LOCUS       NM_020812               6430 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens dedicator of cytokinesis 6 (DOCK6), transcript variant
            1, mRNA.
ACCESSION   NM_020812
VERSION     NM_020812.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6430)
  AUTHORS   Swiderska,M.K., Mostowska,A., Skrypnik,D., Bogdanski,P.,
            Jagodzinski,P.P. and Grzegorzewska,A.E.
  TITLE     Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single-nucleotide
            variants with hypercholesterolemia in the Polish population: a
            cross-sectional study
  JOURNAL   Pol Arch Intern Med 133 (2) (2023)
   PUBMED   36601873
  REMARK    GeneRIF: Associations of ANGPTL6, DOCK6, FABP1, and PCSK9
            single-nucleotide variants with hypercholesterolemia in the Polish
            population: a cross-sectional study.
REFERENCE   2  (bases 1 to 6430)
  AUTHORS   Dessay,M., Couture,E., Maaroufi,H., Fournier,F., Gagnon,E.,
            Droit,A., Brown,J.P. and Michou,L.
  TITLE     Attenuated clinical and osteoclastic phenotypes of Paget's disease
            of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant
            in the DOCK6 gene
  JOURNAL   BMC Med Genomics 15 (1), 41 (2022)
   PUBMED   35241069
  REMARK    GeneRIF: Attenuated clinical and osteoclastic phenotypes of Paget's
            disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare
            variant in the DOCK6 gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6430)
  AUTHORS   Zhang,Z.Y., Sun,Y.Y., Wang,H.C., Fu,W.N. and Sun,C.F.
  TITLE     Overexpression of DOCK6 in oral squamous cell cancer promotes
            cellular migration and invasion and is associated with poor
            prognosis
  JOURNAL   Arch Oral Biol 133, 105297 (2022)
   PUBMED   34742001
  REMARK    GeneRIF: Overexpression of DOCK6 in oral squamous cell cancer
            promotes cellular migration and invasion and is associated with
            poor prognosis.
REFERENCE   4  (bases 1 to 6430)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   5  (bases 1 to 6430)
  AUTHORS   Shaheen,R., Faqeih,E., Sunker,A., Morsy,H., Al-Sheddi,T.,
            Shamseldin,H.E., Adly,N., Hashem,M. and Alkuraya,F.S.
  TITLE     Recessive mutations in DOCK6, encoding the guanidine nucleotide
            exchange factor DOCK6, lead to abnormal actin cytoskeleton
            organization and Adams-Oliver syndrome
  JOURNAL   Am J Hum Genet 89 (2), 328-333 (2011)
   PUBMED   21820096
  REMARK    GeneRIF: A homozygous truncating mutation in dedicator of
            cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine
            exchange factor (GEF) known to activate two members of the Rho
            GTPase family: Cdc42 and Rac1, was identified.
REFERENCE   6  (bases 1 to 6430)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   7  (bases 1 to 6430)
  AUTHORS   Miyamoto,Y., Yamauchi,J., Sanbe,A. and Tanoue,A.
  TITLE     Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the
            dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth
  JOURNAL   Exp Cell Res 313 (4), 791-804 (2007)
   PUBMED   17196961
REFERENCE   8  (bases 1 to 6430)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   9  (bases 1 to 6430)
  AUTHORS   Cote,J.F. and Vuori,K.
  TITLE     Identification of an evolutionarily conserved superfamily of
            DOCK180-related proteins with guanine nucleotide exchange activity
  JOURNAL   J Cell Sci 115 (Pt 24), 4901-4913 (2002)
   PUBMED   12432077
REFERENCE   10 (bases 1 to 6430)
  AUTHORS   Lehman,A., Wuyts,W. and Patel,M.S.
  TITLE     Adams-Oliver Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27077170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011472.7, CV571923.1,
            AB037816.2, DC333132.1, AK316063.1, CX759906.1 and BC008335.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020812.3.
            
            Summary: This gene encodes a member of the dedicator of cytokinesis
            (DOCK) family of atypical guanine nucleotide exchange factors.
            Guanine nucleotide exchange factors interact with small GTPases and
            are components of intracellular signaling networks. The encoded
            protein is a group C DOCK protein and plays a role in actin
            cytoskeletal reorganization by activating the Rho GTPases Cdc42 and
            Rac1. Mutations in this gene are associated with Adams-Oliver
            syndrome 2. [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146786.1, AB037816.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294618.12/ ENSP00000294618.6
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC011472.7         60088-60119         c
            33-72               CV571923.1         1-40
            73-2076             AB037816.2         1-2004
            2077-2450           DC333132.1         204-577
            2451-3590           AB037816.2         2379-3518
            3591-3941           AK316063.1         1585-1935
            3942-4233           CX759906.1         317-608
            4234-6430           BC008335.1         591-2787
FEATURES             Location/Qualifiers
     source          1..6430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6430
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /note="dedicator of cytokinesis 6"
                     /db_xref="GeneID:57572"
                     /db_xref="HGNC:HGNC:19189"
                     /db_xref="MIM:614194"
     exon            1..128
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..6228
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dedicator of cytokinesis protein 6"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 6 isoform 1"
                     /protein_id="NP_065863.2"
                     /db_xref="CCDS:CCDS45975.1"
                     /db_xref="GeneID:57572"
                     /db_xref="HGNC:HGNC:19189"
                     /db_xref="MIM:614194"
                     /translation="MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLG
                     VPLTEVVEPLDFEDVLLSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKD
                     EKLDAQVRAAVEMYIEDWVIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASG
                     DERSGPEDSNDSRRGSGSPEDTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRR
                     NETLRRQHRPPALLTLYPAPDEDEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEP
                     IFGILALYDVREKKKISENFYFDLNSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSP
                     DIFLVIKLEKVLQQGDISECCEPYMVLKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRM
                     PFAWTAVHLANIVSSAGQLDRDSDSEGERRPAWTDRRRRGPQDRASSGDDACSFSGFR
                     PATLTVTNFFKQEAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKIDISPAPENPH
                     FCLSPELLHIKPYPDPRGRPTKEILEFPAREVYAPHTSYRNLLYVYPHSLNFSSRQGS
                     VRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTREAFTPVVYHNKSPEFYEEFKLHLP
                     ACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIPLLQHGRLRTGPFCLPVSVDQPP
                     PSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQDPYLDKFFTLVHVLEEGAFP
                     FRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVLDKLVRLVIRPPIISGQIV
                     NLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAFRLPGTEPSLPDGAPPV
                     TVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVSRILASKLLHEELAL
                     QWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRFPGRFLDDITALV
                     GSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAHYKQVATRLQS
                     SPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSSQA
                     PDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVHSLLCGH
                     DTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDTEGEG
                     DIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWVLK
                     NTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKAR
                     LEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEA
                     LVEGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHG
                     LATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFE
                     IGHNFARVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQ
                     DLMFNLHMILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAEL
                     GNHAEAAQCMVHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPD
                     EEGFCSGKHFTELGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAV
                     HGKLQEAFTKIMHQSSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISH
                     RLEEFYTERFGDDVVEIIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFD
                     RNYGLRTFLFCTPFTPDGRAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLT
                     PVEVAIEDMQKKTRELAFATEQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIP
                     EDPKLFRHHNKLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELERNYCRLREALQP
                     LLTQRLPQLMAPTPPGLRNSLNRASFRKADL"
     exon            129..216
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..392
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..461
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..591
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..804
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..890
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..957
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1107
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1188
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1342
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1470
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1564
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1727
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1845
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1916
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2055
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2157
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2244
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2476
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2638
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2802
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2898
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3039
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3153
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3324
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3464
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3634
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3795
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3978
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4105
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4190
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4287
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4422
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4575
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4734
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4735..4835
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..5028
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5029..5172
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5173..5304
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5305..5319
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5320..5445
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5446..5535
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5536..5772
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5773..5916
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6023
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6024..6185
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            6186..6430
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6430
                     /gene="DOCK6"
                     /gene_synonym="AOS2; ZIR1"
                     /note="major polyA site"
ORIGIN      
        1 gccccgcccc ggctgcccag aaccgggagg cggcggcggc ggcggggccg gggcccgggg
       61 cggcggcggc gggacgcgag gaccatggct gcctccgagc gccgcgcctt cgcgcacaag
      121 atcaacagga cggtggccgc agaggtgcgg aagcaggtgt cccgggaacg cagtggctcc
      181 ccccactcca gcaggcgctg cagcagctcc ctgggggtcc cactgactga agttgtcgag
      241 cccctggact ttgaggatgt acttctgagc cggccaccag atgctgagcc cgggcccctc
      301 agggacctgg tagaattccc agctgatgac ttggagctgc tgctgcagcc ccgggaatgc
      361 cggaccacgg agcccgggat ccccaaggat gaaaaactgg atgcccaggt gagggccgcg
      421 gtggagatgt atattgagga ctgggtcatt gtccacagaa ggtatcagta cctgagtgca
      481 gcatacagcc ccgtcaccac agacacacag cgggagcgac agaagggcct cccccgccag
      541 gtctttgagc aggatgcttc tggagacgag aggtccggcc ctgaggactc gaatgactcc
      601 cggcgtggct cgggctcccc ggaagacacc cctcgaagca gtggtgcctc tagcatcttc
      661 gacctgagga acctggcagc tgactcattg ctgccctctc tgctagagcg ggcggcccca
      721 gaagatgtgg accggcgcaa tgaaaccctt cgacggcagc accggccccc ggccctgctc
      781 accctctacc cggcacctga cgaggatgaa gccgtggaac gctgtagccg cccagagcca
      841 ccccgcgagc actttggaca aaggatcttg gtcaagtgtc tgtcgctcaa gttcgagatt
      901 gaaattgagc ccatctttgg gatcttggct ctgtatgatg tgcgggagaa aaagaagatc
      961 tcggagaact tctacttcga cctgaactcg gactccatga aggggctgct tcgggctcat
     1021 ggcacccacc ctgccatctc caccctggcc cgctctgcca tcttctctgt gacctacccc
     1081 tcacctgaca tcttcctggt catcaagttg gagaaggtgc ttcagcaagg ggacatcagt
     1141 gagtgctgtg agccttacat ggtgttgaaa gaagtggaca cagccaagaa caaagagaag
     1201 ctagagaagc tgcgcctggc ggccgagcag ttctgcaccc gcctgggccg ctaccgcatg
     1261 cccttcgcct ggacggccgt gcacttggcc aacatcgtga gcagcgctgg gcagctggac
     1321 cgggactctg actcggaggg cgagcgccgg ccagcctgga cagaccgccg ccgtcggggg
     1381 ccccaggacc gggcgagtag tggggacgac gcctgcagct tctctggctt ccgtccagcc
     1441 acgctaactg tcacaaactt ctttaagcag gaggctgagc gactcagtga cgaggacctc
     1501 ttcaagttcc tggctgacat gaggcgcccg tcgtccctgc tgcggcgact acgtcctgtg
     1561 actgcccagc tcaagatcga catttctccg gctcctgaaa atccccactt ctgcctctcc
     1621 cctgagctgc ttcatatcaa gccctacccg gaccccaggg gccggcccac caaggagatt
     1681 ctggagttcc ccgcccgcga agtctatgcc ccccatacca gctacaggaa cctgctgtac
     1741 gtgtacccgc acagcctcaa cttcagcagc cgccagggct ccgtgcgcaa ccttgctgtg
     1801 cgagtgcagt acatgacagg cgaggacccc agccaggctc tgccggtcat ctttggcaag
     1861 tccagctgca gtgaatttac ccgcgaggcc ttcacaccgg tggtctacca taacaagtcc
     1921 cccgagttct acgaggagtt caagctgcat cttccagcct gcgtgacaga gaaccatcac
     1981 ctgctgttca ccttctacca tgtcagctgc cagccccggc cgggcactgc cctggagaca
     2041 cccgtgggct ttacttggat cccactgctg cagcacgggc gcctgaggac cggccccttc
     2101 tgtctcccag tgtctgtgga ccagccgccg cccagctatt ccgtgctcac acccgatgtg
     2161 gcgcttccgg gcatgcgctg ggtggacggt cacaagggcg tgttcagtgt ggagctcaca
     2221 gccgtgtcct ctgtgcaccc ccaggacccc tacctggaca aattcttcac cctggtgcac
     2281 gtcctggagg agggagcctt cccattccgg ctcaaggaca ctgtgctgag cgagggcaac
     2341 gtggagcagg agctgcgggc cagtcttgca gcactgcgcc tggccagccc cgaacccctt
     2401 gtggccttct cccaccacgt gctggacaag ctcgtgcgtc tggtcatcag gcccccgatc
     2461 atcagtggcc agattgtgaa cctgggccgt ggagcctttg aagcaatggc ccatgtagtc
     2521 agccttgttc accggagcct ggaggcagcc caggatgccc gcggtcactg cccacagctg
     2581 gctgcctacg tccactacgc ctttcgcctt cctggcactg agcccagcct cccggatggg
     2641 gcccctccag tgacagtgca ggctgccaca ctggcccgtg gctctggtcg ccccgcaagc
     2701 ctctacctgg cgcgttccaa gagcatcagc agcagcaacc ctgacctcgc cgtggcccct
     2761 ggctctgtgg atgacgaggt ttcccgcatc ctggccagca agctgcttca cgaggagctg
     2821 gctctgcagt gggtggtcag cagcagtgcc gtacgcgagg ccatcctcca gcacgcctgg
     2881 ttcttcttcc agctcatggt gaagagtatg gcgctgcacc tgctgcttgg ccagcgacta
     2941 gacacacccc gcaagctgcg cttccccgga cgcttcctgg acgacatcac tgccttggtg
     3001 ggctctgtgg gcctggaggt catcacccgt gtccacaagg atgtggagct ggccgagcac
     3061 ctcaacgcca gcctggcttt cttcctcagt gaccttctgt ccctggtgga ccggggcttt
     3121 gtcttcagcc tggtccgggc ccactacaag caggtggcca cgcggctcca gtcgtcccct
     3181 aatccagcag ccctgctgac cctgcgcatg gaattcaccc gcatcctgtg cagccacgag
     3241 cactacgtga ccctcaacct cccctgctgc cccctgtcac ctccagcctc gccctccccc
     3301 tctgtgtcct ccaccacctc ccagagctcc accttctcca gccaagcccc ggaccccaag
     3361 gtgaccagca tgttcgaact gagtggacca ttccggcagc agcacttcct agctgggctc
     3421 ctgctgacgg agctggcact ggccctcgaa cctgaggctg aaggggcatt cctgttgcac
     3481 aagaaggcca tcagtgctgt gcacagcctg ctatgtggcc atgacactga cccccgctac
     3541 gccgaggcca ctgtgaaggc tcgtgtggcc gagctgtacc tgccactgct atcgattgca
     3601 cgggatacct tgccacggct gcatgacttt gctgagggcc caggtcagcg gtcaagactg
     3661 gcctcaatgc ttgactcaga cacagaaggc gaaggggaca ttgcgggtac catcaacccc
     3721 tctgtggcca tggccattgc tggtggcccc ctagcccctg gctcccgggc cagcatctcc
     3781 caggggccac caacggcttc tcgcgcaggc tgtgccctct ctgctgagtc aagccggacc
     3841 ttgctggcgt gtgtgctgtg ggtgctgaaa aacaccgagc cggcgctcct gcagcgctgg
     3901 gccactgacc tgacactccc ccagctggga cgtctgttgg atttgctgta cctttgccta
     3961 gctgcctttg agtacaaggg gaaaaaggcc tttgaacgca tcaacagcct cacattcaaa
     4021 aaatctctgg atatgaaggc gcggctagag gaagccattc tgggtaccat cggagctcga
     4081 caagaaatgg ttcggcgaag tcgtgagagg agcccgtttg ggaatccgga gaatgtgcgc
     4141 tggcggaaga gcgtcacaca ctggaagcaa acctcagacc gcgtggacaa gaccaaggat
     4201 gaaatggaac acgaggcctt ggtggaaggg aacctggcaa ccgaggcaag cctagtggtt
     4261 ctggacacac tggagatcat cgtgcagacg gtgatgcttt cagaagcccg ggagagcgtc
     4321 ttgggggcag tgctgaaggt tgtgctgtac agcctgggca gtgcccagag tgccctcttc
     4381 ttgcagcatg gcctggccac ccagagggcc cttgtgtcca agttcccgga gctgctgttc
     4441 gaggaggaca cggagctgtg tgccgacctg tgcctgaggc tcctacgaca ctgtggcagc
     4501 cgcatcagca ccatccgcac gcacgccagc gcctcgctgt acctgctcat gcgacagaac
     4561 ttcgagatcg gccacaactt tgcccgtgtg aagatgcagg tcaccatgtc tctctcgtcc
     4621 ctggtgggga cgacgcagaa cttcagtgaa gagcacctgc gacgttcact caaaaccatc
     4681 ctcacctatg ctgaggagga catggggctg cgggacagca ccttcgcaga gcaggtccag
     4741 gacctgatgt tcaacctgca catgatcctg acggacacgg tgaagatgaa ggaacaccag
     4801 gaggaccctg agatgctcat cgacctcatg tacagaattg cccggggcta ccagggctca
     4861 ccggaccttc ggctgacctg gttgcagaac atggccggga agcacgcgga gctgggcaac
     4921 cacgccgagg ccgcccagtg catggtgcac gcggccgccc tcgtggctga gtacctcgcc
     4981 ctgctcgagg accaccgcca cctgcccgtg ggctgcgttt ccttccagaa catctcatcc
     5041 aacgtgctag aggagtccgc catctccgac gacatcctgt cgcccgacga ggagggcttc
     5101 tgctccggga agcacttcac tgagctgggg ctggtagggt tgctggaaca ggcagccggc
     5161 tacttcacca tgggcgggct ctacgaggcg gtgaatgagg tctacaagaa cctcatcccc
     5221 atcctggaag cccaccgtga ctacaagaag ctggccgcgg tgcacggcaa actgcaggag
     5281 gccttcacca agatcatgca ccagagttcc ggctgggagc gcgtgttcgg gacgtatttc
     5341 cgcgtgggct tctacggcgc ccacttcggt gacctggatg agcaggagtt tgtgtacaag
     5401 gagccatcga tcacgaagct ggcagagatc tcacaccggc tggaggagtt ctacacggag
     5461 agatttggcg acgacgtcgt tgagattatc aaagactcta accctgtgga caagtccaag
     5521 cttgactcac aaaaggccta catccagatc acgtatgtgg aaccgtactt tgatacctac
     5581 gagctcaagg accgggtgac ctactttgac cgcaactatg ggcttcgcac attcctgttc
     5641 tgcacgccgt tcacgccgga tgggcgcgca cacggggagc tgcccgagca acacaagcgt
     5701 aagacgctgc tcagcaccga ccacgccttc ccctacatca agactcgcat ccgtgtgtgc
     5761 caccgggagg agacggtgct gacgccagtg gaggtggcca tcgaggacat gcagaagaag
     5821 acacgggagc tggcctttgc caccgagcag gacccaccag atgctaagat gctacagatg
     5881 gtgcttcagg gctctgtagg gcccaccgtg aaccagggtc ccctggaggt ggcccaggtg
     5941 tttttagcag agatcccgga agaccccaag ctcttccggc atcacaacaa attgcggctc
     6001 tgcttcaagg acttctgcaa gaaatgtgag gatgcgctgc ggaaaaataa ggccctgatt
     6061 gggccggacc agaaggagta ccaccgtgag ctggagcgca actactgccg cctgcgggag
     6121 gctctgcagc ccctgcttac ccagcgcctg ccccagctga tggcacccac cccacccggc
     6181 ctcaggaact ccttgaacag agcaagtttc cgaaaggcag acctctgagc ccacaaggac
     6241 caaagctgta cctagaggaa ccagcacccg ggcctcagct gtctgtgctg cgaggggagt
     6301 ctgccctggt gcccactggg ctgtggggtg accacactgt acttggggct gggccctctg
     6361 cccctgtgtc cccatctgtg tgcactgatg cttcctccct tttttaattt aaaatggttt
     6421 ttataagcaa
//
