgt ataagaagtt
      481 atacagaaga ctgggcaatt gtcatcagaa aatatcataa attgggaaca ggatttaatc
      541 ccaatacatt agataaacag aaagaaaggc aaaaaggttt gccaaaacaa gtttttgaat
      601 ctgatgaagc tccagatggc aacagctacc aggatgatca agatgacctt aaaagacgtt
      661 caatgtcaat agatgatacc ccaaggggta gctgggcctg tagtatcttt gacttgaaaa
      721 attcacttcc tgatgctttg cttcccaatt tacttgatcg aactccaaat gaagaaatag
      781 accgtcagaa tgatgaccaa aggaaatcaa accgtcacaa agaacttttt gctttgcatc
      841 catcaccaga tgaggaagaa ccaatagaac ggcttagtgt tcctgatata cccaaagaac
      901 attttggtca aagacttctt gtaaaatgct tatcactcaa gtttgaaatt gaaattgaac
      961 ccatttttgc aagtttggct ttatatgatg tcaaggaaaa gaaaaagatt tcagaaaact
     1021 tttattttga ccttaattct gagcagatga aagggttgtt acgtccacat gtaccacctg
     1081 ctgccattac taccctggca agatcagcaa ttttttctat cacttatcct tcccaagatg
     1141 tttttcttgt aataaagcta gaaaaagtcc tacagcaagg agacattgga gagtgtgcag
     1201 aaccatatat gattttcaaa gaagcagatg ccaccaagaa taaagaaaaa ctggagaaac
     1261 tgaagagtca agcagatcag ttttgccaaa gacttgggaa atatcgcatg ccttttgctt
     1321 ggactgcaat ccatttaatg aatattgtta gcagtgctgg gagtttggaa agagattcta
     1381 cagaagtaga aatcagtact ggagaacgaa aagggtcttg gtcagagagg aggaattcta
     1441 gtattgttgg cagacgatca cttgaaagga caacaagtgg agatgatgct tgtaacttga
     1501 cgagctttcg accagctact ctcacagtga caaatttttt taagcaggaa ggagaccgct
     1561 taagtgatga agatctctac aaattccttg ctgatatgag aaggccatct tctgtcttac
     1621 ggcgactaag acctattaca gctcagctca agatagacat ttctcccgca cctgaaaatc
     1681 cccattattg cctaactccg gagctgcttc aagtgaagct ttaccctgac agtagagtta
     1741 gacctaccag agaaatctta gagtttcccg caagggatgt ttatgttcca aacactactt
     1801 acagaaatct tctctacata taccctcaga gtcttaattt tgccaatcgt caaggttctg
     1861 ctagaaatat aacagtgaaa gtccagttta tgtatggaga ggatccaagc aatgccatgc
     1921 cggtaatctt tggtaaatct agctgttcag aattttcaaa ggaagcctat acagccgtag
     1981 tatatcataa caggtctcct gattttcatg aagaaatcaa ggttaagctt cctgctactt
     2041 taactgacca tcatcacttg ctttttactt tttatcatgt tagttgtcaa caaaaacaaa
     2101 atactcctct tgaaacacca gttggatata catggatacc aatgcttcag aatggacggt
     2161 tgaagactgg ccagttttgc ttgccagtct cattggaaaa accaccacag gcttattctg
     2221 tactgtctcc tgaggttcct ctacctggca tgaaatgggt agataatcac aaaggtgttt
     2281 ttaatgttga agttgttgct gtttcgtcta tccatacaca agatccttat cttgacaaat
     2341 tttttgctct ggtcaatgct ctggatgaac acctgttccc agtccgaatt ggggacatgc
     2401 gaatcatgga aaataactta gaaaatgaat tgaagagcag tatttcagca ctgaattcat
     2461 cccagctgga accagtggtc cgatttcttc atcttctgct agataaactg atacttttag
     2521 ttattagacc tcctgtcatt gctggccaaa tagttaacct aggtcaagca tcttttgaag
     2581 ccatggcatc aattataaat cgacttcaca aaaacttgga aggaaatcat gaccagcatg
     2641 gcagaaacag ccttcttgca tcatatattc attatgtttt ccgcctacca aatacttacc
     2701 ctaattcatc atcaccaggt cctgggggtt tgggaggatc agtgcattat gccacaatgg
     2761 ctagatctgc ggtgagacct gcaagcctta atttaaatcg ttctcgaagc cttagtaata
     2821 gcaatccaga tatatctggg actcccacgt caccagatga tgaagttcga tcaatcatcg
     2881 ggagtaaggg tttagatcgc tccaattcct gggttaacac tggtggtcca aaagctgccc
     2941 catggggatc caaccccagt ccaagtgcag aatcaacaca ggctatggat cgaagttgta
     3001 atcgtatgtc ttcgcacaca gagacgtcaa gtttcttaca aacattaacg ggacgcttac
     3061 caactaaaaa gctttttcac gaggagctgg ctttgcagtg ggttgtttgc agtggcagcg
     3121 ttcgggaatc agctttgcaa caagcctggt tcttttttga attaatggta aagagcatgg
     3181 tgcaccattt atactttaat gataaacttg aggctccaag gaaaagtcgt tttccagaac
     3241 gtttcatgga tgacattgca gctcttgtca gcacgattgc tagtgatata gtttcacgat
     3301 ttcagaagga cacagaaatg gttgagagac tcaatacaag ccttgcattc tttctcaatg
     3361 atctgttgtc tgttatggac agaggatttg tttttagcct tataaagtcc tgctataaac
     3421 aggtgtcttc aaagctttac tcattaccga atcccagtgt tctggtgtcc ttgaggctgg
     3481 attttctacg aatcatctgc agtcatgagc actatgttac attaaactta ccctgcagct
     3541 tacttactcc acctgcatct ccatcacctt ctgtttcttc tgcaacatct cagagttctg
     3601 gattttctac gaatgtacaa gaccaaaaga ttgcaaatat gtttgaatta tccgtgcctt
     3661 tccgccaaca gcattatttg gcaggacttg tgttaacaga gctggctgtc attttagacc
     3721 ctgatgctga aggactgttt ggattgcata agaaagtcat caatatggta cacaatttac
     3781 tctccagtca cgactcagac ccgcggtact ctgaccctca gataaaggct cgagtggcca
     3841 tgttgtatct acctctgatt ggtattatca tggaaactgt acctcagctg tatgatttta
     3901 cagaaactca caatcaacga ggaagaccaa tttgtatagc cactgatgat tatgaaagtg
     3961 agagcggaag tatgataagc cagaccgttg ccatggcaat cgcagggaca tcggtccctc
     4021 aactaacaag gcctggcagt ttcctcctca cgtcaacgag tggcaggcaa cacactacct
     4081 tttcagcaga atcaagtcga agccttttga tctgtctact ttgggttctc aaaaatgcag
     4141 atgaaacagt tctacagaag tggtttacag atctctcagt cttgcagcta aaccggctat
     4201 tagatctgct ttatctctgt gtgtcttgct ttgagtataa agggaaaaaa gtgtttgaac
     4261 gaatgaatag cttgaccttt aagaaatcaa aagacatgag agcaaagctt gaagaagcta
     4321 ttcttgggag cataggtgcc aggcaagaaa tggtacggcg aagccgagga cagctcggta
     4381 cgtacacaat agcttctcct cctgagagaa gcccatctgg aagtgccttt ggaagtcaag
     4441 aaaatttgag gtggaggaaa gatatgactc actggcgtca aaacacagag aagcttgaca
     4501 aatcaagagc agagattgaa cacgaagcac tgattgatgg aaacctggct acagaagcaa
     4561 acctaatcat tttagataca ttagagattg ttgttcagac cgtttctgta acggaatcca
     4621 aagagagcat tcttggtgga gtgctaaaag tgctactaca cagcatggcc tgtaaccaaa
     4681 gtgcagttta tctacaacac tgttttgcta cacagagagc cttggtttca aagtttcctg
     4741 aactcttatt tgaagaagag acagagcagt gtgctgattt atgcctcagg cttctccgac
     4801 actgtagcag tagcatcggt acaatacggt cacacgccag tgcctccctt tacctactaa
     4861 tgaggcaaaa ctttgagatt gggaataact ttgccagggt taaaatgcag gtaacaatgt
     4921 cactatcctc cttggtgggc acatctcaga attttaatga agaattctta agacgttctc
     4981 taaagactat attgacatat gctgaagaag atctggaatt gagggaaaca acatttcctg
     5041 atcaggtcca ggatctggtt ttcaatctcc atatgattct ttctgatact gtgaaaatga
     5101 aggaacacca ggaggatcct gaaatgttga ttgatctaat gtacagaatt gccaagggtt
     5161 accagacctc tccagatctg cgattgacct ggttgcagaa catggcaggc aagcactcag
     5221 aacgaagcaa tcatgctgaa gctgcacagt gtctagtcca ctcagcagca cttgttgctg
     5281 aatatttgag catgctggag gaccggaaat atcttcctgt gggatgtgta acatttcaga
     5341 atatttcatc taatgtttta gaagaatctg cggtctcaga tgatgtggta tctccagatg
     5401 aagaaggtat ctgctctgga aaatacttta ctgagtcagg acttgtggga ttactggaac
     5461 aagcagctgc ttccttctct atggctggca tgtatgaagc agttaatgaa gtttacaaag
     5521 tacttattcc tattcatgaa gctaatcggg atgcaaagaa actatccaca attcatggta
     5581 aacttcaaga agcattcagc aaaattgttc atcagagtac tggctgggag cggatgtttg
     5641 gcacctattt tcgtgttggt ttttatggaa ccaagttcgg ggatttggat gaacaagaat
     5701 ttgtttacaa ggagcctgca ataaccaaac ttgcagagat atctcacaga ttggagggat
     5761 tttacggaga aagatttgga gaggatgtgg ttgaagtaat caaagactct aatcctgtag
     5821 acaagtgtaa attagatcct aacaaggcat atattcagat tacctatgtg gagccatact
     5881 ttgacacata tgagatgaag gacagaatca cctatttcga caaaaattac aatcttcgtc
     5941 gattcatgta ctgtacaccc tttactttag atggccgtgc ccatggggaa cttcatgaac
     6001 aattcaaaag gaagaccatt ctgactacgt ctcatgcctt tccttatatt aaaacaaggg
     6061 tcaatgtcac tcataaagaa gagatcatct taacaccaat tgaagttgct attgaggaca
     6121 tgcagaaaaa gacacaggag ttggcatttg caacacatca ggatcccgca gaccccaaaa
     6181 tgcttcagat ggtactccag ggatctgtag gcaccacagt gaatcagggg cctttggaag
     6241 ttgcccaggt ttttctgtct gaaataccta gtgacccaaa gctcttcaga catcataata
     6301 aactgcgact ctgctttaaa gattttacta aaaggtgtga agatgcctta agaaaaaata
     6361 agagcttaat tgggccggat caaaaggagt atcaaaggga actggagaga aactatcatc
     6421 gccttaaaga ggccctacag ccactgatca acagaaagat ccctcagtta tacaaggcag
     6481 tattgcctgt cacctgccac agagattcct tcagtcgaat gagccttcgc aaaatggatc
     6541 tctaaactga atgcacttgt tttattcatc tgcaaagagc catgtattca acatcgagtg
     6601 tgaaaagatc tattggaaaa caacatggaa tggaattctg gaaattatta ttcattgaag
     6661 aatgcagtgg ccaagaaaat atcaaatgta gattgttaac gcttgagaat catggctatg
     6721 gtttctaatg ttctggtaac aagctgttat cttttaagac attttaatga ctcaaaggta
     6781 cactatacat ttaccattat ttataccata gctaaggtta aaaatttatt cactttaagt
     6841 tcgtattttt taatttatat taccatttat agattcattt tggaaccatt ttaaatgtag
     6901 taatgcttat tttaaaggta ctattaaata tgtgaatgtt tacactaatt ttaccgagtg
     6961 ggacttcaaa atttttatta ttgacaatgg cagagaacaa ttaaagggtt gactcaagaa
     7021 ctagttccaa acctagcaga ataaaaatca tagatagccc caaattaatg agtttggtaa
     7081 ctgtttcaaa gttattttcc atttacatac ccaaaacagg aatttagaat tgcagaactt
     7141 tacttagtaa aacctttgtg taaaataatt taaatacggg gataactaat accagtgaca
     7201 acaccttaac ttgattaaat cttattacac caa
//
